Liyuan Song1, Lizhi Xie2, and Junfang Xian1
1Department of Radiology,Beijing Tongren Hospital,Capital Medical Universityy, Beijing, China, People's Republic of, 2GE Healthcare, MR Research China, Beijing, Beijing, China, People's Republic of
Synopsis
This work assessed the feasibility of quantitative parameters
derived from dynamic contrast enhanced MR imaging (DCE-MRI) and evaluate the
value of quantitative dynamic contrast enhanced MR imaging in the diagnosis and
differential diagnosis of orbital masses in adults. From the result we can see
that it is feasible that quantitative parameters of orbital masses can be
derived from DCE-MRI. ROI onf the earliest and most enhanced area was optimal
for distinguishing benign masses from malignant masses in orbit.Purpose
To assess the feasibility of quantitative parameters derived from dynamic
contrast enhanced MR imaging (DCE-MRI) and evaluate the value of quantitative dynamic contrast enhanced MR
imaging in the diagnosis and differential diagnosis of orbital masses in
adults.
Methods
One hundred and forty two patients
with orbital masses confirmed by pathology were enrolled in the study
consisting of 89 benign masses and 53
malignant masses in orbit
[1,2]. Three methods of selecting regions of interest (ROI)
[3,4] were compared to obtain quantitative parameters: (a) covering
the whole lesion on the largest slice, (b) a round or ovoid region of 8mm
2 covering the earliest and most enhanced
area, and (c) covering the lesion excluding the hemorrhage and necrosis on the
largest slice (Figure.1).
Parametric maps were obtained for quantitative parameters including
Ktrans，
Ve
and
Kep
(Figure.2).
Quantitative
parameters that distinguishing benign from malignant masses were analyzed by using independent rank sum
test, independent T-test, receiver operating characteristic curves (ROC) and Z test. P value of less
than 0.05 was considered to represent a significant difference.
Results
There were significant differences between orbital benign and
malignant masses in
Ktrans and
Kep
(p<0.01)(Table.1).
However,
Ve showed no difference between orbital benign and malignant masses（p>0.05）. ROI on the earliest and
most enhanced area was best for distinguishing benign from malignant
masses in orbit (p<0.05) (Table.2). The corresponding
Ktrans
distinguished malignant masses from benign masses with
sensitivity, specificity, positive predictive value, negative predictive value
and accuracy of 79.2%, 64.0%, 56.7%, 83.8%, 69.7% respectively. The
corresponding
Kep distinguished
malignant masses from benign masses with sensitivity, specificity, positive predictive
value, negative predictive value and accuracy of 88.7%, 59.6%, 56.7%, 89.8%,
70.4% respectively.
Conclusions
It is feasible that quantitative
parameters of orbital masses can be derived from DCE-MRI. ROI on the earliest and most enhanced area was
optimal for distinguishing benign masses from malignant masses in
orbit.
Acknowledgements
No acknowledgement found.References
[1] Xian J,
et al. European Radiology, 2010, 20(7): 1692-1702.
[2] Khalek
AA, et al. Neuroradiology, 2011, 53(7): 517-522.
[3]
Yankeelov TE, et al. Magnetic Resonance Imaging, 2005, 23(4): 519-529.
[4] Craciunescu
OI, et al. International Journal of Radiation Oncology, Biology, Physics, 2012,
82(3): 345-350.