Huijun Chen1, Jiaqi Dou1, Le He1, Chunyao Wang1, Haikun Qi1, Qiang Zhang1, and Xihai Zhao1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua university, Beijing, China
Synopsis
Dynamic
contrast-enhanced MRI (DCE-MRI) has been proven to be able to quantify the
inflammation and neovasculature in the atherosclerotic plaque of carotid
artery. However, few studies has focus on the DCE-MRI of intracranial artery
atherosclerosis, which is another major cause of cerebral ischemic events. This
study found that the Ktrans of
intracranial artery calculated from DCE-MRI was significantly lower at
follow-up comparing with baseline after 6-month statin therapy, suggesting
DCE-MRI a good tool for therapeutic response evaluation for intracranial artery
atherosclerosis
Purpose
Dynamic
contrast-enhanced MRI (DCE-MRI) has been proven to be able to quantify the
inflammation and neovasculature in the atherosclerotic plaque of carotid artery
[1]. Higher transfer constant (Ktrans) calculated from pharmacokinetic modeling of
carotid DCE-MRI was found to be a risk factor of cardiovascular events [2].
However, carotid plaque, on which many previous studies focus, only responsible
for part of the stroke, atherosclerosis of the intracranial artery is another
major cause of stroke [3]. Recently, Vakil et al. have studied the DCE-MRI
of plaque in intracranial arteries [4]. This study further investigate the
quantitative change of the intracranial plaque after 6-month statin therapy
with black-blood DCE-MRI technique.Methods
Fifteen
patients with stroke or transient ischemic attack (TIA) happened within 10 days
and an intracranial plaque found in middle cerebral artery (MCA) considered to
be responsible were enrolled in this study. All the patients were imaged twice
by a turbo spin-echo (TSE) black-blood DCE-MRI sequence on a 3T whole body MR scanner (Philips TX) with a head
coil. The first scan was carried out within 10 days of the first ischemic event,
and the second scan was acquired at six months later. During this period, all
patients were under statin therapy. The imaging parameters were: slice
number=1, slice thickness=5 mm, TR/TE=900/7 ms,
in-plane resolution=0.6 mm,
temporal resolution=16.2 s, phases=15, total acquisition time = 243s. During the
DCE acquisition, 0.1mmol/kg Gd-DTPA were injected with a power injector at
2ml/s coincident with the third phase. Both DCE imaging was done perpendicular
to the MCA and at the location with most severe stenosis. In the image
analysis, the vessel walls were manually outlined blind to the time-point and
patient information. The mean intensity curve of the vessel wall were then calculated.
Then, the Ktrans was calculated by the Patlak model [5]. A
population AIF consistent with a
traditional biexponential equation [6]
was used. The concentration curve of intracranial
vessel wall was converted from intensity based on assumed preconstrast T1 (1150 ms) and signal equation
[7].
The Ktrans value of
all the patients at the baseline scan and 6-month follow-up were reported and
compared using paired t-test.Results
The images and intensity curve of an example
case were shown in Fig.1 The enhancement of the follow-up scan was obvious
lower. Overall, significant decreased Ktrans can be observed at the follow-up after the patients having
statin therapy for 6-month, comparing with the base-line scan (mean: 0.27±0.05 min-1 vs. 0.15±0.04 min-1, p<0.001), as shown in
Fig. 2.Discussion and Conclusion
In
this study, we found that the Ktrans of intracranial artery calculated from DCE-MRI
was significantly lower at follow-up comparing with baseline after 6-month
statin therapy. Previous study [8]
showed that 1-year statin therapy can reduce the neovasculature in carotid
plaque. Although the physiological meaning of the Ktrans still needs further histological
investigation, it may be related to the angiogenesis of plaque, according to
the experience in carotid artery plaque [1]. If so, the results of this study suggested that the statin
therapy also can reduce the neovasculature in intracranial plaque. Also, this
change can be observed within only 6-month, indicating that the DCE-MRI can detect
very early change in intracranial plaque. Thus, the DCE-MRI could be a useful
tool in therapeutic response evaluation for intracranial artery atherosclerosis.Acknowledgements
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