Sarah Keller1, Fabian Kording1, Hendrick Kooijman2, Christoph Schramm3, Roland Fischer4, Adam Gerhard1, Ansgar Lohse3, Harald Ittrich1, and Jin Yamamura1
1Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, 2MRI, Philips GmbH, Hamburg, Germany, 3Department of Internal Medicine, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, 4Biochemistry, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany
Synopsis
Hepatic osteodystrophy is a frequent complication in patients with
chronic cholestatic and non-choleatatic liver disease, affecting up to 20-30%
of patients [1, 2].
Besides conventional dual x-ray absorbtiometry (DXA) scans, diffusion-weighted
MRI (DWI) has been performed for the evaluation of osteoporosis and osteopenia
in risk patients. Follow up MRI examinations of PSC patients, to exclude
malignancy and identify bile duct stenosis, are frequently performed in
clinical routine. The aim of this study was to test the feasibility of add-on
DWI sequences during routine examination for the detection of early changes of
the bone marrow density (BMD) in comparison to DXA T-score values of the
vertebral bone and healthy controls.Purpose
The aim of this study was to test the feasibility of add-on DWI sequences
during routine examination for the detection of early changes of the bone
marrow density (BMD) in comparison to DXA T-score values of the vertebral bone
and healthy controls.
Methods
22 patients (age 49.5y;7-78y) with
histopathological diagnosed PSC and 11 controls (age 48.0y;28-48y) were included. MR-imaging was
performed at a Philips Ingenia 3.0 Tesla scanner (Ingenia, Philips Medical
Systems, The Netherlands) with a eight-channel SENSE body coil. Axial T2w imaging (T2wI TSE Sense) for anatomical orientation (TR
1250ms; TE 80ms; FA 90; Fov 400x400mm) was performed over the
epigastric region prior to the DWI. A diffusion weighted (DWI) spin echo echo-planar sequence (ssEPI) was
generated in transversal orientation including the whole vertebral body (coil combination: TR 1985ms; TE 69ms; FOV
400x400mm; voxel size 1.79x1.79x3.0mm; slice thickness 5mm;
intersection gap 0mm; b-factors 0, 50, 100, 200, 400, 800s/mm2;
average 35 slices, NEX 2). SPIR
technique was used for fat-suppression. A starting b-value of 50 s/mm² was applicated to suppress vascular signal
in the initial T2w EPI image.
IMAGE
ANALYSIS To avoid the susceptibility artefact of surrounding air in the basal
lung, an upper lumbar vertebral body (L1 or L2) was selected. The grey value of
the pixel corresponded to the ADC value [mm2/sx10-3] with a pixel-to-pixel ADC
map calculated for each slice. The value itself was calculated with the
equation Si(I) = Si(0) exp(-bi•ADC); where S(I) is the signal intensity
measured on the ith b-factor image and b1 is the corresponding b-factor. S(0)
estimates the signal intensity for a b-factor of 0s/mm2 i.e. without the noise
induced by the MR measurement [3]. The ROIs (mean size 1.8mm2 (SD±0.56)) were
localized onto the ADC-maps in the vertebral body excluding the intravertebral
space (Fig. 1).
STATISTICAL ANALYSIS was performed using GraphPad Prism 6.0f (GraphPad
Software Inc., USA). Correlation and significance was tested by the Student’s T-test and
parametric Pearson correlation analyses. The difference was considered
statistically significant if the significance level α = 0.05 was reached.
Results
Patients mean ADC was slightly, but not significantly
decreased compared to controls (02951±0.0648 mm
2/s x10
-3
vs. 0.3163±0.02221 mm
2/sx10
-3)
(Fig. 2). No significant bias of the ROI location in
the vertebral body (upper, mid and base portion) on the ADC-value was found. Mean T-score of the vertebral bone was -0.245±1.669, corresponding to
a Z-score of -0.233±1.517. Using non-parametric Pearson test, a slight correlation between the patients ADC and T-score (r=0.3334; 95%CI-0.1280-0.6762; p=0.15) was evident. No difference between the mean ADC in
patients with normal, osteopenic and osteoporotic BMD, according to T-score,
was observed.
Laboratory data
resulted as followed: AP 231.0±180.16(U/l); IgG 13.1±1.4(g/l); Bilirubin
1.05±1.03(mg/dl); Calcium 2.3±0.09(mmol/l); bAP 29.04±26.93(μg/l);
Osteocalcin 13.1±1.4(μg/l); 25OH-D3 22.67±10.03(μg/l); Parathormone 13±7.6(ng/l). The duration of PSC disease since diagnosis was 35.5 month (range
2-166.0 month) (
Tabl. 1). Neither a correlation of the ADC with PTH (r=0.01143; 95%CI
-0.4451-0.4632), 25OH VitD
3 (r=0.4522; 95%CI -0.1643-0.8147), Osteocalcin (r=0.03783, 95%CI -0.4368 to 0.4959) or bAP
(r=-0.1093; 95%CI -0.6429 to 0.4957), nor the liver parameters
AP (r= -0.1825; 95%CI -0.5693-0.2705), or bilirubin (r=-0.1914;
95%CI -0.5939-0.2879) was observed. Analysing the T-score in
further detail, a significant correlation with the patients duration of PSC
disease was found (r=-0.4984; 95%CI -0.7768- -0.05718; p=0.0298).
Discussion
OSTEOPOROSIS is a frequent comorbidity in chronic liver diseases [4].Particularly to date,
no reports evaluating the ADC using diffusion weighted MR
imaging (DWI) in patients with PSC, have been published. The aim of this study
was to test the feasibility of an additional added vertebral bone DWI for the
detection of hepatic osteodystophy during the standard follow up liver- MRI
examination of PSC patients. The obtained ADC values of patients and controls
were in the normal range of previous studies, reporting a vast range of 0.2-0.6
mm
2/sx10
-3 [5]. Nevertheless, ADC values obtained in our study did only show a tendency
of correlation to the T-score. This might be explained
by a lower number of study patients, especially with a T-score <-2.5.
A pathological decrease of the T-score (<-1.0) was found in 8 of 22 patients
proving the higher risk of PSC patients for low BMD. Furthermore, the T-score
values correlated significantly to the disease duration upon diagnosis,
underlining the hypothesis of disease progression on the osseous affection.
Conclusion
The results of this study show that the DWI add-on is
applicable in the routine MRI follow up examinations of PSC patients and might
serve to identify changes of the BMD during disease course. Larger studies
cohorts, using optimized DWI sequences are needed for further proving.
Acknowledgements
No acknowledgement found.References
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