Jana Hutter1,2, Paddy J Slator3, Jonathan O'Muircheartaigh4, Rui P Azeredo Gomes Teixeira1, Anthony N Price1, Ana Dos Santos Gomes4, Laura McCabe4, Sophie Arulkumaran4, Mary Rutherford4, and Joseph V Hajnal1
1Biomedical Engineering Department, King's College London, London, United Kingdom, 2Centre for the Developing Brain, London, United Kingdom, 3Centre for Medical Image Computing, University College London, London, United Kingdom, 4Centre for the Developing Brain, King's College London, London, United Kingdom
Synopsis
The
crucial role of the placenta in successful pregnancies is the
transfer of oxygen within functional units – cotyledons. However,
current screening falls short of visualizing this in-vivo. This study
explores a multi-model in-vivo MRI acquisition able to visualize and
depict a range of spatial and temporal processes and the underlying
micro-structure. Diffusion characteristics such as Mean Diffusivity
and fractional anisotropy, quantitative T2* maps, temporal
characteristics and the depiction of vasculature allow insights and
can be applied to a range of research questions.
Background
The transfer of oxygen to the growing fetus
is a crucial function of the human placenta. It occurs within the key
functional lobules (Fig.1). Developmental abnormalities that cause
variations in the properties of the maternal blood supply or
decreased fetal villous surface area, have been hypothesized from
ex-vivo studies and in models (1) to result in major pregnancy
complications such as fetal growth restriction and early onset
pre-eclampsia. However, current available screening (e.g. Ultrasound)
fails to access internal placental function, while previous MRI
studies (2,3) focused on individual modalities. This study presents a
first multi-model MR imaging capability combining anatomical and
micro-structural information seeking to inform on both spatial and
temporal oxygenation variation within the placenta.Methods
A
bespoke quiet EPI sequence was used to acquire both multi-echo GE
(meGE) and diffusion-weighted Spin Echo (dSE) data on the placenta
and adjacent myometrium in 4 healthy pregnant volunteers on a
clinical 3T Philips Archieva scanner using the 32-channel cardiac
coil. Scanning parameters were: resolution 2.2mm3, FOV
310x310x[55-77] mm33.
The
parameters for meGRE were TE = 20,62,104,146ms, TR = 8.1s, 50
dynamics, TA=6:48., for dSE five b=0 images, three images for each of
b=15, 25, 80, 115, 206, 246, 346 s/mm2,
and eight images each for b=40, 400, 1000, 2000 s/mm2,
TA= 3:55. One T2 TSE scan was acquired for anatomical reference and
to visualise maternal arteries (TA= 1:21).
Time
series of quantitative T2* maps were calculated from the meGE data
after motion-correction
using MCFLIRT (5), and analysed with MELODIC Independent
component analysis (ICA) (4).
The dSE data was processed using Camino (6) to obtain Mean
Diffusivity (MD) and fractional anisotropy (FA) information to assess
the microstructure. The process is illustrated in Fig. 2.Results
Data
from all modalities is depicted in Fig.3 for one subject, showing the
maternal uterine and spiral arteries feeding the lobule centres in
bright white (inverted color scale)
in Fig.3a. The
arrows indicate from left to right the maternal circulation from
uterine to radial to spiral arteries.
The dMRI data in Fig.3b differentiates the maternal basal plate and
the lobules as functional compartments through the spatial variation
in diffusivity and anisotropy and shows differentiation within the
lobule.
Additionally,
the relaxation time maps in Fig.3c depict T2* gradations co-localised
with functional units, consistent with decreasing concentration in
oxy-haemoglobin from the lobule centres to their periphery, and
perhaps signifying oxygen exchange from the maternal to the fetal
compartments.
Finally,
the ICA components, shown in Fig.4 together with the corresponding
time courses, may demonstrate spatial components of placental
function. The first component hints at rhythmic inflow patterns on
the fetal placental side, component
2 with a slightly different time series
potentially depicts
spatially inhomogeneous bursts of maternal blood (7). The 3rd component shows a different time
series and a single clearly pronounced area of activation.
Corresponding results were seen for all modalities across all
subjects.Discussion and Outlook
The proposed multi-modal functional
placental MRI acquisition approach shows encouraging capability to
reveal potential signatures of placental function at many levels
within the functional lobules. It could provide a foundation to
explore biologically hypothesised physiology in-vivo, but will need
further testing, particularly in pathological pregnancies with
abnormal placental function as evidenced by Doppler blood flow
studies and fetal and maternal clinical state.Acknowledgements
MRC strategic funds (MR/K006355/1), GSTT BRC and NIH-funded Placenta imaging Project: project number 1U01HD087202-01.References
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