Lina Zhang1, Jinli Meng2, Jianxun Qu 3, Jianguo Chu1, Ailian Liu1, Yanwei Miao1, Qingwei Song1, Zhijin Lang1, Jianyun Kang1, Qiang Wei1, and Bin Xu1
1The 1st affiliated hospital of Dalian Medical University, Da lian, China, People's Republic of, 2Chengban Branch of West China Hospital, Chengdu, China, People's Republic of, 3GE Healthcare, MR Research China, Beijing, Beijing, China, People's Republic of
Synopsis
To evaluate the diagnosis
value of conventional MRI and Diffusion-weighted
imaging in different subtypes of benign inflammation breast lesions.
From the result we can see that morphological features as while as MR
manifestations especially ADC findings may be of significant value for
diagnosing different benign breast inflammatory lesions.Purpose
A retrospective study was performed to investigate the diagnostic value of Diffusion-weighted
imaging (DWI) in differentiating benign breast inflammatory lesions.
Methods
This retrospective study was
approved by the institutional review board and requirement for informed consent
was waived. Sixty one female patients with pathology-proven single
benign breast inflammatory lesion
underwent routine MR examination including axial and sagittal STIR, axial DWI with b value of 0 and 800 s/mm2,
and 3D DCE MRI acquired with VIBRANT. Both DCE-MRI and DWI results were
reviewed. Patients were categorized
into three groups based on pathologic results: Nonspecific Mastitis group (NM, 32 patients, age, 41.34 ± 12.71);
Abscess
group (AB,12
patients,
age, 41.33 ± 18.79); and Granulomatous Mastitis
group (GM, 17
patients,
age, 44.47 ± 14.68). ADC values were recorded. Intra-class correlation coefficient (ICC)
was used to test the consistency of the different ADC values. One-way
ANOVA test was applied to compare ADC values of the three groups. Logistic
analysis was applied to analyze the general data of three groups. Discriminative
abilities of models were compared using the area under the receiver operating
characteristic curve (AUC). P≤0.05 was considered indicative
of a statistically significant difference.
Results
The ICC value of consistency of the
two measurement of ADC values for three groups were 0.829, 0.794, and 0.844, the
total is 0.853. There was significant difference of the
ADC value among three groups (Fig.1, P=0.003). The reliable range
of ADC values in diagnosing
different kinds
of breast inflammatory lesions is as
follows: NM> 1.348 × 10
-3 mm
2/s, AB
< 1.125 × 10
-3 mm
2/s, and 1.125 ×10
-3 mm
2/s
< GM<
1.328 × 10
-3 mm
2/s (Table1). There was no significant difference between mass
and non mass enhancement or mass
lesion enhancement characteristics among three groups, while
there was significant difference in distribution
of non mass
enhancement among three groups (Table2). There was
also no significant difference in location of lesion, patient age or T
2WI signal among three groups.
Discussion and Conclusion
The results of our study indicate
that ADC values difference between NM and AB lesions is most, while difference is smallest between AB and GM group, suggesting the
degree of inflammation of the inflammatory cells infiltration, tissue necrosis
and regeneration of different levels
[1]. Some
previous studies pay attention to distinguishing
inflammation from tumor lesions
[2-3]. We analyzed DWI evaluation on different subtypes of inflammation lesions and assume ADC
value maybe a potential parameter in classification of inflammation lesions of breast. ADC value is the most efficient indicator in differentiating
benign breast
inflammatory lesions. Combining
morphological features and DWI characteristics, classification of benign breast
inflammatory lesions could be performed accurately.
Acknowledgements
No acknowledgement found.References
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