External Sensors & Real-Time Compensation
Maximilian Haeberlin1

1Electrical Engineering, Institute for Biomedical Engineering, University of Zurich and ETH Zurich

Synopsis

This talk will provide an overview on current methods in prospective motion correction for head MRI. It includes both optical motion correction methods as well as NMR-based methods. A selection of currently available technologies will be discussed, including moiré phase tracking, self-encoded optical markers, and gradient tones.

Talk Overview: Adaptive Motion Correction for Head MRI

In this talk, motion correction methods for head MRI are presented that rely on signals from external sensors as opposed to ones from tissue magnetization. Head motion is primarily rigid, that is, the head's pose can be captured by determining three rotational and an additional three translational degrees of freedom, which simplifies the motion correction task to a degree that enables the use of markers as a proxy for the head pose. This shifts the head pose encoding from pulse sequence design to marker tracking. This shift enables independent MR image encoding and pose tracking, whose consequences are manifold and the content of this talk. Finally, once the head pose has been faithfully estimated, the sequence geometry must be adapted using the updated head pose information, which requires the transmission of the geometry information to the real-time sequence controller.We will cover the elements of a prospective motion correction system and present current solutions and remaining challenges:

1. Marker and Receiver Subsystem

2. Signal Encoding Principles

3. Signal Processing Chain

4. Transmission of the Geometry Updates to the Sequence Controller

Marker and Receiver Subsystem

Optical markers and cameras are the most commonly employed motion correction systems in head MRI, and several different implementations thereof have been devised. This technology has matured since the early publications An early system published in [1] is based on a set of four reflective markers whose individual positions were recorded with a camera standing outside of the scanner bore. The markers are attached to a bite bar in order to ensure a rigid configuration among themselves as well as the skull of the subject.A second approach [2] relies on a single marker whose relative position to an initial reference is encoded in moiré patterns, i.e. the motion-dependent interference pattern between two gratings. The camera system employed in [2] was now placed inside the scanner bore, which proved to be more robust and practical compared to the camera systems outside the bore.Another approach that was presented in [3,4] employs a checkerboard marker that is recorded with an in-bore camera placed directly on the head coil. An important feature of that type of marker is a digital code printed on checkerboard pattern, which provides tracking stability in cases when the line-of-sight from the camera to the marker is partially interrupted.This talk will cover the individual strengths and weaknesses of the different optical marker designs and their technology.NMR-based markers will be discussed as an important alternative to optical systems. They consist of a set of small NMR active droplets (diameter ~ 0.5 - 2 mm) whose position is encoded with dedicated gradient waveforms, which modulate the phase of the droplet's signal as a function of position. The marker's signal is received by a small RF coil that is tightly wrapped around the droplet and connected to tuned RF receive hardware.NMR Markers for motion correction were developed as early as 1998 by Derbyshire et al. [5], but gained traction only with the first in-vivo data presented by Ooi and Krueger [6,7]. A step forward in NMR marker design was done by Barmet et al. [8] whose markers, or "field probes", were applied to motion correction by Haeberlin et al. in 2013. The sensitivity of their field probes was high enough to enable two things that will be covered in this talk: First, a novel position encoding method that enabled concurrent field probe localisation and image encoding ("gradient tones"), a feature that had not been possible with the previous approaches. Second, they allow to additionally correct for imperfections in the image encoding field by field monitoring that is performed concurrently to the image acquisition.We will give an overview on how NMR marker systems are designed and applied in practice.

Signal Encoding Principles

In this part of the talk, we will discuss how the different markers actually encode the head pose. For the optical methods, we will include the functionalities of the moiré-patterned marker as well as the checkerboard marker. For the NMR-markers, we will discuss the sequence module using static gradients as well as methods employing dynamic gradient waveforms such as gradient tones.

Signal Processing Chain

An important aspect of all motion correction system is the speed at which the position updates can be computed. We will discuss signal processing aspects for both the optical methods, which contain 2D pattern recognition algorithms, as well as NMR-based methods, which process 1D NMR signals.

Transmission of the Geometry Updates to the Sequence Controller

An overview on how the geometry updates are fed back to the MR system will be presented. The discussing includes the communication protocol between the motion correction system and the MR scanner, and the incorporation of the updated geometry information into the running MR sequence.

Acknowledgements

The author thanks his colleagues at the IBT, in particular Prof. Dr. Klaas Pruessmann, Dr. Lars Kasper, Dr. Christoph Barmet, Dr. David Brunner, Alexander Aranovitch, and Dr. Bertram Wilm for insightful discussions.

The author gratefully thanks Drs. Murat Aksoy and Julian Maclaren for helpful discussions regarding the optical motion correction technique and the courtesy of providing figures for this talk.

References

[1] Zaitsev M, Dold C, Sakas G, Hennig J, Speck O. Magnetic resonance imaging of freely moving objects: prospective real-time motion correction using an external optical motion tracking system. Neuroimage2006;31:1038–1050.

[2] Andrews-Shigaki BC, Armstrong BSR, Zaitsev M, Ernst T. Prospective motion correction for magnetic resonance spectroscopy using single camera retro-grate reflector optical tracking. J Magn Reson Imaging2011;33:498–504.

[3] Aksoy M, Liu C, Moseley ME, Bammer R. Single-step nonlinear diffusion tensor estimation in the presence of microscopic and macroscopic motion. Magn Reson Med 2008;59:1138–1150.

[4] Forman C, Aksoy M, Hornegger J, Bammer R. Self-encoded marker for optical prospective head motion correction in MRI. Med ImageAnal 2011;15:708–719.

[5] Derbyshire JA, Wright GA, Henkelman RM, Hinks RS. Dynamic scanplane tracking using MR position monitoring. J Magn Reson Imaging1998;8:924–932.

[6] Ooi MB, Krueger S, Thomas WJ, Swaminathan SV, Brown TR. Prospective real-time correction for arbitrary head motion using activemarkers. Magn Reson Med 2009;62:943–954.

[7] Ooi MB, Krueger S, Muraskin J, Thomas WJ, Brown TR. Echo-planar imaging with prospective slice-by-slice motion correction usingactive markers. Magn Reson Med 2011;66:73–81.

[8] Barmet C, De Zanche N, Pruessmann KP. Spatiotemporal magnetic field monitoring for MR. Magn Reson Med 2008;60:187–197.

[9] Haeberlin M, Kasper L, Barmet C, Brunner DO, Dietrich BE, Gross S, Wilm BJ, Kozerke S, Pruessmann KP. Real-time motion correction using gradient tones and head-mounted NMR field probes. Magn Reson Med 2014.



Proc. Intl. Soc. Mag. Reson. Med. 24 (2016)