Yingna Li1, Fengmei Fan2, Zhiyuan Feng1, Shuping Tan3, and Fude Yang3
1Radiology department, Beijing Huilongguan Hospital, Beijing, China, 2Psychiatric research center, Beijing huilongguan Hospital, Beijing, China, 3Psychiatric research center, Beijing Huilongguan Hospital, Beijing, China
Synopsis
To explore the brain structual imaging differences between schizophrenic patients with or without violence risk. By structual MRI and Freesurfer software,the study founds that schizophrenic patients with violence risk show the brain cortex thickness and volum reduction and cortical meancurvature increase , especially the reduction of the cortex thickness in the postdorsal cingulate gyrus .
Purpose
This study utilized structual magnetic resonance imaging (MRI) with FreeSurfer software to assess different brain cortical morphology changes(whole brain cortical thickness,surface area,volume and meancurvature) in schizophrenic patients with violence risk and to elucidate the correlation between the obtained brain characteristics and clinical parameters.
Method
Sixty-six schizophrenic patients(M:F=40:26) were classfied into 2 groups (violence: nonviolence group =49:17) based on the Modified Overt Aggression Scale(MOAS) to analyze the brain structure differences. Individuals in each group underwent structual MRI, then, FreeSurfer was used to carry out subsequent brain structure analysis.The statistical software used in this study was SPSS22.0.Result
There were no statistical significance difference in gender, age ,duration of education,diagnosis ,family history between violence and nonviolence group (P>0.05). Compared with nonviolence group, the violence group showed increased cortical meancurvature in the left cingulate sulcus (0.0104±0.0132 vs.0.1131±0.0107，P=0.006),reduced cortical thickness in the right postdorsal cingulate gyrus (3.2771±0.2993vs.2.999±0.2637,P=0.001)and the left occipital pole（2.2471±0.2237 vs.2.0971±0.1856,P=0.008）.Brain volume showed reductions in the left temporal middle gyrus(8734.12±1091.164 vs.7562.33±1195.055,P=0.001), the left transverse temporal sculus(567.71±143.795 vs.466.57±117.752,P=0.005）and the right superior frontal sculus(4503.53±737.935 vs.3856.24±799.814,P=0.005) in violence risk schizophrenia brains .The ROC(Receiver operating characteristic) curve demonstrated that the left cingulate sulcus and left superior precentral sulcus meancurvature can be used to diagonse the violence risk of the schizophrenia, the AUC(area under curve ) is 0.715(95%CI:0.566-0.865,P=0.008)and 0.726(95%CI:0.578-0.875,P=0.006)respectively. The multinomial logistic regression model adjusting the age, gender,the diagnosis,duration of schizophrenia and education,and family history,the right postdorsal cingulate gyrus cortical thickness is shown to be an independent factor for the violence risk of schizophrenia (OR:0.003[0.000，0.174],P=0.005).All results were adjusted by FDR(false discovery rate) correction(P<0.05).Conclusion
A reduction in the brain cortex thickness and volum and an increase in the cortical meancurvature may be associated with schizophrenia with violence risk. The right postdorsal cingulate gyrus cortex thickness could predict violence of schizophrenia as an independent factor.
Acknowledgements
No acknowledgement found.References
No reference found.