Chemical exchange spin-lock (CESL) is a recently reported technology for probing metabolites which have intermediate to fast chemical exchange with bulk water. However, the conventional CESL is susceptible to B1 radiofrequency (RF) and B0 field inhomogeneity. The presence of these system imperfections leads to signal distortions and errors in contrast map. In this work, we report an approach to address this problem. We used simulation and in vivo experiments to demonstrate our proposed method.
The proposed RF pulse cluster for CESL is shown in Figure 1. We placed adiabatic half passage (AHP) and reverse AHP pulses at the two sides of a constant amplitude spin-lock. It can be shown that if the following condition is satisfied:$$\omega_{1,max}=\omega_{sl}, [1]$$where $$$\omega_{1,max}$$$ is the maximum B1 amplitude of the AHP and the reverse AHP pulse, and $$$\omega_{sl}$$$ is the frequency of spin-lock (FSL), the spins will be effectively locked by the effective spin-lock field at the following orientation: $$\theta(r)=\begin{cases}\arctan(\frac{\tilde{\omega}_{sl}\left(r\right)}{\triangle\omega_{c}+\triangle\omega_{0}(r)})+\pi, & if\quad \triangle\omega_{c}>0\quad and\quad\triangle\omega_{c}+\triangle\omega_{0}(r)\leq0 \\\arctan(\frac{\tilde{\omega}_{sl}\left(r\right)}{\triangle\omega_{c}+\triangle\omega_{0}(r)})-\pi, & if\quad \triangle\omega_{c}<0\quad and\quad\triangle\omega_{c}+\triangle\omega_{0}(r)\geq0\\\arctan(\frac{\tilde{\omega}_{sl}\left(r\right)}{\triangle\omega_{c}+\triangle\omega_{0}(r)}), &otherwise\end{cases}, [2]$$where $$$\triangle\omega_{c}$$$ is the resonance frequency offset (FO), $$$\triangle\omega_{0}(r)$$$ is the B0 field inhomogeneity, and $$$\tilde{\omega}_{sl}$$$ is the actual spin-lock B1 amplitude, which is the expected spin-lock amplitude under the influence of B1 RF inhomogeneity. We measured R1rho at different resonance frequency offsets with the following relaxation model5-7:$${M}_{e}(TSL)=A\cdot{e}^{-R_{1rho}\cdot{TSL}}+B, [3]$$where $$${M}_{e}(TSL)$$$ is the longitudinal magnetization at the end of the reverse AHP at different time of spin-lock (TSL), and A and B are terms independent of TSL. R1rho can be understood as superposition of three terms, including the water relaxation, relaxation due to the magnetization transfer effect (MT), and relaxation due to the chemical exchange effect.8 Assuming symmetrical MT effect with respect to the reference water point accross a range of FO, performing R1rho asymmetry analysis, i.e. R1rhoasym=R1rho(-FO)-R1rho(+FO) can theoretically removes water relaxation and MT effects, leaving only the chemical exchange term that is specific to the metabolite of interest.
We performed CEST, conventional CESL and our proposed method (adiCESL) using simulation and in vivo experiments. Simulations were performed using cartilage parameters, firstly without and then with 90% B1 and 50Hz B0 field inhomogeneity. In vivo knee data sets were acquired from a Philips Achieva TX 3.0T system using an eight channel T/R knee coil (Invivo Corp, Gainesville, USA). 2D Fast Spin Echo was used for imaging data acquisition. CEST, CESL and adiCESL were performed at resonance frequency offset same as the simulations. The CEST pulse waveform consists of 4 repeated 200ms constant amplitude B1 RF pulses. The acquisition parameters include: resolution 1mm x 1mm, slice thickness 5mm, TR/TE 2000/16ms, B1 of CEST 85Hz, CESL FSL 200Hz, and adiCESL FSL 300Hz. The region of interest (ROI) was drawn on patella cartilage and muscle. For both simulation and in vivo experiments, an order of 12 polynomial fitting was used to fit the z-spectrum or R1rho-spectrum to perform asymmetry analysis. For CEST, the lowest signal intensity of the interpolated fitted curve at each pixel was used to calculate B0 field inhomogeneity and the Z-spectrum was shifted along the frequency offset axis correspondingly to correct the field inhomogeneity effect.
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