Intervertebral disc degeneration (IVDD) is one of the major health problems at the present. Although IVDD is a multifactorial disease, it is generally accepted that limited nutrition is the final common pathway, of which the endplate pathway is the most important nutrition pathway of the intervertebral disc. There are two key structures in this pathway, that is, the vertebra subchondral bone (VSB) and the cartilage endplate (CEP) and recent studies have revealed a positive relationship between CEP perfusion and degenerated discs ¹. In this work, we explore the relationship between IVDD and perfusion parameters of both VSB and CEP, based on which quantitative perfusions changes were presented regarding to different Pfirrmann grades.90 lumbar discs from 18 individuals (7 male, 11 female, age: 56.72±3.08 years) were evaluated by Dynamic Contrast Enhance Magnetic Resonance Imaging (DCE-MRI) sequence of 3D-LAVA-XV (TR/TE = 3.5ms/1.7ms, flip angle 10º) and conventional FRFSE T2WI (TR/TE = 2036.0ms/120 ms), FRFSE T1WI (TR/TE = 503.0ms/11.8ms), respectively. Raw DCE-MRI data were post-processed by the Omni Kinetics software, and the cranial and caudal VSB and CEP perfusion parameters (K^trans, K_ep, V_e) were measured (as shown in Figure. 1). Final values were obtained by averaging the cranial and caudal perfusion parameters. These 90 lumbar discs were classified according to the conventional Pfirrmann grade system into Pfirrmann I- IV grades. Univariate ANOVA with post-hoc tests (Newman-Keuls Multiple Comparison Test) was employed to judge the difference of the DCE-MRI perfusion parameters (K^trans, K_ep, V_e) among these grades, and p＜0.05 was considered statistically significant.In 90 intervertebral discs, there were 5 Pfirrmann I (5.56%), 27 Pfirrmann II(30.00%), 21 Pfirrmann III (23.33%), 32 Pfirrmann IV (35.56%), 5 Pfirrmann V (5.56%). The parameters K^trans of Pfirrmann I-V was (0.069±0.057),( 0.276±0.207),(0.150±0.136),(0.227±0.172) and (0.166±0.113) min-1, K_ep was (0.545±0.572), (1.267±0.544), ( 0.992±0.500),(1.416±0.555) and (1.165±0.528) min-1, V_e was (0.096±0.040), (0.182±0.087), (0.136±0.075), (0.154±0.090) and (0.134±0.060) %, respectively. The CEP perfusion of parameters K^trans of Pfirrmann I-V was (0.014±0.024), (0.059±0.099), (0.030±0.047), (0.035±0.034) and (0.023±0.021) min-1, K_ep was (0.206 ±0.328), (0.411 ±0.265), (0.225 ±0.131), (0.361 ±0.181) and (0.333±0.208) min-1,V_e was (0.128±0.046), (0.178±0.141), (0.169±0.132), (0.121±0.070) and (0.086±0.048) %, respectively. As shown in Figure. 2,Except for VSB perfusion parameters K_ep of Pfirrmann I and II, Pfirrmann I and IV, Pfirrmann III and IV, the cranial VSB perfusion parameters K_ep of Pfirrmann I and II, Pfirrmann I and IV, Pfirrmann III and II, Pfirrmann III and IV, the caudal VSB perfusion parameters K_ep of Pfirrmann I and II, the cranial CEP K_ep of Pfirrmann III and II ,other perfusion parameters K_ep,K^trans and V_e of two different grades had no significant difference observed in VSB and CEP. The results of this study have demonstrated that the VSB perfusion increase in Pfirrmann II and then decrease in Pfirrmann III. It does not show a single change trend in the progress of IVDD. This phenomenon could be interpreted that metabolism compensatory increase occurs in early IVDD, especially in Pfirrmann II. The cranial VSB perfusion is also higher than caudal VSB perfusion. The perfusion in Pfirrmann IV and V increase, it may be influenced by the inflammatory factors. However except for cranial CEP K_ep of Pfirrmann II and III,there is no other significant change in CEP perfusion, the limitation of it maybe the scan time in DCE-MRI sequence, CEP attained the peak enhancement only at 2 hours later ².In the early progress of IVDD, its metabolism increases for compensation, clinical research should put more emphasis on early onset stage of IVDD such as in Pfirrmann II,and it will then decreases with severe degeneration.