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Voxel Level Radiologic–Pathologic Validation of DCE-MRI with ISUP Grade in Prostate Cancer
Qing Zhang1, Xiaoyu Lv1, Chengwei Zhang1, Qinglei Zhang2, Ming Li2, Yao Fu3, Jun Xie4, Jiangfen Wu5, Bing Zhang2, and Hongqian Guo1

1Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, China, 2Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 3Department of Pathology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, 4United Imaging Healthcare Co., Ltd, Shanghai, China, 5GE Healthcare, Nanjing, China

Synopsis

The biggest challenge in patients with newly diagnosed PCa is shifting from cancer detection or staging alone to identifying them with aggressive disease. The PI-RADS v 2 recognizes the role of DCE-MRI is limited but is essential. This work presented a radiology pathology correlation framework that enabled identification of promising in vivo DCE MRI markers of PCa risk at voxel level. The relationship between ISUP grade and DCE-MRI (Ktrans and Kep) suggests that it may be used as a component of active surveillance to noninvasively detect high-grade PCa and affect staging and treatment.

Introduction

The goals of prostate cancer (PCa) diagnosis are detecting, staging, and characterizing the biologic aggressiveness as a prognostic marker[1]. The biggest challenge in patients with newly diagnosed PCa is shifting from cancer detection or staging alone to identifying those patients with aggressive disease who would benefit from more radical therapy, while sparing those with indolent cancers[2]. The Prostate Imaging Reporting and Data System (PI-RADS) version 2 recognizes that the evidence supporting the role of dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) is limited, and that the added value provided by DCE MRI appears to be modest[3]. Nonetheless, PI-RADS version 2 recommends that DCE be included in MRI scans, describing the DCE sequence as essential. Prior reports show that the quantitative signal derived from DCE MRI is associated with aggressive PCa as measured by ISUP grade[4]. We evaluated the reliability of DCE MRI to predict variance with ISUP grade at the voxel-level within clinically demarcated PCa regions.

Experimental Design

Thirteen patients (age: 67.31±9.16 year) were scanned, given institutional ethics approval and informed written consent, on a 3.0T MR scanner system (MR770, UIH, Shanghai, China). The DCE protocols were used to obtain the precontrast T1map and dynamic contrast data with 3D SPGR sequence, TR=4.3ms, TE=1.8ms, 28 slices, slice thickness 2mm, FOV 28x38cm2, resolution 306x416, BW=450Hz. T1map scan was based on VFA method with FA=15/12/9/6/3 degrees. The dynamic scan was performed for 75 phases with temporal resolution of 4.7 sec, scan time=5’50’’ in total, administration of 0.1 mmol/kg GD-DPTA at the beginning of dynamic scan, using FA=10 degree. The Pharmokinetic parameters including Ktrans and Kep for prostate were obtained by processing the presurgical DCE MRI data using the extended Tofts model. All DCE MRI data were processed using whole mount sectioning after radical prostatectomy. Regions of tumor were identified by an uropathologist. Stained prostate sections were scanned at high resolution (75 mm/pixel). A grid of tiles corresponding to voxel dimensions was graded using the ISUP grade system (Fig. 1).

Results

Ktrans and Kep dirived from DCE-MRI were found to distinguish between PCa and benign tissue. Significant differences were also found between benign tissue (ISUP 0 Grade) and PCa classified as low-grade or high-grade (Fig. 2).

Conclusions

This work presented a radiology pathology correlation framework that enabled identification of promising in vivo DCE MRI markers of PCa risk. The relationship between ISUP grade and DCE-MRI (Ktrans and Kep) suggests that DCE-MRI may be used as a component of active surveillance to noninvasively detect high-grade PCa and affect staging and treatment. Furthermore, because it can detect variations in tumor grade with voxel-level precision, DCE-MRI may be a promising option for planning of focal procedures, such as MRI-guided targeted biopsies and targeted radiotherapy, where identifying the area with the most aggressive disease is particularly important. Moreover, the MRI images matched to histopathology sections were selected by experience, and automatic algorithm image matching will be better in our future work.

Acknowledgements

No acknowledgement found.

References

[1] van Niekerk CG, van der Laak JA, Hambrock T, et al. Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer. Eur Radiol. 2014. 24(10): 2597-605.

[2] Guneyli S, Erdem CZ, Erdem LO. Magnetic resonance imaging of prostate cancer. Clin Imaging. 2016. 40(4): 601-9.

[3] Weinreb JC, Barentsz JO, Choyke PL, et al. PI-RADS Prostate Imaging - Reporting and Data System: 2015, Version 2. Eur Urol. 2016. 69(1): 16-40.

[4] Epstein JI, Zelefsky MJ, Sjoberg DD, et al. A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. Eur Urol. 2016. 69(3): 428-35.

Figures

Fig.1 Ktrans, Kep, "Digital whole mount prostate pathology map" grid, and "Digital prostate map" ISUP grade for one patient. (A), Ktrans and Kep MR images, after transformation to correspond to the histopathology slides, (B), MR images grid overlay "Digital whole mount prostate pathology map" (C), "Digital whole mount prostate pathology map" grid overlay color-coded for ISUP grade.

Fig.2 Ktrans and Kep derived from DCE-MRI grouped by pathologic ISUP grade using data from all voxels graded in all cases. Error bars, SEM.

Proc. Intl. Soc. Mag. Reson. Med. 26 (2018)
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