Hongmei Zhou1, Xue Lin1, Haiyan Ding2, and Quan Fang1
1Cardiology, Peking Union Medical College, Beijing, China, People's Republic of, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of
Synopsis
Left Ventricular Non-compaction (LVNC) manifesting with
myocardial fibrosis can cause cardiac dysfunction, arrhythmia, and sudden death.
Native T1 mapping is an emerging CMR technique in quantitative evaluation of myocardial
fibrosis. This study aimes to investigate the usefulness of native T1 mapping
in characterization of myocardial abnormalities in LVNC patients by comparing
with late gadolinium enhancement. It may suggest that native T1 mapping may provide information for early
detection of fibrosis in compacted myocardium and stratification of severity in
Left Ventricular Non-compaction.Aims
The aim of this study was
to investigate the usefulness of native T1 mapping in characterization of
myocardial abnormalities in Left
Ventricular Non-compaction (LVNC) patients as compared with Late
Gadolinium Enhancement (LGE).
Background
LVNC manifesting with myocardial fibrosis can cause cardiac dysfunction, arrhythmia,
and sudden death in patients. However, identifying the high risk patients from
the wide clinical spectrum of LVNC patients is difficult. Native T1 mapping is an emerging cardiac magnetic resonance
technique in quantitative evaluation of myocardial fibrosis. This study aimed
to investigate the usefulness of native T1 mapping in characterization of myocardial
abnormalities in LVNC patients by comparing with LGE.
Methods
Thirty-one LVNC patients(19
males and 12 females; mean age, 42 ± 12 years), and 14 normal controls(9 male and 5 female; mean age, 45 ± 15 years) underwent CMR(3.0T, Achieva TX, Philips Healthcare,
Best, Netherlands) with modified look-locker inversion recovery sequence
(MOLLI) to acquire native T1 maps. Furthermore, all the patients were scanned
with an inversion-recovery sequence, after injecting 0.2 mmol/kg of
gadolinium-DTPA 5 ± 5 min to obtain LGE images. Patients were divided into two groups: patients with LGE (LGE+) and patients without LGE (LGE-). All CMR data were analyzed
using MATLAB (MathWorks, Natick, Massachusetts, USA). One Way ANOVA and
Univariate Logistic Regression were used for statistical analysis. A p value of
p <0.05 was considered as statistically significant.
Results
As it was shown in Figs. 1 and 2. Of 31 LVNC patients, 14 (45%)
had LGE. LVNC patients with LGE showed significantly higher native T1 values
than those without LGE (1181.4±53.7 ms vs. 1140.6±32.8 ms, p=0.014). The native
T1 of LVNC patients without LGE was significantly higher than normal controls (1140.6±32.8
ms vs. 1,098.8±40.8 ms, p=0.011). In discriminating presence of LGE in LVNC
patients, the odds ratio and coresponding 95% confidence interval (CI) of
native T1 was respectively 2.966 (95% CI: 1.123-7.835, p=0.028) and 4.330 (95%
CI: 1.175-15.957, p=0.028) before and after adjusting for age, gender, and body
surface area with the increment of 1 standard deviation (SD) of the native T1
value.
Conclusions
Myocardial native T1 is significantly associated with LGE in LVNC patients, indicating its potential in stratification of disease severity. The findings of LVNC patients without LGE having elevated native T1 compared with normal controls suggests that the native T1 mapping might be a useful tool for early detection of myocardial fibrosis.
Acknowledgements
This study was supported by Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (No.2011BAI11B11).References
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