Isabelle Saniour1, Anne-Laure Perrier2, Gwenaël Gaborit2,3, Jean Dahdah3, Lionel Duvillaret3, and Olivier Beuf1
1CREATIS, Université de Lyon ; CNRS UMR5220 ; Inserm U1044 ; INSA-Lyon ; Université Claude Bernard Lyon 1, Villeurbanne, France, 2IMEP-LAHC, UMR 5130 ; Université de Savoie, Le Bourget-du-Lac, France, 3Kapteos, Sainte-Hélène du Lac, France
Synopsis
In MRI, a
real time monitoring of the magnitude of the electric field prevents the
patient from safety hazards due to heating phenomenon. A sub-cm electro-optical
probe was used to localize and measure the E-field in 4.7-T MRI. This probe is
formed from an electro-optic crystal that changes its refractive indexes
according to the applied E-field. The results show that the probe is non-perturbative
regarding the E-field and does not affect the quality of MR images. Six clear E-field
concentrations were localized at proximal and distal sides of the transceiver
coil. Their magnitudes vary between 10000V/m and 20000V/m. Purpose
In magnetic resonance imaging (MRI), the real time measurement of
electrical field E associated with the radiofrequency (RF) magnetic
field B1 is important to quantify the energy absorbed by the
tissues and to assess possible safety hazards due to local heating phenomenon. E-field
could effectively increase the temperature in the tissues nearby by inducing RF
currents in any implant or metallic cables used for signal transmission and
placed inside the transmit body-coil1, 2. For the measurement of the
intensities and the distribution of E-field, the adequate probe should
be non-magnetic and non-perturbative regarding the E-field and must have
a large working frequency range depending on B0.
The commonly used probes have either a metallic structure or a large dimension
which limits their bandwidth3, 4 and may disturb the
electro-magnetic field with bias measurements. Others optical probes do not
measure directly the E-field 5. In the following, the E-field
measurement experiment using a sub-cm electro-optical (EO) probe in a
preclinical 4.7-T MR system is presented.
Methods
The EO probe is basically formed from a monocentrosymetric crystal
(ZnTe, BSO…) that changes its refractive indexes proportionally to the applied
E-field (Pockels’ effect). In fact, this index variation leads to a
modification of the polarization state of the distributed feedback (DFB) laser
(wavelength
λ=1.55 µm), according to the
E-field. This DFB laser is
emitted toward the crystal through a 15 m optical fiber. Then, this optical
polarization is transmitted, using the same optical fiber, to be analyzed in
real time and to be converted to an analogue electrical signal due to
optoelectronic components. This small size probe (sub-cm) is non-invasive and
insensitive to the variation of the temperature or the magnetic field (static
or dynamic)
6 which is suitable for MRI environment. It can operate
in a frequency range from 30 Hz to 18 GHz and the electrical field is directly
proportional to the measured output signal. The experiment was performed using
a 4.7-T preclinical MRI using a 60 cm inner diameter transceiver birdcage
linear coil (figure 1). A moving EO probe was inserted into the transceiver
coil to localize
E-field concentrations. The optical detected signal was
transmitted via an optical fiber to the signal processing unit in order to be
visualized by an oscilloscope. The trigger signal was provided by MR system. For
this experiment, a RARE sequence with hermite shape RF pulse was used. The
imaging parameters are: TR/TE =6020.6ms/14ms, flip angle=90° and turbo factor=8.
Results
First of all, in order to demonstrate that the probe is completely dielectric
and non-perturbative; the EO probe was placed on the NiSO
4 phantom .The
presence of the probe had no impact on the image quality (absence of artefacts
and similar signal to noise ratio). Second, the probe was moving (axial and
radial movement) inside the RF coil to detect the presence of
E-field. Three
hot spots of the
E-field were detected clearly at proximal and distal
sides of the transceiver coil corresponding to three different probe’s locations
(figure 2). Their magnitudes vary between 10000 V/m and 20000 V/m. Figure 3 shows the shape of the detected EO
signal and related electric field during the emission of RF signals. The
E-field
is linearly proportional to the EO signal with a factor of linearity around 38000
and with a dynamic range exceeding 120 dB. Using the Fast Fourier Transform
(FFT), the frequency of the detected signal is 200 MHz that corresponds exactly
to the proton resonant frequency at 4.7-T (figure 4).
Discussion
The EO probe can detect directly the
E-field in real time at
Larmor frequency with a transverse spatial resolution lower than 5mm. The
analysis of hot spots’ magnitudes shows that the field is not uniform and
it depends on both the position of the EO probe inside the transceiver and the
orientation of the probe itself. Further experiments will be performed to study
this correlation. The results exhibit the effectiveness of measuring directly the
E-field in a preclinical 4.7-T MRI using an optical probe without
alteration of environment. Due to availability, the experiments were performed
at 4.7-T but will be further addressed in a clinical 3-T MRI system.
Conclusion
The objective of this study was to validate the use of a specific EO
probe to determine the local magnitude of the
E-field associated to the RF magnetic field. During the RF emission, a
non-perturbative EO probe can be used to give a real time measurement of the
electrical field in order to protect the patient from any safety risk. Such
probe could be used to provide localized
E1-field map.
Acknowledgements
This work was supported by the Région Rhône-Alpes and performed within the
framework of the LABEX PRIMES (ANR-11-LABX-0063) of Université de Lyon, within
the program "Investissements d'Avenir" (ANR-11-IDEX-0007) operated by
the French National Research Agency (ANR).References
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