Mahamadou Diakite1, Steve Roys2, Taehoon Shin2, Jiachen Zhuo2, Jaydev P. Desai3, and Rao P. Gullapalli2
1Radiology, Center for Metabolic Imaging and Therapeutics, University of Maryland, School of Medicine, Parkville, MD, United States, 2Radiology, Center for Metabolic Imaging and Therapeutics, University of Maryland, School of Medicine, Baltimore, MD, United States, 3Department of Mechanical Engineering, University of Maryland, College Park, Maryland, United States, Baltimore, MD, United States
Synopsis
We
present a prospective motion correction (PMC) technique using a miniature
passive magnetic sensor. The motion sensor can virtually work with any imaging
technique that is sensitive to motion. Especially
techniques such as fMRI, DTI and spectroscopy sequences are likely to benefit greatly
when dealing with non-cooperative subjects.
In this study, the GRE sequence was initially modified by adding three bipolar gradients along the read, phase, and slice-selection directions
respectively. The bipolar gradients were used to trigger the position and orientation tracking sensor. A dynamic
feedback loop mechanism was implemented into the sequence to receive the sensor
position and orientation for real-time update of the imaging slice using an
in-house developed application.
We demonstrate
that our PMC method in brain imaging using a passive magnetic sensor is capable
of tracking the patient head motion with high accuracy.
Introduction:
Head motion during imaging remains a major hurdle
in brain imaging. Problems associated with motion can be severe particularly
among pediatric patients, stroke patients and in the elderly patients
[1].
Motion during imaging translates to phase errors in k-space which results in
ghosting or blurring in the reconstructed images. Although several motion
correction and prevention techniques have been explored with different level of
success, very few techniques that provide prospective correction techniques
have resulted with limited applications
[2]. Here we present a
prospective motion correction (PMC) technique using a miniature passive magnetic
sensor. The motion sensor can virtually work with any imaging technique that is
sensitive to motion.
Methods:
Tracking sensor: The tracking sensor (Robin
Medical, Inc. Baltimore, USA) (Fig 1) consists of six coil loops which are
placed in pairs orthogonal to each other. They are designed to pick up the
voltages induced by the tracking gradients magnetic fields generated by static
bipolar gradients embedded in the imaging sequence.The induced voltages into
these coils are compared with pre-recorded calibration chart of voltage map of
the MR space which reports the position and orientation of the sensor in the
magnet.
MRI methods: MRI scans were performed using
3T TIM TRIO (Siemens Healthcare, Erlangen, Germany) equipped with a 32 channel
head coil (Siemens). A series of high resolution gradient echo (GRE) axial
slice brain scans were acquired from a normal healthy volunteer. The GRE
sequence was initially modified by adding three bipolar gradients (total
duration = 1.5 ms) along the read, phase, and slice-selection directions
respectively (Fig 2). A dynamic feedback loop mechanism was implemented into
the sequence to receive the sensor position and orientation for real-time
update of the imaging slice using an in-house developed application [3]. Phase correction is then performed based on
the motion information before reconstructing the k-space data.
To test the accuracy of our PMC technique, we
conducted three experiments. In the first
experiment, the subject with the tracking sensor taped on the left side of his
head was asked to remain as still as possible to acquire the base line images
which were used as reference. In the second experiment, the subject was
instructed to move during the scan whenever prompted by the MRI technician
while the PMC was turned off. The third experiment was same as the second,
except now the PMC was turned on. In all three cases the sensor’s relative
position and orientation were recorded in time. The data consisted of 30 time
frames of a single 5 mm axial slice. The image matrix was 256x256 pixels with a
resolution of 1.4x1.4 mm2. The acquisition parameters were: TR/TE =
10.7/3.19 ms, α = 15o, bandwidth = 330 Hz/pixel.
Results:
The standard deviations of the position and
orientation coordinates are listed in Table 1 and demonstrate very little
variation in position and orientation coordinates while the subject head is
still. Fig 3 shows five time frames of
the axial images of the subject brain: a) with no motion b) with PMC off and c)
with PMC on. To estimate the error from
motion, we subtracted images of time series from the first image in each of the
above two time series b) and c). Row (c) shows the difference images series with
PMC turned off and Row (d) shows the difference images with PMC turned on.
Comparison of images in d) and e) shows that motion
artifacts are significantly reduced when the PMC is turned on. However images
in e) show some residual errors which can be caused by the field distortions
during motion and the gradient nonlinearities which resulted in images
misalignment with those acquired at rest.
Conclusions:
We demonstrate
that our PMC method in brain imaging using a passive magnetic sensor is capable
of tracking the patient head motion with high accuracy. Our results suggest
that our PMC technique can correct rigid body motion that is normally
encountered in routine clinical scanning. The small footprint of the sensor
makes it an ideal tool for tracking motion and can be positioned on the subject
at a location out of line of sight unlike optical tracking systems [4].
Furthermore, the method is compatible with virtually any imaging sequence with
long acquisition time. Especially techniques such as fMRI, DTI and spectroscopy
sequences are likely to benefit greatly when dealing with non-cooperative
subjects. Further investigation is necessary to reduce the errors that result
from field distortions and to understand the extent of motion that can be
effectively corrected by our PMC technique.
Acknowledgements
Funding sources: This work was partially supported by NIH grants R01 EB015870 and R44 CA168271References
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Maclaren J. et al., Prospective Motion Correction in Brain Imaging: A Review,
MRM 69:621-636 (2013)
[2] Pipe
J., Motion Correction with PROPELLER MRI: Application to Head Motion and
Free-Breathing Cardiac Imaging, MRM 42:963-969 (1999)
[3]
Diakite M. In Proceedings of the 23th Annual Meeting of ISMRM,
Toronto, Ontario, Canada, 2015, p. 4143
[4] Singh A. Optical Tracking with
Markers for Robust Prospective Motion Correction for Brain Imaging, Magn Reson
Mater Phy DOI 10.1007/s10334-015-0493-4 (2015)