Hailong Luo1, Yong Zhang2, Xueying Ling1, Ying Wang1, and Li Huang1
1Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China, People's Republic of, 2GE Healthcare MR Research China, Beijing, China, People's Republic of
Synopsis
In patients with crossed cerebellar
diaschisis (CCD), the blood flow and glucose metabolism in the cerebellar was reduced. In this study, arterial spin labeling (ASL) and intravoxel incoherent imaging (IVIM) techniques were used to assess the micro-perfusion change in patients with CCD.Purpose
Crossed cerebellar
diaschisis (CCD) is a common radiological phenomenon manifested as reduced
blood flow and glucose metabolism in the cerebellar hemisphere contralateral to
a supratentorial cerebral lesion [1]. It is reported that neural function recovery of
cerebral infarction patients accompanied with CCD are worse than those without CCD [2]. Intravoxel incoherent motion (IVIM) imaging was performed to separately quantify the diffusion and perfusion characteristics [3,4]. In this work, arterial spin labeling (ASL) and
IVIM are performed on cerebral infarction patients with CCD, in order to explore the contributory
factor of diffusion and perfusion in CCD.
Methods
45 patients with unilateral supratentorial cerebral infarction or brain stem infarction at
our hospital underwent conventional MRI, DWI, ASL perfusion imaging, and 27 of
which underwent IVIM scan. The data of ASL perfusion imaging and IVIM scan were
transferred to the workstation to be postprocessed. Cerebellar asymmetry
index (CSI) was based on rCBF map which calculated from ASL perfusion
imaging. All patients were divided into non-CCD group (CSI ≤ 10%) and CCD group (CSI > 10%). Reference
to DWI, the volume
and rCBF (regional cerebral blood
flow) of infarct in two groups were measured and compared by nonparametric
tests. D, D*, f, fD* calculated
from IVIM scan of bilateral cerebella were recorded and analyzed between two
groups by paired t test.
Results
The volume
of infarcts of CCD group was larger than non-CCD group (Table.1). There were no
statistical differences of rCBF of infarcts
between two groups (Table.2). fD*, f of
contralateral cerebellar hemisphere
declined compared to the ipsilateral hemisphere (Table.3,Table.4) (Fig.1). While
the value of D, D* was not
significant different between two groups.
Discussions and conclusion
ASL and
IVIM imaging can be used to detect CCD of
infarction. IVIM imaging can provide
more information of hemodynamics. CCD are more likely occurred
in larger infarcts which may because larger infarcts are more likely involved
cortico-ponto-cerebellar fibers. The
degree of reduction of rCBF of
infarct was independent of CCD, consistent with previous
studies.
Acknowledgements
No acknowledgement found.References
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