Myocardial microcirculation perfusion dysfunction plays a significant role in assessing cardiac function, detecting heart failure and predicting prognosis. Diabetes often accompanies with hypertension, both are the majority of causes of myocardial microcirculation status dysfunction in the world ^[1]. There have many methods to assess myocardial microcirculation perfusion such as SPECT, PET, MR first-pass perfusion, etc, but they have some limitations and deficiencies ^{[2, 3]}. Intravoxel Incoherent Motion diffusion weighted magnetic resonance could be used to reflect water diffusion and blood perfusion noninvasively ^{[4, 5]}. Because of cardiac and respiratory motion, there are many limitations in cardiac imaging. The aim of this study is to assess myocardial microcirculation perfusion status in patients with diabetes and/or hypertension using IVIM.8 patients with diabetes and/or hypertension (4 male, 46-68 years) and 20 health volunteers (9 man, 22-56 years) were registered in the study and were underwent Intravoxel Incoherent Motion diffusion weighted cardiac magnetic resonance imaging (b values=0, 20, 50, 80, 120, 150, 200, 300, 500 s/mm²) on a 3.0T MRI scanner (GE Signa HDxt) with 8 channel cardiac coli. The IVIM images were performed on apex, mid and basal slice short axis respectively with breath-hold. The scan time was about 20-24s every slice. We countered endocardium and epicardium avoiding blood pool and part volume effect to obtain main measurement parameters, including Standard _ADC, Slow _ADC, Fast _ADC, fraction of Fast _ADC values. Nonparametric test were performed to analyze differences of myocardial perfusion between healthy volunteers and patients. P＞0.05 were defined as significance.The Fast _ADC (10^-3 mm²/s) of health volunteers was higher than patients with diabetes and hypertension (129.95±21.12 vs 99.18±18.17, P＜0.01). The Standard _ADC (10^-3 mm²/s), Slow _ADC (10^-3 mm²/s), and fraction of Fast _ADC (%) values had no significant differences between healthy and patients (1.95±0.63 vs 1.81±0.39, 3.35±3.24 vs 3.04±0.34, 0.329±0.078 vs 0.323±0.069, P=0.82, 0.60, 0.98).IVIM theory provides us a new method to quantitatively evaluate water molecular diffusion and blood perfusion, reflecting organization pathologic characteristic. Lower b values (b ＜200s/mm2) imaging could mainly monitor myocardial tissue microcirculation perfusion status without contrast agents[4]. Fast _ADC value presents for microcirculation perfusion. We found that Fast _ADC vales in patients were lower than in healthy volunteers, so it reflected microcirculation perfusion dysfunction in patients with ventricular remolding and heart failure. But the other IVIM parameters had no differences between patients and healthy volunteers in this study. Whether the other IVIM parameters could use to assess myocardial perfusion or not, it still needs further research, even though f values. IVIM CMR could avoid the risk of contrast medium allergy and nephrogenic systemic fibrosis. It would also be advantageous to repeatedly follow-up. Cardiac magnetic resonance IVIM diffusion weighted imaging could noninvasively be used to assess and monitor myocardial microcirculation perfusion dysfunction in patients with diabetes and/or hypertension without contrast agents.