7 Tesla quantitative hip MRI: A comparison between TESS and CPMG for T2 mapping
Oliver Kraff1, Andrea Lazik-Palm1,2, Rahel Heule3,4, Oliver Bieri3,4, and Harald H Quick1,5

1Erwin L. Hahn Institute for MRI, University Duisburg-Essen, Essen, Germany, 2Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, University Hospital, Essen, Germany, 3Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 4Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 5High Field and Hybrid MR Imaging, University Duisburg-Essen, University Hospital, Essen, Germany

Synopsis

Purpose was the assessment of TESS T2 relaxometry in comparison to standard CPMG as a potential candidate to improve workflow in quantitative hip MRI protocols at 7T. A total of 8 healthy volunteers were included. T2 relaxation times were measured by manually drawing regions of interest in both acetabular and femoral cartilage in multiple regions of the hip joint. Compared to CPMG, TESS provides systematically reduced T2 values in both hip cartilage layers, in line with previously reported values. Nevertheless, with a 5-fold increase in spatial coverage TESS seems to be a good candidate to improve hip protocols at 7T.

Purpose

While quantitative MR techniques at 7 T for imaging hip cartilage have been previously reported 1, the applicability of conventional transverse relaxation time (T2) mapping techniques based on multi-echo multi-slice spin echo sequences (CPMG) are generally compromised due to specific absorption rate (SAR) issues at ultra-high fields (UHF). Recently, a triple-echo steady state (TESS) relaxometry method has been introduced as a fast and in particular B1-insensitive alternative 2. So far, the TESS method has only been evaluated for regions with rather small cross-section like brain 3 and wrist 4 at 7 T. The aim of this preliminary study was the assessment of TESS T2 relaxometry in pelvic imaging in comparison to standard CPMG as a potential candidate to improve workflow in quantitative hip MRI protocols at 7 T.

Methods

After protocol optimization in two pilot subjects, a total of eight healthy volunteers (5 male and 3 female, 21-39 years, BMI: 19.8-26.3 kg/m2) were included in this study after signing informed consent. All subjects were imaged at their left hip using a whole-body research system (Magnetom 7T, Siemens Healthcare GmbH, Germany) and an in-house developed 8-channel RF transmit/receive body coil consisting of two arrays with four elements each placed ventrally and dorsally on the pelvis and operated in CP2+ transmission mode. Flip angle maps obtained with the dual refocusing echo acquisition mode (DREAM) technique were used to assess the B1 homogeneity and performance. Acquisition time of both mapping techniques was kept similar and clinically reasonable with 6:00 min (TESS) and 4:53 min (CPMG), respectively, for obtaining a high spatial resolution of 0.5 x 0.5 x 2.5 mm3. Main difference between both methods was the spatial coverage as CPMG would need to be repeated 5 times to yield the same spatial coverage. Sequence parameters are given in Figure 1. Images from the first CPMG echo were not considered for calculating T2 times. A qualitative analysis focused on the homogeneity of the signal in the hip-joint region and regarding artifacts affecting image quality, as well as delineation of acetabular and femoral cartilage. T2 relaxation times were measured by manually drawing regions of interest (ROIs; approximately 200 pixels each) in both acetabular and femoral cartilage in central regions of the hip joint, as well as in two adjacent slices 5 mm next to the center slice.

Results

For the TESS sequence a minimum TR/TE in combination with water excitation pulse and PAT averaging suppressed motion and pulsation artifacts efficiently and yielded best image quality during protocol optimization. Both TESS and CPMG images were of high quality, rendering a homogeneous signal in the hip-joint region and allowed a good delineation of acetabular and femoral cartilage (Figure 2). Quantitatively, mean T2 values measured by CPMG were consistently higher compared to those measured with TESS in both regions: 43.3±7.2 ms vs. 19.2±5.3 ms for acetabular cartilage, and 41.4±5.4 ms vs. 21.7±5.1 ms for femoral cartilage (cf. Figure 3). This difference was more pronounced for the 5 male subjects (factor of 2.4 between TESS and CPMG for acetabular, and factor of 1.9 for femoral cartilage) than for the 3 female subjects (factors of 1.9 and 1.8, respectively). B1 performance was also better by approximately 23% in the female subjects. As shown in Figure 4, no correlation between both methods was found. A comparison of intra-individual T2 values between three adjacent slices (ratio of maximum and minimum T2 values per subject) yielded a 20-25% higher mean deviation for the TESS sequence (acetabular: 1.6±0.3; femoral: 1.5±0.3) compared to CPMG (acetabular: 1.3±0.1 femoral: 1.2±0.1).

Discussion and conclusion

Compared to CPMG, TESS provides systematically reduced T2 values in both hip cartilage layers, in line with previously reported differences between both methods for brain and wrist at 7 T 3,4 as well as for knee cartilage at 3 T 5. The strong overestimation of T2 could be due to contributions from stimulated echoes as a result from imperfect refocusing pulses (120° effective, cf. Figure 1) in multi-echo spin echo sequences 6. While B0- and B1-insensitivity 2 along with a 5-fold better spatial coverage with TESS seem to be highly advantageous to improve workflow in UHF hip protocols, in particular with regard to SAR limitations, the increased intra-individual deviation of T2 values needs further investigation. A follow-up study will be performed to test the methods for reproducibility, and to evaluate the ability of TESS to distinguish between healthy cartilage and lesions or repair tissue in the hip joint.

Acknowledgements

Research funding was received from the Interne Forschungsförderung Essen (IFORES), University Hospital Essen, University Duisburg-Essen.

References

[1] Lazik A., et al., 7 Tesla quantitative hip MRI: T1, T2 and T2* mapping of hip cartilage in healthy volunteers, Eur Radiol 2015, DOI 10.1007/s00330-015-3964-0.

[2] Heule R., et al., Triple echo steady-state (TESS) relaxometry, Magn Reson Med. 2014; 71:230-7.

[3] Heule R., et al., Triple-echo steady-state T2 relaxometry of the human brain at high to ultra-high fields, NMR Biomed. 2014; 27:1037-45.

[4] Riegler G., et al., Triple-echo steady-state T2 mapping and high resolution axonal bundle assessment of the median nerve in healthy volunteers and patients with carpal tunnel syndrome at 7 Tesla, Proceedings ISMRM 2015, # 4226.

[5] Juras V., et al., Assessment of the clinical relevance of triple-echo steady-state T2 mapping in articular cartilage, Proceedings ISMRM 2015, # 4178.

[6] Lebel R.M., Wilman A.H. Transverse relaxometry with stimulated echo compensation. Magn Reson Med 2010; 64:1005–1014.

Figures

Figure 1: Sequence parameters. FA effective is the mean effective flip angle calculated from DREAM B1 maps. Here, SAR limits and maximum available peak RF power restricted the flip angle. For CPMG, a saturation pulse was applied to suppress pulsation artifacts from adjacent blood vessels.

Figure 2: Example of TESS and CPMG source images (left) as well as corresponding T2 map (center) and their magnification (right). Additionally, the two ROIs for assessing acetabular (1) and femoral (2) cartilage are shown.

Figure 3: T2 values obtained with both methods, measured in adjacent slices with 5 mm distance. Given are mean values over all 8 subjects.

Figure 4: Displayed are the T2 values for acetabular (blue circles) and femoral (red triangles) cartilage measured with CPMG versus TESS in all 8 subjects and all 6 ROIs per subject. Note that TESS systematically shows lower T2 values than CPMG.



Proc. Intl. Soc. Mag. Reson. Med. 24 (2016)
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