Neuroimaging studies have demonstrated that major depression disorder (MDD) patients showed blunted activity response to reward-related tasks. However, whether abnormal reward circuits affect the cognition, depression, and trait property in MDD patients remains unknown.Seventy five drug-naive MDD patients and 42 cognitive normal (CN) subjects underwent a resting-state functional magnetic resonance imaging (R-fMRI) scan. Bilateral nucleus accumbens (NAc) were selected as seeds to construct reward circuits across all subjects. Multivariate linear regression analysis was employed to investigate neural substrates of cognitive function, depression severity, age, education, and course of disease on the reward circuits in MDD patients. The common pathway underlying cognitive deficits and depression was identified with conjunction analysis approach.Compared with CN subjects, MDD patients showed decreased reward network connectivity was primarily located in the prefrontal-striatal regions. Importantly, distinct and common neural pathways underlying cognition and depression were identified, implying the independent and synergistic effects of cognitive deficits and depression severity on reward circuits. Additionally, right NAc and middle cingulate cortex connectivity positively correlated with education level was found in CN subjects but not in MDD patients, while decreased connectivity in bilateral rostral anterior cingulate cortex was negatively correlated with course of disease in MDD patients.This study demonstrated that disrupted topological organization within reward circuits was significantly associated with cognitive deficits, depression severity, and trait property in MDD patients. These findings suggest that besides antidepressant treatment, normalized reward circuits should be focused and may improve depression and cognitive deficit for MDD patients.