Synopsis
Lung
MR-Imaging is challenging due to low proton density in the lung. Ventilation
can only be visualized directly using exogenous contras agents such as hyperpolarized
noble gases or 19F-containing gasses as a “contrast agents”. This
work proposes a multi-channel transmit and receive (TX/RX) radiofrequency (RF)
coil that supports eight TX/RX channels (4 loop- and 4 dipole-elements) for 19F
and 1H lung imaging at 7.0T using a pTX-array.Purpose
Diagnostic
imaging of lung disorders is of high clinical relevance. MRI of the lung
constitutes a challenge [1], due to low
proton density. Consequently, lung ventilation is commonly visualized using
hyperpolarized noble gases [2], sulphur hexafluoride (SF
6) [3] or other
exogenous agents.
19F-containing gasses presents a valuable
alternative. In recognizing of this opportunity, this study proposes an eight channel
19F/
1H
transceiver array tailored for lung imaging at 7.0 T using a pTX-Array. The feasibility of the proposed RF coil array
for
19F/
1H-MRI is demonstrated in phantom experiments and
in in vivo studies.
Materials and Methods
The RF coil
consists of a planar posterior (Fig1. A) and an anterior (Fig1. B) section
which is modestly
curved to conform to an average chest. Each section contains 2 loops and two dipoles
optimized for
19F (f=279 MHz, element size
300 x 50 mm²) and a RF-shield (Fig1 C). EMF-simulations were
performed using CST Studio Suite 2014 (CST AG, Darmstadt, Germany) with a
phantom (Fig 3 A), voxel model Duke (Fig. 2) and Ella (Virtual family, IT’IS
Foundation, Zurich, Switzerland). B
1+-shimming using
simulated data was performed to improve the transmission field homogeneity at
minimum SAR within a VOI covering the lung (Fig. 2). Local SAR averaged over
10g of tissue was calculated and the input power was adjusted to meet the
limits of IEC 60601-2-33 Ed.3. This procedure was applied for the
19F-
and
1H-frequency.
Measurements
were performed on a torso phantom containing Agarose-gel+NaCl and a cylindrical
insert containing Galden (Apollo Scientific Ltd., Denton, Manchester, UK), a Perfluoropolyether, using a 7 T whole body MRI system with an 8-channel pTX-Array (Magnetom,
Siemens, Erlangen, Germany). Two different phase settings where employed-
phaseset 0: same phase setting for all channels, phaseset 1: phase setting deduced
from EMF simulation of the human voxel models Duke and Ella.
To validate
the simulation a Bloch-Siegert B1-mapping technique was utilized[4]
(Fig.3 B).
1H-MRI: 2D-FLASH, TR/TE=100/3.3ms,
FA=20°, resolution=(0.78x0.78x5)mm3, avg=1 (Fig. 3 C).
19F-MRI: 2D-FLASH,
TR/TE=20/3ms,FA=20°, resolution=(1.95x1.95x5)mm3, avg=32 (Fig. 3 D).
Whole VOI
coverage
19F 3D datasets were acquired with a density-adapted 3D
radial acquisition technique [5]: TE=0.4 ms, TR=11 ms, TRO=7.1
ms, TX amplitude 115 V (~90% SAR) equivalent to a tip angle of 30-40°, number
of projections=50000, averages=2, voxel size=(1.95x1.95x1.95) mm³,
scantime = 18:20min (Fig. 4).
In-vivo
cardiac
1H imaging was performed using 2D CINE FLASH: matrix
256x256, TE=1.84 ms, TR=4.14 ms, voxel size (1.4x1.4x4.0) mm³, cardiac
phases=30, total acquisition time=0:16 min. An MR stethoscope (EasyACT,
MRI.TOOLS GmbH, Berlin, Germany) was employed for cardiac gating [6]
Results
The
reflection coefficients of the eight channels were less than -20dB@279MHz and
less than -7dB@297MHz. The coupling between the channels was less than
-12dB@279MHz and less than -20dB@297MHz. Maximum local SAR10g did not exceed
the limits of 20 W/kg for an input power of 34 W for 279MHz and 297MHz. Whole
body and partial body SAR were well below the IEC limits. The combination of independent
loops and dipole-elements was of advantage for decoupling reasons. The outer
loop-elements could be easier tuned and matched to the human body. The inner
dipoles provided higher depth-penetration, which was instrumental to cover the entire VOI. B
1+ mapping confirmed
the transmission fields deduced from EMF simulations (Fig. 3+4). To demonstrate
the in-vivo B
1+ uniformity of the array for deep lying
organs in the torso, cardiac and renal MR was conducted at 297 MHz (Fig. 5).
Conclusion
This work demonstrates the feasibility of an
eight channel transceiver array tailored for
19F lung MRI. Our
results show that the array can be also used for
1H imaging, therfore supports anatomical
1H imaging as well as functional
19F MRI of the lung in clinically acceptable scan times. The proposed eight channel
1H/
19F transceiver RF
coil array contributes to the technological basis for the clinical assessment
of lung ventilation and pulmonary inflammation but also to research into the bio
distribution and bioavailability of
19F-containing drugs. The results underscore the challenges of fluorine MR in humans and
demonstrate that these issues can be offset by using tailored RF coil hardware.
The benefits of such improvements would be in positive alignment with the
technological requirements of further studies, that are designed to examine the potential of
19F MR to trace and
quantify
19F-containing agents and drugs.
Acknowledgements
This project was supported in part (H.W.) by the German Federal Ministry of Education and Research, “KMU-innovativ”: Medizintechnik MED-373-046.References
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Biederer, J. et al., 2012, Insights Imaging 3, 355–371
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et al., 2009, Magn Reson Imaging 27:549–556
[4] F. Carinci,
D. Santoro, et al., 2013, PloS One. 8
[5] Nagel,
AM, et al., Magnetic resonance in, 2009, 62(6):1565–1573
[6]
Frauenrath, T, et al., Journal of cardiovascular magnetic, 2010;12:67