We propose connecting the acquisition and processing of cardiovascular MR (CMR) data with biomechanical cardiac modeling. Physical and physiological character predisposes biomechanical models to predictivity, and CMR data turn them into patient-specific regime. A high computational demand is addressed by applying a spatially-reduced model: the geometry and kinematics are simplified, but all other physical properties kept. The approach is illustrated by example of Tetralogy of Fallot patients, in whom we are able to access the myocardial contractility pre- and post-pulmonary valve replacement aiming at deciding on optimal therapy timing – the problem that has not been completely solved by sole CMR.
Patients with repaired tetralogy of Fallot (rToF) suffer from right ventricular (RV) volume and/or pressure overload due to chronic pulmonary regurgitation (and possible residual RV outflow tract stenosis) leading to RV dilatation (hypertrophy). Pulmonary valve replacement (PVR) is an intervention of choice. Timely PVR may cease the pathological RV remodeling, and the ventricle may even reverse-remodel back to normal size (Fig. 1). Considering the lifespan of a biological valve being ~10 years1, however, PVR tends to be deferred ideally until the latest point before irreversible changes of RV occur.
Cardiovascular Magnetic Resonance (CMR) is an invaluable technique in assessing the morphological and functional properties and the progress of remodeling changes during chronic ventricular overloading thanks to a limited inter-observer variability2 and no ionizing radiation. Among the main CMR indicators for performing PVR belong RV EDV, ESV, level of valvular regurgitation and RV ejection fraction. These measures, however, do not provide a sufficient sensitivity and specificity3 to predict the RV reverse-remodeling, therefore other criteria need to be sought. In this work, we suggest including biomechanical modeling4 – which puts into consideration physical and physiological principles of the cardiovascular system – to augment the information obtained from the acquired and processed CMR. By constraining the biomechanical model by clinical data, we access additional information not directly visible in the data, e.g. the parameters of myocardial contractility, relevant for the ventricular reverse-remodeling.
Methods
Cine MRI covering the heart ventricles in short axis, and the phase-contrast flow through the aortic and pulmonary valves were acquired prior to percutaneous PVR of 3 rToF patients. Additionally, one healthy subject with CMR and invasive ventricular pressures was included. MRI data were processed to time-vs-ventricular volume, and time-vs-flow by using image registration-based segmentation (IRTK library5 included in the visualizer Eidolon6). Pressures in the RV, pulmonary artery, LV and aorta were recorded during percutaneous PVR before and after deploying the valve. The volume, flow and pressure data were combined into a common time-space (Fig. 2).
The spatially-reduced order biomechanical model7 of a single ventricle (geometry and kinematics are simplified, but all other physical properties correspond to the complex 3D heart model8, Fig. 2) was calibrated separately to the LV and RV of each patient by using the measured data and following the steps:
Results
Fig. 3 demonstrates that our spatially-reduced model can be calibrated to the patient’s data even for the pathological RV. The values of myocardial contractilities for each ventricle (in all subjects) are displayed in Table 1. Firstly, in comparison to the healthy RV, the contractility in all rToF cases is chronically increased as the RV works against an increased afterload. Thanks to the model, we can also quantify a reduction of RV contractility post-intervention: a nearly complete normalization in Patient 1, a decrease by 15-20% in Patient 3 (clearly beneficial for the patients), however, no reduction in Patient 2.Conclusion
Turning a 3D model8 into patient-specific regime provides some clinically relevant predictive capabilities11. Due to a high computational demand and complexity of setting up the model, this time-consuming process should be rather seen as an offline platform after CMR exam. The spatially-reduced order model used in this work, however, is fast to set up, can run nearly real-time, and provides an additional insight into the acquired MRI data. This preliminary work shows potential in coupling simplified biomechanical modeling techniques with the MR imaging process. A direct inclusion within the MRI console could be realistically envisioned to augment the interpretation of the CMR exam. This study used interventional pressures in addition to CMR (XMR procedure). The potential of the model while using the invasive data, and also solely non-invasive CMR will be further explored to predict the long-term reverse remodeling12.1. Oosterhof T, Meijboom FJ, Vliegen HW, et al. Long-term follow-up of homograft function after pulmonary valve replacement in patients with tetralogy of Fallot. Eur Heart J. 2006;27(12):1478-1484. doi:10.1093/eurheartj/ehl033.
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