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Study of functional connectivity of default mode network and frontoparietal network in neuromyelitis optica
Han Yongliang1, Li Yongmei1, LUO Qi1, ZENG Chun1, WANG Jingjie1, DU Silin1, ZHANG Xiaohui1, and GUO Youyou1

1Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China

Synopsis

Neuromyelitis optica (NMO) is an inflammatory, demyelinating syndrome of the central nervous system characterized by severe attacks of optic neuritis and myelitis, but investigators in several studies observed abnormalities in deep gray matter. Functional MRI (fMRI) has the potential to further understanding of the neuropathologic mechanisms of NMO. In the present study, our aim was to investigate patients with NMO-related alterations of brain functional connectivity(FC) in resting state in default mode network (DMN) and frontoparietal network(FPN) using independent component analysis(ICA) and their correlations with clinical features.

Objective

To evaluate the difference of brain default mode network (DMN) and frontoparietal network (FPN) connectivity of neuromyelitis optica (NMO) by using independent component analysis (ICA), and the correlation with clincal score.

Methods

Twenty patients with NMO (NMO group) and twenty healthy controls (control group) underwent rest-state fMRI. The fMRI data were analyzed by using GIFT software, and the differences of functional connectivity(FC) between the two groups were compared with SPM8. The correlation between altered parameters of FC and expanded disability status scale (EDSS) scores, disease duration were further explored using the Pearson correlation coefficients.

Results

Compared with the control group, the FC score of DMN in NMO group significantly decreased in the right middle frontal cortex and right middle occipital cortex, while increased in bilateral lingual gyrus, extended to right superior parietal lobule and left supplementary motor area; the FC score of FPN decreased in bilateral cuneus cortex, while no FC score increased area. In addition, the FC score changes of right lingual gyrus correlated with disease duration.

Conclusion

The FC abnormalities in DMN and FPN in NMO patients may provide a evidence that the spinal cord and optic neuritis not only caused corresponding clincal symptoms but also latent brain damage, valuable method to evaluate neurophysiological changes, which probably caused by a retrograde degeneration of neurons secondary to spinal cord damage or functional network reconstitution, and may help to differential diagnosis with spinal multiple sclerosis.Brain functional networks are complex and interconnected networks with the complexity of damage and compensatory process.

Acknowledgements

This study was supported by the National Nature Science Foundation of China under Grant (81371309) and Chongqing Health Bureau Grant (2012-1-017) and the National key clinical specialist construction Programs of China ([2013] 544).The authors would like to thank all the subjects who participated in this study.

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Figures

The FC score of DMN in NMO group significantly increased in bilateral lingual gyrus, extended to right superior parietal lobule and left supplementary motor area(Uncorrected, P < 0.001, the cluster size was greater than 15 voxels).

The FC score of DMN in NMO group significantly dcreased in the right middle frontal cortex and right middle occipital cortex(Uncorrected, P < 0.001, the cluster size was greater than 15 voxels).

The FC score of FPN in NMO group significantly decreased in bilateral cuneus cortex(Uncorrected, P < 0.001, the cluster size was greater than 15 voxels).

The correlations between the duration and FC score in right lingual gyrus in NMO patients(r = 0.682，P = 0.001).

Proc. Intl. Soc. Mag. Reson. Med. 25 (2017)
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