Gregor Körzdörfer1, Thorsten Feiweier1, Yun Jiang2, and Mathias Nittka1
1Siemens Healthcare GmbH, Erlangen, Germany, 2Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States
Synopsis
Quantitative parameter maps obtained from Magnetic Resonance Fingerprinting (MRF) are sensitive to B1+ inhomogeneities. In principle, one could reduce this dependency by using a dictionary with an additional B1+ dimension. However, if the dictionary entries are not well distinguishable, the simultaneous pattern matching of three parameters (T1, T2, B1+) will not work reliably. In order to improve the separation of data in the B1+ dimension, we implemented a novel B1+ sensitive encoding. This approach employs a dedicated composite RF excitation pulse which directly encodes B1+ magnitude information into the phase of the acquired signal. Here we present an experimental proof of principle using a 1D projection MRF sequence.Purpose
Magnetic
Resonance Fingerprinting (MRF) [1] is a new technique that promises
multi-parametric, quantitative MRI. A series of RF pulses generates a complex
signal response in non-steady-state. For each voxel, the measured complex signal
evolution is then matched against a series of simulated signal evolutions. This
so called “dictionary” contains all possible signal evolutions that are
simulated for a combination of T1 and T2. The dictionary entry being most
similar to the simulated signal evolution determines the voxel’s T1 and T2.
Spatial
variation of the RF transmit field (B1+) is a commonly observed effect, in particular
due to dielectric properties of the sample at higher field strengths. Such
changes may lead to systematic errors in MRF results [2, 3], since the B1+
field impacts the applied flip angles and thus not only scales the acquired
signal evolution but also changes its characteristic behavior (for an example
see Figure 1). A straight-forward approach would incorporate the magnitude of
the B1+ field as a separate dimension into the dictionary. But also a
dictionary with a B1+ dimension is vulnerable for mismatches in case of the
additional dimension.
In order to improve the reliable
assignment of quantitative parameters, we propose a novel encoding scheme for
MRF which introduces an additional B1+ dependent component into the complex
signal evolution.
Methods
We
use the MRF method from [5] that is based on a fast imaging with a steady-state
precession (FISP) sequence. Instead of a two-dimensional spatial encoding using
a spiral readout trajectory, a one-dimensional Cartesian encoding was applied
which measures a projection of the object perpendicularly to the readout
direction. This prototype projection sequence enables the investigation of the
MRF signal in short scan times, without any undersampling artifacts and at high
SNR.
Usually,
the MRF sequence employs conventional slice-selective RF excitation pulses with
identical phase. We propose to replace each conventional RF pulse by a
composite variant comprising two pulses with a relative phase shift of 90
degree. For simplicity, in the current implementation both pulses are played
out successively, rewinding the slice selective gradient in between. This
results in a phase evolution of the signal depending mainly on B1+, a property
that has been used for the purpose of mapping the B1+ field before [4].The
impact of an artificial B1+ variation on the phase evolutions was measured,
simulated and compared. All scans were performed using a quantitative phantom (EuroSpin
“Test Object T05", Sonar Diagnostics Ltd, Livingston/UK) on a clinical 3T MR
scanner (MAGNETOM Skyra, Siemens Healthcare, Erlangen, Germany). For the
measurements, selected tubes of the phantom with defined T1 and T2 values were
located side by side such that their signal contributions could be clearly separated
despite the one-dimensional spatial encoding.
Results
Simulated
and measured signal evolutions show the same B1+ dependent phase evolution
behavior. Figure 2 exemplarily displays three measured phase evolutions for one
tube with specific T1 and T2 values at three different B1+ field settings.
Figure 3 displays the corresponding simulated phase evolutions. Comparing these
results to the conventional MRF sequence reveals the advantage of the new
technique. Figure 4 exemplarily shows two measured phase evolutions for one
tube with different B1+ field settings. Figure 5 shows the corresponding
simulated phase evolutions. Simulated and measured curves do not contain phase
information depending on B1+ that can be used for the pattern matching.
Conclusion
We demonstrate a novel method to better
discriminate entries of an MRF dictionary including the B1+ field as a separate
dimension. Results show that this can be achieved using dedicated composite RF
pulses. Future work will investigate more sophisticated, frequency-modulated,
single-pulse designs. The new degree of freedom can be used in different ways,
for example, only for a fraction of the RF pulse series or with varying
relative phase shift.
References
1. Ma D. et al., Magnetic
Resonance Fingerprinting, Nature 2013
2. Chen Y. et al, Magnetic
Resonance Fingerprinting (MRF) for Rapid Quantitative Abdominal Imaging, ISMRM
2014.
3. Jiang Y. et al.
Simultaneous T1 and T2 Quantitation of the Human Brain at 7 Tesla by MR
Fingerprinting, ISMRM 2015
4. Feiweier T., Method for
determining the B1 field strength in MR measurements, 2003, Patent No. US
75064546 B2
5.
Jiang Y. et al, MR fingerprinting using fast imaging with steady state
precession (FISP) with spiral readout, MRM 2014