Magnetic resonance (MR) imaging appears to be increasing used for the diagnosis of abnormalities in fetuses because of the absence of ionizing radiation and superior contrast of soft tissues. T1-weighted sequences are of choice for detection of hemorrhage, calcification and grey/white matter abnormities in fetus brain. However, it remains very challenging as it is more prone to the motion artifacts caused by the respiratory of the mother and the movement of the fetus, compared to the T2-weighted sequences. In this study, we evaluated the feasibility of a free-breathing 3D T1-weighted gradient-echo imaging with radial data sampling for fetus imaging, and compared with a standard breath-hold imaging with Cartesian k-space acquisition.This study was approved by the local ethics committee, and all pregnant women gave written informed consent. 74 fetuses (74 pregnant women) with abnormal findings in brain at obstetric ultrasound were recruited in this study. The mean gestational age was 29 weeks ± 5, ranged from 21 to 41 weeks gestation. All MR imaging was performed on a 1.5 T MR scanner (MAGNETOM Aera, Siemens AG, Erlangen, Germany) with a 18-channel phased-array body coil and 6 elements of the spine coil positioned over the lower pelvic area. A standard Cartesian VIBE was acquired during breath-hold of the mother with the following parameters: TR/TE = 6.7/2.4 ms, flip angle = 12 degree, slice thickness = 3 mm, matrix =240×320, FOV = 380×380 mm2, iPAT = 2. The acquisition time is 12 second. A free-breathing radial VIBE acquisition was performed with matching spatial resolution with TR/TE of 3.7/1.8 ms, flip angle of 10 degree, slice thickness of 3 mm, matrix of 320×320, FOV of 380×380 mm2. 2400 radial spokes were acquired using 3:30 minutes. The All images were assessed by two radiologists with more than 5 years of experience on a five-point scale: 1, image quality too poor to correctly identify anatomy of the fetus brain; 2, image quality below diagnostic standards; 3, diagnostic image quality; 4, very good image quality; 5, optimal diagnostic quality. Kappa statistics were used to measure the degree of agreement between the two radiologists. Paired t-test were used to compare the scores of overall image quality between two sequences. The agreements between the two radiologists for the independent qualitative data analysis were good. Radial VIBE had higher scores for overall image quality than Cartesian VIBE (3.74±1.05 vs. 1.93±0.55, p <0.001). Compared with the standard Cartesian VIBE, radial VIBE showed higher contrast between grey matter and white matter, clearer description of basal nuclei, and less motion artifacts. In all 74 cases, 10 diagnosed as agenesis of the corpus callosum in Radial VIBE, and 8 cases in Cartesian VIBE (Figure 1); 7 fetus diagnosed as hemorrhage in Radial VIBE, and 5 cases in Cartesian VIBE (Figure 2).With standard Cartesian k-space sampling, motion is an important reason for image blurring and ghost artifacts. Breath-hold T1-weighteed sequences are short-duration for motion-free acquisition. However, with the movement of the fetus and diminished breath-hole capacity of the pregnant women, a free-breathing technique is more acceptable for fetus imaging in clinical practice. Radial k-space sampling advantages in decreased sensitivity to motion. In this study, we showed the feasibility of using radial VIBE for free-breathing 3D T1 weighted imaging on fetus brain for better image quality and higher lesion detection rate than a standard breath-hold Cartesian VIBE.Radial VIBE can be performed for fetus imaging under free-breathing condition with higher image quality and lesion detection rate than a standard breath-hold Cartesian VIBE.