Radiologists, physicists and data scientists focusing on the prostate cancer MRI and its quantitation.T2WI MRI is an integral part of prostate cancer (PCa) multiparametric MRI (mpMRI) which has been used to identify structures in the prostatic tissue. Therefore, quantitative T2 values has the potential to reliably and reproducibly differentiate prostate abnormalities, which may result in better distinction in PCa, benign prostate hyperplasia（BPH）and normal prostate tissue (NPT). Recently, an accelerated ME-TSE MRI known as k-t-T2 mapping has been developed to obtain high resolution whole prostate T2 mapping in clinically feasible scan times. The purpose of this study is to use k-t-T2 technique to obtain the T2 maps and test the diagnostic performance of T2 mapping in differentiating PCa from NPT and BPH in the peripheral zone.The institutional review board approved this prospective study. Twenty-eight patients with biopsy-proven peripheral zone PCa without prior treatment underwent routine mpMRI for PCa along with k-t-T2 MRI for T2 mapping at PHILIPS 3.0T Ingenia scanner with an abdomen array coil. ROI were drawn over mpMRI suspicious PCa, BPH and NPT identified by two radiologists in consensus. The mean T2 value for each ROI was determined. Mean T2 values over three types of ROI were tested for statistical significance using ANOVA analysis. The area under the receiver operating characteristic curve was used to assess the optimal threshold T2 value for PCa discrimination.The mean T2 value over PCa (58.7±10.8 ms), BPH (98.7±12.4 ms) and NPT (206.7±19.8 ms) were statistically different (p<0.0001). T2 threshold value of 68.3 ms yielded a sensitivity of 94% and a specificity of 98% for PCa detection.It is widely appreciated that peripheral zone PCa often has low signal on T2 weighted images, making T2WI imaging a key, if subjective, assessment for cancer detection. Quantitative measurement of T2 values derived from fast T2 mapping sequence for prostate cancer detection was possible. We sought to determine if a rapid and clinically practical T2 mapping could provide T2 values that, although probably not “accurate” due to stimulated-echo effects, could still provide clinically significant discrimination in PCa, NPT and BPH in the peripheral zone. Although there is an overlap between T2 values of PCa and BPH pathologies identified using this sequence. The values so obtained and analyzed in this study appear quite useful for cancer discrimination with, for example, a threshold T2 of 68.3 ms yielded a sensitivity of 94% and a specificity of 98% for prostate cancer discrimination.Fast T2 mapping generates accurate T2 maps over the whole prostate in clinically feasible scan times that can be used to distinguish PCa, BPH and NPT. Although there is an overlap between T2 values of PCa and BPH pathologies, fast T2 mapping can be used to assist radiologists for lesion detection prior to biopsy.