Lukas Winter1, Haopeng Han1, Antonia Barghoorn2, Werner Hoffmann3, Stefan Hetzer4, Simone Winkler5, Larry Wald6, Andrew Webb7, Peter Blümler8, and Thoralf Niendorf1,9,10
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany, 2Department of Physics, Technische Universität Berlin, Berlin, Germany, 3Physikalisch Technische Bundesanstalt (PTB), Berlin, Germany, 4Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin, Berlin, Germany, 5Department of Radiology, Stanford University, Stanford, CA, United States, 6Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States, 7Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 8Institute of Physics, University of Mainz, Mainz, Germany, 9Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany, 10MRI.TOOLS GmbH, Berlin, Germany
Synopsis
Regardless public or private
healthcare system, MR costs determine healthcare outcomes. There is a high
demand for affordable MR technology around the world to improve patient
diagnosis and treatment. The aim of the open source imaging initiative (www.opensourceimaging.org) is to collaboratively build an affordable MR scanner and make its technical documentation available according
to the standards of open source hardware. Combining innovation and open source
allows major reduction of investment and operational costs with the ideal: From
the community to the community.Motivation
Magnetic resonance imaging (MRI)
is the most powerful diagnostic imaging modality available. The major drawbacks
are cost and complexity, limiting its use mainly to industrialized countries
and larger hospitals making MRI a scarce commodity around the world
1. The
aim of the open source imaging initiative is to address this issue by
developing an affordable MR scanner which is easy to site, operate, maintain
and repair and make its technical documentation available according to the
standards of open source hardware. Combining innovation and open source allows
major reduction of investment and operational costs with the ideal: From the
community to the community.
Innovation
State
of the art clinical MRI scanners operate at magnetic field strength of B0=1.5T
and 3.0T. These “high” magnetic fields are achieved using superconductors
together with a liquid helium cooling system to reach cryogenic temperatures.
This makes the magnet by far the most expensive hardware component. Multiple
studies showed that there are several clinical applications where the
diagnostic value gathered from low field MRI (B0=0.2T) is equivalent
to high field systems (B0≥1.0T)2-6. Low field permanent magnets in
Halbach arrangements are a viable alternative avoiding superconductors and
liquid helium, and can even be designed such that gradients in the magnetic field
can be used for spatial encoding, removing the need for high power gradient
amplifiers7. In addition low field systems are safer for patients and
workers than their high field counterparts. Lower B0 reduces hazards of injury from ferromagnetic objects such as medical equipment or implants and permanent magnets eliminate any risk of a quench. The lower SNR of low field scanners is partially offset by
reduced SAR, favorable
changes in some relaxation parameters, reduced susceptibility shifts and thus
the ability to use low imaging bandwidths. Halbach magnets are much smaller in size allowing for a “mobile”
application while B0≈0 outside the magnet makes the need for an
extra scanner room obsolete.
The
pursuit of an inexpensive RF electronics console benefits from recent
developments in digital signal synthesis and reception allowing significant reductions in price and
complexity8. Our
estimated total price for such an MR system using permanent magnets is below $20000.
Such a price makes it a viable alternative to computed tomography, x-ray and
ultrasound imaging for dedicated clinical applications. Open Source Imaging is
not limited to MR systems using permanent magnets alone. On the contrary we
want to foster collaboration, education, knowledge transfer and customized
development without restrictions on technological specifications.
Open Source
The Open Source Imaging
initiative follows the values of open source hardware. We want to grant
complete access to the technical documentation (circuit diagrams, part lists,
PCB layouts, CAD designs etc.). Developments will be licensed under the CERN
OHL license. While the Open Source Imaging initiative is not-for-profit, the
licensing strategy supports commercial use, which is intended in order to
support distribution of the technology at a later stage (Fig.1). The
technological complexity of MRI and the fact that development in MRI is
predominantly carried out by the research community justifies an open source
approach. The advantages of open source development are:
1. No
more black boxes; Transparency for research, education and innovation.
2. Fast
and cost effective maintenance
3. Technology
transfer to regions where trained staff are a scarcity
4. Customized
development; Reduction of complexity by simple push button systems (e.g. knee
scans with hard coded imaging protocols). Design influences of local environments
(e.g. rural hospital with unstable power supply).
5. Encouraging
scientific values: collaboration, reproducibility and citations. At the same
time open source hardware benefits from good documentation by means of
scientific publications.
The website www.opensourceimaging.org
functions as the communication platform with an overview of running projects
and links to external developer/documentation sites. So far we included our
developments on a multipurpose 3-axis measurement system (~$3000) (Fig.2). Halbach
magnet designs and an RF power amplifier (~$1000) will be incorporated next
(Fig.2). We will furthermore add past and future open source soft- and hardware
projects from the MR community. Outsourcing development to the community, will eventually
allow for long-term affordable prizes. The open source hardware movement is
gaining momentum and will most likely follow the footsteps of open source
software.
Conclusion
Regardless public or private
healthcare system, MR costs determine healthcare outcomes. There is a high
demand for affordable MR technology around the world to improve patient
diagnosis and treatment. We, the MR research community are able to meet this
demand. By means of collaboration we can lay the ground for affordable, high
quality medical devices. Please visit
www.opensourceimaging.org, contribute, and help us making this vision reality.
Acknowledgements
The author wants to thank Blanca Lopez-Aranguren Blazquez for valuable discussions. Johannes Meyer, Sergej Haas and Lukas Thiele for their creative support with the website.References
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