Diffusion weighted imaging (DWI) has been a powerful tool for lesion detection in clinical application. DW images are often acquired with single-shot Echo-planar imaging (ss-EPI) because it can offer high imaging speed. However it also suffers geometry distortion and signal loss in the case of susceptibility difference ^[1], especially for high resolution imaging. Reduced filed-of-view (rFOV) imaging is proposed to overcome these shortcomings by reducing the FOV at the phase-encode (PE) direction ^[2]. Multi-shot DWI (ms-DWI) is another effective way to weaken the distortion issue. Since small FOV and ms-DWI are methods based on different principle, it is nature the combine these two methods together to further reduce distortion. In this work, using iZOOM ^[3] and IRIS ^[4] as specific examples of small FOV and ms-DWI, the performance of the combination of these 2 techniques, named ms-iZOOM, was investigated.This study was performed on a 1.5T Philips Multiva scanner (Philips healthcare, Suzhou, The Netherlands) with 16-ch head and spine coil. Spine study was applied to evaluate the performance of ms-iZOOM. Four data sets for conventional single shot DWI (ss-DWI), single shot iZOOM (ss-iZOOM) ^[3], multi-shot DWI ^[4], and multi-shot ZOOM were acquired. All the DW images of spine in the sagittal direction were acquired from a healthy volunteer using the following parameters: 1) ss-DWI: FOV = 260*260 mm², TR = 2000 ms, TE = 73 ms, SENSE factor = 2, NSA = 8; 2) ss-iZOOM: 2D RF excited, FOV = 260*54 mm², TR = 2000 ms, TE= 126 ms, NSA=6; 3) ms-DWI (IRIS): FOV = 260*152 mm², TR = 2000ms, TE1/TE2 = 68/108 ms, 3 shots, SENSE factor = 2, NSA = 8; 4) ms-iZOOM: 2D RF excited, FOV = 260*70 mm², TR = 2000ms, TE1/TE2 = 75/122 ms, 3 shots, NSA = 6; and the other parameters of these four protocols are identical: 11 slices, in-plane resolution = 1.35*1.1 mm², slice thickness = 5 mm, b-value = 500 s/mm² .The diffusion weighted images of spine with four different protocols are shown in Fig 1. The contour of spine indicated by red curve is obtained from a T2 weighted TSE image. It can be seen that the distortions are reduced most in IRIS and ms-iZOOM, the spine geometry is almost the same as that of TSE image. Compared to ms-DWI using IRIS, ms-iZOOM provides a higher image SNR with less scan time. The scan time of these two protocols are 2 min 30 s and 3 min 18 s respectively.Combination of iZoom and ms-DWI using IRIS resulted in images better than either iZOOM or IRIS. Multi-shot iZoom using IRIS reconstruction can be an effective way to provide high resolution images with improved image quality, and a potential application for the research and clinical diagnosis in diffusion imaging.