Haojie Li1, Lili Liang1, Anqin Li1, Qiong Li1, Yao Hu1, Hui Lin2, Daoyu Hu1, and Zhen Li1
1Departments of Radiology, Tongji Hospital, Tongji Medical College, WU HAN, China, People's Republic of, 2GE Healthcare,MR Research China,WU HAN, WU HAN, China, People's Republic of
Synopsis
Since DWI with different models may demonstrate
different aspects of tissue properties, it should be valuable to compare and
explore their roles in renal tumors. To our knowledge, however, no comparison
of these different diffusion imaging approaches for the differential diagnosis in
renal tumors has been investigated so far. The purpose of this study was to
quantitatively compare and evaluate the potential clinical value of various
diffusion parameters obtained from monoexponential, biexponential, and
stretched exponential DWI models for differentiation of MFAML from ccRCC.Purpose
To qualitatively evaluate and compare the potential of
various diffusion parameters obtained from monoexponential, biexponential,
and stretched exponential Diffusion-weighted imaging models in differentiating
between Minimal Fat Angiomyolipoma (MFAML) and clear cell Renal Cell Carcinoma
(ccRCC).
Materials
and Methods
The Institutional
Review Board (IRB) approved this retrospective study and waived the informed
consent requirement.
Multi-b values DWI（0-1700 sec/mm2）were performed in 126 patients with either pathologic analysis-confirmed
MFAML (n=24) or ccRCC (n=102) on a 3-T MRI scanner. For the obtained diffusion
weighted images, biexponential model was employed to calculate parameters
including isotropic apparent diffusion coefficient (ADC), true ADC (ADCslow)
and perfusion fraction (f) while water
molecular diffusion heterogeneity index (a)
and distributed diffusion coefficient (DDC) was calculated using stretched
exponential model. Parameters from all models were compared between MFAML and
ccRCC through two-sample t-test.
Receivers operating characteristic (ROC) and intra-class correlation
coefficient analysis were applied for statistical evaluations
Results
ADC, ADCslow and a values were significantly lower in the
MFAML group than that in the ccRCC group (P < 0.01) while f and DDC values were significantly higher in the MFAML group than that in
the ccRCC group (P < 0.01). The area under the ROC curve (AUC) of both a (0.991) and ADCslow (0.920)
were significantly greater than those of ADC (0.742), f (0.787), and DDC (0.762) in differentiating MFAML from ccRCC.
Conclusion
Multi-b values DWI are feasible and useful in the
noninvasive tissue characterization of renal tumors. Water molecular diffusion
heterogeneity index (a) and ADCslow may provide additional information and improve the
differential diagnosis between MFAML and ccRCC compared with conventional
diffusion parameters.
Acknowledgements
No acknowledgement found.References
[1]Cohen HT, et al. New
England Journal of Medicine 2015;353:2477-2490.
[2]Rheinheimer S, et al.Eur J Radiol 2012;81:e310-6.
[3]Gaing B, et al. Invest Radiol 2015;50:144-52.