Introduction

We aimed to find the endophenotype of type 2 diabetes mellitus (T2DM) by investigating the gray matter volume and cerebral blood flow (CBF) of T2DM population and their discordant siblings of first degree relatives without diabetes (high risk, HR group) using voxel-based morphometry (VBM) analysis and three-dimension arterial spin labeling (3D-ASL) scan.

Methods

Twenty six pairs of T2DM patients and their discordant siblings of first degree relatives without diabetes were included in this study. We also recruited twenty six healthy volunteers as control (HC group). All participants underwent scannings of 3D T1WI and 3D pseudo-continuous ASL on a 3.0T whole-body MRI scanner (Discovery 750, GE Medical System, Milwaukee, WI). Data post-processing and statistical analysis were performed using SPM8 package in MATLAB (version 7.6).

Results

As compared with HC group, T2DM group exhibited significant atrophy mainly in frontal, temporal, parietal, occipital and insular lobes. Meanwhile CBF was increased in right prefrontal and temporal lobes. The HR group showed significant atrophy in right temporal and left insular lobes. Decreased CBF was found in left rolandic operculum area, bilateral temporal lobes (mainly in the right including mesial temporal lobe) and right supramarginal gyrus.

Discussion and Conclusion

The high risk population exist atrophy in right temporal and left insular lobes in consistent with T2DM patients, which may indicate an endophenotype of T2DM in morphological imaging. The decrease of CBF was more popular in high risk group other than T2DM patients (most of them have been treated with medications) and it was often found in the right temporal lobe accompanied with atrophy, which may be regarded as another endophenotype of T2DM in hemodynamic imaging.

Acknowledgements

No acknowledgement found.

References

No reference found.