Frank C Eibofner1, Hansjörg Graf1, and Petros Martirosian1
1University Hospital Tübingen, Tübingen, Germany
Synopsis
A technique
for the visualization of interventional devices by use of transient, local
magnetic field alterations and bSSFP sequences is presented. It allows the generation of distinct artifacts
with controllable dimension. The instrument is visualized in the phase image
obtained in the same scan as the undisturbed anatomical image. Localization is
done by subsequent superposition.Purpose
Instrument
guidance in interventional MRI is often performed on the basis of signal voids
generated by the interventional device, either as a result of different
magnetic susceptibility compared to the tissue (e.g., titanium needles) or the displacement
of hydrogen protons (e.g., catheters). These guidance techniques suffer from
difficult controllability of the signal void size especially for small plastic
devices (limited conspicuity) or larger metallic devices (overwhelming
artifacts). Recently, the visualization of a conductor by the use of a spin-echo phase imaging was reported.
1 However, spin echo sequences are
time consuming, making instrument tracking during interventional treatment
impracticable. To overcome these problems, a triggered direct current based
technique in combination with a bSSFP sequence was developed.
2Methods
Transient,
local magnetic field alterations generate unique phase variations in spin-echo phase
images.
1 This principle can be transferred to bSSFP sequences,
because of similar rephasing characteristics for TE = TR/2 and TR << T
1,
T
2.
3 Magnetically homogeneous image areas or such with
static magnetic field alterations are displayed in the bSSFP phase image either
as values of zero or +/- pi. By use of a simple linearly rising mask function,
phase variations in a certain range uniquely originating from transient
magnetic field alterations (e.g., from 0.2 to 1.57 rad) are translated in an
RGB color space. The colored mask image is superimposed to the magnitude image
displaying the position of the device. If needed, a k-space low-pass filter can
be used to remove false positive pixels in areas with low signal intensity.
A bSSFP sequence was modified to obtain a trigger signal at the output of the
scanner. To avoid disturbed spatial encoding, the trigger signal was set
between the end of RF excitation and the start of signal acquisition (Fig. 1a).
The trigger signal switched a relay that let a direct current flow through a
conductor with a double-helical geometry wound on the surface of a catheter (Fig.
1b). This geometry was capable to generate an effective magnetic field
component in every orientation to B
0.
4 The modified
catheter was placed in a water basin with a gimbal.
Results
The double-helical wound wire
generates strong magnetic field gradients in its vicinity resulting in
characteristic phase offset pattern (Fig. 2). In all three orientations (perpendicular (a), 45° (b), and parallel (c)
toward B
0) the catheter is clearly visible. The dimension of the phase
offset pattern can be increased by setting the trigger duration to 1.5 ms (d).
In the magnitude image of the porcine liver, the catheter is visible because of
its water filled lumen but cannot be distinguished from other bright structures
(Fig. 3). The
characteristic pattern is visible in the phase image. By combination of the
post-processed phase image with the magnitude image, the superimposed phase
pattern reveals unambiguously the position of the catheter in the resulting
image. Application of the k-space low pass filter removes colored pixels in
areas with low signal intensity (white arrows point on air cavities).
Discussion
The
described technique allows distinct localization of interventional devices with
a fast sequence commonly used in interventional magnetic resonance imaging. The
choice of sequence parameters is not restricted and no additional acquisition
time is needed. Care has to be taken that the device or the connecting cables
are not coupling to the radiofrequency pulses and that safety regulations are
satisfied. Further, the material of the metallic devices must have a water
equivalent magnetic susceptibility (e.g., brass).
Conclusion
The
visualization of devices by transient, local magnetic field alterations was
successfully adapted to a bSSFP sequence, allowing short acquisition times
mandatory for MR guided interventions. Further investigations have to be
performed to optimize and minimize the setup, possibly by use of a battery and
optical relay switching.
Acknowledgements
No acknowledgement found.References
1. Eibofner F, Wojtczyk H, Graf H, et al. Magnetic resonance visualization of
conductive structures by sequence-triggered direct currents and spin-echo phase
imaging. Med Phys. 2014;41(6):062301.
2. Eibofner
F, Martirosian P, Würslin C, et al. Technical Note: MR-visualization of
interventional devices using transient field alterations and balanced
steady-state free precession imaging. Med Phys. 2015;42(11):6558.
3. Scheffler K, Hennig J. Is TrueFISP a gradient-echo or spin-echo sequence?
Magn Reson Med. 2003;49(2):395-7.
4. Glowinski A, Kürsch J, Adam G, et al. Device visualization for
interventional MRI using local magnetic fields: basic theory and its
application to catheter visualization. IEEE Trans Med Imaging. 1998;17(5);786-793.