David G Norris1,2 and Jenni Schulz1
1Donders Institute for Brain Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands, 2Erwin L Hahn Institute, University Duisburg Essen, Essen, Germany
Synopsis
This abstract describes the use of pulses that have a quadratic phase profile in the spatial dimension for simultaneous multi-slice imaging. The quadratic profile reduces the peak voltage needed by an amount dependent on the number of simultaneously excited slices. The pulses have to be used as an excitation-refocusing pair, with the refocusing pulse having half the phase gradient. The echoes from each slice are simultaneously refocused and there are no additional constraints on the pulse duration.Purpose
Simultaneous Multi-Slice (sms) imaging has found widespread
application particularly for BOLD fMRI, and DWI, as it offers high acceleration
factors for sequences that are required to operate at a fixed TE. Peak RF power
can be a serious impediment to the implementation of these pulses in spin-echo
imaging. In this abstract we propose a method to reduce the peak power based on
a quadratic phase modulation of the phase of the magnetisation in the spatial
domain. In the excitation k-space the multiband RF waveform is then convolved
with the FT of a chirp function. The properties of the resultant pulses are
explored with respect to their peak power reduction; slice profiles, and
ability to simultaneously rephase multiple slices.
Theory
Hitherto the peak power has been reduced by modifying the
phases of the substituent pulses; time shifting the RF pulses with respect to
each other. Quadratic phase modulation in the excitation k-space is equivalent
to the application of a linear frequency sweep, and can be used to reduce the
peak power, but similarly to adiabatic RF pulses this results in a sequential
excitation of the MB slices, which imposes additional constraints on the
excitation/refocusing pulse pair. The FT of a quadratic phase function has the
desirable properties that it has an approximately box-car form while of course
preserving the amplitude of the MB pulse. Convolution with the MB pulse form
thus offers a perspective for reducing peak power while retaining other
desirable characteristics including simultaneous refocusing of all slices. The
key idea is that in the spatial domain a single quadratic phase function is
used of the form φ=Kz
2,
where K is the scaling factor. As this function is superimposed across slices
this implies that not all slices have identical phase profiles and are hence no
longer identical in excitation k-space. If a single excitation pulse is used
then of course there will be a quadratic phase modulation through the slice(s).
This may be refocused by using a pulse with half the amplitude of the phase
modulation, or more exotically with a quadratic shim pulse.
Methods
In order to explore the pulse characteristics in the high
flip angle domain SLR optimised 90 and 180 (256 points, BWTP12 and 8
respectively) pulses were used as the basis for generating MB pulses. MB
factors of 3 and 5 were considered. MB pulses were generated in the standard
fashion by shifting and adding the FT of the pulse forms. Quadratic phase
modulation was applied using ten increments of K from zero up to a value
corresponding to a phase change of π between adjacent spatial points at the
maximum z-coordinate excited. This ensured that no phase aliasing occurred
within the excited slices. Magnetisation trajectories were calculated using the
Bloch equations. All simulations were performed in IDL (Bolder Colorado, USA).
Results
As the quadratic scaling factor increased the peak voltage fell
to a plateau well before the phase-aliasing limit was reached, as is shown in
figure 1, for the example of 5 slices. This means that the necessity to use
half K for refocusing pulses does not lessen the power reduction, as both
excitation and refocusing can be accommodated within the plateau. Hence we
consider further the pulses associated with K=5. For 5 slices the reduction in
peak voltage is about 70% and for 3 slices it was about 60% (data not shown). Slice
profiles for 90 and 180 pulses at K=5 are shown in figure 2. The pulse form
corresponding to the 90 is shown in figure 3. The pulses all rephased to have
the same phase and hence would have the same TE.
Discussion and Conclusions
A quadratic phase modulation in the spatial domain could
potentially be refocused by a non-linear gradient pulse. An alternative would
be to have the quadratic modulation only within the slices (i.e. modulate as if
all the slices were adjacent). Quadratic modulation does lead to some
deterioration of the slice profile, but this is relatively minor, and could
possibly be corrected by designing the pulses a priori to have a quadratic modulation. There could also be
further potential in exploring other phase modulation functions. In conclusion
the pulses proposed offer a reduction in peak power without further constraints
on the pulse durations.
Acknowledgements
No acknowledgement found.References
1.
Hennig, J. MRM 25; 289-98, 1992
2.
Auerbach
E. J. et al. MRM 69; 1261-7, 2013
3.
Sharma
A. et al. MRM DOI 10.1002/mrm.25629, 2015