Simon Reiss1, Axel Joachim Krafft1,2,3, Marius Menza1, Constantin von zur Mühlen4, and Michael Bock1
1Dept. of Radiology - Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2German Cancer Consortium (DKTK), University Medical Center Freiburg, Heidelberg, Germany, 3German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Department of Cardiology and Angiology I, University Heart Center, Freiburg, Germany
Synopsis
Black-blood preparation is a tool for improved contrast
generation in cardiovascular MRI to assess vessel wall constitution, to
delineate plaques and to characterize myocardial tissue. Conventionally, black-blood MRI can be done with dual inversion
recovery pulses so that selective signal nulling of the inflowing blood is
achieved. The inversion delays required to establish the black-blood contrast
can be favorably integrated into ECG-triggered diastolic cardiac measurements,
but they are by far too time-consuming for dynamic measurements that cover the
total cardiac cycle.
In this work we investigate the use of conventional
saturation pulses for black-blood imaging. We propose a very time-efficient pulse
implementation that combines the saturation and the imaging RF pulse into a
single pulse structure and enables black-blood contrast in dynamic measurements.Introduction
Black-blood preparation is a tool for improved contrast
generation in cardiovascular MRI to assess vessel wall constitution, to
delineate plaques and to characterize myocardial tissue. For example, the
efficient suppression of the vascular blood signal is important in imaging
studies of the vessel wall as high signal intensities from inflowing blood can
obscure the subtle signal variations in the different layers of the blood
vessel. Conventionally, black-blood MRI can be done with dual inversion
recovery pulses [1] so that selective signal nulling of the inflowing blood is
achieved. The inversion delays required to establish the black-blood contrast
can be favorably integrated into ECG-triggered diastolic cardiac measurements,
but they are by far too time-consuming for dynamic measurements that cover the
total cardiac cycle.
In this work we investigate the use of conventional
saturation pulses for black-blood imaging. We propose a very time-efficient pulse
implementation that combines the saturation and the imaging RF pulse into a
single pulse structure and enables black-blood contrast in dynamic measurements.
Methods
A combined RF pulse shape (cf. Fig. 1) is defined as
a superposition of the saturation and imaging pulse in complex domain. Both pulses
follow a sin(
x)
/x-shaped amplitude pattern modulated with a Hann window. The shift of
the saturation slab relatively to the imaging slice by a distance
Δz is realized by a linear phase modulation exp(
-2πiγGzΔz) of the saturation pulse (
Gz: slice selection
gradient). To prevent refocusing of the excited signal within the saturation
slab, the saturation pulse is temporally shifted by
Δt relatively
to the imaging pulse. This introduces a dephasing moment that reduces the net transverse magnetization
in the saturation slab.
The combined pulse was implemented in a FLASH
sequence, and measurements were performed on a 3T system (Siemens Prisma). The
saturation-excitation pulse scheme was tested
in vivo in two volunteer experiments in the descending aorta in a
single breath-hold and in the carotids during free-breathing. Images were
acquired using ECG-triggered golden-angle radial sampling with the following
parameters: TE/TR: 4.8/9.1ms, slice thickness: 8mm, saturation slab thickness: 50mm, matrix: 192x192, FoV: 235x235mm², bandwidth: 400Hz/px. The parameters of the combined pulse were set to: pulse duration T
Pulse:
4ms,
Δt = 1.2ms, α
img/α
sat: 10°/30°,
Δz = 69mm.
After image
reconstruction, the efficiency of the black blood preparation was evaluated by
calculating the ratio of the mean signal intensity in the blood vessel over the
mean of the noise (i.e., the SNR of the vessel lumen). Note, that with this
definition the ideal suppression would yield a ratio of 1.
Results
The ECG-triggered radial images in Fig. 2a show the
efficiency of blood suppression in the descending aorta for different time
frames over the cardiac cycle. Suppression is nearly ideal during systole and
at end-diastole, whereas some remaining blood signal is visible (maximum
luminal SNR = 1.6) during early diastole (Fig. 2b). In the neck, arterial and
venous suppression measurements were done separately (Fig. 3). The difference
images (Fig. 3c) clearly show the arterial (white) and venous (black)
structures. Again, blood suppression was very efficient with a maximum arterial/venous
SNR in the vessel lumen of 2.8/4.0. Maximum values are seen at the very
beginning of the cardiac cycle whereas the SNR is well below 2 during
end-systole and diastole. This could be explained by a relatively long
acquisition pause of about 100 ms in end-diastole in combination with slow flow
velocities in this phase of the cardiac cycle leading to non-saturated
spins entering the imaging slice at the beginning of the acquisition in each
heartbeat.
Discussion & Conclusion
The proposed single pulse structure for
saturation and imaging offers very time-efficient blood suppression and enables
continuous data acquisition with spoiled steady state sequences. The quasi
simultaneous saturation and excitation scheme could be successfully demonstrated
for two different scenarios and will be further investigated in cardiac
applications. For example, the use of retrospective gating would increase blood signal nulling at the beginning
of the cardiac cycle.
A limitation of the
method is that imaging and saturation slices are intrinsically orientated in parallel.
However, in cross-sectional
imaging of blood vessels this slice layout is very efficient for blood
saturation. As this method enables short TR times, saturation can be achieved with
flip angles well below 90°, because the inflowing blood experiences multiple excitations
within the saturation slab even at higher flow velocities. Thus, the method could
be beneficial to reduce the SAR over conventional 90°-saturation pulses, which
is important in high-field MRI. The proposed method renders similarities to the
BASS method [2], however, it provides an even more time-efficient
implementation.
Acknowledgements
Grant support by the Deutsche Forschungsgemeinschaft
(DFG) under grant number BO 3025/2-2 is gratefully acknowledged.References
[1] Edelmann RR, et al. Radiology 1991; 181:655-66
[2] Lin H, et al. JMRI 2006; 24:701-7