Frank Seifert1, Harald Pfeiffer1, Ralf Mekle1, Patrick Waxmann1, and Bernd Ittermann1
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany
Synopsis
A
7T 8-channel transmit/receive head volume coil is introduced which is capable
to produce transmit fields in the human brain of more than 50 µT necessary
for single voxel MRS with acceptable chemical shift artifacts. Key to this good
transmit field efficiency was careful design and material selection but also the
choice of relatively short coil elements. From the simulation based design process
appropriate input power limits were concluded which allow safe operation of the
coil in compliance with IEC 60601-2-33.Purpose
A
7T 8-channel transmit/receive volume head coil was designed, built, and tested.
It is capable to produce transmit fields in the human brain of more than 50 µT
when exploiting the RF peak power design limits. This high B1+ efficiency is
necessary either for single voxel spectroscopy to reduce chemical shift
artifacts or for pTx based feature selective excitation methods. The shielded
decoupled loop array coil fits into B0 shim inserts and enables accommodation
of optical stimulation equipment. From the
simulation based design process appropriate input power limits were concluded,
which allow safe operation of the coil in compliance with IEC 60601-2-33.
Methods
Eight rectangular
loop coil elements (L = 16 cm) were arranged (Fig.1) in a slightly elliptical
fashion (A-P distance 250 mm, L-R distance 215 mm) within a cylindrical RF
shield (OD = 34 cm, L = 396 mm). Loop elements were manufactured from a low
loss PCB material (Mercurywave™ 9350) with 30 µm copper thickness. The coil
former was 3D printed from polyamide powder using laser sintering whereas the slotted
RF shield was supported by a GRP liner (Fig.2). Four capacitors were
distributed along each loop element whereupon the capacitor at the feeding port
was split to maintain symmetry. Two capacitors between adjacent elements were
used to decouple the coil elements. The values for these capacitors were taken
from previous simulations [1] and no further optimization was required. During
commissioning only one variable capacitor per element was used for fine tuning
of the element. Since for typical loading conditions the impedance at the
feeding ports is around 50 ohms, no impedance matching network is required. True
symmetric feeding was accomplished by a low-loss half-wave transmission line
together with two quarter-wave lines all made from Sucoform 141 cable (Fig.3).
An additional transformer line was used to ensure that the reference plane
located at the SMA connectors exactly mirrors the conditions at the feeding
ports.
The coil
was designed to withstand at least 1 kW of RF power per channel. B1+
measurements at a 7T Magnetom MR system (Siemens) were performed using an
external Tx/Rx-switch box.
Results
and Discussion
After
assembling of all coil elements and feeding networks fine tuning of each
element was performed using the variable capacitors. This is usually done when
the SMA connector of all other elements was left open resulting in an intrinsic
decoupling. When terminating all ports with 50 ohms no retuning is necessary. A
first validation experiment in a phantom [1] was performed using a B1+ mapping
sequence and a prototype version of the coil (Fig.4). Considering that transmit
field maps are susceptible to coil couplings and internal coil losses the
measured and simulated transmit field maps are in amazingly quantitative
agreement indicating that reasonable assumptions for internal coil losses were
made in [1]. Taking into account this result a reasonable estimation of achievable peak
B1+ values can be done (Fig.5). Due to considerable cable losses downstream the
RF amplifier at 297 MHz only 5 kW from 8 kW of combined RF power is available
at the coil plug. Nevertheless, the aspired peak B1+ values of 50 µT for the CP
mode excitation are much higher than reported peak values for commercial 7T
head coils [2]. For the CP mode, this maximum occurs in the center of the brain,
but using the pTx capabilities of the scanner, it can be steered to other areas
of interest with little loss in intensity.
Key to this high B1+ efficiency was careful design and material
selection, but also the choice of relatively short coil elements. The
concomitant downside of limited whole brain coverage had deliberately been
sacrificed for this dedicated MRS coil.
Conclusion
A 8-channel
pTx head coil optimized for MRS applications at 7T has been built. With
realistic 5 kW of total RF power at the coil connectors, the coil is capable to
generate close to 50 µT B1+ everywhere in the brain. This is needed to deliver
high-bandwidth MRS pulses and thus minimize chemical-shift artifact in localized
7T spectroscopy. Using such strong B1+ fields generated by surface coils,
neurochemical profiles were obtained from the occipital cortex [3, 4]. Providing
this type of methodology in a volume coil would pave the way for a wide range of
clinical and neuroscientific applications including the measurement of
important neurotransmitters, such as glutamate and GABA.
Acknowledgements
This
work was funded by European Metrology Research Program (EMRP) grant HLT06. The
EMRP is jointly funded by the EMRP participating countries within EURAMET and
the European Union.References
[1] Seifert F, et al., Reliable and robust RF safety
assessment of transmit array coils at ultrahigh fields, Proc. ISMRM 22 (2014)
4891.
[2] Pradhan S, et al., Comparison of single voxel
brain MRS at 3T and 7T using 32-channel head coils, MRI 33 (2015) 1013-1018
[3] Tkac I, Andersen P, Adriany G, Merkle H, Ugurbil
K, Gruetter R. In vivo 1H NMR spectroscopy of the human brain at 7 T. Magn
Reson Med 2001;46:451–456.
[4] Mekle R, Mlynarik V, Gambarota G, Hergt M, Krueger
G, Gruetter R, (2009) MR spectroscopy of the human brain with enhanced signal
intensity at ultrashort echo times on a clinical platform at 3T and 7T. Magnet
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