For patients with impaired breath-hold capacity, highly accelerated cardiac cine MRI may be useful. The purpose of this study is to perform functional MR imaging of the whole heart in a single breath-hold using an under-sampled data acquisition in combination with compressed sensing with parallel imaging.Whole heart coverage functional cardiac MRI is acquired in a single breath-hold using compressed sensing (ITSC ¹) combined with parallel imaging (SENSE ²). Measurements were performed using a segmented balanced SSFP sequence (TR= 2.75 ms, TE= 1.21 ms, VPS= 12, field of view= 350 mm x 350 mm, acquisition matrix size= 192 x 192, slice thickness= 8 mm, number of slices= 12, ECG gating with 22 cardiac phases) on a 3.0T whole body MRI system. A sampling strategy was utilized enabling efficient under-sampling of the k-space and thereby accelerating data acquisition. Figure 1 shows the sampling locations for ITSC and ITSC x SENSE. The sampling scheme for ITSC, acquiring dc for every frame, and small positive and negative bands alternatively is proposed. For combining with SENSE, sub-sampling scheme of even phase encodings is added. Data acquisition for all CINE data of each slice was completed in a single R-R interval. The ITSC x SENSE applied for the reconstruction of the missing data. The key components of the ITSC method are to truncate small transformed coefficients in the r-f domain, and to restore the measured data in the k-t domain iteratively, until the reconstructed images converge. And then SENSE reconstruction is performed sequentially. It takes 23 s for reconstruction of single slice CINE (22 frames) on Matlab R2013a programming environment(The MathWorks) with a standard PC equipped with an Intel Core i7 CPU @ 2.93GHz.The proposed technique was applied for in-vivo functional cardiac imaging of the whole heart in a single breath-hold. Applied compression factors are 4 of ITSC and 2 of SENSE. Figure 2 shows the results of whole heart coverage in a single breath-hold using the ITSCxSENSE in a short axis plane. The in-vivo images are acquired with adequate spatial resolution (1.8 mm x 1.8 mm), temporal resolution (31 ms) and image quality for diagnosis. In conclusion, whole heart coverage in a single breath-hold using ITSCxSENSE can be used to achieve adequate spatial resolution (1.8 mm × 1.8 mm) and relatively high temporal resolution (31 ms), with good image quality and functional movement. Furthermore it takes less time for the reconstruction than other compressed sensing methods ^3,4 do. The ITSCxSENSE may be useful for patients with reduced breath-hold capacity.