Imperfect fat suppression, which is common in abdomen 3T magnetic resonance (MR) scan, causes heavy chemical-shift artifacts in diffusion weighted imaging (DWI) and affects lesions detection and clinical diagnosis. Gradient Reversal Fat suppression (LIPO) technique can provide improved fat suppression in a large FOV by reversing the slice selection gradient of the refocusing RF pulse. However, no research has been reported on the performance of this technique in normal pancreas. To evaluate the clinical value of Gradient Reversal Fat Suppression technology (LIPO) in diffusion-weighted MR imaging of pancreas in normal volunteers on 3.0T MR scanner. DWI-LIPO and conventional DWI sequence (b values 800 s/mm²) were performed among twenty healthy volunteers on a 3.0T whole-body MRI system (Ingenia, Philips Healthcare, The Netherlands). Apparent diffusion coefficient (ADC) values were calculated. ROIs were drawn on the head, body and tail of pancreas, The ADC value and image quality parameters including signal to noise ratio (SNR), blurring and artifacts level were evaluated by two experienced radiologists and the final result was reached after discussion when disagreement occurred. One–way ANOVA analysis and LSD test were used to compare DWI-LIPO sequence with conventional DWI whether statistically significant differences exist through the software SPSS 19.0.ADC value of pancreas showed no statistical difference between two different DWI sequences(P=0.172). Normal pancreas in DWI with LIPO has more higher SNR than conventional DWI(P=0.014); There was statistically difference between the SNR of pancreatic head or tails in DWI with LIPO and without LIPO(Table.1). Compared with conventional DWI sequence, the artifacts and image blurring degree scores both showed statistically difference in DWI with LIPO(P= 0.001、0.027)(Table.2). Ideal fat suppression is hard to achieve with the conventional frequency-selective fat suppression method alone due to the inhomogeneity of B0 and B1 field in body imaging. The inversion of slice selective gradient, used in LIPO, can avoid the refocus of fat signal with chemical shift. The higher SNR of normal pancreas in LIPO may be caused by the refocus of signal from imperfect slice profile. In this study, normal pancreas in DWI with LIPO has lower artifact scores with uniform signals and clear edge than DWI with conventional fat sat. Therefore, DWI with LIPO may have the potential on improving the image quality of pancreas at 3.0T MR.