John Zhen1, Robin Dykstra1, and Sergei Obruchkov2
1School of Engineering, Victoria University of Wellington, Wellington, New Zealand, 2School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington, New Zealand
Synopsis
Magnetic
Resonance Imaging has established itself as indespensible utility in health
sector for over 3 decades, yet remained inflexible in its form factor. By
taking advantage of modern advances in miniturisation and improved efficiency
of electronic devices along with the developments of single sided magnet probes
this abstract presents a handheld, battery powered portable MR spectrometer
system which can be used for tissue analysis and sample charectarisation
outside of an imaging suite.
Purpose
Develop MR spectrometer console based on modern electronics devices in an attempt to take the MR outside of the imaging suite and enable researchers to explore possible applications of this technology in healthcare and industry.
Introduction
Magnetic Resonance Imaging has
established itself as an indespensible utility in health sector for over 3
decades, yet remained inflexible in its form factor. The idea behind mobile MR system
is to enable users to bring the system to subject instead of bringing the subject to the system,
which yet to be fully realized. By sacrificing high spatial resolution and
utilising a light weight single sided
magnet design enables us to gain most contrast information such as T1,
T2 and self diffusion parameters within the sensitive region of the
system1.
Thus we have developed a fully
integrated mobile MR platform for use with several types of NMR MOUSE sensors
such as the Mini-MOUSE2. The mobile platform was made possible by the successful
development of compact and efficient Class-D RF power amplifiers combined with
a recently released System On a Chip (SoC) device. The SoC device is itself a
combination of a high performance dual core ARM processor and Field
Programmable Gate Array (FPGA) fabric on
a single chip. This allows us to run a linux based operating system, data
processing system, pulse sequencer, digital receiver and Tx/Rx control logic. A
web based user interfaces is accessible through WiFi connectivity, while a high
density LiPo battery pack provides power to the system which can operate for up
to 6 hours of continous use on a single charge.Materials and Methods
A
prototype system was built using a ZYNQ SoC FPGA module running a Linux OS with a
WiFi connection to an iPad running a web based user interface3,4. A 30 W Class-D RF power
amplifier and preamp/duplexer was integrated to work with the 17 MHz, Mini-MOUSE
sensor. DAC and ADC devices were used to provide the necessary Tx/Rx analogue/digital
conversion and a 70 dB gain block was also included
to provide the required signal amplification. One key feature of the new
platform is that the data from the FPGA based digital receiver is automatically
streamed to the main processor system memory via a DMA controller. This allows zero
delay between acquisitions and one can also snoop at the data while it is being
acquired. The fully integrated system, with rechargeable Lithium batteries to
allow six hours of operation, fits in a case measuring 150x120x65 mm and
weighs 800 grams, (Figure 1). Experiments showed successful relaxometry measurements on polymer composites and rubber samples (Figure 2). Conclusion
We have successfully demonstrated the development of an ultra compact and portable MR spectrometer console system which is capable of acquiring relaxometry and diffusion information. Experiments have shown
successful effective T2 measurements of various samples showing promise for potential use of such a system in healthcare and industrial applications.Acknowledgements
No acknowledgement found.References
1.
J. Viess et.al (2016) Monitoring the animals' health status during vivisection by low-field NMR. MRPM 2016 Bologna Italy.
2.
D. Oligschlager, et.al (2015), A Miniaturized
NMR-MOUSE with a High Magnetic Field Gradient (Mini-MOUSE), Springer, Applied
Magnetic Resonance, 181-202, 46
3. www.xilinx.com
4. www.avnet.com