Open Source Imaging Initiative
Lukas Winter1, Haopeng Han1, Antonia Barghoorn2, Werner Hoffmann3, Stefan Hetzer4, Simone Winkler5, Larry Wald6, Andrew Webb7, Peter Blümler8, and Thoralf Niendorf1,9,10

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany, 2Department of Physics, Technische Universität Berlin, Berlin, Germany, 3Physikalisch Technische Bundesanstalt (PTB), Berlin, Germany, 4Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin, Berlin, Germany, 5Department of Radiology, Stanford University, Stanford, CA, United States, 6Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States, 7Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 8Institute of Physics, University of Mainz, Mainz, Germany, 9Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany, 10MRI.TOOLS GmbH, Berlin, Germany

Synopsis

Regardless public or private healthcare system, MR costs determine healthcare outcomes. There is a high demand for affordable MR technology around the world to improve patient diagnosis and treatment. The aim of the open source imaging initiative (www.opensourceimaging.org) is to collaboratively build an affordable MR scanner and make its technical documentation available according to the standards of open source hardware. Combining innovation and open source allows major reduction of investment and operational costs with the ideal: From the community to the community.

Motivation

Magnetic resonance imaging (MRI) is the most powerful diagnostic imaging modality available. The major drawbacks are cost and complexity, limiting its use mainly to industrialized countries and larger hospitals making MRI a scarce commodity around the world1. The aim of the open source imaging initiative is to address this issue by developing an affordable MR scanner which is easy to site, operate, maintain and repair and make its technical documentation available according to the standards of open source hardware. Combining innovation and open source allows major reduction of investment and operational costs with the ideal: From the community to the community.

Innovation

State of the art clinical MRI scanners operate at magnetic field strength of B0=1.5T and 3.0T. These “high” magnetic fields are achieved using superconductors together with a liquid helium cooling system to reach cryogenic temperatures. This makes the magnet by far the most expensive hardware component. Multiple studies showed that there are several clinical applications where the diagnostic value gathered from low field MRI (B0=0.2T) is equivalent to high field systems (B0≥1.0T)2-6. Low field permanent magnets in Halbach arrangements are a viable alternative avoiding superconductors and liquid helium, and can even be designed such that gradients in the magnetic field can be used for spatial encoding, removing the need for high power gradient amplifiers7. In addition low field systems are safer for patients and workers than their high field counterparts. Lower B0 reduces hazards of injury from ferromagnetic objects such as medical equipment or implants and permanent magnets eliminate any risk of a quench. The lower SNR of low field scanners is partially offset by reduced SAR, favorable changes in some relaxation parameters, reduced susceptibility shifts and thus the ability to use low imaging bandwidths. Halbach magnets are much smaller in size allowing for a “mobile” application while B0≈0 outside the magnet makes the need for an extra scanner room obsolete.

The pursuit of an inexpensive RF electronics console benefits from recent developments in digital signal synthesis and reception allowing significant reductions in price and complexity8. Our estimated total price for such an MR system using permanent magnets is below $20000. Such a price makes it a viable alternative to computed tomography, x-ray and ultrasound imaging for dedicated clinical applications. Open Source Imaging is not limited to MR systems using permanent magnets alone. On the contrary we want to foster collaboration, education, knowledge transfer and customized development without restrictions on technological specifications.

Open Source

The Open Source Imaging initiative follows the values of open source hardware. We want to grant complete access to the technical documentation (circuit diagrams, part lists, PCB layouts, CAD designs etc.). Developments will be licensed under the CERN OHL license. While the Open Source Imaging initiative is not-for-profit, the licensing strategy supports commercial use, which is intended in order to support distribution of the technology at a later stage (Fig.1). The technological complexity of MRI and the fact that development in MRI is predominantly carried out by the research community justifies an open source approach. The advantages of open source development are:

1. No more black boxes; Transparency for research, education and innovation.

2. Fast and cost effective maintenance

3. Technology transfer to regions where trained staff are a scarcity

4. Customized development; Reduction of complexity by simple push button systems (e.g. knee scans with hard coded imaging protocols). Design influences of local environments (e.g. rural hospital with unstable power supply).

5. Encouraging scientific values: collaboration, reproducibility and citations. At the same time open source hardware benefits from good documentation by means of scientific publications.

The website www.opensourceimaging.org functions as the communication platform with an overview of running projects and links to external developer/documentation sites. So far we included our developments on a multipurpose 3-axis measurement system (~$3000) (Fig.2). Halbach magnet designs and an RF power amplifier (~$1000) will be incorporated next (Fig.2). We will furthermore add past and future open source soft- and hardware projects from the MR community. Outsourcing development to the community, will eventually allow for long-term affordable prizes. The open source hardware movement is gaining momentum and will most likely follow the footsteps of open source software.

Conclusion

Regardless public or private healthcare system, MR costs determine healthcare outcomes. There is a high demand for affordable MR technology around the world to improve patient diagnosis and treatment. We, the MR research community are able to meet this demand. By means of collaboration we can lay the ground for affordable, high quality medical devices. Please visit www.opensourceimaging.org, contribute, and help us making this vision reality.

Acknowledgements

The author wants to thank Blanca Lopez-Aranguren Blazquez for valuable discussions. Johannes Meyer, Sergej Haas and Lukas Thiele for their creative support with the website.

References

[1] Rylands-Monk F, Aunt Minnie Europe, 2015 [2] Pääkkö E, Eur Radiol, 2005; 15(7):1361-8 [3] Ejbjerg B, Ann Rheumat Dis, 2005; 64(9):1280-7 [4] Kersting-Sommerhoff B, Eur Radiol, 1996; 6(4):561-5 [5] Parizel PM, Eur J Radiol, 1995; 19(2):132-8 [6] Jhaveri K, JMRI, 2015; 41(4):866-9 [7] Cooley CZ, MRM, 2015; 73(2):872-83 [8] Hasselwander CJ, et al., ISMRM, 2015; 710

Figures

Figure 1 – Schematic of the open source imaging initiative. Development is performed by and for the community. www.opensourceimaging.org functions as a communication platform providing an overview of running projects, publications, links to technical documentation files and wikis of open source soft- and hardware projects around MRI.

Figure 2 – Current developments that will be published on the website. (left) 3-axis multipurpose robot with submillimeter accuracy (e.g. for static magnetic field or electromagnetic field mapping, 3D printing, CNC machinery). (middle) Halbach magnet and gradient designs for low field low cost MRI. (right) 1kW RF power amplifier 1.8-54MHz.



Proc. Intl. Soc. Mag. Reson. Med. 24 (2016)
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