Matthias Weigel1 and Oliver Bieri1
1Dept. of Radiology, Radiological Physics, University of Basel Hospital, Basel, Switzerland
Synopsis
For
fast spinal cord images of high in-plane resolution and estimable contrast, an
image combination of different inversion recovery (IR) prepared balanced steady
state free precession (bSSFP) images acquired by a Modified Look Locker IR
(MOLLI) sequence with fixed RR-intervals is suggested. The strength of the
approach lies in its simplicity and that for short acquisition times of
currently about 2mins per slice already a good contrast can be achieved at the
high in-plane resolution of 0.4mm.Purpose
The
depiction of human spinal cord (SC) morphology is challenging due to fine
structures, bulk motion, CSF pulsation and low contrast between gray matter
(GM) and white matter (WM) in the SC [1,2]. Different approaches such as rapid
T1 weighted gradient echo and T1 and T2 weighted turbo spin echo sequences have
been suggested [1,2]; however, the acquisition and postprocessing techniques
become more and more complex and acquisition times tend to increase constantly.
In the following, we suggest a simple image combination technique of different
inversion recovery (IR) prepared balanced steady state free precession (bSSFP)
images acquired by a Modified Look Locker IR (MOLLI) sequence [3], which leads
to SC images with estimable contrast and resolution considering the short
acquisition time.
Methods
The work
is based on a MOLLI sequence with single-shot bSSFP sampling, which was
originally developed for cardiac T1 relaxometry [3]: FOV = 128mm x 128mm,
resolution = 0.4mm x 0.4mm, one slice of thickness 8mm that is orthogonal to
the course of the spinal cord, signal averaging = 2, GRAPPA parallel
acquisition technique with acceleration factor 2, flip angle = 35deg, TE =
2.28ms, TR(bSSFP sampling) = 5.4ms, non-selective IR preparation. The effective
inversion times TI(1) = [251,2251,4251] ms, TI(2) = [331,2331,4331] ms and TI(3) = [411,2411,4411,6411,8411] ms
were used over three consecutive heartbeats (R-R cycles) in accordance with the
published MOLLI scheme [3]. For the present measurements an “artificial”, fixed
ECG triggering with a permanent R-R interval of 2000ms was employed. The total
acquisition time TA was 2min 14sec.
The acquired IR sampling images with different
TI were directly averaged and used. All measurements were performed on a 3T
whole-body MR system with a healthy volunteer on two different days.
Results
Figure
1 shows a series of acquired MOLLI images with the different TI as described in
the Methods section. Figure 2 presents such proposed mean images over the acquired
series of IR prepared images. For the short TA of a bit more than 2mins the
mean images demonstrate a remarkable GM-WM contrast at the very high in-plane
resolution of 0.4mm at 3T. The “butterfly” within the SC – as often
colloquially referred to – can be observed in a nice way. No bulk motion or CSF
pulsation artifacts are observed.
Discussion & Conclusion
As
a simple but efficient means for high-resolution imaging of the SC an averaging
of the inversion images of a MOLLI sequence was suggested. The strength of the
approach lies in its simplicity and that for short acquisition times of about
2mins already a good contrast can be achieved at the high in-plane resolution
of 0.4mm. Though the triggering is fixed to a constant interval so far, the
images are free of CSF pulsation artifacts (and other motion artifacts). For
the future, more thorough analyses will be performed on the interesting nature and
origin of this contrast and its further potential for optimization and
exploitation. Based on the MOLLI timing scheme with the global inversion RF
pulse, an extension to a multi-band acquisition concept is almost
straight-forward and, thus, acquisition times of less than 1min per slice are
feasible. Another focus will be to study “real ECG triggering” combined with
the presented concept for further improvement.
Acknowledgements
No acknowledgement found.References
[1]
Kearney H et al. Nat Rev Neurol 2015;11:327-338.
[2] Li L
et al. Magn Reson Med 2015;74:971-977.
[3] Messroghli DR
et al. Magn Reson Med 2004;52:141–146.