Synopsis
Image
quality in high field MRI is limited by B1 inhomogeneity. This work describes a
new approach to improving B1 homogeneity using parallel transmission. Rather
than transmitting a conventional traveling wave, which is diffracted and
reflected by the human body, thereby creating a non-uniform internal field, the
new method seeks a solution to the inverse problem—what external field produces
a traveling plane wave within the body? Simulations suggest dramatic
improvements in B1 homogeneity can be obtained given a sufficient number of
transmitted field modes. Purpose
Despite
recent advances in parallel transmit technology, there is a critical need to
improve the uniformity of $$$B_1^+$$$ in high field MRI. A
traveling wave
1 in an empty magnet bore can produce a uniform amplitude
magnetic field, but once a human body is positioned in the bore, refraction and
reflection of the incident wave produce strongly varying field amplitudes in
the body. This work describes a new approach that aims to induce a traveling plane
wave inside the sample, subjecting all spins to the same field amplitude.
Theory
The electromagnetic field both inside and outside the body can be described as a superposition of modes expressed, for example, in terms of the Debye potentials, which are solutions to the scalar Helmholtz equation.2 The field generated by the RF coil in an empty bore is termed the incident field. In spherical coordinates, the Debye potentials, $$$\Pi$$$, for both the incident field and the field within the body have the general form $$r\Pi=\sum_{p=1}^\infty\sum_{q=0}^p\psi_p(kr)P_{pq}(cos\theta)[a_{pq}cos(q\phi)+b_{pq}sin(q\phi)]\ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ \ (1)$$ where $$$k$$$ is the wavenumber, the radial functions $$$\psi_p(kr)$$$ are related to the spherical Bessel functions $$$j_p(kr)$$$ by $$$\psi_p(kr)=kr{\cdot}j_p(kr)$$$, and $$$P_{pq}$$$ are the associated Legendre polynomials. Each term in the series designates one mode of the field; transverse magnetic (TM) and transverse electric (TE) fields are described by independent series.
Each mode of the incident field generates multiple modes within the body. The (complex) amplitude of the $$$n^{th}$$$ within-body mode generated by the $$$m^{th}$$$ incident mode equals the element $$$c_{nm}$$$ of the coupling matrix, $$$\tilde{C}$$$. There are two steps in the technique. First, the coupling matrix is estimated by mapping the transverse magnetic fields within the body generated by each incident field mode. Since the transverse field for each within-body mode can be calculated from Eq (1), this allows the coupling matrix to be estimated. Second, the superposition of incident modes corresponding to an internal plane wave is determined. The amplitude of the $$$n^{th}$$$ internal mode in an ideal plane wave defines the element $$$b_n$$$ of the known column vector $$$\vec{b}$$$. The incident mode amplitudes that generate the internal plane wave are the elements of the unknown column vector $$$\vec{\beta}$$$. The coupling matrix relates the two vectors: $$$\tilde{C}\cdot\vec{\beta}=\vec{b}$$$. Solving for the incident mode amplitudes, we have $$$\hat{\vec{\beta}}=\tilde{C}^+\cdot\vec{b}$$$, where $$$\tilde{C}^+$$$ is the pseudo-inverse of $$$\tilde{C}$$$. $$$\hat{\vec{\beta}}$$$ defines the amplitude and phase of the RF coil modes that produce an internal plane wave. Hence the method is known as Traveling Internal Plane-wave Synthesis (TIPS).
Methods
The
procedure was simulated for a uniform ellipsoidal sample (relative permittivity
$$$\epsilon_r = 80$$$, relative permeability $$$\mu_r=1$$$, conductivity $$$\sigma=0$$$ and principal axes of
length 12, 14, and 16 cm, rotated by $$$20^{\circ}$$$ and $$$10^{\circ}$$$ to simulate
chin-to-chest and left-to-right head rotation, respectively) imaged at 7T. The transverse
field within the sample generated by each incident field mode was calculated by
matching the transverse electric and magnetic fields at the surface of the
ellipsoid. The resulting coupling matrix was used to evaluate two cases. First,
the internal field was calculated assuming incident plane wave excitation.
Second, the TIPS superposition of incident field modes was used to calculate
the internal fields. The appropriate incident fields can be generated by arrays
of radial electric and magnetic dipoles distributed over the surface of a coil former. The radial electric dipole array creates 48 TM field modes, while
the radial magnetic dipole array generates 48 TE modes (96 channels in total).
Results
The
$$$B_y$$$ fields for both types
of incident wave are shown in the figure (traveling waves propagate from left
to right). The coefficient of variation of the internal $$$|B_y|$$$
for the incident traveling wave is 62.5%, compared to 0.7% in the TIPS case.
Discussion
While
the simulation was performed for a simple ellipsoidal phantom, the method
relies only on the existence of a linear relationship between incident and
internal mode amplitudes. Even in the heterogeneous, multilayered structure of
the head, the linearity of Maxwell’s equations guarantees such a relationship,
and hence the technique is expected to yield nearly uniform traveling waves in
the human brain as well. Work is underway to evaluate performance using more
realistic models of the human head.
Conclusion
The
TIPS method induces a traveling plane wave within a volume of interest (VOI) in
the body by driving an appropriate superposition of external, incident field
modes. Spins within the VOI are subjected to a $$$B_1^+$$$ magnetic field with
nearly uniform amplitude. This method promises to improve image uniformity in
high field MRI.
Acknowledgements
No acknowledgement found.References
1. Brunner DO, De Zanche N, Frohlich J, et al.
Travelling-wave Nuclear Magnetic Resonance. Nature 2009; 457: 994-998.
2. Born M and Wolf E. Principles of Optics, 6th
ed. Oxford, UK: Pergamon Press; 1980.