Oliver Kraff1, Andrea Lazik-Palm1,2, Rahel Heule3,4, Oliver Bieri3,4, and Harald H Quick1,5
1Erwin L. Hahn Institute for MRI, University Duisburg-Essen, Essen, Germany, 2Department of Diagnostic and Interventional Radiology and Neuroradiology, University Duisburg-Essen, University Hospital, Essen, Germany, 3Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, 4Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 5High Field and Hybrid MR Imaging, University Duisburg-Essen, University Hospital, Essen, Germany
Synopsis
Purpose
was the assessment of TESS T2 relaxometry in comparison to standard CPMG as a
potential candidate to improve workflow in quantitative hip MRI protocols at 7T.
A total of 8 healthy volunteers were included. T2 relaxation times were
measured by manually drawing regions of interest in both acetabular and femoral
cartilage in multiple regions of the hip joint. Compared to CPMG, TESS provides
systematically reduced T2 values in both hip cartilage layers, in line with
previously reported values. Nevertheless, with a 5-fold increase in spatial
coverage TESS seems to be a good candidate to improve hip protocols at 7T.Purpose
While
quantitative MR techniques at 7 T for imaging hip cartilage have been
previously reported
1, the applicability of conventional transverse
relaxation time (T2) mapping techniques based on multi-echo multi-slice spin
echo sequences (CPMG) are generally compromised due to specific absorption rate
(SAR) issues at ultra-high fields (UHF). Recently, a triple-echo steady state (TESS)
relaxometry method has been introduced as a fast and in particular
B1-insensitive alternative
2. So far, the TESS method has only been evaluated
for regions with rather small cross-section like brain
3 and wrist
4 at
7 T. The aim of this preliminary study was the assessment of TESS T2
relaxometry in pelvic imaging in comparison to standard CPMG as a potential
candidate to improve workflow in quantitative hip MRI protocols at 7 T.
Methods
After
protocol optimization in two pilot subjects, a total of eight healthy
volunteers (5 male and 3 female, 21-39 years, BMI: 19.8-26.3 kg/m
2)
were included in this study after signing informed consent. All subjects were
imaged at their left hip using a whole-body research system (Magnetom 7T,
Siemens Healthcare GmbH, Germany) and an in-house developed 8-channel RF transmit/receive
body coil consisting of two arrays with four elements each placed ventrally and
dorsally on the pelvis and operated in CP
2+ transmission mode. Flip
angle maps obtained with the dual refocusing echo acquisition mode (DREAM)
technique were used to assess the B
1 homogeneity and performance. Acquisition
time of both mapping techniques was kept similar and clinically reasonable with
6:00 min (TESS) and 4:53 min (CPMG), respectively, for obtaining a
high spatial resolution of 0.5 x 0.5 x 2.5 mm
3.
Main difference between both methods was the spatial coverage as CPMG would
need to be repeated 5 times to yield the same spatial coverage. Sequence
parameters are given in Figure 1. Images from the first CPMG echo were not
considered for calculating T2 times. A qualitative analysis focused on the homogeneity
of the signal in the hip-joint region and regarding artifacts affecting image
quality, as well as delineation of acetabular and femoral cartilage. T2 relaxation
times were measured by manually drawing regions of interest (ROIs;
approximately 200 pixels each) in both acetabular and femoral cartilage in
central regions of the hip joint, as well as in two adjacent slices 5 mm
next to the center slice.
Results
For
the TESS sequence a minimum TR/TE in combination with water excitation pulse
and PAT averaging suppressed motion and pulsation artifacts efficiently and
yielded best image quality during protocol optimization. Both TESS and CPMG
images were of high quality, rendering a homogeneous signal in the hip-joint
region and allowed a good delineation of acetabular and femoral cartilage
(Figure 2). Quantitatively, mean T2 values measured by CPMG were consistently
higher compared to those measured with TESS in both regions: 43.3±7.2 ms
vs. 19.2±5.3 ms for acetabular cartilage, and 41.4±5.4 ms vs. 21.7±5.1 ms
for femoral cartilage (cf. Figure 3). This difference was more pronounced for
the 5 male subjects (factor of 2.4 between TESS and CPMG for acetabular, and
factor of 1.9 for femoral cartilage) than for the 3 female subjects (factors of
1.9 and 1.8, respectively). B
1 performance was also better by approximately 23%
in the female subjects. As shown in Figure 4, no correlation between both
methods was found. A comparison of intra-individual T2 values between three
adjacent slices (ratio of maximum and minimum T2 values per subject) yielded a 20-25% higher mean deviation for the TESS
sequence (acetabular: 1.6±0.3; femoral: 1.5±0.3) compared to CPMG (acetabular:
1.3±0.1 femoral: 1.2±0.1).
Discussion and conclusion
Compared
to CPMG, TESS provides systematically reduced T2 values in both hip cartilage
layers, in line with previously reported differences between both methods for
brain and wrist at 7 T
3,4 as well as for knee cartilage at 3 T
5. The strong overestimation of T2 could be due to contributions from stimulated
echoes as a result from imperfect refocusing pulses (120° effective, cf. Figure
1) in multi-echo spin echo sequences
6. While B
0- and B
1-insensitivity
2
along with a 5-fold better spatial coverage with TESS seem to be highly
advantageous to improve workflow in UHF hip protocols, in particular with
regard to SAR limitations, the increased intra-individual deviation of T2
values needs further investigation. A follow-up study will be performed to test
the methods for reproducibility, and to evaluate the ability of TESS to
distinguish between healthy cartilage and lesions or repair tissue in the hip
joint.
Acknowledgements
Research funding was received from the Interne Forschungsförderung Essen (IFORES), University Hospital Essen, University Duisburg-Essen.References
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