Shanker Raja1,2, Wafa AlShawkeer3, Lama Mohammed Almudaimeegh3, Sadeq Al Dandan4, and Sharad P George5
1Radiology, Baylor College of Medicine, Bellaire, TX, United States, 2Radiology, KFMC, Riyadh, Saudi Arabia, 3King Khalid University Hospital, Riyadh, Saudi Arabia, 4King Fahad Medical City, Riyadh, Saudi Arabia, 5Baylor College of Medicine, Houston, TX, United States
Synopsis
We utilized quantitative FA-maps derived from DTI to evaluate the
fibrous content consistency and grade of meningioma. Our results suggest that, quantitative FA mapping
is promising in pre-operative prediction of meningioma consistency pre-operatively, but
only modestly correlates with histologic gradingINTRODUCTION:
Curative surgical resection is
treatment of choice for meningiomas. We explored if fractional anisotropy (FA)
maps can preoperatively predict meningioma consistency and grade.
METHODS AND MATERIALS:
Retrospective analysis of 15
patients ( age=30-90 years) with meningioma and having DTI preoperatively.
Quantitative metrics on the FA maps
(mean and SD), were obtained from ROI of tumor (encompassed on T2,C+ and Flair)
and contralateral normal brain. FA of the tumor was normalized (NorFA) to the
contralateral brain. NorFA estimates were correlated with histological features
(grade, Ki-67, fibrous content). Correlation with peri-operative lesion consistency was performed.
RESULTS AND DISCUSSION: Results, revealed that NorFA has good correlation with fibrous content (R2=0.57). Furthermore, a positive trend between NorFA and peri-operative consistency was noted. (hard (FA=1.7), firm (FA=1.16), soft(FA=0.95)). A modest differentiation of NorFA between different histologic grades and, a weak negative correlation with Ki-67 (R2=0.077) was also observed.
CONCLUSION: Quantitative FA maps appears promising in predicting meningioma consistency. It may not be useful in tumor grading. We believe that this is the first attempt to utilize FA histometrics to preoperatively assess tumor consistency, and correlate with fibrous content on histology. A larger prospective series is warranted.
Acknowledgements
No acknowledgement found.References
No reference found.