INTRODUCTION & OBJECTIVE: The objective of this study was to investigate whether T2 weighted images, MR spectroscopy, diffusion-weighted imaging (DWI) of the locally advanced cervical cancer (LACC) could be used to assess to post-treatment response of CCRT at the higher magnetic field strength of 3.0 T. METHODS: Retrospectively thirty nine women with LACC received magnetic resonance were enrolled at one more different times after CCRT. If high signal intensity was still observed on T2WI after CCRT we considered as viable cancerous tumor area. In MRS pattern, we considered as positive viable cancer if the calculated choline peak were 2 times than the creatinine peak. In DWI, we considered as positive viable if high signal intensity observed in cervix. Confirmative diagnoses were determined with PET-CT or cervical biopsy. Accuracy rates were analyzed between MR images and confirmative diagnosis statistically. For the statistical analysis, chi-square test was used with SPSS version 18.0. RESULTS: 73 MR studies of 39 patients were obtained after CCRT. Diagnostic accuracy rates were 66% in T2Wi, 73.1% in Diffusion-weighted images, and 66.7% in MRS. Correlations of MRS and DWI with the cervical biopsy or PET-CT were all statistically significant (p= 0.01 in MRS, p=0.008 in DWI). Correlations of T2Wi with the cervical biopsy or PET-CT were not statistically significant (p= 0.02). CONCLUSIONS: MRS as well as DWI may be used to evaluate the response of LACC to CCRT.

Acknowledgements

We appreciate the hospital collegues for helping to acquire the excellent MR spectroscopic datas.