Committees & Staff

Annual Meeting Program Committee



Summa Merit Awards

Magna Merit Awards

Annual Meeting Program Committee Declaration

Invited Speakers Declaration

Moderator Declaration

Authors with Declaration

Authors without Declaration

Author Index

Traditional Posters

Electronic Posters


Educational Course

Preclinical Cancer Imaging

Organizers:E. Jim Delikatny, Ph.D. & Kristine Glunde, Ph.D.

Space 3                                08:30-16:30                                                                                               Moderators:E. Jim Delikatny, Ph.D. & Kristine Glunde, Ph.D.

The Basics

08:30                       Tumor Physiology

                                Natalie J. Serkova, Ph.D.


09:00                       Tumor Vasculature

                                Arvind P. Pathak, Ph.D.


09:30                       Tumor Metabolism: Glucose, Glutamine & Lipids

                                Carles Arús, Ph.D.


10:00                       Break - Meet the Teachers


Tumor Microenvironment

10:30                       Imaging Tumor Hypoxia

                                Ralph P. Mason, Ph.D.


11:00                       pH in Cancer

                                Robert J. Gillies, Ph.D.


11:30                       Theranostic Probes for Cancer Imaging

                                Anna V. Moore, Ph.D.


12:00                       Lunch & Meet the Teachers


Novel Techniques

13:00                       Exploring Metabolism in Cancer Through MRS

                                Franca Podo, Ph.D.


13:30                       HR-MAS MRS for Cancer Metabolomics

                                Tone F. Bathen, Ph.D.


14:00                       CEST Imaging of Cancer

                                Ravinder Reddy, Ph.D.


14:30                       Break - Meet the Teachers



15:00                       Modeling Cancer in MR Studies: Cells & Animals

                                Marie-France Penet, Ph.D.


15:30                       Monitoring Treatment Response

                                Bradford A. Moffat, Ph.D.


16:00                       Translational MRI/MRS of Cancer

                                Harish Poptani, Ph.D.


16:30                       Adjournment & Meet the Teachers



Educational Course

Molecular Imaging

Organizers:Chris A. Flask, Ph.D. & Mark D. Pagel, Ph.D.

Space 4                                08:30-17:00                                                                                               Moderators:Chris A. Flask, Ph.D. & Mark D. Pagel, Ph.D.

08:30                       Basics of Relaxation & Agents

                                Silvio Aime, Ph.D.


09:00                       Molecular Imaging Applications

                                Zaver M. Bhujwalla, Ph.D.


09:30                       Common Agent Synthesis

                                Janet R. Morrow, Ph.D.


10:00                       Break - Meet the Teachers


10:30                       Targeted Agents

                                Peter Caravan, Ph.D.


11:00                       Switching & Sensing

                                Angelique Louie, Ph.D.


11:30                       Non-Proton MR

                                Andrew G. Webb, Ph.D.


12:00                       Lunch & Meet the Teachers


13:30                       Agent Delivery

                                Zheng-Rong Lu, Ph.D.


14:00                       Cell Labeling & Tracking

                                Eric T. Ahrens, Ph.D.


14:30                       Reporter Genes

                                Assaf A. Gilad, Ph.D.


15:00                       Break - Meet the Teachers


15:30                       How to Hyperpolarize Agents

                                Eduard Y. Chekmenev, Ph.D.


16:00                       How to Detect HP Agents: Pulse Sequences

                                Peder E. Z. Larson, Ph.D.


16:30                       How to Use HP Agents

                                Kevin M. Brindle, Ph.D.


17:00                       Adjournment & Meet the Teachers



Educational Course

An Update on fMRI

Organizers:Jonathan R. Polimeni, Ph.D. & Kamil Uludag, Ph.D.

Blue 1 & 2                           08:30-11:30                                                                                               Moderators:Jonathan R. Polimeni, Ph.D. & Kamil Uludag, Ph.D.

08:30                       Neurovascular Coupling, Revisited

                                Anna Devor, Ph.D.


09:00                       fMRI Analysis Methods: Classics & New Trends

                                Robert W. Cox, Ph.D.


09:25                       fMRI Acquisition Strategies

                                David A. Feinberg, M.D.,Ph.D.


09:50                       Break - Meet the Teachers


10:15                       Basic Neuroscience: fMRI Studies of Sensory Systems

                                Federico De Martino, Ph.D.


10:40                       High-Resolution fMRI in Humans: What is the Limit?

                                Robert Turner, Ph.D.


11:05                       Clinical Applications of fMRI: From Presurgical Planning to Functional Connectivity

                                Natalie L. Voets, Ph.D.


11:30                       Adjournment & Meet the Teachers


Educational Course

Functional Connectivity: MRI Measures of Spontaneous Fluctuations in Intrinsic Networks

Organizers:James J. Pekar, Ph.D. & Jonathan R. Polimeni, Ph.D.

Blue 1 & 2                           13:30-18:00                                                                                               Moderators:James J. Pekar, Ph.D. & Jonathan R. Polimeni, Ph.D.

13:30                       Spontaneous Signal Fluctuations in Intrinsic Networks

                                Catherine E. Chang, Ph.D.


14:00                       Network Discovery with fMRI: Analytic Choices & Their Implications

                                Vince D. Calhoun, Ph.D.



14:30                       Studying Brain Function with Task-Free fMRI

                                Arno Villringer, M.D.


15:00                       Parcellation Based Network Analysis

                                Bertrand Thirion, Ph.D.


15:30                       Break - Meet the Teachers


16:00                       Diseases of Connectivity

                                Gwenaelle L. Douaud, Ph.D.


16:30                       Connectivity Studies in Large Populations

                                Paul M. Matthews, M.D., D.Phil.


17:00                       Roundtable Discussion


18:00                       Adjournment & Meet the Teachers


Educational Course

Diffusion Goes Mad

Organizers:Andrew L. Alexander, Ph.D. & Claudia A. Wheeler-Kingshott, Ph.D.

Yellow 1, 2 & 3                  08:30-11:30                                                                                               Moderators:Andrew L. Alexander, Ph.D. & Claudia A. Wheeler-Kingshott, Ph.D.

08:30                       From Diffusion Weighting to the Diffusion Tensor Indices

                                Gareth J. Barker, Ph.D.


08:50                       Higher Order Diffusion Models & Methods: Going Beyond the Diffusion Tensor

                                Noam Shemesh, Ph.D.


09:10                       Q-Space & Microstructure

                                Daniel C. Alexander, Ph.D.


09:30                       Break - Meet the Teachers


09:50                       Single Subject Diffusion Analysis: ROI, Histogram, Tractography

                                Mara Cercignani, Ph.D.


10:10                       Group Studies of Diffusion Data: Cross Sectional & Longitudinal Challenges

                                Stephen M. Smith, D.Phil.


10:30                       Connectomics

                                Patric Hagmann, M.D.,Ph.D.


10:50                      Flip Charts – Meet the Experts


11:30                       Adjournment & Meet the Teachers


Educational Course

Advanced Diffusion Acquisition

Organizers:Andrew L. Alexander, Ph.D. & Adam W. Anderson, Ph.D.

Yellow 1, 2 & 3                  13:00-17:30                                                                                               Moderators:Andrew L. Alexander, Ph.D. & Adam W. Anderson, Ph.D.

13:00                       Compressed Sensing for Fast Acquisition

                                Bennett A. Landman, Ph.D.


13:25                       Multiband Excitation

                                David G. Norris, Ph.D.


13:50                       Multishot for High Spatial Resolution

                                Stefan Skare, Ph.D.


14:15                       3D  Vs. 2D Acquisition

                                Jennifer A. McNab, Ph.D.


14:40                       Reduced FOV

                                Claudia A. Wheeler-Kingshott, Ph.D.


15:05                       Break - Meet the Teachers


15:30                       Dealing with Susceptibility (R/L, L/R)

                                Jesper Andersson, Ph.D.



15:55                       Mitigating Eddy Current Distortions

                                Timothy G. Reese, Ph.D.


16:20                       Double Pulse Encoding

                                Evren Ozarslan, Ph.D.


16:55                       Oscillating Gradient Acquisition

                                Ivana Drobnjak, Ph.D.


17:20                       Closing Remarks


17:30                       Adjournment & Meet the Teachers


Educational Course

MRI of Sports Related Injuries

Organizers:Richard Kijowski, M.D. & William B. Morrison, M.D.

Space 2                                08:30-17:30                                                                                               Moderators:Richard Kijowski, M.D. & William B. Morrison, M.D.

08:30                       Shoulder:  Instability & Labrum

                                Lynne Steinbach, M.D.


09:00                       Shoulder: Rotator Cuff & Impingement

                                Eric Y. Chang, M.D.


09:30                       Elbow

                                Miriam A. Bredella, M.D.


10:00                       Wrist & Hand

                                Douglas W. Goodwin, M.D.


10:30                       Break - Meet the Teachers


11:00                       Hip: Intra-articular Injuries

                                Christian W.A. Pfirrmann, M.D., M.B.A.


11:30                       Hip: Extra-articular Injuries

                                Suzanne E. Anderson-Sembach, Ph.D.


12:00                       Groin

                                Adam C. Zoga, M.D.


12:30                       Lunch & Meet the Teachers


13:30                       Knee: Ligaments & Tendons

                                David A. Rubin, M.D.


14:00                       Knee:  Menisus & Cartilage

                                Humberto Rosas, M.D.


14:30                       Muscle

                                Robert D. Boutin, M.D.


15:00                       Break - Meet the Teachers



15:30                       Ankle: Tendon & Ligament

                                Andrew J. Grainger, M.R.C.P., FRCR


16:00                       Ankle: Joint & Impingement

                                Gregory Chang, M.D.


16:30                       Foot

                                Eva Llopis, M.D.


17:00                       Adolescent

                                David J. Wilson, D. Phil., M.B.B.S., FRCP, FRCR


17:30                       Adjournment & Meet the Teachers


Educational Course

Multidisciplinary Neuroradiology, Part 1

Organizer:Howard A. Rowley, M.D.

Brown 1 & 2                       08:00-18:00                                                                                              

Acute Stroke Triage & Management

                    Moderators:Patricia M. Desmond, M.D. & Howard A. Rowley, M.D.

08:00                       Acute Stroke Triage & Management: Clinical Perspective

                                Steven Warach, M.D., Ph.D.


08:30                       Acute Stroke Triage & Management: Radiological Perspective

                                Marco Essig, M.D., Ph.D.


09:00                       Acute Stroke Triage & Management: Physics Perspective

                                Ona Wu, Ph.D.


09:30                       Summary Discussion


10:00                       Break - Meet the Teachers


CNS Aneurysms & Vascular Malformations

                    Moderators:Nicoletta Anzalone, M.D. & Roberto Gasparotti, M.D.

10:30                       CNS Aneurysms & Vascular Malformations: Clinical Perspective

                                Carla S. Jung, M.D.


11:00                       CNS Aneurysms & Vascular Malformations: Radiologic Persepctive

                                Myriam Edjlali, M.D.


11:30                       CNS Aneurysms & Vascular Malformations: Physics Persepctive

                                Kevin M. Johnson, Ph.D.


12:00                       Summary Discussion


12:30                       Lunch & Meet the Teachers



Traumatic Brain Injury

                    Moderators:Pratik Mukherjee, M.D., Ph.D. & Howard A. Rowley, M.D.

13:30                       Clinical Needs in Traumatic Brain Injury: How Can Imaging Help?

                                David K. Menon, M.D., Ph.D.



14:00                       MR Imaging of Traumatic Brain Injury: Current Clinical Practice

                                Paul M. Parizel, M.D., Ph.D.


14:30                       Advanced MR Imaging & Spectroscopy of Traumatic Brain Injury: What is the Potential?

                                Alexander P. Lin, Ph.D.


15:00                       Summary Discussion


15:30                       Break - Meet the Teachers


Moderators:Meng Law, M.D., M.B.B.S., FRACR & Kirk Welker, M.D.

16:00                       Dementia: Clinical Perspective

                                David S. Knopman, M.D.


16:30                       Dementia: Radiologic Persepctive

                                Andrea Falini, M.D.


17:00                       Dementia: Physics Perspective

                                Sebastien Ourselin, Ph.D.


17:30                       Summary Discussion


18:00                       Adjournment & Meet the Teachers


Educational Course

MR Systems Engineering

Organizers:Richard W. Bowtell, Ph.D. & Maxim Zaitsev, Ph.D.

Brown 3                               08:30-17:00                                                                                               Moderators:Richard W. Bowtell, Ph.D. & Maxim Zaitsev, Ph.D.

Magnets & Shims

08:30                       Magnets

                                Ian Wilkinson, Ph.D.


09:00                       Siting the System

                                Stuart Clare, Ph.D.


09:30                       Shimming: Fields, Coils & Control

                                Robin A. de Graaf, Ph.D.


10:00                       Break - Meet the Teachers


Gradients & Field Monitoring

10:30                       Gradient Coils

                                Ralph M. Kimmlingen, Dipl.Phys., Dr.Rer.Nat.


11:00                       Systems Engineering of the MR Front End

                                Michael A. Morich, Ph.D.


11:30                      Field Monitoring & System Calibration

                                Christoph Barmet, Ph.D.


12:00                       Lunch & Meet the Teachers



Devices in the Scanner & Low Frequency Interactions

13:30                       Static Field Interactions

                                Gregor Schaefers, Dipl.-Ing.


14:00                       Gradient Interactions

                                Blaine A. Chronik, Ph.D.


14:30                       RF Interactions

                                Pierre-François A. Van de Moortele, Ph.D.


15:00                       Break - Meet the Teachers



RF & Console Electronics

15:30                       RF Power Amps

                                Greig C. Scott, Ph.D.



16:00                       RF Preamps & Receive Chain Architecture

                                Ralph G. Oppelt, Ph.D.


16:30                       System Integration & Console

                                Robert. D. Peters, Ph.D.


17:00                       Adjournment & Meet the Teachers   


Educational Course

MR Physics for Physicists

Organizers:Xiaoping P. Hu, Ph.D. & Jianhui Zhong, Ph.D.

Red 1 & 2                            08:30-18:00                           (no CME credit)                                      Moderators:Xiaoping P. Hu, Ph.D. & Jianhui Zhong, Ph.D.

NMR Physics: Firming Up the Foundations

08:30                       Quantum Mechanical Description of NMR: From Wave Function to Bloch Equation

                                Michael H. Buonocore, M.D., Ph.D.


09:00                       Problems in MR That Need Quantum Mechanics: The Density Matrix Approach

                                Robert V. Mulkern, Ph.D.


09:30                       Multiple Quantum Coherence, Editing & Multidimensional NMR

                                Daniel F. Gochberg, Ph.D.


10:00                       Break - Meet the Teachers


10:30                       From Bloch Equation to MR Contrasts: Relaxation & Physical Bases of Tissue Contrast

                                William D. Rooney, Ph.D.


11:00                       Other Contrast: Polarization Transfer, Chemical Exchange & Magnetization Transfer

                                Penny A. Gowland, Ph.D.


11:30                       Bloch Equation in the Rotating Frame, Multidimensional Excitation

                                Douglas C.  Noll, Ph.D.


12:00                       Bloch-Torrey Equation & Diffusion Imaging (DWI, DTI,  q-Space Imaging)

                                Jennifer A. McNab, Ph.D.


12:30                       Lunch & Meet the Teachers


Electromagnetic Fields in MRI: from Theory to Practice

14:00                       Maxwell Equations & EM Modeling

                                Christopher M. Collins, Ph.D.


14:30                       Static Magnetic Field: Magnetic Field (In)Homogeneity, Effects of Susceptibility, Demagnetizing Field & Lorentz Sphere

                                Jürgen R. Reichenbach, Ph.D.


15:00                       Understanding Gradients from an EM Perspective: Gradient Linearity, Eddy Currents, Maxwell Terms & Peripheral Nerve Stimulation

                                Johan A. Overweg, Ph.D.


15:30                       Break - Meet the Teachers



16:00                       RF Field Generation, Coupling, Traveling Wave Transmission

                                David O. Brunner, Ph.D.


16:30                       RF Field Transmission: B1-Field Non-Uniformity & SAR

                                Lawrence L. Wald, Ph.D.


17:00                       B1-Shimming & Parallel Transmission

                                Ulrich Katscher, Ph.D.


17:30                       Signal Detection, Reciprocity & SNR

                                James Tropp, Ph.D.


18:00                       Adjournment & Meet the Teachers





Educational Course

Multidisciplinary Neuroradiology, Part 2

Organizer:Howard A. Rowley, M.D.

Brown 1 & 2                       07:30-18:00                                                                                              

Pediatric CNS MRI: Neonatal Encephalopathy
Moderators:Serena J. Counsell, Ph.D. & Howard A. Rowley, M.D.

07:30                       Neonatal CNS Ischemia: Clinical Perspective

                                Daniel J.  Licht, M.D.


08:00                       Neonatal CNS Ischemia: Radiologic Persepctive

                                P. Ellen Grant, M.D.


08:30                       Neonatal CNS Ischemia: Physics Persepctive

                                Xavier S. Golay, Ph.D.


09:00                       Summary Discussion


09:30                       Break - Meet the Teachers


Neuroimaging of Autism
Moderators:Andrew L. Alexander, Ph.D. & Adam W. Anderson, Ph.D.

10:00                       What is Autism and How is the Brain Involved?

                                Marco Catani, M.D., M.R.C.Psych


10:30                       What Role Can Neuroimaging Play in Autism Research/Diagnosis?

                                Janet E. Lainhart, M.D.


11:00                       Neuroimaging Studies of Brain Connectivity, Microstructure & Function

                                Timothy P. Roberts, Ph.D.


11:30                       Summary Discussion


12:00                       Lunch & Meet the Teachers



Brain Tumors
Moderators:Howard A. Rowley, M.D. & Toshiaki Taoka, M.D., Ph.D.

13:30                       Brain Tumors: Clinical Perspective

                                Lorenzo M. Bello, M.D.


14:00                       Brain Tumors: Radiologic Persepctive

                                Alberto Bizzi, M.D.


14:30                       Brain Tumors: Physics Perspective

                                Thomas L. Chenevert, Ph.D.


15:00                       Summary Discussion


15:30                       Break - Meet the Teachers



                                Moderators:Meng Law, M.D., M.B.B.S., FRACR & Tchoyonson Lim, M.D.

16:00                       Epilepsy: Clinical Perspective

                                Roberto Spreafico, M.D., Ph.D.



16:30                       Epilepsy: Radiologic Persepctive

                                Eric L.J. Achten, M.D., Ph.D.


17:00                       Epilepsy: Physics Perspective

                                Louis Lemieux, Ph.D.


17:30                       Summary Discussion


18:00                       Adjournment & Meet the Teachers


Educational Course

Cardiac Function, Perfusion & Tissue Characterization

Organizers:Martin J. Graves, Ph.D. & Jeanette Schulz-Menger, M.D.

Space 4                                07:55-12:00                                                                                               Moderators: Daniel R. Messroghli, M.D. & Scott I. K. Semple, Ph.D.

Evaluation of Cardiac Function

07:55                       Evaluation of Cardiac Function: Clinical Needs

                                W. Patricia Bandettini, M.D.


08:20                       Evaluation of Cardiac Function: Technical Foundations

                                Karl-Friedrich F. Kreitner, M.D., Ph.D.


08:45                       Evaluation of Cardiac Function: Research Promises

                                Frederick H. Epstein, Ph.D.


09:10                       Break - Meet the Teachers


Evaluation of Cardiac Perfusion

09:20                       Evaluation of Cardiac Perfusion: Clinical Needs

                                John P. Greenwood M.B.Ch.B., Ph.D., MRCP


09:45                       Assessment of Myocardial Perfusion Using Cardiac MR: Technical Foundations

                                Thoralf Niendorf, Ph.D.


10:10                       Evaluation of Cardiac Perfusion: Research Promises

                                Jürg Schwitter, M.D., FESC


10:35                       Break - Meet the Teachers


Tissue Characterization


10:45                       Tissue Characterization: Clinical Needs

                                Subha V. Raman, M.D., M.S.E.E.


11:10                       Tissue Characterization: Parametric Mapping

                                Daniel R. Messroghli, M.D.


11:35                       Tissue Characterization: Research Promises

                                Michael S. Hansen, Ph.D.


12:00                       Adjournment & Meet the Teachers



Educational Course

Technical Advances in Cardiovascular Imaging

Organizers:Harald Kramer, M.D. & Ian Marshall, Ph.D.

Space 4                                13:30 -18:35                                                                                              Moderators:Peter D. Gatehouse, Ph.D. & Harald Kramer, M.D.

Flow Imaging

13:30                       Flow Imaging: Clinical Needs

                                Jens B. Bremerich, M.D.


13:55                       Flow Imaging: Principles & Applications

                                Daniel B. Ennis, Ph.D.


14:20                       Flow Imaging: Advanced Techniques

                                Michael Markl, Ph.D.


14:45                       Break - Meet the Teachers



14:55                       MRA: Clinical Needs

                                Rolf Weidenhagen, M.D., FEBVS


15:20                       MRA: Contrast Enhanced Techniques

                                Stephen J. Riederer, Ph.D.


15:45                       MRA: Non-Contrast Enhanced Techniques

                                Ruth P. Lim, M.B.B.S., M.Med., FRANZCR


16:10                       Break - Meet the Teachers


Application of Fast Imaging Techniques

16:20                       Application of Fast Imaging Techniques: Parallel Imaging

                                Michael S. Hansen, Ph.D.


16:45                       Application of Fast Imaging Techniques: Real Time

                                Martin Uecker, Ph.D.


17:10                       Application of Fast Imaging Techniques: Compressed Sensing

                                Kyung H. Sung, Ph.D., Assist. Prof.


17:35                       Break - Meet the Teachers


New & Emerging Techniques

17:45                       New & Emerging Techniques: Myocardial Diffusion

                                Sonia Nielles-Vallespin, Ph.D.


18:10                       New & Emerging Techniques: MR-PET

                                Harald H. Quick, Ph.D.


18:35                       Adjournment & Meet the Teachers



Educational Course


Organizers:David L. Buckley, Ph.D. & Eric C. Wong, M.D., Ph.D.

Space 2                                07:40-12:00                                                                                               Moderators:David L. Buckley, Ph.D. & Eric C. Wong, M.D., Ph.D.

07:40                       What is Perfusion & How is it Measured?

                                Richard B. Buxton, Ph.D.


08:20                       Dynamic Susceptibility Contrast

                                Matthias J. P. van Osch, Ph.D.


09:00                       Dynamic Contrast Enhanced

                                Steven P. Sourbron, Ph.D.


09:40                       Break - Meet the Teachers


10:00                       Arterial Spin Labeling

                                Xavier G. Golay, Ph.D.


10:40                       MR Imaging of Cerebral Oxygen Extraction & Metabolism

                                Divya S. Bolar, M.D., Ph.D.


11:20                       Applications of Perfusion MRI

                                Greg Zaharchuk, M.D., Ph.D.


12:00                       Adjournment & Meet the Teachers



Educational Course

Ultra-High Magnetic Field Diffusion, Perfusion & Functional MRI

Organizers:Kamil Uludag, Ph.D. & Kawin Setsompop, Ph.D.

Space 2                                13:30-17:30                                                                                               Moderators:Kamil Uludag, Ph.D. & Kawin Setsompop, Ph.D.

13:30                       Overview

                                Kamil Uludag, Ph.D.


Diffusion MRI

13:50                       Ex vivo Diffusion MRI at Ultra-High Fields

                                Alard F. Roebroeck, Ph.D.


14:20                       In vivo Diffusion MRI at 7 Tesla

                                Robin M. Heidemann, Ph.D.


14:50                       Break - Meet the Teachers


Arterial Spin Labelling

15:10                       Nottingham Experience

                                Susan T. Francis, Ph.D.


15:40                       NIH Experience

                                Wen-Ming Luh, Ph.D.


16:10                       Break - Meet the Teachers




16:30                       Acqusition Methods for fMRI at 7 Tesla

                                Peter J. Koopmans, Ph.D.


17:00                 Applications of Ultra-High Field to Study Human Brain Function

                                Wietske van der Zwaag, Ph.D.


17:30                       Adjournment & Meet the Teachers


Educational Course

A Practical Guide to MR Safety

Organizers:Michael Bock, Ph.D. & Mark E. Ladd, Ph.D.

Yellow 1, 2 & 3                  08:00-12:00                                                                                               Moderators:Michael Bock, Ph.D. & Mark E. Ladd, Ph.D.

08:00                       MR Safety: Where Do the Risks Come From?

                                Harald Kugel, Ph.D.


08:30                       Planning an MR Suite: What Can Be Done to Ensure MR Safety?

                                Emanuel Kanal, M.D., FACR, FISMRM


09:00                       Screening the Patient: How to Deal with the Individual Subject

                                William Faulkner, B.S., R.T.(R)(MR)(CT)


09:30                       Break - Meet the Teachers


10:00                       High Field MRI: What Are the Special Safety Risks at Higher Fields?

                                Matthias J. P. van Osch, Ph.D.


10:30                       Contrast Agent Use in the Age of NSF

                                Stefan Haneder, M.D.


11:00                       MR Safety Testing of Devices: How to Separate the Good from the Bad & the Ugly

                                Roger Lüchinger, Ph.D.


11:30                       MRI Safety Events: Lessons Learned

                                Robert E. Watson, M.D., Ph.D.


12:00                       Adjournment & Meet the Teachers


Educational Course

Methods En Vogue: How Have They Fared Over Time?

Organizers: Brian A. Hargreaves, Ph.D., James G. Pipe, Ph.D. & Nicole E. Seiberlich, Ph.D.

Yellow 1, 2 & 3                  13:30-17:45                                                                                               Moderators:Joseph J. H. Ackerman, Ph.D. & Valentina Taviani, Ph.D.

13:30                       Parallel Imaging

                                Stefan O. Schönberg, M.D.


13:55                       Diffusion Tensor Imaging / Tractography

                                Carlo Pierpaoli, M.D., Ph.D.


14:20                       Perfusion:  Brain & Body

                                Anwar R. Padhani, M.B.B.S, FRCP, FRCR


14:45                       Break - Meet the Teachers



15:00                       fMRI & Tractography for Clinical Applications

                                Andreas J. Bartsch, M.D.


15:25                       Motion-Correction Techniques

                                Oliver Speck, Ph.D.


15:50                       Contrast Agents

                                Martin R.  Prince, M.D., Ph.D.


16:15                       Break - Meet the Teachers


16:30                       uTE

                                Peter Börnert, Ph.D.


16:55                       Susceptibility Weighted Imaging

                                Jürgen R. Reichenbach, Ph.D.


17:20                       Spectroscopy

                                Carolyn E. Mountford, D.Phil.


17:45                       Adjournment & Meet the Teachers



Educational Course

Body MRI: How We Do It

Organizers:John P. Mugler, III, Ph.D., Ivan Pedrosa, M.D., Scott B. Reeder, M.D., Ph.D. & Shreyas S. Vasanawala, M.D., Ph.D.

Blue 1 & 2                           08:30-17:00                                     Moderators:John P. Mugler, III, Ph.D., Ivan Pedrosa, M.D. & Scott B. Reeder, M.D., Ph.D.


08:30                       Basic Strategies on Body MRI: Pulse Sequences

                                Jeffrey C. Weinreb, M.D.


09:00                       Update on Contrast Agents for Body MRI

                                Martin R. Prince, M.D., Ph.D.


09:30                       Dynamic Contrast Enhanced MRI/MRA

                                Stefan O. Schönberg,, M.D.


10:00                       Break - Meet the Teachers


10:30                       Focal Liver Lesions in the Non-Cirrhotic Liver

                                Jeffrey C. Weinreb, M.D.


11:00                       Cirrhotic Liver & HCC

                                Christoph J. Zech, M.D.


11:30                       Diffuse Liver Disease

                                Takeshi Yokoo, M.D., Ph.D.


12:00                       Lunch & Meet the Teachers



13:30                       MRI in Post-Menopausal Bleeding

                                Andrea G. Rockall, MRCP, FRCR


14:00                       Adnexal Masses

                                Evis Sala, M.D., Ph.D.


14:30                       Multiparametric Assessment of Prostate

                                Neil M. Rofsky, M.D.


15:00                       Break - Meet the Teachers


15:30                       Cystic Pancreatic Lesions

                                Masoom A. Haider, M.D., FRCPR


16:00                       MR Cholangiography – from 2D to 4D Imaging

                                Elmar M. Merkle, M.D.


16:30                       Secretin Augmented MRCP

                                Riccardo Manfredi, M.D., M.B.A.


17:00                       Adjournment & Meet the Teachers


Educational Course

Clinical Cancer MRI: Case Based

Organizers:Masoom A. Haider, M.D., F.R.C.P.C. & Elizabeth A. Morris, M.D., F.A.C.R.

Space 3                                08:15-17:15                                                                                               Moderators:Masoom A. Haider, M.D., F.R.C.P.C. & Jeong Min Lee, M.D.

Cancer Detection Issues

08:15                       Routine MRI to Screen for Breast Cancer?

                                Francesco Sardanelli, M.D.


08:45                       Finding Significant Prostate Cancer

                                François K. Cornud, M.D.


09:15                       Cirrhotic Liver: What is that Nodule?

                                Hero Hussain, M.D.


09:45                       Roundtable Discussion


10:00                       Break - Meet the Teachers



Characterization of Incidental Lesions

10:15                       Characterization of Renal Lesions

                                Ivan S. Pedrosa, M.D.


10:45                       Liver Lesions in Cancer Patients: What are They?

                                Kartik S. Jhaveri, M.D.


11:15                       Adnexal Masses: Five Imaging Pearls

                                Susan M. Ascher, M.D.


11:45                       Roundtable Discussion


12:00                       Lunch & Meet the Teachers


Response to Therapy

13:30                       Response to NAC: MRI Test of Choice?

                                Chiara R. Iacconi, M.D.


14:00                       Bone Metastases Response to Therapy:  MRI vs. Nuclear Medicine

                                Anwar R. Padhani, M.B.B.S, FRCP, FRCR


14:30                       Measuring Response to Novel Therapies: Thinking Differently

                                Dow-Mu Koh, M.D., MRCP, FRCR


15:00                       Roundtable Discussion


15:15                       Break - Meet the Teachers


Residual Disease Versus Recurrence

15:30                       Rising PSA in the Treated Prostate Gland

                                Jurgen J. Fütterer, M.D., Ph.D.


16:00                       Treated Pelvis: Scar vs. Recurrence?

                                Caroline Reinhold, M.D., M.Sc.


16:30                       Treated Head & Neck Cancer: Scar vs. Recurrence?

                                Roberto Maroldi, M.D.


17:00                       Roundtable Discussion


17:15                       Adjournment & Meet the Teachers



Educational Course

RF Engineering: Coils

Organizers:Christopher M. Collins, Ph.D. & Nicola F. De Zanche, Ph.D.

Brown 3                               08:30-16:15                                                                                               Moderators:Christopher M. Collins, Ph.D. & Nicola F. De Zanche, Ph.D.

RF Basics

08:30                       Basics of Transmission Lines and Power Transfer

                                Scott B. King, Ph.D.


09:00                       RF Volume & Surface Coils for MR Imaging

                                Xiaoliang Zhang, Ph.D.



09:30                       Radiative Antennas & Travelling Waves

                                Cornelis A. T. van den Berg, Ph.D.


10:00                       Break - Meet the Teachers


RF Arrays

10:30                       Receive Arrays & Circuitry

                                Cecilia Possanzini, Ph.D.


11:00                       Transmit Arrays & Circuitry

                                Gregor Adriany, Ph.D.



11:30                       RF Modelling

                                Alexander J. E. Raaijmakers, Ph.D.


12:00                       Lunch & Meet the Teachers


Emerging RF Coils & Technologies

13:30                       Multi-Tuned Coils

                                Dennis W. J. Klomp, Ph.D.


14:00                       RF Coils for Hybrid Systems

                                Boris R. Keil, Ph.D.


14:30                       Preview: Interesting RF Abstracts to Look for in Milan

                                Nicola F. De Zanche, Ph.D.


14:45                       Break - Meet the Teachers


Live Construction of Coils

15:15                       Construction of Dual Tuned Coil

                                Michela Tosetti, Ph.D., Gianluigi Tiberi, Ph.D, Riccardo Stara, M.D..


16:15                       Adjournment & Meet the Teachers


Educational Course

Imaging Acquisition & Reconstruction

Organizers:Xiaoping P. Hu, Ph.D. & Xiaohong Joe Zhou, Ph.D.

Red 1 & 2                            08:30-17:30                                                                                               Moderators:Xiaoping P. Hu, Ph.D. & Xiaohong Joe Zhou, Ph.D.

Pulse Sequence Building Blocks

08:30                       RF Pulses Designs: From Basics to the State-of-the-Art

                                Gerald B. Matson, Ph.D.


09:00                       Gradients: What Can They Do?

                                Peter Börnert, Ph.D.


09:30                       Dealing with Motion: Gating, Triggering & Sampling

                                Christopher J. Hardy, Ph.D.


10:00                       Break - Meet the Teachers


Contrast Manipulation

10:30                       Pulse Sequence Modules I (IR, DE, Spatial SAT & Chem SAT)

                                John P. Mugler, III, Ph.D.


11:00                       Pulse Sequence Modules II (Tagging, Labeling, Diffusion Sensitization & MT)

                                Eric C. Wong, M.D., Ph.D.


11:30                       Flow Contrast Without Using Exogenous Agent

                                Mitsue Miyazaki, Ph.D.


12:00                       Lunch & Meet the Teachers



Advanced Acquisition Strategies

13:30                       Echo-Train Pulse Sequences: EPI, RARE & Beyond

                                Jürgen K. Hennig, Ph.D.


14:00                       Non-Cartesian k-Space Sampling

                                James G. Pipe, Ph.D.


14:30                       Spoiled & Balanced Gradient-Echo Sequences

                                Karla L. Miller, Ph.D.


15:00                       Break - Meet the Teachers


Image Reconstruction

15:30                       Reconstruction of Non-Cartesian k-Space Data

                                Craig H. Meyer, Ph.D.


16:00                       Parallel Image Reconstruction

                                Daniel K. Sodickson, M.D., Ph.D.


16:30                       Phase-Sensitive Image Reconstruction

                                Qing-San Xiang, Ph.D.


17:00                       Compressed Sensing

                                Lei Leslie Ying, Ph.D.


17:30                       Adjournment & Meet the Teachers



Gold Corporate Symposium: Bracco

Gold Plenary Hall              12:15 - 13:15                         (no CME credit)                                     




Opening Reception in Technical Exhibition

Exhibition Hall                   17:45-19:15                                                                                              




Plenary Session

Mansfield Lecture

Gold Plenary                       07:05-09:00                                                                                                



07:05                      Welcome & Awards
                Peter Jezzard, Ph.D., ISMRM 2013-2014 President
                Elna-Marie Larsson, M.D., Ph.D., ESMRMB President


08:20                      Mansfield Lecture: Innovation in MRI: Seize the First Moment
                Thomas M. Grist, M.D., F.A.C.R.



Plenary Session

How MRI Became the Gold Standard

Organizers:Meng Law, M.D., M.B.B.S., F.R.A.C.R., William Morrison, M.D., & Ivan Pedrosa, M.D.

Gold Plenary                       09:00-10:20                                                                                              

09:20           0001.   Technical Developments: Brain MRI in Stroke

                                Max Wintermark, M.D., Ph.D.


09:40           0002.   Epidemiologic Studies: Cardiac MRI in Thalasemia

                                John C. Wood, M.D., Ph.D.


10:00           0003.   Clinical Experience: MRI Assessment of Cartilage

                                Hollis G. Potter, M.D.


10:20           0004.   Clinical Trials: MRI Staging of Rectal Cancer

                                Gina Brown, M.D., M.R.C.P., F.R.C.R.


10:40                       Adjournment


Traditional Poster Session: Cancer

Traditional Poster Hall     10:45-12:45                           (no CME credit)                                       


Traditional Poster Session: Musculoskeletal

Traditional Poster Hall     10:45-12:45                           (no CME credit)                                       


Electronic Poster Session: Relaxation

Exhibition Hall                   10:45-12:45                           (no CME credit)                                       


Electronic Poster Session: Magnetic Susceptibility Contrast & Mapping

Exhibition Hall                   10:45-12:45                           (no CME credit)                                       


Electronic Poster Session: Magnetization Transfer

Exhibition Hall                   10:45-12:45                           (no CME credit)                                       


Study Group Session: MR Safety

Amber 1 & 2                       10:45-12:45                           (no CME credit)                                       


Study Group Session: Cardiac MR

Amber 7 & 8                       10:45-12:45                           (no CME credit)                                       


Power Poster Session: Neuro: Brains or Bust

Space 1/Power Poster Theater and Traditional Poster Hall        10:45-11:45  (no CME credit)   Moderators: Patricia M. Desmond, M.D. & Pramit M. Phal, M.D.  

10:45           0005.   In-Vivo Mapping of Transcranial Direct Current Stimulation(TDCS) of Human Brain Using MRI

ISMRM_MagnaLogo.jpg                                 Mayank V. Jog1, Robert Smith2, Kay Jann2, Walter Dunn3, Allan Wu2, Danny JJ Wang2

                                1Biomedical Engineering, University of California Los Angeles, Los Angeles, CA, United States; 2Neurology, University of California Los Angeles, Los Angeles, CA, United States; 3Psychiatry, University of California Los Angeles, Los Angeles, CA, United States


Transcranial Direct Current Stimulation (tDCS) is a neuromodulation technique shown to have applications in stroke, pain-relief and cognition.  tDCS is attractive as a treatment modality since it involves low currents and basic electrode placement on the surface of the head. To date, only mathematical modeling has been used to study tDCS-induced currents on the brain.

We used MRI field mapping for in-vivo visualization of tDCS-induced electric currents (Basis:  Ampere’s law). Utilizing concurrent tDCS-MRI with a Real/Sham paradigm, we observed significant magnetic field or phase changes in the brain parenchyma providing imaging evidence that tDCS effects do penetrate inside the brain.

                    0006.   Reproducibility of 2-Hydroxyglutarate Spectroscopic Imaging in IDH-Mutated Glioma Patients at 3.0 T In Vivo

                                Sandeep K. Ganji1, 2, Zhongxu An1, Akshay Madan1, Elizabeth A. Maher3, 4, Changho Choi1, 2

                                1Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States; 3Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States; 4Harold C. Simmons Cancer Center,, UT Southwestern Medical Center, Dallas, TX, United States


Recent studies have developed several techniques for measurement of 2-hydroxyglutarate (2HG) levels in brain gliomas and substantiate 2HG levels as a useful clinical biomarker. However for transitioning these methods to routine clinical use and obtain clinically significant results requires rigorous validation and testing. The purpose of this study was to perform repeated measurement of 2HG levels in a group of glioma patients and to determine intersession reproducibility, and repeatability.

ISMRM_MagnaLogo.jpg                     0007.   Increased Blood-Brain Barrier Leakage in Alzheimer’s Disease Detected with Dual Time-Resolution Dynamic Contrast Enhanced MRI

                                Harm J. van de Haar1, Saartje Burgmans1, Matthias JP van Osch2, Jacobus FA Jansen3, Frank CG van Bussel1, Sau May Wong1, Martijn Wolters3, Cécile RLPN Jeukens3, Mark A. van Buchem2, Paul AM Hofman3, Frans RJ Verhey1, Walter H. Backes3

                                1University of Maastricht, Maastricht, Netherlands; 2Leiden University Medical Center, Leiden, Netherlands; 3Maastricht University Medical Center, Maastricht, Netherlands


Blood-brain barrier defects prior to neuronal damage are a potential underlying mechanism for dementia. A dual-temporal resolution Dynamic Contrast Enhanced (DCE)-MRI protocol was used to detect differences in terms of fractional plasma volume (vp) and BBB leakage (Ki) in patients suffering from Alzheimer’s disease. The results suggest significantly stronger leakage in normal appearing white matter in the patients compared to the healthy controls, which supports our hypothesis that BBB leakage is increased in patients with (preclinical) Alzheimer’s dementia. Longitudinal research is necessary to reveal the exact relationship with Alzheimer pathology and small vessel disease.

                    0008.   Alterations in Cerebral Physiology in Women Suffering from Anorexia Nervosa

ISMRM_SummaLogo.jpg                                 Min Sheng1, Carrie J. McAdams2, Peiying Liu1, Binu P. Thomas1, Hanzhang Lu1

                                1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States


Anorexia nervosa (AN) is a fatal psychiatric disorder. A better understanding of physiological changes in AN patients may help provide a brain-specific health marker, guide treatment, and predict risk for future conditions. In this report, we conducted a systematic study on potential physiological deficits in currently-ill and long term weight-recovered anorexia patients. It appears that, the currently-ill patients receive reduced oxygen delivery to the brain, but the brain compensates for this small reduction. For the recovered patients, they still receive less blood supply to the brain and extract a larger fraction of oxygen from incoming blood to meet their metabolic demand.

                    0009.   Anatomical Location and Multi-Features Based Computer Aided Detection of Cerebral Microbleeds on MR Images

                                Yan Li1, Yining Huang2, Jue Zhang, 13, Jing Fang1, 3

                                1Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China; 2Dept. of Neurology,  Peking University First Hospital, Beijing, China; 3College of Enigneering, Peking University, Beijing, China


Cerebral microbleeds (CMBs) are known to be highly prevalent in patients admitted with ischemic stroke and intracerebral bleeding. Experience depended manual detection of them is time-consuming and has limited reproducibility. In the present study, a computer aided system for the CMBs detection is proposed, which is based on the anatomical location information and the multi-features extracted from the MR images. Compared with the traditional manual method and the other semi-automated methods presented before, the detection system showed a better performance, and has the potential to be used as a convenient tool for clinical detection of CMBs.

                    0010.    Volumetric Analysis of Cingulum in Retired NFL Players: Its Relationship with NFL Experience and Subjects’ Cognitive and Functional Performance

                                Hardik Doshi1, Ira Casson2, David Viano3, 4, John Woodard5, E Mark Haacke3, Zhifeng Kou3

                                1Biomedical Engineering, Wayne State University School, Detroit, mi, United States; 2Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY, United States; 3Biomedical Engineering and Radiology, Wayne State University School of Medicine, Detroit, MI, United States; 4ProBiomechanics LLC, Bloomfield Hills, MI, United States; 5Department of Phychology, Wayne State University School, Detroit, MI, United States


There are about 1.6-3.9 million sports injury only in USA each year. Specially, players of sports like American football, hockey, boxing etc are more susceptible to injury. Many athletes present constellation of post concussion symptoms (PCS). Further, chronic traumatic encephalopathy (CTE) has been also reported related with sports concussion. Cingulum Cortex is an important hub for emotional and memory processing. The main motivation behind this study is to investigate the effects of multiple traumas on the volumes of anterior and posterior cingulum cortex (ACC & PCC) and determine its effects on Neuropsych and functional test scores.

                    0011.   Longitudinal DTI Reveals Presymptomatic White Matter Changes in YAC128 Mouse Model of Huntington Disease

ISMRM_SummaLogo.jpg                                 Xin Hong1, Ling Guo1, Roy Teo2, Yi Lin Tay2, Xuan Vinh To1, Reshmi Rajendran1, Si Kang Lew1, Yee Ling Tan1, Yihui Huang2, Michael R. Hayden2, 3, Mahmoud A. Pouladi2, 3, Kai-Hsiang Chuang1

                                1Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore, Singapore; 2Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore, Singapore; 3Department of Medicine, National University of Singapore, Singapore, Singapore


We performed a longitudinal DTI study to monitor the microstructural changes in white matter (WM) in presymptomatic YAC128 mouse model of Huntington's disease (HD). In YAC128 mice compared to wild-type, decreased fractional anisotropy and parallel diffusivity, and increased radial diffusivity are found in WM regions in a progressive pattern starting from different ages, as early as 1.5 months. This is preceded by deficits in myelin-related transcripts as early as 2 weeks of age. Our results suggest that damage to both myelin and axons may contribute to the observed dynamic and progressive WM abnormalities in presymptomatic YAC128 HD model.


ISMRM_SummaLogo.jpg                     0012.   Elevated ATP Synthase and Creatine Kinase Activities in Human Visual Cortex During Visual Stimulation:  a 31P NMR Magnetization Transfer Study at 7T

                                Byeong-Yeul Lee1, Xiao-Hong Zhu1, Wei Chen1

                                1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States


The cerebral ATP synthase (ATPase) and creatine kinase (CK) reactions are essential in supporting brain energy and function. In this study, we investigated the central role of oxidative phosphorylation of ATP in response to functional visual stimulus in the human visual cortex using the in vivo 31P MRS with magnetization transfer technique at 7T; and to further study its temporal evolution during and after the stimulation. It was found that both ATPase and CK metabolic fluxes increased during the visual stimulation. Interestingly, the elevated ATPase enzyme activity recovered rapidly to the baseline level after the stimulation; in contrast, a high CK enzyme activity persisted during the sustained post-stimulation period, suggesting distinct roles of ATPase and CK reactions in brain function. More importantly, the significant increase of ATPase observed in this study indicates a high demand of oxidative ATP synthesis/utilization in the activated brain region in supporting the elevated neuronal activity.

                    0013.   Atlas of White-Matter Tracts in the Human Spinal Cord

                                Marc Benhamou1, Vladimir Fonov2, Manuel Taso3, 4, Arnaud Le Troter3, 5, Michaël Sdika6, Louis Collins2, Virginie Callot3, 5, Julien Cohen-Adad1

                                1Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada; 2Montreal Neurological Institute, McGill University, Quebec, Canada; 3Aix-Marseille Université, CNRS, CRMBM UMR 7339, Marseille, France; 4APHM, Hôpital de la Timone, CEMEREM, Marseille , France; 5APHM, Hôpital de la Timone, CEMEREM, Marseille, France; 6: Université de Lyon, CREATIS; CNRS UMR5220; Inserm U1044; INSA-Lyon; Université Lyon 1, Lyon, France


Template-based methods offer a reliable way to conduct inter-subject studies. Building upon recent developments of a spinal cord template, this study focuses on the construction of an atlas of spinal white matter pathways. Cross-sectional drawings of Gray’s anatomy were manually segmented, then warped to the MNI-POLY-AMU_v1 template using symmetric diffeomorphic transformation. The atlas was then propagated between C1 and T1 vertebral levels, yielding 30 different regions of interest, taking into account partial volume effect. We demonstrate the utility of this atlas for quantifying diffusion-tensor-imaging data in five healthy volunteers. The method can be extrapolated to other multiparametric techniques.

                    0014.   Mode of Variation in Brain Structure Identifies Network Linking Protracted Development, Early Degeneration and Vulnerability to Disease

                                Gwenaelle Douaud1, Adrian Groves1, Christian Tamnes2, Lars Westlye3, Andreas Engvig2, Kristine Wavhold2, Anthony James4, Achim Gass5, Andreas Monsch6, Paul Matthews7, Anders Fjell2, Stephen Smith1, Heidi Johansen-Berg1

                                1FMRIB Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway; 3KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Oslo, Norway; 4Department of Psychiatry, University of Oxford, Oxfordshire, United Kingdom; 5Department of Neurology, University of Heidelberg, Baden-Württemberg, Germany; 6Memory Clinic, University Hospital Basel, Basel, Switzerland; 7Department of Medicine, Imperial College London, London, United Kingdom


Although several models of brain structure link processes of development and aging, direct evidence for such a relationship remains elusive. Here, we show that brain structural variation across 484 healthy participants identifies one largely transmodal network whose pattern of lifespan age-related change intrinsically supports the “last-in-first-out” hypothesis. We further demonstrate that this network defines areas of heightened vulnerability for disorders impacting the adolescent and ageing brain – specifically schizophrenia and Alzheimer’s. This suggests that the spatial pattern in these disorders is not necessarily specific to these two distinct disease processes, but rather to their timing in disrupting healthy cerebral development and ageing.

                    0015.   Mapping Higher-Order Brain Function and Resting-State Networks with Diffuse Optical Tomography

                                Adam T. Eggebrecht1, Silvina L. Ferradal2, Amy Robichaux-Viehoever1, Mahlega Hassanpour3, Hamid Dehghani4, Abraham Z. Snyder5, Tamara Hershey6, Joseph P. Culver1, 2

                                1Radiology, Washington University School of Medicine, St. Louis, MO, United States; 2Biomedical Engineering, Washington University School of Medicine, MO, United States; 3Physics, Washington University School of Medicine, MO, United States; 4School of Computer Science, University of Birmingham, United Kingdom; 5Neurology, Washington University School of Medicine, MO, United States; 6Psychiatry, Washington University School of Medicine, MO, United States


Mapping distributed brain function has transformed our understanding of brain function. Brain function traditionally, has been studied with positron emission tomography (PET) and with functional magnetic resonance imaging (fMRI). However, PET uses ionizing radiation, which is not permitted as an experimental procedure in children. fMRI involves exposure to strong magnetic fields and induced electric fields, which is contraindicated in patients with implanted electronic devices (e.g., deep brain stimulators, pacemakers, cochlear implants). I present herein a large field-of-view high-density diffuse optical tomography (HD-DOT) system with anatomical modeling approaches that collectively provide new imaging capabilities and enable novel milestones for optical neuroimaging.


                    0016.   Prediction of Tissue Recovery in Chronic Stroke Using Adaptive Models and Acute MR Information

                                Hassan Bagher-Ebadian1, 2, Marie Luby3, James R. Ewing, 24, Panayiotis Mitsias4, Hamid Soltanian-Zadeh1, 5

                                1Radiology, Henry Ford Hospital, Detroit, MI, United States; 2Physics, Oakland University, Rochester, MI, United States; 3National Institute of Neurological Disorders and Stroke, MD, United States; 4Neurology, Henry Ford Hospital, Detroit, MI, United States; 5CIPCE, ECE Dept., University of Tehran, Tehran, Iran


This pilot study introduces four different adaptive-models (the inelastic-collision (IC) model, the Kohonen-Multi-Parametric-Self-Organizing-Map (KMP-SOM), the Generalized-Linear-Model (GLM) and an Artificial-Neural-Network) for multi-parametric analysis. These models are applied on acute MR information of eleven treatment-naïve patients to predict tissue recovery in chronic stroke. All patients presenting with acute neurological deficit consistent with stroke, and had MRI studies done within 24h of onset. Results imply that adaptive models are capable of identifying the ischemic growth (in pattern and size), and may describe tissue viability. Thus adaptive models can play important role in the assessment of acute and sub-acute therapeutic interventions of stroke.

ISMRM_MagnaLogo.jpg                     0017.   Topological Features of Structural Brain Networks in Sub-Clinical Psychosis Revealed by Graph Theoretical Analysis of Tractography Data

                                Mark Drakesmith1, Anirban Dutt2, Glyn Lewis3, Anthony S. David2, Derek K. Jones1

                                1CUBRIC, Cardiff University, Cardiff, Wales, United Kingdom; 2Institute of Psychiatry, Kings College London, London, United Kingdom; 3Academic Unit of Psychiatry, University of Bristol, Bristol, United Kingdom


Psychosis has long been considered a disconnection syndrome. Graph theory is a useful tool for examining dysconnectivity in psychosis. Here we apply the approach to tractography data acquired from subjects with sub-clinical psychotic experiences. We show that density and efficiency of structural brain networks is significantly lower in subjects with psychotic experiences. There were regional decreases in efficiency and node degree and differences in betweenness centrality and clustering coefficient.  Local changes in network structure were found in inferior frontal, temporopolar, cingulate and occipitoparietal cortices. Identifying future transitions to full psychosis will further isolate graph theoretical predictors of psychotic illness.

                    0018.   Accuracy and Reliability of ASL Perfusion in Evaluating Neurodegenerative Disease: Voxel-Wise and Cortical-Regional Comparison with 18F-FDG PET

                                Steve H. Fung1, 2, Christof Karmonik1, 2, Mario F. Dulay1, 2, Belen Pascual1, 2, Daniel Y. Lee1, 2, Stephen B. Chiang1, 2, Ronald E. Fisher1, 2, Robert G. Grossman1, 2, Bryan M. Spann1, 2, Gustavo C. Roman1, 2

                                1Houston Methodist Research Institute, Houston, TX, United States; 2Houston Methodist Hospital, Houston, TX, United States


Pattern of regional cerebral hypometabolism observed by FDG-PET is well-established technique for diagnosing Alzheimer’s disease as well as differentiation from other causes of dementia. Recent studies using ASL have shown similar diagnostic utility by observing regional cerebral hypoperfusion pattern. We compared regional and voxel-level CBF estimated from ASL to SUV from FDG-PET, test-retest reliability of CBF from ASL, and CBF from ASL in eyes-open versus eyes-closed states in patients evaluated for neurodegenerative disease. Aside for occipital lobe, we found good correlation between CBF on ASL and SUV on FDG-PET, in agreement with previous published studies. Due to discrepancy in the occipital lobe, caution should be made in interpreting occipital hypoperfusion with ASL, especially when considering dementia with Lewy bodies or Parkinson’s disease.

                    0019.   Application of Multi-Shell NODDI in Multiple Sclerosis

                                Torben Schneider1, Wallace Brownlee1, Hui Zhang2, Olga Ciccarelli3, David H. Miller1, Claudia A. M. Wheeler-Kingshott1

                                1NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom; 2Department of Computer Science & Centre for Medical Image Computing, UCL, London, United Kingdom; 3Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom


urite orientation and dispersion and density imaging (NODDI) is a new technique that promises unique ins ight into the density and orientation dispersion of neuronal tissue. In this pilot study we apply NODDI for the first time to Multiple Sclerosis  patients and compare with standard DTI metrics. We show that NODDI detects and provides more distinction of the microstructural disruption in Multiple Sclerosis in both lesional  tissue and normal appearing white matter compared to healthy controls.


                    00ZZ. ADiscriminating between Fast- and Slow-moving Zombies using Proton MRS

                                John Port1, Emily Wood3, Laura Rowland2

                                1Institutul pentru Studiul de Death, Transylvania, Romania; 2Frankenstein-Center zur Wiederherstellung Leben, Berlin, Germany

Electronic Power Poster Session: Neuro: Brains or Bust

Traditional Poster Hall     11:45-12:45                           (no CME credit)                                       


Young Investigator Award Presentations

Space 2                                10:45-12:45                                                                                                

10:45           0020.   Diffusion Magnetic Resonance Monitors Intramyocellular Lipid Droplet Size In Vivo

                                Peng Cao1, 2, Shu-Juan J. Fan1, 2, Anna M. Wang1, 2, Victor B. Xie1, 2, Zhongwei Qiao1, 2, Gary M. Brittenham3, Ed X. Wu1, 2

                                1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China; 3Departments of Pediatrics and Medicine, Columbia University College of Physicians and Surgeons, New York, NY, United States


Intramyocellular lipid (IMCL) droplets are dynamic organelles whose morphology reflects their vital roles in lipid synthesis, utilization and storage in muscle energy metabolism. To develop non-invasive means to measure droplet microstructure in vivo, we investigated the molecular diffusion behavior of IMCL with diffusion MR spectroscopy. Our results demonstrate the feasibility of MR diffusion characterization of IMCL droplet microstructure and provide evidence of the sensitivity of this method to metabolic alterations. The use of diffusion MR methodology in vivo promises to provide new biophysical insights in the investigation of droplet dynamics and lipid metabolism in both animal models and human subjects. The diffusion MR results may help contribute to an improved understanding and diagnosis of obesity, diabetes and other metabolic disorders.

11:05           0021.   2D Imaging in a Lightweight Portable MRI Scanner Without Gradient Coils

                                Clarissa Zimmerman Cooley1, 2, Jason P. Stockmann1, 3, Brandon D. Armstrong1, 3, Mathieu Sarracanie1, 3, Michael H. Lev4, 5, Matthew S. Rosen1, 3, Lawrence L. Wald1, 5

                                1A. A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 2Dept. of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States; 3Dept. of Physics, Harvard University, Cambridge, MA, United States; 4Dept. of Radiology, Massachusetts General Hospital, Boston, MA, United States; 5Harvard Medical School, Boston, MA, United States


As the premiere modality for brain imaging, MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations. We construct and validate a truly portable (<100kg) and silent proof-of-concept scanner which replaces conventional gradient encoding with a rotating lightweight low-field magnet. When rotated about the object, the inhomogeneous field pattern is used to create generalized projections which encode the iteratively reconstructed 2D image. The system is validated with experimental images of 2D test phantoms. This new scanner architecture demonstrates the potential for portability by simultaneously relaxing the magnet homogeneity criteria and eliminating the gradient coil.

11:25           0022.   MR-Guided Sclerotherapy of Low-Flow Vascular Malformations Using T2-Weighted Interrupted BSSFP (T2W-ISSFP): Comparison of Pulse Sequences for Visualization and Needle Guidance

                                Di Xu1, Daniel A. Herzka1, Wesley D. Gilson2, Elliot R. McVeigh1, Jonathan S. Lewin3, Clifford R. Weiss3

                                1Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States; 2Imaging & Computer Vision, Corporate Technology, Siemens Corporation, Baltimore, MD, United States; 3Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States


Venous and lymphatic malformations (VMs/LMs) are diagnostically visualized using T2-weighted fat-suppressed MR images. Once identified, lesions typically are treated percutaneously using ultrasound and fluoroscopic guidance. Treatment is limited in lesions that are deep, lie beneath scar, or within bone. Additionally, almost all patients require multiple treatments, accruing significant exposure to ionizing radiation. Real-time MR-guided intervention serves as a safer alternative, with better visualization of critical structures. Conventional sequences are limited: with blurry, distorted edges (HASTE) or with inferior VM/LM delineation because of poor T2-weighting (SSFP). We present real-time imaging for the VMs/LMs visualization during MR-guided sclerotherapy: T2-weighted Interrupted bSSFP (T2W-iSSFP).

11:45           0023.   MRI Demonstrates a Decrease in Myocardial Infarct Healing and Increase in Compensatory Ventricular Hypertrophy Following Mechanical Microvascular Obstruction

                                Hisham Z. Bajwa1, Lois Do1, Mohammed Suhail1, Steve W. Hetts1, Mark W. Wilson1, Maythem Saeed1

                                1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States


Our study was aimed at providing direct evidence that mechanical obstruction of microvessels in the coronary vasculature inhibits myocardial infarct resorption and enhances LV remodeling using MRI and then confirming these findings with histopathology. We found that persistent microvascular obstruction after 3 days was larger on average and more frequently found in animals that underwent LAD occlusion/microemboli delivery/reperfusion than animals that were only subjected to occlusion/reperfusion. The greater microvascular obstruction in the former was associated with less infarct resorption, a greater degree of increase in LV mass and more pronounced decline in LV ejection fraction.

12:05           0024.   Non-Contrast Mapping of Arterial Delay and Functional Connectivity Using Resting-State Functional MRI: A Study in Moyamoya Patients

                                Thomas Christen1, Hesamoddin Jahanian1, Wendy Wei Ni1, Deqiang Qiu1, Michael E. Moseley1, Greg Zaharchuk1

                                1Department of Radiology, Stanford University, Stanford, CA, United States


In this work, we investigated if delays in resting-state spontaneous fluctuations of the BOLD (sfBOLD) signal can be used to create maps similar to time-to-maximum of the residue function (Tmax) in Moyamoya patients and to determine whether these delays affect the results of brain connectivity mapping.

12:25           0025.   Nonrigid Autofocus Motion Correction for Coronary MR Angiography with a 3D Cones Trajectory

                                R Reeve Ingle1, Holden H. Wu2, Nii Okai Addy1, Jieying Luo1, Joseph Y. Cheng1, Phillip C. Yang3, Bob S. Hu1, 4, Dwight G. Nishimura1

                                1Electrical Engineering, Stanford University, Stanford, CA, United States; 2Radiological Sciences, UCLA, CA, United States; 3Cardiovascular Medicine, Stanford University, Stanford, CA, United States; 4Palo Alto Medical Foundation, Palo Alto, CA, United States


A nonrigid autofocus motion correction technique is presented for coronary magnetic resonance angiography (CMRA) using a free-breathing 3D cones non-Cartesian sequence.  Translational motion measurements from 2D or 3D image navigators are used to derive a set of candidate motion trajectories. A bank of motion-compensated CMRA images is generated using these candidate trajectories, and a focusing metric is used to reconstruct the final image by selecting the best-focused pixels.  The proposed technique is shown to improve the depiction of coronary arteries in volunteer and patient studies.


Unique Acquisition Strategies 1

Space 3                                10:45-12:45                                                                                               Moderators:Mariya Doneva, Ph.D. & Christopher P. Hess, M.D., Ph.D.

10:45           0026.   Using Gradient Waveforms Derived from Music in MR Fingerprinting (MRF) to Increase Patient Comfort in MRI

ISMRM_SummaLogo.jpg                                 Dan Ma1, Vikas Gulani1, 2, Mark Griswold1, 2

                                1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Radiology, Case Western Reserve University, Cleveland, OH, United States


The purpose of this study is to use MRF method to potentially mitigate the acoustic noise problem in normal MR scans while simultaneously quantifying multiple tissue parameters.  Instead of producing quiet sequences, we instead take advantage of the extra degrees of freedom in MRF to design acquisitions to replicate music in the magnet. In this study, mp3 music files, which are converted to arbitrary readout encoding gradients, are used with varying flip angles and TRs in the MRF exam to quantify T1, T2, off-resonance and proton density maps simultaneously while providing pleasing sounds to the patient.


10:57           0027.   Magnetic Resonance Fingerprinting Trajectory Optimization

                                Ouri Cohen1, Mathieu Sarracanie2, 3, Brandon D. Armstrong2, Jerome L. Ackerman1, Matthew S. Rosen2

                                1Department of Radiology, MGH/Athinoula A. Martinos Center for Biomedical Imaging, Massachussets General Hospital, Charlestown , MA , United States; 2Department of Radiology, MGH/Athinoula A. Martinos Center for Biomedical Imaging, Massachussets General Hospital, Charlestown, MA, United States; 3 Department of Physics, Harvard University, Cambridge, MA, United States


Current implementations of MR fingerprinting typically require over 1000 measurements to obtain the desired tissue maps. The large number entails an increased specific absorption rate and, to avoid excessive scan times, a subsampling of k-space that may incur undersampling artifacts. Here we propose an optimization method which allows reduction of the needed measurements ~100 fold without affecting image quality.

11:09           0028.   Simultaneous T1, T2, Diffusion and Proton Density Quantification with MR Fingerprinting

                                Yun Jiang1, Dan Ma1, Katie Wright1, Nicole Seiberlich1, Vikas Gulani2, Mark A. Griswold1, 2

ISMRM_SummaLogo.jpg                                 1Department of Biomedical Enginneering, Case Western Reserve University, Cleveland, OH, United States; 2Department of Radiology, Case Western Reserve University, Cleveland, OH, United States


MR Fingerprinting (MRF) is a novel platform for generating multiple parametric maps simultaneously by matching spatially and temporally incoherent signals to a pre-calculated dictionary. Here we explore MRF using a double-echo sequence with a spiral trajectory to simultaneously generate T1, T2, M0 and ADC maps. The result shows quantitative diffusion and relaxation estimates can be simultaneously generated within the MRF framework, extending the concept beyond relaxometry.

11:21           0029.   Small-Tip Fast Recovery (STFR) Imaging Using Spectrally Tailored Pulse

ISMRM_SummaLogo.jpg                                 Hao Sun1, Jeffrey A. Fessler1, Douglas C. Noll2, Jon-Fredrik Nielsen2

                                1Electrical Engineering and Computer Science, the University of Michigan, Ann Arbor, MI, United States; 2Biomedical Engineering, the University of Michigan, Ann Arbor, MI, United States


Small tip fast recovery (STFR) imaging has been proposed recently as a potential alternative to balanced steady state free precession (bSSFP). STFR relies on a tailored “tip-up” RF pulse to achieve comparable signal level and image contrast as bSSFP, but with reduced banding artifacts. Previous STFR implementations used 2D or 3D pulses spatially tailored to the accumulated phase calculated from a B0 field map. Here we propose to replace the spatially tailored pulse with a spectrally tailored pulse, which can be precomputed to a target frequency range. We show that this “spectral-STFR” sequence has reduced banding artifacts compared to bSSFP.

11:33           0030.   Spin Echoes in the Weak Dephasing Regime

ISMRM_MagnaLogo.jpg                                 Jakob Assländer1, Simone Köcher2, Steffen Glaser2, Jürgen Hennig1

                                1Dept. of Radiology - Medical Physics, University Medical Center, Freiburg, Germany; 2Dept. of Chemistry, Technische Universität München, Germany


It is shown that, for small flip angles, it is possible to form spin echoes after a single excitation pulse, where the time between the end of the pulse and the echo is longer than the length of the pulse itself. This is in contrast to standard Hahn-echo pulse sequences, where the length of the pulse sequence is in approximation equal to the time between the end of the composite pulse and the echo. The sequence is implemented into a FLASH sequence. At the example of lung pulmonary imaging signal enhancement is demonstrated in comparison to a standard FLASH sequence.

11:45           0031.   Prephased O-Space Imaging for Reduction of Asymmetrical Local K-Space Coverage

ISMRM_MagnaLogo.jpg                                 Leo K. Tam1, Gigi Galiana1, Haifeng Wang1, Emre Kopanoglu1, Andrew Dewdney2, Dana C. Peters1, R. Todd Constable1

                                1Diagnostic Radiology, Yale University, New Haven, CT, United States; 2Siemens Healthcare AG, Erlangen, Bavaria, Germany


Local k-space, the spatial derivative of the encoded phase has been used to visualize and design strategies to mitigate the spatially-varying encoding of nonlinear gradient encoding.  To reduce the local k-space asymmetry of O-space imaging, the phase prior to readout is adjusted for each readout in a technique called prephasing, first proposed by Gallichan et. al.  Prephased O-space imaging shows reduced MSE, though artifacts from previous simulations of asymmetrical k-space were not corroborated.  Parallel receiver information may sufficiently localize signal conditional on appropriate imaging parameters.

11:57           0032.   Optimal Trajectory Design for Higher-Dimensional Encoding

                                Kelvin J. Layton1, Feng Jia2, Maxim Zaitsev2

                                1Department of Electrical and Electronic Engineering, The University of Melbourne, Melbourne, Victoria, Australia; 2Dept. of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany


Spatial encoding magnetic fields (SEMs) that vary nonlinearly over the field-of-view have the potential to accelerate imaging and overcome current safety limitations. Encoding with combinations of linear and nonlinear SEMs offer great flexibility but also make trajectory design difficult, since traditional k-space is insufficient to represent the higher-dimensional encoding space. This work presents a new method for automated trajectory design based on the predicted variance of the reconstructed pixels. In this way, the condition of the reconstruction problem is explicitly considered during trajectory design. Images reconstructed from simulated data exhibit reduced artifacts and noise using the proposed trajectory.

12:09           0033.   Spatial Resolution in Rotating Spatial Encoding Magnetic Field MRI (RSEM-MRI)

ISMRM_MagnaLogo.jpg                                 Clarissa Zimmerman Cooley1, 2, Jason P. Stockmann1, 3, Brandon D. Armstrong1, 3, Mathieu Sarracanie1, 3, Matthew S. Rosen1, 3, Lawrence L. Wald1, 4

                                1A. A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 2Dept. of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States; 3Dept. of Physics, Harvard University, Cambridge, MA, United States; 4Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States


MRI could find wider applicability if lightweight, portable systems were available for siting in unconventional locations. We have proposed a lightweight magnet whose inhomogeneous field pattern is physically rotated to form a rotating Spatial Encoding Magnetic field (rSEM). This is a way to lower the magnet weight and eliminate gradient coils. The resulting image resolution varies spatially in the FOV with minimal encoding in center, a common problem in non-linear gradient encoding schemes. With the goal of improving encoding throughout the FOV, we assess resolution in different rSEMs through simulations, and compare to experimentally acquired images.

12:21           0034.   Time-Efficient Interleaved 23Na and 1H Acquisition at 7T

                                Paul W. de Bruin1, Maarten J. Versluis1, Peter Koken2, Sebastian A. Aussenhofer1, Ingrid Meulenbelt3, Peter Börnert, 12, Andrew G. Webb1

                                1Radiology Department, Leiden University Medical Center, Leiden, Netherlands; 2Innovative Technologies Research Laboratories, Philips Technologie GmbH, Hamburg, Germany; 3Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands


A flexible sequence interleaving method for different nuclei is used to virtually simultaneously acquire 23Na and 1H scans. This results in a high time-efficiency that is essential for patient studies involving 23Na scans.

12:33           0035.   in Vivo Ultrafast Diffusion Imaging of Stroke at 21.1 T by Spatiotemporal Encoding

                                Jens T. Rosenberg1, 2, Avigdor Leftin3, Eddy Solomon3, Fabian Calixto Bejarano1, Lucio Frydman, 13, Samuel Colles Grant1, 2

                                1National High Magnetic Field Laboratory, The Florida State University, Tallahassee, FL, United States; 2Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States; 3Chemical Physics, Weizmann Institute of Science, Rehovot, Israel


Fast imaging techniques such as echo planar imaging (EPI) are popular techniques for imaging of neuronal injuries. However, there is an inherent problem with these techniques with respect to susceptibility and geometric artifacts that distort not only anatomical information but also the quantification of relevant quantities, such as water diffusion. To provide robust and fast acquisitions at high field, this study utilizes an ultrafast single-shot spatiotemporally encoded (SPEN) imaging sequence with diffusion encoding to measure apparent diffusion coefficient (ADC) in stroke. Results show that SPEN images provide a more accurate way of measuring ADC at high field compared to EPI.

Combined Educational & Scientific Session: PET-MRI & Whole Body MRI

Space 4                                10:45-12:45                                                                                               Moderators:Alexander R. Guimaraes, M.D., Ph.D. & Ullrich Kramer, M.D.

10:45                       Technical Challenges & Opportunities of MR-PET: An Overview

                                Harald H. Quick1, Ph.D.

                                1Friedrich-Alexander-University Erlangen, Erlangen, Germany


11:15                       Clinical Experience in Body MR-PET

                                Ulrich Kramer1, M.D.

                                1University of Tuebingen, Dep Diagnostic and Interventional Radiology


11:45           0036.   Hybrid PET/MRI for Evaluation of Nodal Disease in Lymphoma

                                Laura Heacock1, Joseph Weissbrot1, Roy Raad1, Naomi Campbell1, Kent Friedman1, Christian Geppert2, Hersh Chandarana1

                                1Radiology, NYU Langone Medical Center, New York, NY, United States; 2Siemens Medical Solutions, New York, NY, United States


PET/CT is routinely performed in evaluation of disease burden in patients with Non Hodgkin Lymphoma (NHL). MRI with diffusion weighted imaging (DWI) has shown promise. In this study we compared the accuracy of morphologic MRI including DWI and PET/MR in detection of nodal disease with PET/CT as a reference. Our results suggest that PET/MR outperformed DWI for assessment of nodal disease and had sensitivity similar to PET/CT. Furthermore there was excellent correlation in SUVmax as measured with PET/MR and PET/CT. Thus PET/MR may be a viable option to PET/CT in evaluation of patients with lymphoma.

11:55           0037.   Preliminary Results of Metabolic-Flow Relationship in Primary Cervical Cancer: Correlation of Combined PET/Dynamic Contrast-Enhanced MRI

                                Omer Aras1, Volkan Beylergil2, Mark Hinton3, Olga Kubassova3, Oguz Akin4

                                1Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States; 2Radiology, Memorial Sloan Kettering Cancer, NY, United States; 3Image Analysis, London, United Kingdom; 4Radiology, Memorial Sloan Kettering Cancer, New York, NY, United States


In this preliminary data from 18F-FDG-PET/DCE-MRI in cervical cancer are reported. 18F-FDG PET and DCE-MRI tumor measures of tumor metabolism and vascularity were not correlated in this study indicating a complex interaction between tumor enhancement characteristics and tumor metabolism. information on the tumor.

12:05           0038.   Whole Body 18FDG-PET/MRI as Compared with 18FDG-PET/CT in Metastatic Breast Cancer

                                Amy Melsaether1, Akshat C. Pujara2, Kristine Pysarenko2, Roy A. Raad2, Fabio Ponzo2, Kent Friedman2, Hersh Chandarana2, Komal Jhaveri2, Eric Sigmund2, Sungheon Kim2, Linda Moy2

                                1NYU, New York, United States; 2NYU, NY, United States


In this prospective disease-specific study of 50 breast cancer patients, 18FDG-PET/MRI detected potentially treatment changing brain, liver and bone metastases not seen on PET/CT in 8 (16%) or patients and PET/CT occult in situ breast cancers in 5 (10%).  Average 18FDG-PET/MRI radiation dose was 50% that of 18FDG-PET/CT.

12:15           0039.   Hybrid PET/MRI Incorporating Dynamic 18F-FDG PET Imaging: Correlation with Biopsy Findings-Preliminary Observations

                                Andrew B. Rosenkrantz1, Anne-Kristin Vahle1, Christian Geppert2, Christopher Glielmi2, Fabio Ponzo1, Kent P. Friedman1, Samir S. Taneja3, Yu-Shin Ding1, Thomas Koesters1

                                1Center for Advanced Imaging Innovation and Research, Department of Radiology, NYU Langone Medical Center, New York, NY, United States; 2Siemens Healthcare, Erlangen, Germany; 3Urologic Oncology, NYU Langone Medical Center, New York, United States


This pilot study of 12 prostate cancer patients explores associations between metrics obtained from PET/MRI incorporating dynamic 18F-FDG PET imaging and biopsy findings.  DCE-MRI and dynamic PET were performed simultaneously following sequential injections of gadolinium-chelate and FDG.  Dynamic PET data was reconstructed in 30-second bins for the first 5 minutes, followed by 5-minute bins for the remainder of a 30-minute acquisition.  Peak and 30-minute FDG activity were determined from FDG time-activity-curves and compared among benign and low- and high-grade tumors.  The peak FDG activity showed the strongest association with biopsy results, supporting the value of dynamic PET imaging during PET/MRI.

12:25           0040.   PET/MRI and PET/CT in Follow-Up of Head and Neck Cancer Patients

                                Marcelo Queiroz1, Christian Meerwein2, Gerhard Huber2, Martin Hüllner1, Felix Kuhn1, Spyros Kollias3, Gustav von Schulthess1, Patrick Veit-Haibach1

                                1Medical Imaging, Zurich University Hospital, Zurich, Switzerland; 2Otorhinolaryngology, Zurich University Hospital, Zurich, Switzerland; 3Neuroradiology, Zurich University Hospital, Zurich, Switzerland


Our abstract compares the novel PET/MRI and the well established PET/CT in the follow-up of head and neck patients. PET/MRI emerges as a potential imaging modality that joins the functional ability of PET and the high-soft tissue contrast provided by MRI, but it might be shown the real advantages of this method.


12:35           0041.   In Vivo Characterization of Inflammation by Combined [11C]-PBR28 PET Imaging and 7 Tesla MRI in Multiple Sclerosis

                                Costanza Gianni'1, Audrey Fan1, Sindhuja Tirumalai Govindarajan1, Marco Loggia1, Nicole Zurcher Wimmer1, Ciprian Catana1, Jacob Hooker1, Emanuele Tinelli2, Celine Louapre1, Thomas A. Anderson3, R.P. Kinkel4, Caterina Mainero1

                                1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy; 3Massachusetts General Hospital, Boston, MA, United States; 4Beth Israel Deaconess Medical Center, Boston, MA, United States


Inflammation through activation of macrophages and microglia is a prominent feature in multiple sclerosis. However, the relationship between activated microglia / macrophages and structural damage in the brain relies mainly on neuropathological studies. Here, we combined [11C]PBR28 imaging of activated microglia on a high resolution, simultaneous human MR-PET system with 7 Tesla in patients with secondary progressive multiple sclerosis. We observed diffuse microglia and macrophage activation across the cortex and WM, which topographically overlapped with visible lesions on 7 T T2* images in some regions.


Cancer Preclinical:  Animal Studies

Silver                                    10:45-12:45                                                                                               Moderators:Tone F. Bathen, Ph.D. & Kristine Glunde, Ph.D.

10:45           0042.   A Novel Approach to Tracer-Kinetic Modeling of (Macromolecular) Multi-Bolus DCE-MRI Data, Applied in a Murine Tumor Model

ISMRM_SummaLogo.jpg                                 Igor Jacobs1, 2, Gustav Strijkers1, 2, Henk Keizer3, Henk Janssen3, Klaas Nicolay1, 2, Matthias Schabel4

                                1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Center for Imaging Research and Education, Eindhoven, Netherlands; 3SyMO-Chem BV, Eindhoven, Netherlands; 4Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States


Conventional low-molecular-weight DCE-MRI and tracer-kinetic modeling does not support separate estimates of blood flow and microvascular permeability, while this would be advantageous for accurate cancer treatment evaluation. In this research a multi-bolus DCE-MRI protocol was developed, in which contrast agents of various molecular weights were injected sequentially. A novel tracer-kinetic modeling approach, based on the two-compartment exchange model, was applied to simultaneously fit multi-bolus data. The feasibility of this approach was shown in a murine tumor model. Single-pixel multi-bolus curves were of good quality and significant differences in extraction fraction and washout rate constant were observed between the different contrast agents.

10:57           0043.   Altered Choline Phospholipid Metabolism in Pancreatic Cancer Cells and Tumor Xenografts

                                Marie-France Penet*1, Tariq Shah*1, Santosh Bharti1, Yelena Mironchik1, Flonné Wildes1, Anirban Maitra2, Zaver M. Bhujwalla1

                                1JHU ICMIC Program, Division of Cancer Imaging Research, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2The University of Texas MD Anderson Cancer Center, Houston, TX, United States


Pancreatic cancer is an aggressive disease usually advanced at the time of diagnosis.  Biomarkers with sensitivity and specificity for early diagnosis are urgently needed.  Here we have investigated the metabolism of a panel of pancreatic cell lines in vitro and in vivo.  Using high-resolution 1H MRS we observed elevated choline-containing compounds, along with high levels of choline kinase.  Total choline signal was detected in vivo in tumor xenografts, with the highest concentration in the Panc1 tumors.  Our study showed that the altered choline phospholipid metabolism could be used for noninvasive detection of pancreatic cancer and for treatment strategies.

11:09           0044.   In Vivo 1H MRS Detection of Choline Compounds in Pancreas of MEN1 Knock-Out Mice

                                Min-Hui Cui1, 2, Ziqiang Yuan3, Sean Cahill4, Asha Adem3, Steven K. Libutti3, Craig A. Branch1, 2

                                1Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, United States; 2Radiology, Albert Einstein College of Medicine, Bronx, NY, United States; 3Surgery, Albert Einstein College of Medicine, Bronx, NY, United States; 4Biochemistry, Albert Einstein College of Medicine, Bronx, NY, United States


We have demonstrated that in vivo 1H MRS has a potential role in diagnosis of pancreatic cancer, in a multiple endocrine neoplasia type 1 (MEN1) conditional knock-out mouse model. Choline was detected in Men1 KO mice via in vivo 1H MRS, but not in WT mice. The elevated total choline levels in Men1 KO mice were mainly due to high levels of phophocholine and glycerophosphocholine in pancreas tissues. Our approach may provide additional beneficial information in the context of pancreatic lesion diagnosis and allow monitoring tumor responsiveness to treatment.

11:21           0045.   Assessment of the Tumor Type-Specific Microenvironment – Lactate, Vascularity, Hypoxia, Extracellular PH

                                Ellen Ackerstaff1, Natalia Kruchevsky1, Ekaterina Moroz1, Nirilanto Ramamonjisoa1, Rui V. Simoes1, H. Carl LeKaye1, Kristen L. Zakian1, Hansol Lee2, HyungJoon Cho2, Radka Stoyanova3, Inna Serganova1, Ronald G. Blasberg1, Jason A. Koutcher1

                                1Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Ulsan National Institute of Science and Technology, Ulsan, Korea; 3Miller School of Medicine, University of Miami, Miami, FL, United States


A hostile tumor microenvironment impacts tumor growth, progression, metastases, and treatment resistance. More aggressive tumors have been associated with increased lactate production, acidity, and suppressed T-cell immune response. Here, we characterize noninvasively in vivo the tumor microenvironment in tumor models of different origin and aggressivity and investigate the relationship of lactate metabolism, vascularity, hypoxia, and extracellular pH (pHe) to tumor type / aggressivity, using 1H MRI/MRS/MRSI. Our data suggest that pHe does not directly relate to tumor lactate levels and that interplay of tumor metabolic activity and vascularization regulates tumoral pHe, showing the importance to assess these parameters independently.

11:33           0046.   Multiparametric MRI Mapping of Oxygen Delivery and Hypoxia in Renal 786-O-R Murine Xenografts

                                James PB O'Connor1, Yann Jamin2, Jessica KR Boult2, Muhammad Babur3, John C. Waterton1, Damien McHugh1, Andrew R. Reynolds4, Kaye J. Williams3, Geoff JM Parker1, Simon P. Robinson2

                                1Imaging Sciences, University of Manchester, Manchester, Greater Manchester, United Kingdom; 2Radiotherapy and Imaging, Institute of Cancer Research, Sutton, London, United Kingdom; 3School of Pharmacy, University of Manchester, Manchester, Greater Manchester, United Kingdom; 4Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Sutton, London, United Kingdom


T1weighted oxygen-enhanced MRI can measure oxygen delivery and hypoxia in tumors. We report the first study to combine this method with BOLD, DCE-MRI and immunohistochemistry. We show how combining these modalities provides fresh insight into the spatial and temporal oxygen handling of 786-O-R renal xenografts.

11:45           0047.   Is R1 of Lipids Related to PO2? Lessons from Two Tumor Models

ISMRM_MagnaLogo.jpg                                 Florence Colliez1, Marie-Aline Neveu1, Julie Magat1, Thanh Trang Cao Pham1, Bernard Gallez1, Bénédicte F. Jordan1

                                1Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium


Variations in T1 and T2* are potentially valuable MRI tools to follow changes in tumor oxygenation. T2* is sensitive to the relative Hb/HbO2 ratio in vessel, while T1 change is sensitive to dissolved oxygen which acts as a T1-shortening paramagnetic contrast agent. The aim of the current work is to investigate the quantitative aspect of a new oxygen mapping method: MOBILE. Two tumor models were submitted to (i) hyperoxic challenges induced by carbogen breathing and (ii) hypoxic challenges induced by Combetastatin A-4 Phosphate. Actual pO2 values were obtained by EPR oximetry and significantly correlated to Lipids R1 values.


11:57           0048.   Noninvasive MRI of Tissue Redox State Based on Endogenous Chemical Exchange Saturation Transfer (CEST) Contrast

                                Kejia Cai1, 2, He N. Xu1, Anup Singh1, Lily Moon1, Mohammad Haris1, 3, Xiaohong Joe Zhou2, Ravinder Reddy1, Lin Z. Li1

                                1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2CMRR 3T Research Program, Radiology, University of Illinois at Chicago, Chicago, IL, United States; 3Sidra Medical and Research Center, Doha, Qatar


The disturbed balance of the redox state, such as excessive oxidative stress, can lead to many pathologic changes including cancer, heart diseases, neurodegenerative diseases, and diabetes. Imaging biomarkers for oxidative stress are a key research area. The purpose of this study is to develop a non-invasive MR imaging method for mapping the tissue redox state based on the endogenous Chemical Exchange Saturation Transfer (CEST) contrast. We report herein a CEST MRI technique, together with correlations to optical redox scanning to characterize tumor redox heterogeneity. The mechanism on such correlation has also been investigated.

12:09           0049.   Probing Cancer Metabolism with Hyperpolarized 5-13C-Glutamine

                                Claudia Cabella1, Magnus Karlsson2, Carolina Canapè3, Giuseppina Catanzaro1, Sonia Colombo Serra1, Luigi Miragoli1, Luisa Poggi1, Fulvio Uggeri1, Luca Venturi3, Pernille R. Jensen2, Mathilde H. Lerche2, Fabio Tedoldi1

                                1CRB Bracco Imaging SpA, Colleretto Giacosa, Torino, Italy; 2Albeda Research Aps, Copenhagen, Denmark; 3University of Torino, Torino, Italy


Glutamine metabolism is a key marker of cancer development. In particular, strong correlations have been reported between oncogene expression and activity of the glutaminase enzyme. Hyperpolarized 13C-MR spectroscopy can provide insight to glutamine metabolism and should hence be a valuable tool to study changes in glutaminase activity as tumours progress. This work reports on an improved preparation of hyperpolarized 5-13C-glutamine, providing a highly sensitive MR marker. Physiological tolerable glutamine solutions with remarkable polarization levels were obtained by dissolution and used to perform 13C metabolic analysis in vivo in healthy and tumour bearing rats and for testing pharmacological treatments in vitro.


ISMRM_MagnaLogo.jpg 12:21           0050.   Measuring Tumor Metabolism in Diffuse Intrinsic Pontine Gliomas (DIPG) Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging

                                Ilwoo Park1, Rintaro Hashizume2, Peder EZ Larson1, C. David James2, Daniel B. Vigneron1, 3, Sarah J. Nelson1, 3

                                1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 2Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States; 3Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States


Diffuse intrinsic pontine gliomas (DIPGs) are one of the most difficult pediatric cancers to treat. The methods for assessing treatment response and tumor progression are based on radiographic response but conventional MRI is not sufficient for predicting clinical outcome. We have demonstrated the feasibility of using hyperpolarized 13C metabolic imaging to evaluate in vivo metabolism in orthotopic brainstem xenografts injected with human DIPG cells. The results suggest that this technique may provide a unique non-invasive imaging tool that is able to differentiate between different tissue pathologies and aid in the management of patients with DIPG.

12:33           0051.   19F MRI for Evaluating ERK1 as a Factor Regulating Dendritic Cell Migration in High Grade Glioma

ISMRM_MagnaLogo.jpg                                 Min-Chi Ku1, Martin Günther1, Conrad Martin1, Stefano Lepore1, Helmar Waiczies1, 2, Andreas Pohlmann1, Susanne A. Wolf3, Helmut Kettenmann3, Thoralf Niendorf1, Sonia Waiczies1

                                1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany; 2MRI.TOOLS GmbH, Berlin, Germany; 3Cellular Neurosciences, Max Delbrück Center for Molecular Medicine, Berlin, Germany


Immunotherapy with dendritic cell based vaccines for treating glioma has become one attractive approach. To access the efficiency of DC vaccine, it is necessary to monitor the distribution of DCs in the CNS or lymphoid organs. Our goal is to target molecules, which are involved in regulating DCs within the glioma context. In this study we found that deficiency of ERK1 result in tumor regression. 19F/1H MRI monitored the migration of DCs and found that ERK1 can regulate DC migration.

Diffusion Applications

Red 1 & 2                            10:45-12:45                                                                                               Moderators:Alexander Leemans, Ph.D. & Claudia A. Wheeler-Kingshott, Ph.D.

10:45           0052.   Connectivity Based Segmentation of the Periaqueductal Grey Matter in Humans with Diffusion Tensor Imaging

                                Martyn Ezra1, Olivia Kate Faull1, Saad Jbabdi2, Kyle Thomas Shane Pattinson1

                                1Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, Oxfordshire, United Kingdom


The periaqueductal gray matter (PAG) is involved in a number of key neurobiological functions. Animal research has identified four sub-divisional columns that differ in both connectivity and function. This study used high-resolution diffusion tensor imaging and probabilistic tractography to segment the human PAG based upon voxel connectivity profiles. While we identified four distinct subdivisions demonstrating spatial concordance with the columns of the animal model, the connectivity profiles of these subdivisions were different to those in animals. This is the first study to resolve subdivisions within the human PAG, and may aid stereotactic interventions and interpretation of functional imaging studies.

10:57           0053.   Imaging Gray Matter in Human Brainstem In Vivo by High Spatial Resolution Diffusion Tensor Imaging at 7 Tesla

                                Marta Bianciardi1, Nicola Toschi1, 2, Cornelius Eichner3, Kawin Setsompop3, Florian Beissner3, Vitaly Napadow3, Jonathan R. Polimeni1, Lawrence L. Wald3

                                1Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH, Harvard Medical School , Boston, MA, United States; 2Department of Medicine, University of Rome “Tor Vergata”, Rome, Italy; 3Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH, Harvard Medical School, Boston, MA, United States


The human brainstem plays an important role in several vital functions, including sleep, and respiration. Our current knowledge of gray matter (GM) structure within the brainstem mostly derives from ex-vivo studies. Aim of this work was to develop novel in-vivo MRI-tools to identify GM-structure. We employed in-vivo high spatial-resolution DTI at 7Tesla, and scrutinized the contrast in DTI-maps, including fractional-anisotropy (FA). In single subject FA-maps, major clusters of brainstem-nuclei were visible with high contrast including the median-raphe-nucleus, the reticular-formation, and the vestibular/olivary/pontine nuclei. High-resolution DTI is a promising tool to delineate GM-structure in the brainstem in-vivo on a subject-by-subject basis.

11:09           0054.   Heritability of White Matter (WM) Fibres Based on Fibre Orientation Distribution (FOD) Measurements on Hardi Data

                                Kaikai Shen1, Stephen Rose1, Jurgen Fripp1, Katie McMahon2, Greig de Zubicaray3, Nicholas Martin4, Paul Thompson5, Margaret Wright4, Olivier Salvado1

                                1Australian e-Health Research Centre, CSIRO, Herston, Queensland, Australia; 2Centre for Advanced Imaging, University of Queensland, St Lucia, Queensland, Australia; 3School of Psychology, University of Queensland, St Lucia, Queensland, Australia; 4Queensland Institute of Medical Research, Herston, Queensland, Australia; 5Imaging Genetics Centre, University of Southern California, Los Angeles, CA, United States


We aim to estimate the genetic influence on WM structures using Fibre Orientation Distrubution (FOD) based measurements. We hypothesize that because FOD resolves the crossing fibres, it will allow measuring genetic influence on intra-voxel fibre structures. We estimated the heritability of FOD measures over a twin cohort, by projecting the heritability of FOD onto fibre tracks, and estimating the genetic influence along fibre tracks.


11:21           0055.   Derivation and Evaluation of Amygdalo-Prefrontal Connections in Humans and Monkeys Using Diffusion Tractography

                                Longchuan Li1, Xiaoping Hu2, Jocelyne Bachevalier3, Warren Jones1, Sarah Shultz1, Ami Klin1

                                1Department of Pediatrics, Marcus Autism Center, Children's HealthCare of Atlanta, Emory University, Atlanta, GA, United States; 2Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, United States; 3Yerkes National Primate Research, Emory University, GA, United States


Amygdala-cortical connections consist of major regions of “social brain” and mapping such a network may be critically informative of its roles in autism. In this study, diffusion tractography was used to delineate the connections between the amygdala and the prefrontal areas in macaque monkeys and humans. The results in monkeys were compared with the tracer literature and were also compared with those in humans. We found a generally similar pattern of connections between the tracer and tractography studies and between two species. Such work serves as the first step in realistically mapping amygdala network for the neural underpinnings of autism.

11:33           0056.   Multi-Centre Reproducibility of Diffusion MRI Parameters for Clinical Sequences in the Brain

ISMRM_SummaLogo.jpg                                 Matthew Grech-Sollars1, Patrick W. Hales1, Keiko Miyazaki2, Felix Raschke3, Daniel Rodriguez4, 5, Martin Wilson6, Simrandip K. Gill6, Tina Banks7, Dawn E. Saunders7, Jonathan D. Clayden1, Matt Gwilliam2, Thomas R. Barrick3, Paul S. Morgan4, 5, Nigel P. Davies8, James Rossiter9, Dorothee P. Auer4, 5, Richard Grundy5, Martin O. Leach2, Franklyn A. Howe3, Andrew C. Peet6, Chris A. Clark1

                                1UCL Institute of Child Health, University College London, London, United Kingdom; 2CR UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Foundation Trust, Surrey, United Kingdom; 3Division of Clinical Sciences, St George's, University of London, London, United Kingdom; 4Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom; 5The Children‘s Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom; 6School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; 7Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom; 8Imaging and Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 9Electrical & Computer Engineering, University of Birmingham, Birmingham, United Kingdom


The reproducibility of diffusion MRI parameters, and more specifically the apparent diffusion coefficient (ADC), intra-voxel incoherent motion (IVIM) parameters – the diffusion coefficient (D) and perfusion fraction (f), and diffusion tensor imaging (DTI) parameters – mean diffusivity (MD) and fractional anisotropy (FA), was analysed across multiple centres using standard clinical protocols. ADC, D, MD and FA were found to have a good reproducibility and research studies can benefit from incorporating multi-centre data without any loss of reproducibility compared to what would be achieved from a single scanner at a single site.

11:45           0057.   The Effect of Spatial Registration Algorithm on Detection of White Matter Abnormalities in Multiple Sclerosis: A TBSS Study.

                                Giovanni Giulietti1, Barbara Spano'1, Mara Cercignani2, Barbara Basile1, Carlo Caltagirone3, 4, Marco Bozzali1

                                1Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom; 3Clinical and Behavioural Neurology, Santa Lucia Foundation, Rome, Italy; 4Departement of Neuroscience, University of Rome "Tor Vergata", Rome, Italy


In the current study we compared the results obtained repeating twice the same FSL-TBSS analyses on the fractional anisotropy (FA) maps, belonging to patients with relapsing remitting multiple sclerosis and healthy subjects, only changing the spatial normalization algorithms. In particular, we tested the differences in using a cubic B-splines (FNIRT, used as default in FSL) and a diffeomorphic (ANTs) transformations algorithms, in terms of the produced skeleton layout and the results of the statistical group comparison. We found that the TBSS-ANTs analysis was able to reconstruct more WM tracts  and to detect FA group differences in more brain regions.

11:57           0058.   Preventing Visual Field Deficits from Neurosurgery Using Intraoperative MRI

ISMRM_SummaLogo.jpg                                 Gavin P. Winston1, Pankaj Daga2, Mark J. White3, 4, Caroline Micallef3, 4, Anna Miserocchi5, Laura Mancini3, 4, Marc Modat2, Jason Stretton1, Meneka K. Sidhu1, Mark R. Symms1, David J. Lythgoe6, John Thornton3, 4, Tarek A. Yousry3, 4, Sebastien Ourselin2, John S. Duncan1, Andrew W. McEvoy5

                                1Epilepsy Society MRI Unit, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, England, United Kingdom; 2UCL Centre for Medical Image Computing, London, United Kingdom; 3Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom; 4Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom; 5Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom; 6Centre for Neuroimaging Sciences, Institute of Psychiatry, Kings College London, England, United Kingdom


Anterior temporal lobe resection (ATLR) for refractory epilepsy may cause a visual field deficit (VFD) that precludes driving. We studied 21 patients undergoing ATLR in an intraoperative MRI (iMRI) suite. Preoperative tractography of optic radiation was displayed on the navigation and operating microscope displays either without (9 patients) or with (12 patients) correction for brain shift. Display of the optic radiation during surgery significantly reduced the degree of VFD and no patient developed a VFD that precluded driving (compared to 13% of a historical non-iMRI cohort). Outcome did not differ between iMRI guidance with and without brain shift correction.

12:09           0059.   Plasticity of the Human Visual Pathways Formed by Ocular Gene Therapy

                                Manzar Ashtari1, Gary Hui Zhang2, Laura Cyckowski1, Philip Cook3, Amanda Viands1, Kathleen Marshall4, James Gee3, Albert Maguire5, Jean Bennett6

                                1Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States; 2Computer Science, University College London, London, United Kingdom; 3Radiology, University of Pennsylvania, Philadelphia, PA, United States; 4CCMT, Children's Hospital of Philadelphia, Philadelphia, PA, United States; 5Ophthalmology, University of Pennsylvania, PA, United States; 6Ophthalmology, University of Pennsylvania, Philadelphia, PA, United States


Visual deprivation and blindness are debilitating disorders with no available treatment.  Recently, retinal gene therapy has successfully treated a group of patients with Leber's congenital amaurosis (LCA) and has profoundly affected the quality of their lives.  Of all sensory systems, vision provides the most information to the brain and plays a central role in how we relate to and interact with the world. Thus, the success of this exciting treatment raises the question of the effect this therapy may have on the brain’s visual pathways. We have employed advanced functional and structural imaging to answer this question.

12:21           0060.   Diffusion Tensor MRI and Tractography of the Sacral Plexus in Children with Spina Bifida

ISMRM_SummaLogo.jpg                                 Wieke Haakma1, 2, Pieter Dik3, Bennie ten Haken4, Martijn Froeling1, Rutger Jan Nievelstein1, Jeroen Hendrikse1, Inge Cuppen5, Tom de Jong3, Alexander Leemans6

                                1Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2Department of Forensic Sciences and Comparative Medicine Lab, Aarhus University, Aarhus, Central Denmark, Denmark; 3Pediatric Urology, University Medical Center Utrecht, Utrecht, Netherlands; 4Institute for Biomedical Technology & Technical Medicine, University of Twente, enschede, Overijssel, Netherlands; 5Pediatric Neurology, University Medical Center Utrecht, Utrecht, Netherlands; 6Image Science Institute, University Medical Center Utrecht, Utrecht, Netherlands


It is still largely unknown how neural tube defects in spina bifida (SB) affect the nerves at the level of the sacral plexus. Visualizing the sacral plexus in 3D could improve anatomical understanding regarding neurological problems. 10 SB patients underwent DTI on a 3 Tesla MRI. With tractography the microstructural properties of the nerves were investigated and were compared with 10 healthy controls. The sacral plexus of SB patients showed asymmetry, disorganization and lower diffusion values compared to healthy controls. We expect that this technology can provide a valuable contribution to a better analysis of these patients in the future.


12:33           0061.   Basal Ganglia-Cortical Structural Connectivity in Huntington’s Disease

                                Marianne J U Novak1, 2, Kiran K. Seunarine3, Clare R. Gibbard2, 3, Bogdan Draganski4, 5, Karl Friston1, Sarah J. Tabrizi2, 6, Christopher A. Clark3

                                1Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom; 2Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom; 3Imaging and Biophysics, UCL Institute of Child Health, London, United Kingdom; 4LREN, Département des Neurosciences Cliniques, Université de Lausanne, Switzerland; 5Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 6National Hospital for Neurology and Neurosurgery, London, United Kingdom


Huntington's disease (HD) is a genetic condition that affects both the white and grey matter of the brain.  Striatal volume loss is the earliest and most characteristic structural abnormality seen using brain imaging in HD.  In this work we present a statistical approach that allows us to quantitatively compare connectivity patterns of subcortical nuclei between groups. We apply our technique to a Huntington's disease cohort and find structured differences in patterns of connectivity compared to healthy controls.  Conversely, we see no significant differences between premanifest HD patients and controls, which suggests progressive changes to patterns of connectivity with disease progression.

MRS of the CNS 1

Blue 1 & 2                           10:45-12:45                                                                                               Moderators: Peter B. Barker, D.Phil. & Graham Galloway, Ph.D.

10:45           0062.   Regional Metabolism During Healthy Aging in Mice Brain: A 1H-[13C]-NMR Study

                                Anant Bahadur Patel1, Pandichelvam Veeraiah1, Mohammad Shamim1, M Jerald Mahesh Kumar1

                                1NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India


Despite key role of neurotransmitters in brain function, brain energy metabolism has not been explored during healthy aging. In this study, we have investigated neuronal and astroglial metabolism in the cerebral cortex, hippocampus and striatum of adult and aged C57BL6 mice by using 1H-[13C]-NMR spectroscopy together with infusion of 13C labeled substrates. The 13C turnover of amino acids was analyzed using a three compartment metabolic model to derive the metabolic rates. Aging is associated with an increased in astroglial flux and decrease in glutamatergic and GABAergic rates across different brain regions.

10:57           0063.   Manganese Induced Changes in Thalamic GABA Levels Influence Cognitive and Motor Performance

                                Ruoyun Ma1, 2, Ann-Kathrin Stock3, S.Elizabeth Zauber4, James B. Murdoch5, Shalmali Dharmadhikari1, 2, Zaiyang Long1, 2, Christian Beste3, Ulrike Dydak1, 2

                                1School of Health Sciences, Purdue University, West Lafayette, IN, United States; 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States; 3Cognitive Neurophysiology Department of Child and Adolescent Psychiatry, Technical University Dresden, Dresden, Germany; 4Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States; 5Toshiba Medical Research Institute USA, Mayfield Village, OH, United States


Chronic occupational exposure to Manganese (Mn) has been associated with cognitive and motor disorders similar to Parkinson disease. Based on a previous observation of elevated GABA levels in Mn-exposed workers, this study investigates the connection between thalamic GABA levels measured by MRS, motor function, and behavior measures of action control and inhibition in typical US welders. The significant correlations between these measures indicate that GABA may serve as biomarker for early diagnosis of Mn-induced neurotoxicity.

11:09           0064.   High Field MRS Is More Sensitive to Progression of Neurodegeneration Than Clinical Decline in Spinocerebellar Ataxia Type 1 (SCA1)

                                Dinesh K. Deelchand1, Uzay E. Emir1, 2, Diane Hutter1, Christopher M. Gomez3, Lynn E. Eberly4, Khalaf O. Bushara5, Gulin Oz1

                                1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 2FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; 3Department of Neurology, University of Chicago, Chicago, IL, United States; 4Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States; 5Department of Neurology, Medical School, University of Minnesota, Minneapolis, MN, United States


In this study, MR spectroscopy was used to monitor disease progression in SCA1 patients. Subjects were scanned at baseline and after an ~18 month follow-up on 3 T. We found that in pons, [tNAA]/[Ins] was significantly reduced in SCA1 at visit #2 vs. visit #1 while no difference was detected in controls. The change in ataxia rating scale between the two visits did not reach significance suggesting that MRS is more sensitive to detect a small change due to disease progression than clinical assessment.

11:21           0065.   Caloric Restriction Impedes Age-Related Decline of Neuronal Function and Energy Demand

                                Ai-Ling Lin1, Daniel Coman2, Lihong Jiang2, Douglas L. Rothman2, Fahmeed Hyder2

                                1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Magnetic Resonance Research Center, Yale University, New Haven, CT, United States


While caloric restriction extends mammalian lifespan, its effect on neuronal function and energy demand – especially in healthy aging – remains largely unknown. Using 1H[13C] MRS techniques, we show that healthy aging rats had significantly lower rates of neuronal energy production and neurotransmission relative to their younger counterparts; however, caloric restriction mitigated the age-related deceleration of brain physiology. These results provide a rationale for caloric restriction-induced sustenance of brain health with extended lifespan.

11:33           0066.   Absolute Quantification of Brain Metabolites in Small MRS Voxels

ISMRM_MagnaLogo.jpg                                 Niklaus Zoelch1, Andreas Hock1, 2, Anke Henning1, 3

                                1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 2Department of Psychiatry, Psychotherapy and Psychosomatics , University of Zurich, Zurich, Switzerland; 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany


The goal of this work was to enable absolute quantification of brain metabolites in small voxels, which is desirable in the clinical routine, especially to improve the diagnosis of brain lesion. For this purpose, non-water suppressed MRS via the metabolite cycling technique was combined with the calibration method ERETIC. The combination of these two techniques was tested invivo in 6 healthy volunteers. The concentrations obtained with MC and ERETIC are in good agreement with concentrations determined from water suppressed spectra by using the internal water as reference.

11:45           0067.   A Method for Quantifying Average Metabolite Concentrations in Anatomically-Defined Brain Regions

                                Ryan J. Larsen1, Michael Newman1, 2, Chao Ma3, 4, Bradley Sutton1, 5

                                1Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States; 2Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL, United States; 3Beckman Institute, Urbana, IL, United States; 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States; 5Department of Biomedical Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States


Much work has been performed to use structural MRI scans as prior knowledge to construct anatomically-constrained metabolites maps from multi-voxel Magnetic Resonance Spectroscopy Imaging scans.   In many implementations, the anatomical reconstruction is performed on the signal from the metabolite, without quantitation.  We demonstrate a post-processing pipeline that combines both quantitation and anatomical reconstruction based on prior knowledge.    Our technique employs water-scaling to quantify the distribution of metabolites.  We then apply a Projection on a Convex Set (POCS)  algorithm that revises the metabolite distribution by using prior knowledge from the MRI scan.  The final result is average metabolite concentration values within anatomically distinct regions of the brain.

11:57           0068.   Lipid Suppression for Brain MRI and MRSI by Means of a Dedicated Crusher Coil

ISMRM_MagnaLogo.jpg                                 Vincent O. Boer1, Tessa N. van de Lindt1, Peter R. Luijten1, Dennis W.J. Klomp1

                                1radiology, UMC Utrecht, Utrecht, Netherlands


Lipid suppression in MRI and MRSI is generally associated with delays in the sequence and increased TR’s. In this work we apply a crusher coil for lipid suppression  where a switchable local distortion of the magnetic field in the skull is induced instead of RF excitation or inversion. With the crusher coil lipid suppression is possible without increases in SAR, or lengthening of the sequences. For MSRI this allows a shortening of the TR of an order of magnitude, leading to the possibility to acquire very high resolution MRSI of the human brain.


12:09           0069.   Detection of Cerebral NAD+ by in Vivo 1H NMR Spectroscopy

                                Robin A. de Graaf1, Kevin L. Behar1

                                1Yale University, New Haven, CT, United States


Nicotinamide adenine dinucleotide (NAD+) has a central role in cellular metabolism and energy production and is related to gene expression, calcium mobilization, aging, cell death and timing of metabolism via the circadian rhythm. The in vivo detection of NAD+ has been limited and has only recently become feasible with high-field 31P NMR spectroscopy. Here 1H NMR spectroscopy is presented as a simple, but robust alternative for the in vivo detection of NAD+. Special attention is given to the interaction between NAD+ and water magnetization. Perturbation of the water protons should be minimized to ensure full NAD+ signal detection efficiency.

12:21           0070.   Metabolite Proton T1 Relaxation Times in the Rat Brain In Vivo at 17.2 Tesla

ISMRM_MagnaLogo.jpg                                 Alfredo Liubomir Lopez Kolkovsky1, Boucif Djemai2, Fawzi Boumezbeur2

                                1CEA/Saclay/Neurospin , Commissariat a l'Energie Atomique, Gif-sur-yvette, Essonne, France; 2CEA/Saclay/Neurospin , Commissariat a l'Energie Atomique, Gif-sur-yvette  , Essonne, France


At ultra-high magnetic fields such as 17.2 T, it is crucial to establish T1 and T2 relaxation times in order to optimize MRS acquisition parameters and to achieve proper quantification. In this study we present measurements of T1 relaxation times of 20 metabolites and macromolecules in the rat brain in vivo at 17.2T. Results show a convergence of T1 relaxation times to 1690 ms, with the exception of Taurine (2212 ± 99 ms) and Cr-CH2 (1152 ± 32 ms). T1 values were slight longer than those measured at lower magnetic fields, which is consistent with the Bloembergen-Purcell-Pound theory of dipolar relaxation.

ISMRM_MagnaLogo.jpg 12:33           0071.   Assessment of Macromolecular and Metabolic Alterations During Normal Brain Aging in the Dark Agouti Rat Using 1H MRS at 17.2 Tesla

                                Alfredo Liubomir Lopez Kolkovsky1, Boucif Djemai1, Fawzi Boumezbeur1

                                1CEA/Saclay/Neurospin, Commissariat a l'Energie Atomique, Gif-sur-yvette, Essonne, France


Normal brain aging is usually associated with a decline in brain function. Yet, the neural basis of age-related cognitive dysfunction in normal brain aging remains to be entirely elucidated. In this study, we sought to explore further these metabolic alterations in the brain of healthy rats with in vivo short echo time  1H MRS at 17.2 T. Comparing metabolic profiles from young and elderly rats (1 and 16 months old respectively), it was found a decrease in neurotransmitters (Gln+Glu, GABA) and increase in Ins and tCho consistent with decline of neural function and chronic low-level glial activation consistent with previous observations in humans.

Normal Developing Brain

Yellow 1, 2 & 3                  10:45-12:45                                                                                               Moderators:Petra S. Hüppi, M.D. & Fabio Triulzi, M.D

10:45           0072.   High Resolution HARDI of Early Embryonic Mouse Brain Development

                                Dan Wu1, Ilan Gobius2, Linda J. Richards2, Susumu Mori3, Jiangyang Zhang3

                                1Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Queensland brain Institute, The University of Queensland, Brisbane, Queensland, Australia; 3Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States


Diffusion MRI is an ideal tool to characterize the microstructures in the embryonic mouse brain, and high resolution is key to delineate these fine structures. Using a 3D diffusion-weighted gradient and spin echo sequence, we were able to acquire HARDI data of the embryonic mouse brains at 30 to 45 μm isotropic resolution and 30 diffusion directions. The high-resolution data from embryonic day 10.5 (E10.5) to E15.5 (n=5 per stage) revealed the dynamic changes in the early gray and white matter structures with unprecedented details.


10:57           0073.   Sex Differences in Structural and Functional Network Topology Are Present at Birth: A Multi-Modal Graph Theory Study

                                Vincent Jerome Schmithorst1, Jessica Wisnowski1, Ashok Panigrahy1

                                1Radiology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States


We investigated possible sex differences in structural and functional network topology in healthy neonates using DTI and intrinsic-connectivity fMRI, respectively.  While structural network topology is similar, females show greater modularity due to a more developed frontal interhemispheric subnetwork.  Functionally, females show more developed frontal and fronto-temporo-parietal interhemispheric subnetworks, resulting in greater modularity, efficiency, and small-worldness.  Results show that at least some brain sex differences arise during prenatal development.  Moreover, these differences may account for the greater risk of white matter injury and poorer neurocognitive outcomes in males following perinatal stressors such as preterm birth or congenital heart disease.

11:09           0074.   Development of Visual Cortex in Infants

                                Laura Biagi1, Sofia Allegra Crespi2, 3, Michela Tosetti1, Maria Concetta Morrone1, 4

                                1IRCCS Stella Maris Foundation, Calambrone, Pisa, Italy; 2Department of Psychology, Vita-Salute San Raffaele University, Milan, Italy; 3CERMAC and Neuroradiology Unit, San Raffaele Hospital, Milan, Italy; 4Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy


There is little information about the developmental timelines of the cortical areas comprising the neural network that analyses visual motion. We measured at 1.5T cortical bold response in 11 full-term awake 7-weeks-old infants, contrasting coherent flow motion to blank or random noise. Areas MT and V6 respond well to motion at 7 weeks. Correlation analysis suggests weak connectivity between V1 and MT in young infants, but a stronger functional connectivity between the cuneus/MT and V6. The fast development and immature connectivity between V1 and MT points to a possible alternative V1-independent input to MT.

11:21           0075.   Molecular MRI Detection of the Brain Development in Normal Children with Magnetization Transfer (MT) and Amide Proton Transfer (APT) Imaging

                                Hong Zhang1, 2, Xuna Zhao3, Jinyuan Zhou2, Yun Peng

                                1Imaging Center,Beijing Children’s Hospital, Capital Medical University, Beijing, China; 2Neurosection, Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States; 3Peking University, Beijing, China


MT-MRI is sensitive to a semi-solid macromolecular phase in tissue, and APT-MRI is sensitive to the amide protons of mobile proteins and peptides, both accomplishing detection using the water signal. We detected brain development patterns in normal children using MT and APT imaging at 3T. Our preliminary results showed that MTRasym(3.5ppm) decreased exponentially and MTR increased exponentially with age, with the most significant changes occurring within the first 2 years of life. MT and APT imaging may be useful to assess the progress of myelination.

11:33           0076.   Investigation of Longitudinal Neurodevelopment Using Quantitative MRI

ISMRM_MagnaLogo.jpg                                 Douglas C. Dean1, Jonathan O'Muircheartaigh1, 2, Holly Dirks1, Nicole Waskiewicz1, Lindsay Walker1, Sean C.L. Deoni1

                                1School of Engineering, Brown University, Providence, RI, United States; 2Neuroimaging, King's College London, Institute of Psychiatry, United Kingdom


Quantitative MRI affords a unique opportunity to map the dynamic patterns of neurodevelopment and provide insight into the relationships between brain maturation and emerging cognition. Longitudinal developmental trajectories of quantitative T1, T2, and the myelin water fraction (VFM) from 103 typically developing children are presented and characterized using non-linear mixed effects modeling. We furthermore examine the relationships between changes in these quantitative parameters and measures of cognition. Our results reflect the coincident development of myelinated white matter and cognitive ability; providing an important step for understanding the typical patterns of normative white matter maturation and its relationship to emerging function.

11:45           0077.   Concurrent ASL and BOLD fMRI of Working Memory in Typically Developing Population

ISMRM_MagnaLogo.jpg                                 Lirong Yan1, Emily Kilroy2, Mayank Jog3, Danny JJ Wang3

                                1University of California Los Angeles,  Los Angeles, CA, United States; 2University of Southern California, Los Angeles, CA, United States; 3University of California Los Angeles, Los Angeles, CA, United States


Due to the lack of assays of baseline function and absolute quantification of task-induced effect size, it is hard to interpret developmental BOLD fMRI findings. In this study, a concurrent ASL/BOLD fMRI paradigm of working memory tasks was employed to investigate the relationship between CBF and BOLD responses in 57 children and adolescents aged 7 to 17. Our results showed that while the percentage of BOLD response increases with age, both baseline CBF and absolute task-induced CBF decrease with age, suggesting more efficient use of oxygen of the brain during development.


11:57           0078.   Affective Context Affects the Response of the Fusiform Gyrus: fMRI Investigations of the Face Processing Network in Adolescence

                                Marta Re1, Vaibhav Diwadkar2, Paolo Brambilla1

                                1RUBIN, ICBN, University of Udine and University of Verona, Udine, Italy; 2Dept of Psychiatry & Behavioral Neurosciences, Wayne State University SOM, Detroit, MI, United States


Emotion processing and the ability to decode facial expressions is crucial for normal emotional development but the evolution of these processes and of the neural systems associated with this over the adolescence remains unclear. Moreover, understanding cognitive top-down effects during affective processing is of relevance as these mechanisms may modulate the response of the face processing network. In this study, by means of an fMRI task, we evaluated differential top-down effects on the modulation of the face processing network and founded an affected response of the fusiform gyrus in adolescents.

12:09           0079.   Age-Dependent Diffusion and Perfusion Normal Values in Gray Matter Brain Structures in Children

                                Nils Daniel Forkert1, Zhaoying Han1, Matthew Daniel Li1, Roland Bammer1, Kristen Yeom1

                                1Department of Radiology, Stanford University, Stanford, CA, United States


The extraction of diffusion and perfusion parameters from MRI is of high clinical utility in various neurological diseases. However, adult normal values cannot be applied directly to pediatric patients due to age-dependent parameter changes. The aim of this work is to investigate the age-dependent change of ADC and CBF values in healthy children over the entire pediatric age range by applying an atlas-based analysis of ASL and ADC datasets in different brain regions. Overall, logarithmic relations between age and ADC as well as CBF values were found, which may help to identify neuropathological conditions of childhood in future.

12:21           0080.   Cortical Maturation in the Preterm Period Revealed Using a Multi-Component Diffusion-Weighted MR Model.

                                Zach Eaton-Rosen1, Andrew Melbourne1, Eliza Orasanu1, Alan Bainbridge2, Giles S. Kendall3, Nicola J. Robertson3, Neil Marlow3, Sebastien Ourselin1

                                1CMIC, UCL, London, United Kingdom; 2Medical Physics, UCH, London, United Kingdom; 3Academic Neonatology, EGA UCL Institute for Women's Health, London, United Kingdom


During normal cortical development, there is a period of high fractional anisotropy (FA) measured in the cortex as revealed by diffusion tensor imaging. In a longitudinal study of a preterm neonatal population, we fitted the NODDI model to multi-shell diffusion MR and separated the FA into contributions from orientation dispersion (ODI) and from the volume fraction of the intra-cellular component (vic). We found that the decrease in FA is predominantly attributable to increased ODI rather than changing vic. Establishing biomarkers of cortical maturation from diffusion-weighted data will aid in developing measures of cognitive outcome in this at-risk population.

12:33           0081.   Substructural Topographic Map of the Interhemispheric-Cortices Connectivity in Neonate Boys and Girls.

                                Malek I. Makki1, Cornelia Hagmann2

                                1MRI Research, University Children Hospital of Zurich, Zurich, Switzerland; 2Neonatalogy, University Hospital of Zurich, Zurich, Switzerland


Using fiber tracking we draw a topographic map of the interhemispheric-cortices pathways in healthy neonates by segmenting the corpus callosum in 5 substructures: genu, rostral body, body, isthmus and splenium. The connectivity of the genu and rostrum to premotor cortex, the body to the motor cortex as well as the splenium to occipital and temporal occipital lobes were more developed in girls compared to boys (significantly lower mean and radial diffusions in girls). The isthmus connectivity to the superior temporal and posterior parietal is similar in both groups and is the last substructure to develop (lowest anisotropy, and axial diffusion).


Educational Course

Spine Imaging

Brown 1 & 2                       10:45-12:45                                                                                               Moderators:Laura W. Bancroft, M.D. & John A. Carrino, M.D., M.P.H.

10:45                       Disc Degeneration:  Classification of Disc Disease

                                Eoin Kavanagh, M.D.


11:15                       Bone Marrow Abnormalities

                                John A. Carrino, M.D., M.P.H.


11:45                       Bone Infection

                                Laura W. Bancroft, M.D.


12:15                       Trauma & Sports Related Injuries

                                Gabrielle P. Konin, M.D.


12:45                       Adjournment


Educational Course

MR Guided HIFU

Brown 3                               10:45-12:45                                                                                               Moderators:Kagayki Kuroda, Ph.D. & Viola Rieke, Ph.D.

10:45                       Physics of Therapeutic Ultrasound

                                Paul Prentice, Ph.D.


11:09                       Therapeutic Ultrasound Devices

                                L. Wilbert Bartels, Ph.D.


11:33                       Advantage/disadvantage of MR Guidance

                                Kullervo Hynynen, Ph.D.


11:57                       MR Thermometry in Depth

                                Chrit T.W. Moonen, Ph.D.


12:21                       MR Guided Focused Ultrasound: New Clinical Applications

                                Clare Tempany-Afdhal, M.D.


12:45                       Adjournment


Gold Corporate Symposium: Siemens

Gold Plenary                       13:00-14:00                           (no CME credit)                                       



Traditional Poster Session: Young Investigator Poster Session

Traditional Poster Hall     14:15-16:15                           (no CME credit)                                       


Electronic Poster Session: Neuro 1

Exhibition Hall                   14:15-16:15                           (no CME credit)                                       


Study Group Session: High Field Systems & Applications

Amber 1 & 2                       14:15-16:15                           (no CME credit)                                       



Study Group Session: Hyperpolarized Media MR

Amber 7 & 8                       14:15-16:15                           (no CME credit)                                       


Power Poster Session: Powerful Acquisition & Reconstruction Techniques

Space 1/Power Poster Theater and Traditional Poster Hall          14:15-15:15             (no CME credit)                         
 Moderators: Priti Balchandani, Ph.D. & Nicholas R. Zwart, Ph.D.

14:15           0082.   Simultaneous MR-PET Reconstruction Using Multi Sensor Compressed Sensing and Joint Sparsity

ISMRM_MagnaLogo.jpg                                 Florian Knoll1, Thomas Koesters1, Ricardo Otazo1, Tobias Block1, Li Feng1, Kathleen Vunckx2, David Faul3, Johan Nuyts2, Fernando Boada1, Daniel K. Sodickson1

                                1Bernard & Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, United States; 2Department of Nuclear Medicine, K.U. Leuven, Leuven, Belgium; 3Siemens Medical Solutions USA, NY, United States


While both measurements can be performed simultaneously with current state of the art PET-MR scanners, the data sets are processed in two separate reconstruction pipelines. The two different datasets are only combined at the visualization stage. We propose a new iterative reconstruction framework that treats MR and PET as one single data acquisition, and jointly reconstructs both image sets. In this way joint information of the underlying anatomy is shared during the iterations between both sets of images. In particular the lower resolution and lower SRN PET reconstruction can benefit from the superior soft tissue contrast of the MR.

                    0083.   k-SPIRiT: Non-Cartesian SPIRiT Image Reconstruction with Automatic Trajectory Error Compensation

ISMRM_SummaLogo.jpg                                 Julianna Ianni1, William A. Grissom1

                                1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States


An algorithm for joint non-Cartesian image reconstruction and k-space trajectory error correction is presented. Results are shown from validations in simulated radial phantom data and in-vivo brain data collected with a center-out radial trajectory at 7T.

                    0084.   Fast Non-Cartesian L1-SPIRiT with Field Inhomogeneity Correction

ISMRM_SummaLogo.jpg                                 Daniel S. Weller1, Jeffrey A. Fessler1

                                1EECS, University of Michigan, Ann Arbor, MI, United States


Fast, undersampled single-shot k-space trajectories have applications in functional and dynamic imaging, but their long readouts cause artifacts in the presence of field inhomogeneity.  We propose an extension of a recently developed algorithm for fast L1-SPIRiT reconstruction of undersampled non-Cartesian parallel imaging data, using a system matrix augmented with time-segmentation and a circulant preconditioner to yield high quality images quickly.  We compare our method to the existing fast non-Cartesian L1-SPIRiT using both simulated brain and real phantom data sets, where our proposed method effectively eliminates artifacts from field inhomogeneity.

                    0085.   LORAKS: Low-Rank Modeling of Local k-Space Neighborhoods

                                Justin P. Haldar1

                                1Signal and Image Processing Institute, University of Southern California, Los Angeles, CA, United States


This work presents a novel framework for constrained image reconstruction based on Low-Rank Modeling of Local k-Space Neighborhoods (LORAKS).  We first demonstrate that k-space data for low-dimensional images can be mapped into high-dimensional matrices, such that the resulting matrices possess low-rank structure when the original images have limited support and/or slowly-varying phase.  Subsequently, we propose a flexible approach to exploiting this low-rank structure that enables image reconstruction from undersampled data.  The approach is analogous to a single-channel calibrationless generalization of GRAPPA, and is demonstrated to outperform sparsity-guided reconstructions of undersampled data in certain contexts.

                    0086.   Rapid QSM Acquisition with Wave-CAIPI

ISMRM_SummaLogo.jpg                                 Berkin Bilgic1, Borjan Gagoski2, Stephen Cauley1, Audrey Fan3, Jonathan Polimeni1, Ellen Grant2, Lawrence Wald1, Kawin Setsompop1

                                1Martinos Center for Biomedical Imaging, Charlestown, MA, United States; 2Boston Children's Hospital, Boston, MA, United States; 3EECS, MIT, Cambridge, MA, United States


Wave-CAIPI acquisition enables highly accelerated parallel imaging with low g-factor penalty in a 3D gradient echo (GRE) scan by using i) 2D CAIPIRINHA controlled aliasing and ii) additional sinusoidal Gy and Gz encoding gradients during the readout of each phase encoding line. Herein, data acquisition and reconstruction time of QSM are dramatically reduced by the combination of Wave-CAIPI acquisition and fast phase processing and QSM algorithms. For Wave-CAIPI reconstruction, we extend the initial proposal by i) reducing the Wave reconstruction time 25× (from 360 min to 14 min), ii) estimating accurate point spread functions from a fast prior training acquisition, and iii) increasing the resolution 4-fold. This enables high quality whole-brain 7T QSM at 1×1×2 mm3 voxel size in 40 seconds.


                    0087.   New Pulse Sequence Combining Diffusion MRI and MR Elastography (DMRE)

ISMRM_MagnaLogo.jpg                                 Ziying Yin1, Richard L. Magin1, Dieter Klatt1

                                1Bioengineering, University of Illinois at Chicago, Chicago, IL, United States


Here we introduce a new pulse sequence, Diffusion-MRE (dMRE), for concurrent MRE and diffusion MRI. In dMRE shear motion and diffusion attenuation are encoded into the MR phase and magnitude by using a pair of bipolar gradients. The sequence timing is adjusted so that the bipolar gradients are sensitive to both coherent and incoherent intravoxel motion. The phantom results showed that simultaneous MRE and diffusion acquisition is feasible with no interference between MRE/diffusion acquisitions. The dMRE method may play a role in improving the use of MRE and diffusion for the detection of the diseases in liver and brain.

                    0088.   Accelerated Radial Diffusion Spectrum Imaging Using a Multi-Echo Stimulated Echo Diffusion Sequence

                                Steven Baete1, 2, Fernando Emilio Boada1, 2

ISMRM_MagnaLogo.jpg                                 1Center for Biomedical Imaging, Dept. of Radiology, NYU Langone Medical Center, New York, United States; 2CAI2R, Center for Advanced Imaging Innovation and Research, NYU Langone Medical Center, New York, United States


Diffusion Spectrum Imaging (DSI) is able to non-invasively image the microstructure of the brain, including its complex distributions of intravoxel fiber orientations. A drawback of DSI is the requirement for a large number of q-space samples to adequately sample the Orientation Diffusion Function, leading to large measurement time. In order to accelerate DSI acquisitions we use a multi-echo stimulated echo diffusion sequence which samples multiple samples along a radial line in q-space in a single readout. This is combined with the recently proposed radial q-space sampling scheme, leading to, in the current configuration, a nearly fourfold speedup.

                    0089.   Sliding-Slab 3D TSE Imaging with a Spiral-In/Out Readout

                                Zhiqiang Li1, Dinghui Wang1, Ryan K. Robison1, Nicholas R. Zwart1, Michael Schär, 12, James G. Pipe1

                                1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States; 2Philips Healthcare, Cleveland, OH, United States


Multi-slab 3D TSE imaging has better scan efficiency than its single-slab counterpart but suffers ringing and venetian blind artifacts. Meanwhile, spiral acquisition has high SNR efficiency and has been incorporated into 3D TSE imaging, but mostly using a spiral-out only trajectory. In this work we propose a 3D TSE technique, using a spiral-in/out trajectory to provide higher SNR efficiency, using sliding-slab to minimize the venetian blind artifacts, and using non-uniform slice phase encoding to reduce the ringing artifacts. The preliminary results demonstrate that the image quality is comparable to 2D Cartesian results.

                    0090.   Generating T2- And T1-Weighted Images Using Radial T-One Sensitive and Insensitive Steady State Imaging (RA-TOSSI)

ISMRM_MagnaLogo.jpg                                 Thomas Benkert1, Martin Blaimer1, Peter M. Jakob, 12, Felix A. Breuer1

                                1Research Center Magnetic Resonance Bavaria (MRB), Würzburg, Bavaria, Germany; 2Experimental Physics 5, University of Würzburg, Würzburg, Bavaria, Germany


Using balanced SSFP in combination with unequally spaced inversion pulses in between allows generating images with pure T2-contrast. Here, this concept is adapted using a radial trajectory to simultaneously generate several T2-weighted images and a standard bSSFP image (T2/T1-weighted) out of one single acquisition in a very short scan time (~1.3s). Additionally, a T1-weighted image can be obtained by a simple combination of these contrasts. Therefore, the proposed method is a promising candidate for clinical practice, especially for situations where long scan times limit the applicability of established protocols.


                    0091.   Fast SEMAC by Separation of On-Resonance and Off-Resonance Signals

ISMRM_SummaLogo.jpg                                 Daehyun Yoon1, Valentina Taviani1, Pauline Worters2, Brian Hargreaves1

                                1Stanford University, Palo Alto, CA, United States; 2GE Healthcare, Menlo Park, CA, United States


We present a novel acquisition and reconstruction method to accelerate the Slice Encoding for Metal Artifact Correction (SEMAC) sequence for MR imaging near metallic implants.  SEMAC adopted an additional encoding for slice-select dimension to resolve the off-resonance induced slice distortion, which severely increased the total scan time. In this abstract, we present a fast undersampling scheme and a simple reconstruction algorithm exploiting that the support of the extreme off-resonance spins is spatially limited. Our approach is to acquire on-resonance spins using less slice directional encoding and then to apply reduced FOV acquisition and reconstruction for off-resonance spins.

                    0092.   Noise Variance of an RF Receive Array Reflects Respiratory Motion: A Novel Respiratory Motion Predictor

ISMRM_MagnaLogo.jpg                                 Anna Andreychenko1, Sjoerd Crijns1, Alexander Raaijmakers1, Bjorn Stemkens1, Peter Luijten1, Jan Lagendijk1, Cornelis van den Berg1

                                1Imaging Division, UMC Utrecht, Utrecht, Netherlands


Conventional methods to detect patient motion are based either on an external device, e.g. respiratory belt, or MR acquisition, i.e. navigator. An alternative technique has been proposed which monitors RF coil's impedance changes induced by the patient motion. However, this technique requires additional hardware. Here, we propose to detect the motion induced impedance variation by means of noise measurements. Using clinical MR systems we demonstrated the feasibility of the RF coil's thermal noise variance to detect respiratory motion. Moreover, noise covariance matrix of an array of coils contains spatial information which can potentially be used for motion prediction.

                    0093.   Obtaining B1 Distributions by Encoding in B1 Instead of Image Space

ISMRM_SummaLogo.jpg                                 Kalina V. Jordanova1, Dwight G. Nishimura1, Adam B. Kerr1

                                1Electrical Engineering, Stanford University, Stanford, CA, United States


A new method to estimate the B1 distribution in a volume by encoding in B1 rather than along image space is presented. By acquiring multiple 1D projections using the BEAR B1 mapping method with different phase sensitivities to B1, an estimate of the B1 distribution in each projected pixel is calculated using a convex optimization formulation. We validate this method through simulations and in vivo at 3T. With this method, the B1 distribution in a volume can be estimated faster than in acquiring a 2D B1 map. The method is potentially useful when B1 varies rapidly in space.

                    0094.   Validation of Tissue Characterization in Mixed Voxels Using MR Fingerprinting

ISMRM_SummaLogo.jpg                                 Anagha Vishwas Deshmane1, Dan Ma1, Yun Jiang1, Elizabeth Fisher2, Nicole Seiberlich1, Vikas Gulani1, 3, Mark Griswold1, 3

                                1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 2Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States; 3Radiology, University Hospitals of Cleveland, Cleveland, OH, United States


In conventional weighted MRI, the presence of multiple species within a single voxel can alter signal intensity.  However, it remains difficult to determine the species content which gives rise to this intensity change due to similarity in exponential-shaped signal evolutions.  The uniqueness of signal evolutions generated through Magnetic Resonance Fingerprinting (MRF) allows for the identification of multiple species present within a single voxel.  Here we demonstrate that MRF is able to resolve multiple material components from single, mixed voxels and validate the derived tissue fractions in a realistic simulation model.

                    0095.   Automated Segmentation of Bone with Single Zero-Echo Time Imaging

                                Sandeep Kaushik1, Dattesh Shanbhag1, Florian Wiesinger2

                                1GE Global Research, Bangalore, Karnataka, India; 2GE Global Research, Munich, Germany


In this work, we propose a method for segmentation of bones in the head using a single echo zero TE (ZTE) pulse sequence using complex (magnitude and phase) information for efficient segmentation of bone and air regions in the head. We also introduce a histogram-based RF intensity correction method which enables threshold-based segmentation of bone, soft-tissue and air structures. We demonstrate excellent depiction of skull and vertebrae.

                    0096.   Finding the Ideal IDEAL Acquisition Scheme for Multi-Echo UTE Imaging

ISMRM_SummaLogo.jpg                                 Ethan M. Johnson1, John M. Pauly1

                                1Electrical Engineering, Stanford University, Stanford, CA, United States



Electronic Power Poster Session: Powerful Acquisition & Recon Techniques

Traditional Poster Hall     15:15-16:15                           (no CME credit)                                       


This work investigates UTE imaging with Dixon estimation of water, fat and short-T2 anatomy.  By searching over the space of feasible echo times, an acquisition scheme for multi-echo UTE acquisitions is identified that facilitates computation of component images using the echo images from a given acquisition strategy and field strength.

Diffusion Biophysics & Microstructural Imaging

Space 2                                14:15-16:15                                                                                               Moderators:Silvia De Santis, Ph.D. & Sune N. Jespersen, Ph.D.

ISMRM_SummaLogo.jpg 14:15           0097.   Metabolic Confinements in Normal and Stroked CNS In Vivo Revealed by Localized Double-Pulsed-Field-Gradient MRS at 21.1 T

                                Noam Shemesh1, Jens T. Rosenberg2, 3, Jean-Nicolas Dumez1, Samuel Colles Grant2, 3, Lucio Frydman1, 2

                                1Chemical Physics, Weizmann Institute of Science, Rehovot, Israel; 2National High Magnetic Field Laboratory, The Florida State University, Tallahassee, FL, United States; 3Chemical & Biomedical Engineering, The Florida State University, Tallahassee, FL, United States


Microstructural characterizations of the Central Nervous System are limited by water’s non-specificity. Whereas diffusion Magnetic Resonance Spectroscopy (MRS) methods utilize a spectral dimension to impart specificity, they still rely on detection of Apparent Diffusion Coefficients (ADCs), whose relationship with underlying microstructural determinants are tenuous. Here, we combine a recent spectrally-specific Longitudinal Relaxation Enhancement (LRE) approach with the double-Pulsed-Field-Gradient (dPFG) approach that provides unambiguous and clear indications for restricted diffusion. The ensuing localized dPFG MRS provides unique signatures for metabolic confinements, which are shown to vary in stroked rats. These unique measurements provide a glimpse into the nature of ADC variations in stroke.

14:27           0098.   Diffusion MRI with Q-Vector Magic Angle Spinning (QMAS) Disentangles Effects of Micro-Anisotropy and Orientation Dispersion

ISMRM_SummaLogo.jpg                                 Filip Szczepankiewicz1, Samo Lasic2, Jimmy Lätt3, Danielle van Westen4, Carl-Fredrik Westin5, Freddy Ståhlberg1, 4, Daniel Topgaard6, Markus Nilsson7

                                1Department of Medical Radiation Physics, Lund University, Lund, Sweden; 2CR Development, AB, Lund, Sweden; 3Center for Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden; 4Department of Diagnostic Radiology, Skane University Hospital, Lund, Sweden; 5Laboratory of Mathematics in Imaging, Harvard Medical School, Boston, MA, United States; 6Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden; 7Lund University Bioimaging Center, Lund University, Lund, Sweden


In this work we present the first in vivo experiments employing magic angle spinning of the q-vector (qMAS) to map the microscopic anisotropy of the brain. This technique allows for the parameterization of anisotropy that is unaffected by the orientation dispersion. This means that the anisotropy is probed on a sub-voxel scale, and can potentially be useful in complex white matter geometries and gray matter, where conventional metrics such as FA are confounded by the tissue micro architecture.


14:39           0099.   In Vivo Estimation of Axon Diameter in the Human Spinal Cord Using 300 MT/m Gradients

ISMRM_MagnaLogo.jpg                                 Tanguy Duval1, Jennifer A. McNab2, Kawin Setsompop3, Thomas Witzel3, Torben Schneider4, Susie Yi Huang2, Boris Keil3, Eric Klawiter3, Lawrence L. Wald3, Julien Cohen-Adad1

                                1Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada; 2Department of Radiology, Stanford University, Stanford, CA, United States; 3A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; 4NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom


Composite hindered and restricted model of diffusion was shown to retrieve white matter micro-structural information, such as axon diameter. Using a dedicated human gradient system that can achieve 300 mT/m, we produced the first in vivo mapping of axon diameter in the human spinal cord. State-of-the-art methods were deployed to overcome the numerous artifacts associated with spinal cord imaging. Maps of axon diameter were generated for each patient, and diffeomorphic registration on a white-matter template yielded an average atlas of axon diameter. Qualitative comparison with histological data on a rat suggests consistent trends of axon diameter across specific spinal pathways.

14:51           0100.   A Combined Acquisition of T1 and AxCaliber Can Link Between Axon Diameter and Myelination

                                Daniel Barazany1, 2, Derek K. Jones2, Yaniv Assaf1

                                1Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel; 2CUBRIC School of Psychology, Cardiff University, Cardiff, United Kingdom


AxCaliber is a diffusion MRI method that models the axon diameter distribution. here we introduce a noval acquisition that Combines T1 and AxCaliber to provide further insight into white matter micro-structure as it links between axons at different size and their T1. This kind of combined acquisition and analysis allows to estimate the effect of myelin content on T1 and its relation to axon diameter. The results of this work demonstrate that MRI allows to probe white matter tissue micro-structure providing invaluable high details that so far could be extracted only by invasive techniques.

15:03           0101.   On the Use of the Two-Pool Model to Improve the Accuracy of Axon Calibration

                                Alice Lebois1, Chun Hung Yeh2, Denis Le Bihan3, Ching-Po Lin2, Cyril Poupon3

                                1NeuroSpin/CEA, Gif-Sur-Yvette, France; 2National Yang-Ming University, Taiwan; 3NeuroSpin/CEA, France


We here propose to study the reason for the systematic overestimation of the smaller radius in available axon diameter mapping techniques when a simple cylinder model is used for the axon. Recent studies have introduced an alternative model, assuming that water molecules close to the axon membranes have a slow diffusivity while those far from the membranes are characterized by a fast diffusivity, yielding the two-pool cylinder model. This study shows how attenuations from this model when varying the thickness of the layer close to axonal membranes can be similar to attenuations from the simple cylinder model with higher radius for small radii.

15:15           0102.   In Vivo Measurement of the Myelin G-Ratio with Histological Validation

ISMRM_MagnaLogo.jpg                                 Nikola Stikov1, Jennifer S.W. Campbell1, Mariette Lavallée1, Thomas Stroh1, Stephen Frey1, Jennifer Novek1, Stephen Nuara1, Ming-Kai Ho1, Barry Bedell1, G. Bruce Pike1, 2

                                1Montreal Neurological Institute, McGill University, Montreal, QC, Canada; 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada


The myelin g-ratio, defined as the ratio between the inner and the outer diameter of the myelin sheath, is a fundamental property of white matter that can be computed from a simple formula relating the myelin volume fraction (MVF) to the fiber volume fraction (FVF). Recent studies have suggested that the sexual dimorphism in white matter development is due to a higher g-ratio (thinner myelin) in adolescent boys. Additionally, in vivo imaging of the myelin thickness in multiple sclerosis could provide a real-time tool for tracking myelination in lesions, facilitating the development and evaluation of new therapeutic agents that promote remyelination.  In this abstract, a unique combination of magnetization transfer, diffusion imaging and histology is presented, providing a novel method for validating the in vivo measurements of the myelin g-ratio. We show that the g-ratio computed from MRI exhibits a high correlation with histology.

15:27           0103.   Resolving Myelin and Axonal Properties Within the Same Voxel in Presence of Crossing Fibers by Combining Inversion Recovery and Diffusion Acquisitions

ISMRM_MagnaLogo.jpg                                 Silvia De Santis1, 2, Daniel Barazany1, 2, Derek K. Jones1, Yaniv Assaf2

                                1School of Psychology, CUBRIC, Cardiff, UK, United Kingdom; 2Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel, Israel


The purpose of this work is to develop a new acquisition&analysis strategy, by combining inversion recovery with conventional diffusion tensor imaging, and by acquiring CHARMED protocol to calculate fiber orientations and volume fractions. For each fiber population present within a voxel, we extract a specific longitudinal relaxation time T1 by exploiting the orientational dependence of the diffusion-weighted signal that has been previously inversion-prepared. As the relaxation time T1 has been established as a solid proxy for myelination, this method effectively succeeds, for the first time, to resolve both axonal and myelin properties in presence of crossing fibers.


15:39           0104.   NODDI with Dispersion Anisotropy

                                Maira Tariq1, Torben Schneider2, Daniel C. Alexander1, Claudia AM Wheeler-Kingshott2, Hui Zhang1

                                1Department of Computer Science & Centre for Medical Image Computing, University College London, London, United Kingdom; 2NMR Research Unit, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom


We present a clinical technique to estimate the anisotropy of the orientations distribution of neurites, using Neurite Orientation Dispersion and Density Imaging (NODDI) technique. We show that NODDI can be utilised in vivo with a more realistic description of orientations of neurites, using a clinically feasible protocol, while the NODDI technique introduced in the original publication is still an accurate model for estimating neurite density and their concentration about the dominant orientation.

15:51           0105.   Imaging the Microstructure of the Developing Cerebral Cortex in the Mouse Embryo with Diffusion MR Microscopy

                                Manisha Aggarwal1, Linda J. Richards2, Susumu Mori1

                                1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2The Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia


This work demonstrates diffusion MRI (dMRI) for imaging the microstructure of the developing cerebral cortex in the mouse embryo. 3D diffusion micro-imaging at high SNR was achieved using accelerated diffusion-weighted gradient and spin echo based acquisition. The resulting dMRI data allowed resolving the microscopic structure of transient zones in the developing cortex from embryonic day 12 (E12) to E18 (n=3 at each stage) based on diffusion as an endogenous probe, and revealed 3D imaging of cortical microstructure in unprecedented detail.

16:03           0106.   Oscillating Gradient Spin-Echo (OGSE) DTI Yields Mechanistic Insights in Human Stroke

                                Corey A. Baron1, Mahesh P. Kate2, Laura C. Gioia2, Ken Butcher2, Derek Emery3, Matthew D. Budde4, Christian Beaulieu1

                                1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Neurology, University of Alberta, Alberta, Canada; 3Radiology, University of Alberta, Alberta, Canada; 4Department of Neurosurgery, Medical College of Wisconsin, WI, United States


The mechanisms behind the marked reduction of mean diffusivity (MD) of water using standard pulsed gradient spin echo (PGSE) diffusion MRI after acute ischemic stroke are still not well understood. Here, oscillating gradient spin-echo (OGSE) diffusion MRI that enables short diffusion times of 4 ms demonstrated only a 14% drop of MD within human acute ischemic stroke lesions, as opposed to a 44% drop using PGSE with a much longer 40 ms diffusion time. This agreed well with Monte Carlo simulations of axon beading at the two diffusion times, supporting its role for MD reductions during stroke.


Vessel Wall Imaging

Space 3                                14:15-16:15                                                                                               Moderators:Niranjan Balu, Ph.D. & Chun Yuan, Ph.D.

ISMRM_MagnaLogo.jpg 14:15           0107.   High Resolution Inner Volume Imaging of Human Coronary Atherosclerotic Plaque: Impact and Limits of Parallel Acquisition

                                Paula Montesinos1, 2, Jonathan R. Polimeni3, Berkin Bilgic3, Stephen F. Cauley3, Manuel Desco1, 2, Reza Nezafat4, Lawrence L. Wald3, Elfar Adalsteinsson3, David E. Sosnovik3

                                1Universidad Carlos III, Madrid, Spain; 2Instituto de Investigación Sanitaria Gregorio Marañón  (IiSGM), Madrid, Spain; 3Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, MA, United States; 4Beth Israel Deaconess Medical Center, Harvard Medical School, MA, United States


The aim of this study was to determine the impact of parallel acquisition on the imaging of coronary plaque under conditions of physiological motion and reduced FOV (inner volume) imaging. Our results indicate that parallel acquisition can improve the resolution of coronary plaque morphology due to a reduction in motion sensitivity. However, the high degree of overlap among coil element profiles in a small FOV focused on the coronary arteries dramatically reduces the potential benefits of using multi-channel receive coils in low SNR scenarios

14:27           0108.   Coronary Wall Thickening in HIV-Infected Youth in Association with Antiviral Therapy Using Time-Resolved DIR MRI (TRAPD)

                                Khaled Z. Abd-Elmoniem1, Aylin Unsal1, Julia B. Purdy1, Rohan Hazra1, Colleen Hadigan1, Ahmed M. Gharib1

                                1National Institutes of Health, Bethesda, MD, United States


HIV early in life may result in premature vasculopathy and cardiovascular disease. To this effect 35 young adults infected with HIV early in life and 11 health controls were included in this study. All subjects underwent coronary vessel wall imaging using TRAPD method at 3T and coronary MDCT. HIV infected subjects had significantly thicker vessel wall than controls as measured by MR without accompanying difference in plaque burden as measured by CT. The former was related to years of antiviral therapy exposure. This MR method provides evidence of vascular injury in antiviral therapy exposure and not associated with coronary atherosclerosis.

14:39           0109.   Multiplatform Reproducibility of 3D Carotid Vessel Wall MRI

                                Niranjan Balu1, Jie Sun1, Daniel S. Hippe1, David Zhu2, Seong-Eun Kim3, John Roberts3, J. Kevin DeMarco2, Dennis L. Parker3, David Saloner4, Michael V. McConnell5, Chun Yuan1, Thomas S. Hatsukami1

                                1Radiology, University of Washington, Seattle, WA, United States; 2Radiology, Michigan State University, Lansing, MI, United States; 3Radiology, Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States; 4Radiology, University of California San Francisco, San Francisco, CA, United States; 5Stanford University, CA, United States


Large coverage 3D isotropic vessel MRI has recently been proposed for carotid atherosclerotic plaque characterization. Use of a multicontrast 3D MRI protocol for serial MRI studies of atherosclerosis requires standardized protocols across multiple scanner platforms for use in multicenter studies. Reproducibility of plaque measurements has not been established in a multicenter setting. We demonstrate using patients with 50-79% stenosis that a standardized 3D carotid MRI protocol can provide reproducible measurement across three major scanner platforms (GE, Philips and Siemens). Plaque burden measurements and identification of plaque components showed good to excellent reproducibility comparable to traditional 2D multicontrast vessel wall MRI.

14:51           0110.   High-Resolution 3D Diffusion MRI: Detection of Lipid-Rich Necrotic Core in Plaques Without Contrast Media

ISMRM_MagnaLogo.jpg                                 Yibin Xie1, 2, Wei Yu3, Zhaoyang Fan1, Christopher Nguyen1, 2, Jing An4, Zhaoqi Zhang3, Debiao Li1, 2

                                1Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2University of California, Los Angeles, Los Angeles, CA, United States; 3Anzhen Hospital, Beijing, China; 4Siemens Healthcare, Beijing, China


Diffusion MRI has shown great promises for the detection of lipid-rich necrotic core (LRNC) with excellent image contrast. However current 2D EPI-based methods suffer from poor image quality due to susceptibility-induced artifacts and limited resolution for imaging fine anatomy in plaques. A novel diffusion weighted 3D sequence is developed in this work with features including motion compensation and dark blood. High resolution 3D carotid vessel wall images with excellent image quality were acquired for the first time. Significantly lower ADC values were observed in LRNC than fibrous plaque tissue and normal vessel wall. This technique could be used to detect lipid-rich necrotic core in carotid plaque in vivo without the use of contrast agents.

15:03           0111.   In Vivo Quantification of Lipid-Rich Necrotic Core Using Contrast-Enhanced Three-Dimensional Vessel Wall Imaging

                                Jie Sun1, Niranjan Balu1, Kiyofumi Yamada1, Jinnan Wang2, Daniel S. Hippe1, Dongxiang Xu1, Thomas S. Hatsukami1, Chun Yuan1

                                1University of Washington, Seattle, WA, United States; 2Philips Research North America, Briarcliff Manor, NY, United States


In vivo quantification of lipid-rich necrotic core size not only reveals prognostic information on patients’ atherothrombotic risk, but also provides a novel means for understanding effects of risk factors on plaque progression. Although a 2D multi-contrast protocol is traditionally used for classifying LRNC areas in advanced plaques, recently developed 3D sequences offer the opportunity to move LRNC quantification from 2D to 3D. This report represents one of the first studies to evaluate the performance of 3D MRI with contrast-enhanced imaging in delineating LRNC areas, which showed good agreement with a histologically validated 2D multi-contrast protocol across various lesion complexities.


15:15           0112.   Quantitative Relaxation Time and Susceptibility Mapping of Thrombus

ISMRM_MagnaLogo.jpg                                 Jingwei Zhang1, 2, Thanh D. Nguyen2, Xavier J. Candela3, Kory P. Witmer3, Keefe B. Manning3, 4, Yi Wang1, 2

                                1Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States; 2Department of Radiology, Weill Cornell Medical College, New York, NY, United States; 3Department of Bioengineering, The Pennsylvania State University, PA, United States; 4 Department of Surgery, Penn State Hershey Medical Center, Hershey,, PA, United States


The purpose of this study was to design and construct an in vitro flow-driven thrombus model and to apply quantitative MR methods to study its T1, T2 and magnetic susceptibility changes in comparison with histological findings.

15:27           0113.   Carotid Multicontrast Atherosclerosis Characterization (MATCH) in a Single Scan: Technical Development and Preliminary Validation

                                Zhaoyang Fan1, Yibin Xie1, 2, Wei Yu3, Antonio H. Conte1, Xiaoming Bi4, Yutaka Natsuaki4, Gerhard Laub4, Jing An5, Prediman K. Shah1, Debiao Li1

                                1Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2University of California, Los Angeles, CA, United States; 3Anzhen Hospital, Beijing, China; 4MR R&D Siemens Healthcare, Los Angeles, CA, United States; 5MR Collaborations NE Asia, Siemens Healthcare, Beijing, China


The conventional MRI protocol for the characterization of atherosclerotic plaques involves a series of scans that provide multiple contrast weightings. Despite the success in previous investigations, it has some major limitations such as limited slice resolution, substantially long examination time, image registration needed due to interscan motion. This work developed a 3D MRI technique that acquires multiple image sets in a single 5-minute scan with distinct contrast weightings that help simplify compositional analysis in carotid plaques. Preliminary healthy volunteer and patient studies were performed to demonstrate the promise of this technique in a clinical setting.

15:39           0114.   Fast Three-Dimensional Black-Blood MR Imaging for Carotid Artery Intra-Plaque Haemorrhage Using DANTE-Prepared FLASH (3D-DASH)

                                Linqing Li1, Luca Biasiolli2, Joshua T. Chai3, Matthew D. Robson2, Robin P. Choudhury3, Ashok I. Handa4, Peter Jezzard1

                                1FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; 2OCMR, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; 3Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; 44Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom


In this study we introduce a new DANTE-prepared 3D FLASH T1 weighted (T1w) sequence (denoted ‘3D-DASH’) that is able to generate 0.6 mm isotropic resolution carotid artery intra-plaque haemorrhage images with an imaging speed better than 2 sec/slice. Imaging efficiency comparisons were also made between the current best 3D black blood (BB) technique, MSDE prepared FLASH (3D-MERGE)and the new 3D-DASH technique.

15:51           0115.   3D T1 and T2 Mapping of the Carotid Vessel Wall Using Variable α and Variable TE IMSDE Black-Blood Imaging

                                Bram F. Coolen1, Henk Smit2, Dirk HJ Poot2, 3, Gyula Kotek2, Stefan Klein2, Aart J. Nederveen1

                                1Department of Radiology, Academic Medical Center Amsterdam, Amsterdam, Netherlands; 2Biomedical Imaging Group Rotterdam, Erasmus MC Rotterdam, Netherlands; 3Imaging science and Technology, Delft University of Technology, Delft, Netherlands


We present a novel protocol for 3D carotid T1 and T2 mapping using an adapted iMSDE black-blood sequence. The method is validated using phantom experiments and simulations. Feasibility of this approach was tested using in vivo measurements in a healthy volunteer.

ISMRM_MagnaLogo.jpg 16:03           0116.   Monitoring Vascular Permeability and Remodelling Following Endothelial  Injury in a Murine Model Using an MR Albumin Binding Contrast Agent

                                Begoña Lavin Plaza1, Alkystis Phinikaridou1, Silvia Lorrio Gonzalez1, Carlos Zaragoza Sanchez2, Rene Botnar1

                                1King's College London, London, United Kingdom; 2Centro Nacional Investigaciones Cardiovasculares, Spain


Endothelial cells play a critical role in maintaining vascular homeostasis. However, vascular damage may lead to endothelial dysfunction characterized by decreased bioavailability of nitric oxide, a signalling molecule involved in vasodilatation, with several anti-atherogenic and anti-inflammatory properties. Previous studies have shown that contrast enhanced MRI using gadofosveset, an albumin binding gadolinium contrast agent, can detect endothelial damage, angiogenesis and vascular permeability in different animal models. In this study, we explored whether imaging with gadofosveset could be used to monitor endothelial cell recovery, permeability and vessel wall remodelling in a murine model of aortic endothelial denudation.

Normal Brain Anatomy

Silver                                    14:15-16:15                                                                                               Moderators: Marco Catani, M.D., M.R.C.Psych. & Feroze B. Mohamed, Ph.D.  

14:15           0117.   Literacy and the Arcuate Fasciculus

                                Michel Thiebaut de Schotten1, 2, Laurent Cohen1, Eduardo Amemiya3, Lucia Braga3, Stanislas Dehaene4

ISMRM_SummaLogo.jpg                                 1Brain and Spine Institute, Paris, France; 2Natbrainlab - Institute of Psychiatry, London, United Kingdom; 3SARAH Network–International Center for Neurosciences and Rehabilitation, Brasilia, Brazil; 4Collège de France, Paris, France


The acquisition of literacy results from an effortful learning process that leads to functional changes in several cortical regions. We explored whether learning to read also leads to anatomical changes within the left intrahemispheric white matter pathways that interconnect these regions. We revealed that the acquisition of literacy is associated with a reinforcement of left temporo-parietal connections whose microstructure predicts overall reading performance and the functional specialization of the Visual Word Form Area. This anatomical magnetic resonance imaging marker may be useful to predict developmental reading disorders.

ISMRM_MagnaLogo.jpg 14:27           0118.   A Combined High Spatial- And High Angular-Resolution Diffusion MRI Atlas of the Human Brainstem and Thalamus

                                Evan Calabrese1, Christine Hulette2, G. Allan Johnson3

                                1Biomedical Engineering, Duke University, Durham, NC, United States; 2Pathology, Duke University, Durham, NC, United States; 3Radiology, Duke University, Durham, NC, United States


Deep brain stimulation (DBS) provides symptomatic relief from a number of otherwise refractory neurologic conditions through stimulation of small structures in the brainstem and diencephalon. As researchers and clinicians continue to investigate new DBS targets, there is a need for accurate 3D maps of brainstem anatomy and structural connectivity. Diffusion MRI can provide important insight, but clinical studies lack the spatial and/or angular (diffusion) resolution needed for detailed mapping. We present a high spatial- and high angular-resolution diffusion MRI atlas of the postmortem human brainstem and thalamus with an emphasis on structural mapping of DBS targets.


ISMRM_MagnaLogo.jpg 14:39           0119.   Contralateral Cerebello-Thalamo-Cortical Pathways with Prominent Involvement of Associative Areas in Humans In Vivo

                                Fulvia Palesi1, 2, Donald Tournier3, 4, Fernando Calamante3, 4, Nils Muhlert5, 6, Gloria Castellazzi, 27, Declan Chard5, 8, Egidio D'Angelo, 29, Claudia A. M. Wheeler-Kingshott5

                                1Department of Physics, University of Pavia, Pavia, Italy; 2Brain Connectivity Center, National Neurological Institute C. Mondino, Pavia, Italy; 3The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Heidelberg, Australia; 4Department of Medicine, Austin Health and Northern Health, University of Melbourne, Heidelberg, Australia; 5NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom; 6Department of Psychology, Cardiff University, Cardiff, United Kingdom; 7Department of Industrial and Information Engineering, University of Pavia, Pavia, Italy; 8National Institute for Health Research, UCLH Biomedical Research Centre, London, United Kingdom; 9Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy


In addition to motor functions, growing evidence indicates that in humans the cerebellum plays a significant role in cognition. This is occurs through connections with cerebral associative areas via synapsis in the thalamus. While recognizing that tractography provides an indirect evidence of anatomical connectivity between regions, using advanced diffusion MRI tractography we aimed to characterise the cerebello-thalamo-cortical pathway in terms of functional and anatomical areas touched by streamlines. Almost 80% of the streamlines reached the cerebellar hemispheres on one side and the associative cerebral cortex on the other, suggesting a prominent connectivity and supporting the coevolution of the two structures.

14:51           0120.   Multiple Echo and Inversion Time MPRAGE with Inner Loop GRAPPA Acceleration and Prospective Motion Correction for Minimally Distorted Multispectral Brain Morphometry

                                Andre J. W. van der Kouwe1, M. Dylan Tisdall1, Himanshu Bhat2, Bruce Fischl1, Jonathan R. Polimeni1

                                1Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 2Siemens Healthcare USA, Charlestown, MA, United States


Conventional MPRAGE suffers from blurring in the inner phase encoding direction (between inversions) and readout direction, due to T1 and T2* decay that broadens the point spread functions in these directions, respectively. This can be mitigated by combining multiple GRAPPA accelerated phase encoding blocks and multiple higher bandwidth echoes (shorter readouts that also reduce susceptibility distortion), respectively. This also enables estimation of absolute T1 and T2* times for each voxel. To minimize blurring, real-time prospective motion tracking with EPI volume navigators is included. The resulting generalized MPRAGE sequence provides high quality images for brain morphometry without affecting total acquisition time.

15:03           0121.   Quantitative Properties (Water Content, Relaxometry, MT) of the Post Mortem Brain: A Baseline for Normal Tissue

                                Ana-Maria Oros-Peusquens1, N. Jon Shah1, 2

                                1INM-4, Research Centre Jülich, Jülich, Germany; 2Department of Neurology, RWTH Aachen University, Aachen, Germany


MRI of fixed tissue is increasingly used to investigate the brain. However, properties of tissue change with fixation. This study investigates post mortem formalin-fixed brains quantitatively in order to provide a baseline for MR parameters characteristic of healthy brain tissue. The variability of several quantitative MRI parameters is characterized in fixed brain tissue obtained from donors unaffected by neurological conditions. Among other parameters, quantitative water content determined non-invasively with MRI is reported on whole human post mortem brains for the first time to our knowledge. Correlations between different parameters were investigated and compared to the same quantities measured in vivo.

15:15           0122.   Visualizing Intrathalamic Structures with Combined Use of MPRAGE and SWI at 7T

                                Allen Newton1, 2, Benoit Dawant3, Pierre D'Haese3

                                1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 2Institute of Imaging Science, Vandebrilt University, Nashville, TN, United States; 3Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States


Visualizing intrathalamic structures anatomically is important for guidance of surgical interventions, as well as validating existing thalamic parcellations from functional connectivity or DTI tractography, though it has proven quite difficult. Recent reports have begun to identify methods capable of identifying these structures via susceptibility weighted imaging, or by visualizing white matter boundaries between these structures using optimized MPRAGE acquisitions. We present evidence of the potential for the combined use of these techniques to increase the structures that can identified on an individual level. Furthermore, we demonstrate the utility of imaging with MPRAGE imaging with shorter inerversion delays for intrathalamic parcellation.


15:27           0123.   Region-Specific Microstructure of Cortical Areas Revealed with High Angular Resolution Diffusion MR Microimaging

                                Manisha Aggarwal1, Olga Pletnikova2, Juan Troncoso2, Susumu Mori1

                                1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States


We demonstrate high angular resolution diffusion MR microimaging to resolve the region-specific microstructure of cortical areas in the fixed human brain.  Diffusion MRI of cortical tissue microstructure is challenged by both the low anisotropy in gray matter microenvironments and the level of resolution necessary to delineate the layered architecture. Here, using 3D gradient and spin echo based acquisition, HARDI data of cortical specimens were acquired with 30 diffusion directions at 90 µm isotropic resolution. The diffusion micro-imaging data of the prefrontal, primary motor, and primary visual areas revealed the region-specific laminar microstructure of cortical gray matter with unprecedented detail.

15:39           0124.   Brain Volume Variations in Postmenopausal Women: A Voxel-Based Morphometry (VBM) Study

ISMRM_MagnaLogo.jpg                                 Tae-Hoon Kim1, Gwang-Woo Jeong2

                                1Research Institute of Medical Imaging, Chonnam National University Medical School, Gwangju, Korea; 2Radiology, Chonnam National University Medical School, Gwangju, Korea


During the past two decades, several studies in females of animal models and human have been performed to unveil the reproductive system changes and the complex interactions with the ovaries. However, morphologic variations in the central nerve system following menopause have not yet been studied. Therefore, this study utilized voxel-based morphormetry (VBM) to evaluate the age-related changes and the effects of menopause on the brain volumes in postmenopausal women.

15:51           0125.   Structural Brain Changes After Rotarod Training in Mice

                                Jan Scholz1, Yosuke Niibori2, Paul Frankland2, 3, Jason Lerch1, 4

                                1Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada; 2Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada; 3Department of Psychology & Physiology, University of Toronto, Toronto, ON, Canada; 4Medical Biophysics, University of Toronto, Toronto, ON, Canada


Here we investigate how rotarod training affects brain volume and microstrucure using ex-vivo MRI in mice. The rotarod is a standard test that taxes motor coordination and balance. Volume of motor and balance-related regions increases after rotarod training. Volume of the motor cortex is positively correlated with rotarod performace. Diffusion imaging indicates that trained mice have higher FA in the hippocampus. Time spent on the rotarod is associated with higher FA in the hippocampus and lower FA in V1. By using complementary measures of microstructure and volume this study reveals the substantial structural reorganization of the adult mouse brain following a brief period of motor training.

16:03           0126.   Hippocampal Surface Dentation Characteristics Through Sub-Pixel Segmentation

                                Yi Gao1, Lawrence Ver Hoef1

                                1University of Alabama at Birmingham, Birmingham, AL, United States


We present a segmentation scheme utilizing sub-voxel precision for the hippocampal dentation structure extraction from 3T MR images. This reveals the degree of dentation varies between normal individuals from prominently dentated to minimally dentated.


Fetal/Neonatal/Pediatric MRI

Red 1 & 2                            14:15-16:15                                                                                               Moderators:P. Ellen Grant, M.D. & Joseph V. Hajnal, Ph.D.

14:15           0127.   Assesment of Late-Onset Iugr in the Fetal Brain Using 1H-MRS

ISMRM_SummaLogo.jpg                                 Rui Vasco Simoes1, Magdalena Sanz-Cortes1, Nuria Bargallo2, Francesc Figueras1, Eduard Gratacos1

                                1Dept of Maternal-Fetal Medicine, Hospital Clinic, Barcelona, Spain; 2Dept of Radiology, Hospital Clinic, Barcelona, Spain


Intrauterine growth restriction (IUGR) is associated with impaired neurodevelopment. Late-onset IUGR cases are particularly difficult to diagnose in the clinic and the metabolic changes underlying their long-term brain dysfunctions remain poorly understood. We show that the NAA/Cho ratio (LCModel) is significantly lower in late-onset IUGR fetuses than in age-matched controls, independent of clinical risk factors. Our preliminary MRS pattern classification results (SpectraClassifier) suggest the existence of metabolic signatures for each group: control, IUGR without risk factors, and IUGR with risk factors. Further work will validate these results with a follow-up study in a larger population cohort.

14:27           0128.   Blood Oxygenation of Human Fetal Brain in the Second and Third Trimester

                                Pavan Kumar Jella1, Uday Krishnamurthy1, 2, Jaladhar Neelavalli1, 2, Swati Mody1, Lami Yeo3, 4, E. Hernandez-Andrade3, 4, E. Ehterami1, M.D. Cabrera1, S.J. Korzeniewski3, E.M. Haacke1, 2, Sonia Hassan3, Roberto Romero3

                                1Department of Radiology, Wayne State University, Detroit, MI, United States; 2Biomedical Engineering, Wayne State University, Detroit, MI, United States; 3NICHD, NIH, DHHS, Perinatology Research Branch, Detroit, MI, United States; 4Obstetrics and Gynecology, Wayne State University, Detroit, MI, United States


A major issue in studying fetal hypoxic ischemic injury (HII); utero in humans and its identification is limited and often the diagnosis is postponed till the post neonatal period when the injury becomes evident in neuroimaging. Hence, non-invasive imaging methods for assessing hypoxic-ischemic brain injury in-utero are of high clinical interest. Magnetic resonance (MR) susceptibility weighted imaging (SWI), was used to measure fetal blood oxygenation that helps in assessing difference in fetal oxygen utilization between second and third trimester.

14:39           0129.   Exploring the Diffusivity Changes of Diffuse Excessive High Signal Intensity (DEHSI) in Preterm Neonates by Using Two-Compartment White Matter Model Based on DKI

ISMRM_SummaLogo.jpg                                 Jie Gao1, Xianjun Li1, 2, Yumiao Zhang1, Yanyan Li1, Qinli Sun1, Xue Luo1, 2, Bolang Yu1, Jian Yang1, 2

                                1Department of radiology, the first affiliated hospital of medical college, Xi'an Jiaotong University, Xi'an, Shannxi, China; 2Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shannxi, China


Diffuse excessive high signal intensity (DEHSI) is extremely common in preterm infants. It¡¯s still under debate about whether it represents a true white mater(WM) abnormality or just the relative immature in WM. Two-compartment WM model based on DKI can provides analytical expressions for the intra- and extra-axonal diffusion tensors and may be helpful in further exploring the diffusivity changes in DEHSI. So in this study, 8 preterm neonates with DEHSI and 8 matched controls who underwent MRI at term-equivalent age were enrolled. All diffusion parameters(FA=fractional anisotropy, MD=mean diffusivity, AD=axial diffusivity, RD=radial diffusivity, MK=mean kurtosis, AK=axial kurtosis, RK=radial kurtosis, AWF= axonal water fraction, Da=intra-axonal diffusivity, De¡Î=axial extra-axonal space diffusivity, De¡Í= radial extra-axonal space diffusivity, ¦Á=tortuosity) were compared between the two groups. The increased MD, AD, RD, De¡Î, De¡Í and no significantly changed MK, AK, RK, Da, AWF indicated that the diffusion changes in DEHSI were mainly due to the increased water and/or enlarged space in extra-axonal space, rather than injuries to axons or the process of myelination.

14:51           0130.   Brain Temperatures During Therapeutic Hypothermia of Birth Asphyxia Are Significantly Different in Patients with Poor Outcome Versus Patients with Mild to Moderate Injury

                                Stefan Bluml1, 2, Tai-Wei Wu3, 4, Ashok Panigrahy1, 5, John P. Grimm1, Marvin D. Nelson1, Thomas G. Perkins6, Jonathan Chia6, Jessica L. Wisnowski1, 5

                                1Children's Hospital Los Angeles/USC, Los Angeles, CA, United States; 2Rudi Schulte Research Institute, Santa Barbara, CA, United States; 3Neonatology, Children's Hospital Los Angeles/USC, CA, United States; 4Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 5Children's Hospital of Pittsburgh, Pittsburgh, PA, United States; 6Philips Healthcare, Cleveland, OH, United States


Therapeutic hypothermia (TH) aims to lower brain temperature to prevent secondary energy failure in newborns with birth asphyxia. However, newborn brain temperature during TH is unknown as generally rectal temperatures are monitored.  In this study we show, by direct brain temperature measurement using MR spectroscopy, that the brain temperatures during TH were higher in patients with poor outcome when compared with patients with mild to moderate injury. It may be necessary to measure brain temperature directly in individual patients to ascertain that the targeted level of cooling has been achieved.

15:03           0131.   Arterial Spin Labeling Perfusion MRI in Neonates with Hypoxic-Ischemic Encephalopathy.

ISMRM_SummaLogo.jpg                                 Jill B. De Vis1, Jeroen Hendrikse1, Esben T. Petersen1, Linda S. de Vries2, Frank van Bel2, Thomas Alderliesten2, Floris Groenendaal2, Manon J.N.L. Benders2

                                1Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2Neonatology, University Medical Center Utrecht, Utrecht, Netherlands


Hypoxic-ischemic injury in neonates can cause impaired autoregulation of the cerebral vasculature resulting in hyperperfusion of brain tissue and probably secondary injury. In this study we investigated whether hyperperfusion, evaluated with arterial spin labeling MR imaging is associated with an adverse outcome in neonates with hypoxic-ischemic encephalopathy. We found higher perfusion in the basal ganglia and thalami of neonates with adverse compared to favorable outcome (69 ± 27 versus 31 ± 10 ml/100g/min, p < 0.01). Hyperperfusion in the basal ganglia and thalami had a sensitivity of 86% and a specificity of 100% for the prediction of adverse outcome.

15:15           0132.   Imaging the Developing Brain at the Bedside: A Comparison of Diffuse Optical Tomography and Functional MRI

ISMRM_SummaLogo.jpg                                 Silvina L. Ferradal1, Steve M. Liao2, Adam T. Eggebrecht1, Joshua S. Shimony1, Terrie E. Inder3, Joseph P. Culver1, Christopher D. Smyser2

                                1Radiology, Washington University in St. Louis, St. Louis, MO, United States; 2Pediatrics, Washington University in St. Louis, St. Louis, MO, United States; 3Harvard Medical School, Boston, MA, United States


Adverse neurodevelopmental outcomes in preterm infants remain a clinical challenge. While functional connectivity (fc) using functional MRI opens a window to study brain function in neonates, frequent longitudinal monitoring is often restricted in the sickest infants. Diffuse optical tomography (DOT) provides a portable alternative modality for evaluating brain function at the bedside. Here we demonstrate that our DOT system generates resting-state maps exhibiting strong agreement with non-concurrent fcMRI maps in identical subjects. Our results suggest that fcDOT provides satisfactory spatial localization and resolution, and illustrates its potential as a viable imaging tool for bedside monitoring.

15:27           0133.   Hemiplegic Cerebral Palsy and Constraint-Induced Movement Therapy: Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging Predictors and Neuroplastic Changes

                                Kathryn Yvonne Manning1, Darcy Fehlings2, Ravi S. Menon3

ISMRM_SummaLogo.jpg                                 1Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; 2Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, Ontario, Canada; 3Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada


Hemiplegic cerebral palsy patients experience learned non-use where the hemiplegic arm is further inhibited from healthy development as most tasks are performed with the unaffected limb. Constraint-induced movement therapy (CIMT) has rendered significant functional improvement in many patients, though not all experience success and little is known about the possible neurological predictors.  Resting state functional MRI and diffusion tensor imaging reveal altered global network organization and quantify white matter tract integrity. Potential predictors of clinical success are identified, and resting state network reorganization after CIMT provides evidence of neuroplasticity.

15:39           0134.   Reduced GABA Concentration in Children with Tourette's Syndrome Is Linked to Sensory Impairments and Tic Severity

ISMRM_SummaLogo.jpg                                 Nicolaas A. Puts1, 2, Stewart H. Mostofsky3, 4, Mark Tommerdahl5, Richard A. Edden1, 2

                                1Russell H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University, Baltimore, MD, United States; 2FM Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Department of Neurology, The Johns Hopkins University, Baltimore, MD, United States; 4Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, United States; 5Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States


GABA concentration is reduced in children with TS and is linked to behavior and diagnostic measures

15:51           0135.   Longitudinal  Analysis of Brain Network Reorganization in Preterm IUGR Children at 1, 6 and 9 Years of Age

                                Emma Muñoz-Moreno1, Elda Fischi-Gomez2, 3, Dafnis Batalle1, Lana Vasung3, Elisenda Eixarch1, 4, Jean-Philippe Thiran2, 5, Eduard Gratacos1, 4, Petra Susan Huppi3

                                1Fetal and Perinatal Medicine Research Group, IDIBAPS, Barcelona, Spain; 2Signal Processing Laboratory 5 (LTS5), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 3Division of Development and Growth. Department of Pediatrics, University of Geneva, Geneva, Switzerland; 4Maternal-Fetal Medicine Department, ICGON, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; 5Department of Radiology, University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland


Intrauterine Growth Restriction (IUGR) due to placental insufficiency is associated with short and long-term neurodevelopmental disorders. In this study, connectomic analysis based on diffusion magnetic resonance (dMRI) was performed in cohorts of 1-, 6- and 9-year-old children that were born preterm. Two groups were considered at each age, children with normal growth and children with IUGR. Tractography was used to infer the connections between brain regions, and estimate the connectome matrix of each subject, and graph measures were computed. Results showed that a pattern of alterations in graph measures describing brain organization in IUGR persists along childhood.

16:03           0136.   Tract-Based Spatial Statistics Analysis of Diffusion Tensor Data in Very Preterm 7 Year-Olds

                                Claire E. Kelly1, Deanne K. Thompson1, 2, Alexander Leemans3, Chris Adamson1, Jian Chen1, Terrie E. Inder4, Jeanie LY Cheong1, 5, Lex W. Doyle1, 5, Peter J. Anderson1, 6

                                1Murdoch Childrens Research Institute, Melbourne, VIC, Australia; 2Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; 3Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 4Brigham and Women's Hospital, Boston, MA, United States; 5Royal Women's Hospital, Melbourne, VIC, Australia; 6Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia


Very preterm birth (VPT, <32 weeks’ gestation) increases the risk of white matter injury. Tract-Based Spatial Statistics (TBSS) provides a method for studying whole brain white matter microstructure in VPT children. This study analysed diffusion tensor data from 150 VPT children and 35 term controls (born &#8805;37 weeks’ gestation) at 7 years of age. There were regions of higher diffusivity in the VPT children compared with controls. Increasing brain abnormality scored on neonatal MRI was associated with widespread lower fractional anisotropy and higher diffusivity in VPT children. TBSS provides a sensitive method for studying white matter microstructure in VPT children.

Hepatobiliary 1

Blue 1 & 2                           14:15-16:15                                                                                               Moderators:Diego Hernado, Ph.D. & Kartik S. Jhaveri, M.D.

14:15           0137.   Hyperpolarized [1,3-13C2]ethyl Acetoacetate Is a Novel Diagnostic Metabolic Marker of Liver Cancer.

                                Sonia Colombo Serra1, Pernille Rose Jensen2, Luigi Miragoli1, Magnus Karlsson2, Claudia Cabella1, Luisa Poggi1, Luca Venturi3, Fabio Tedoldi1, Mathilde Lerche2

                                1Centro Ricerche Bracco, Bracco Imaging SpA, Colleretto Giacosa, Torino, Italy; 2Albeda Research, Copenhagen, Denmark; 3CEIP, University of Torino, Colleretto Giacosa, Torino, Italy


Hepatocellular carcinoma (HCC) is most often found in cirrhotic livers and can be hardly diagnosed relying on anatomical information alone. Magnetic resonance is commonly used to identify anatomical lesions, but can also provide information on cellular metabolism by an emerging method that uses 13C labeled hyperpolarized molecules. This study aimed at probing the potential of hyperpolarized [1,3-13C2]ethyl acetoacetate as a metabolic marker of HCC. A liver cancer implanted in rats is diagnosed due to a higher substrate-to-product ratio in tumors than in healthy livers demonstrating that the metabolism of the liver isoform of carboxyl esterase can be monitored in vivo.

14:27           0138.   Agreement of 2-, 3-, 4-, 5- And 6-Echo MRI-PDFF with MRS-PDFF in 580 Adults with Known or Suspected Non-Alcoholic Fatty Liver Disease (NAFLD)

                                Elhamy R. Heba1, Claude B. Sirlin2, Tanya Wolfson, Anthony Gamst, Rohit Loomba3, Michael S. Middleton2

                                1Radiology, UCSD, san diego, CA, United States; 2Radiology, UCSD, San Diego, CA, United States; 3Internal medicine, UCSD, San Diego, CA, United States


This study was done to compare the agreement of different MRI-PDFF liver fat quantification analysis methodologies in 580 adults with known or suspected non-alcoholic fatty liver disease (NAFLD), using MRS-PDFF as reference standard. We found that 3-, 4-, 5- and 6-echo MRI accurately quantify hepatic PDFF in adults, with 3-echo MRI informally showing the closest and 2-echo MRI the worst agreement.


14:39           0139.   Differentiation of Hypointensity Nodules on Gadoxetic Acid-Enhanced Hepatobiliary Phase MRI Using Non-Balanced Spin-Echo SSFP (T2FFE)

                                Masami Yoneyama1, Masanobu Nakamura2, Taro Takahara3, Thomas Kwee4, Yukihisa Takayama5, Akihiro Nishie5, Atsushi Takemura2, Yasutomo Katsumata2, Makoto Obara2, Satoshi Tatsuno1, Seishi Sawano1

                                1Yaesu Clinic, Tokyo, Japan; 2Philips Electronics Japan, Tokyo, Japan; 3Tokai University School of Engineering, Kanagawa, Japan; 4University Medical Center Utrecht, Netherlands; 5Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan


This study introduced a novel approach to differentiate hypointense nodules on gadoxetic acid-enhanced hepatobiliary phase images by use of a non-balanced spin-echo SSFP (T2FFE) sequence. T2FFE typically provides T2-weighted contrast, but theoretically has high sensitivity to T1 shortening effects due to gadoxetic acid. This approach might particularly be useful for distinguishing metastases and hemangiomas.

14:51           0140.   Liver R2* Dependence on Liver Storage Iron in Highly Iron Overloaded Patients: Comparing 1.5 T to 3 T

                                Arthur Peter Wunderlich1, Steffen Klömpken1, Holger Cario2, Markus Juchems1, Meinrad Beer1

                                1Dept. for Diagnostic and Interventional Radiology, Univ.-Clinic Ulm, Ulm, Germany; 2Pediatry, Univ.-Clinic Ulm, Ulm, Germany


The liver of iron overloaded patients was scanned with breathhold multicontrast GRE sequences at 1.5 T and 3 T. To address high liver iron content (LIC) resulting in high R2* values we used short echo spacing resulting in out-of-phase signal for fat and water. Therefore, liver fat fraction had to be included as free parameter for data fit. Four different flip angles lead to sufficient measurement data reliably above image noise at the cost of T1 as additional fit parameter. Data were fit to theory by Levenberg-Marquardt algorithm. Dependence of R2* on LIC was compared between field strengths.

15:03           0141.   In-Vivo Evaluation of Hepatic Function Using Dynamic Gd-EOB-DTPA Enhanced MRI with a Dual-Input One Output Two-Compartment Pharmacokinetics Model

ISMRM_SummaLogo.jpg                                 Jia Ning1, Sheng Xie2, Lei Wang2, Hua Guo1, Xihai Zhao1, Chun Yuan1, 3, Huijun Chen1

                                1Center for Biomedical Imaging Research & Department of Biomedical Engineering, Tsinghua University, Beijing, China; 2Department of Radiology, China-Japan Friendship Hospital, Beijing, China; 3Department of radiology, University of Washington, Seattle, WA, United States


Liver function is an important and sensitive indicator for liver damage. In this study, we proposed a new hemodynamic model to better describe the behavior of the Gd-EOB-DTPA by adding a directly measured contrast excretion term from hepatic vein. Validations with serum liver functional parameters were carried out for the proposed model and original model. Model parameters Ki is found significantly correlated with the concentration of preALB and ALB in serum. The proposed dual-input one output two-compartment pharmacokinetics model for dynamic Gd-EOB-DTPA enhanced liver MRI is capable of localized liver function evaluation in-vivo.fibrosis can envolve to cirrhosis and finally end up with hepatic carcinoma. Various studies have shown that fibrosis of level 1 and level 2 can be reversible [2], early diagnosis of liver fibrosis is critical for treatment and recovery. Dynamic contrast enhanced MR imaging is one of the most powerful protocols to evaluate the condition of liver. Gd-EOB-DTPA is a new type of hepatocyte specific contrast agent [3] for liver function evaluation. It has the advantages of specific binding with hepatocytes, and excretion through the hepatic vein, kidney and biliary. According to the properties of this contrast agent, we propose a new hemodynamics model to describe the perfusion of the liver. It is supposed that the parameters of the model can give an instruction of hepatic function and provide useful information for diagnosis of liver fibrosis.


ISMRM_MagnaLogo.jpg 15:15           0142.   Gadoxetate-Enhanced MRI in Rats with Liver Cirrhosis: Comparison Between Functional Liver Parameters Obtained with Deconvolution Analysis and Compartmental Models as Markers of Hepatocyte Transporter Expression

                                Céline Giraudeau1, Jean-Luc Daire1, Matthieu Lagadec1, Sabrina Doblas1, Catherine Pastor2, Bernard Van Beers1

                                1INSERM Centre de Recherche Biomédicale Bichat Beaujon,CRB3 U773, Université Paris Diderot, Sorbonne Paris Cité, Clichy, France; 2Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire,Hôpitaux Universitaires de Genève, Geneva, Switzerland


We have previously shown that the hepatic functional parameters (hepatic extraction fraction (HEF) and mean residence time (MRT)) obtained with deconvolution analysis at gadoxetate-enhanced MRI correlate with the expression of the oatp/mrp transporters in liver cirrhosis. The aim of this study was to assess if a multicompartmental model of hepatocytic transport gives further insight into the expression of the oatp/mrp transporters in liver cirrhosis. Both methods were evaluated in normal and cirrhotic rats through calculation of Akaike criteria and multiple regression analysis. The superiority of a multicompartmental relative to a deconvolution model remains here to be proven.

15:27           0143.   R2* of Water and Fat in Hepatic Iron Overload: Implications for R2*-Corrected Fat Quantification

ISMRM_MagnaLogo.jpg                                 Debra E. Horng1, 2, Diego Hernando1, Scott B. Reeder1, 2

                                1Radiology, University of Wisconsin-Madison, Madison, WI, United States; 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States


Accurate fat quantification using chemical shift-encoded techniques requires correction for R2* (=1/T2*) decay. Correction for a common R2* for both fat and water (“single-R2*”) has been shown to be accurate for FF quantification in patients without iron overload. In this work, the accuracy of single-R2* correction is assessed in patients with iron overload. Fat-fraction and R2* were measured in 42 subjects at 1.5T and 3.0T, with both imaging and spectroscopy. The R2* of fat and water are very similar even in the presence of iron overload, showing that fat quantification with single-R2* correction is accurate even for patients with iron overload.

15:39           0144.   Rician-Noise Based R2* Estimation for Severe Hepatic Iron Overload: Simulation, Phantom, and Early Clinical Experience

                                Takeshi Yokoo1, 2, Qing Yuan1, Julien Senegas3, Andrea Wiethoff, 24, Ivan M. Pedrosa1, 2

                                1Radiology, UT Southwestern Medical Center, Dallas, TX, United States; 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States; 3Philips Research Laboratories, Hamburg, Germany; 4Philips Research North America, Briarcliff Manor, NY, United States


Patients with severe hepatic iron overload are at risk for developing end-stage liver disease and in greatest need for therapy. An R2*-based measure has been proposed as a surrogate for liver iron, but its estimation is challenging in severe iron overload due to rapid signal decay.  In this series of simulation, phantom, and human studies, we compared R2* estimation performance of several existing methods: linear least squares, nonlinear least squares (NLS), weighted NLS, NLS with constant noise offset, and Rician-noise based. Our results show that Rician-noise based method is clinically feasible and may be necessary to accurately estimate R2* for severe iron overload.

15:51           0145.   Poor Gadoxetate Disodium Hepatobiliary Enhancement in MRI of Patients with Cirrhosis: Factors for Prediction

                                Amelia Wnorowski1, Flavius Guglielmo1, Laurence Parker1, Sandeep Deshmukh1, Patrick O'Kane1, Christopher Roth1, Donald Mitchell1

                                1Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, United States


Gadoxetate disodium is a useful MRI contrast agent for the diagnosis of hepatocellular carcinoma in cirrhosis. Its use is limited by poor hepatic and biliary enhancement in some patients. The purpose of this study was to identify predictors of poor enhancement, which was assessed in 91 cirrhotic patients and compared to various laboratory parameters, liver length and degree of ascites. A correlation matrix was performed, followed by multiple and logistic regressions. Several variables independently correlated with enhancement. However, the first variable chosen, either albumin or MELD score, accounted for almost all of the variance in the model.

16:03           0146.   Same Day 1.5T Vs 3T Reproducibility of Liver Proton Density Fat Fractions in Obese Patients

ISMRM_MagnaLogo.jpg                                 Nathan Artz1, William Haufe2, Tanya Chavez2, Gavin Hamilton2, Michael Middleton2, Jeff Schwimmer3, Diego Hernando1, Ann Shimakawa4, Jonathan Hooker2, Claude Sirlin2, Scott Reeder1, 5

                                1Radiology, University of Wisconsin, Madison, WI, United States; 2Radiology, University of California, San Diego, CA, United States; 3Pediatrics, University of California, San Diego, CA, United States; 4Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 5Medicine, University of Wisconsin, Madison, WI, United States


The purpose of this work is to examine the 1.5T vs 3T reproducibility of hepatic proton density fat fraction (PDFF) measurements. Obese patients were scanned using three distinct quantitative MR techniques on the same day at both field strengths. Regression analysis was used to compare co-localized 1.5T and 3T PDFF measurements.  All three techniques demonstrated very good agreement between 1.5T and 3T liver PDFF measurements, indicating that PDFF quantification is reproducible across field strengths.


Clinical & Translational Cartilage MRI

Yellow 1, 2 & 3                  14:15-16:15                                                                                               Moderators:Neal K. Bangerter, Ph.D. & Edwin H. G. Oei, M.D., Ph.D.

14:15           0147.   3D Visualization of Quantitative T2 Relaxation Times in the Femoral Condylar Cartilage in Healthy and ACL-Injured Individuals

                                Uchechukwuka D. Monu1, 2, Emily J. McWalter2, Caroline D. Jordan, 23, Brian A. Hargreaves, 12, Garry E. Gold2, 3

                                1Electrical Engineering, Stanford University, Stanford, CA, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Bioengineering, Stanford University, Stanford, CA, United States


Osteoarthritis is a degenerative joint disease that may affect more than half of the ACL-injured population. Current MRI osteoarthritis studies often evaluate just a single slice from the medial and lateral compartments of the full knee, which may not fully describe the cartilage volume variation or longitudinal changes. In this work, we provide a method of visualizing quantitative maps of the entire cartilage surface using projection maps. T2 relaxation time differences between healthy volunteers and ACL-injured subjects are clear and the global percent short term CV of the implemented technique is comparable to the ROI approach reported in literature.

14:27           0148.   The Angular Dependence of T1ρ Relaxation in Normal and Abnormal Patellae with Histological Correlation

                                Jiang Du1, Chantal Pauli2, Shihong Li1, Sheronda Statum1, Won Bae1, Eric Chang1, Christine B. Chung1

                                1Radiology, University of California, San Diego, San Diego, CA, United States; 2Pathology, University Hospital Zürich, Zürich, Switzerland


Both T2 and T1rho have been employed to evaluate articular cartilage degeneration. The magic angle effect in T2 relaxation is well understood. However, the literature regarding T1rho relaxation mechanisms is inconsistent. Some researchers reported much reduced or negligible magic angle effect in T1rho, while other researchers have reported significant magic angle effect in T1rho relaxation. Furthermore, magic angle effects in normal vs. abnormal cartilage are unknown. In this study we aimed to systematically evaluate the magic angle effect on T2 and T1rho in histological confirmed normal and abnormal cartilage at 3T

14:39           0149.   Sensitivity of Multicomponent Driven Equilibrium Single Observation of T1 and T2 (McDESPOT) to Magic Angle Effects in Bovine Articular Cartilage at 3.0T

                                Rajeev Chaudhary1, Fang Liu2, Nade Sritanyaratana1, Jarred M. Kaiser3, Samuel A. Hurley2, Walter F. Block1, 2, Richard X. Kijowski4

                                1Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 3Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States; 4Radiology, University of Wisconsin-Madison, Madison, WI, United States


This study was performed to investigate the influence of the magic angle effect on multi-component T2 parameters measured using mcDESPOT.  Ex-vivo articular cartilage specimens were imaged using mcDESPOT at angles of 0°, 30°, 55°, and 60° relative to the main magnetic field.  Percent changes in T2 parameters from 0° to 55° where there was maximum magic angle effect was 42.9% for single-component T2, 20.0% for T2 of bulk water loosely bound to the macromolecular matrix, 40.0% for the T2 of water tightly bound to proteoglycan, and -4.9% for the fraction of water tightly bound to proteoglycan.


14:51           0150.   Hip T1rho and T2 Relaxation Times in Individuals with and Without Cartilage Lesions

                                Cory Wyatt1, Deepak Kumar1, Karupppasamy Subburaj1, Divya Narayanan2, Sonia Lee1, Lorenzo Nardo1, Thomas Link1, Thomas Vail3, Richard Souza1, Sharmila Majumdar1

                                1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 2Bioengineering, University of California Berkeley, Berkeley, CA, United States; 3Orthopaedic Surgery, University of California San Francisco, San Francisco, CA, United States


The purpose of this study was to measure T1rho and T2 relaxation times in vivo in healthy controls, subjects with mild OA, and subjects with femoroacetabular impingement (FAI).  The volunteers were scanned with a segmented 3D SPGR MAPSS T1rho/T2 sequence on one hip and the cartilage was clinically scored for lesions.  The femoral and acetabular cartilage were segmented separately and then segmented into 8 equal regions.  Significant increases in the T1rho and T2 relaxation times were seen in the acetabular cartilage while no significant changes were seen in the femoral cartilage.

15:03           0151.   Diagnostic Performance of a 3D FSE T2 and T1rho Sequence for Quantitative Mapping of Articular Cartilage Composition for the Detection of Morphological Internal Knee Derangements

                                Edwin H. Oei1, 2, Weitian Chen3, Jason L. Dragoo4, Garry E. Gold1, 5

                                1Radiology, Stanford University, Stanford, CA, United States; 2Radiology, Erasmus MC, Rotterdam, ZH, Netherlands; 3GE Healthcare, Menlo Park, CA, United States; 4Orthopaedic Surgery, Stanford University, Stanford, CA, United States; 5Bioengineering, Stanford University, Stanford, CA, United States


Although quantitative MRI for articular cartilage composition shows promise for early detection of osteoarthritis (OA), large-scale application is hampered by long scan times if added to routine MRI protocols. We assessed the performance of a quantitative 3D FSE T2 and T1rho mapping sequence to diagnose cruciate ligament and meniscal tears, bone marrow lesions, and cartilage defects. For anterior cruciate ligament and medial meniscal tears, diagnostic performance of the 3D FSE T1rho mapping sequence was good and superior to T2 mapping. This sequence may be used to replace routine clinical pulse sequences, enhancing scan time efficiency and potentially accelerating large-scale implementation.

15:15           0152.   Sodium MRI of Articular Cartilage with Improved SNR Using Coherent SSFP Imaging at 7T

ISMRM_SummaLogo.jpg                                 Stefan Zbyn1, Oliver Bieri2, Vladimir Mlynarik1, Vladimir Juras1, Siegfried Trattnig1

                                1High Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Vienna, Austria; 2Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland


Coherent steady state sequences, such as FISP or TrueFISP, may provide higher SNR than spoiled gradient echo (SPGR). However, to our best knowledge, they have not yet been investigated for in vivo 23Na-MRI. In this study, in vivo and ex vivo knee measurements at 7T were performed to assess optimal measurement parameters for FISP and TrueFISP, and to evaluate their SNR compared to SPGR. FISP and TrueFISP provided significantly higher SNR than SPGR in cartilage, muscle and blood. The higher SNR may be traded off for higher resolution or shorter measurement times and help to get 23Na-MRI into clinical practice.

15:27           0153.   UTE MR Morphology and Histopathology of the Osteochondral Junction of the Knee

                                Won C. Bae1, Sheronda Statum1, Reni Biswas1, Darryl D. D'Lima2, Eric Y. Chang3, Christine B. Chung3

                                1Department of Radiology, University of California, San Diego, San Diego, CA, United States; 2Scripps Clinic, La Jolla, CA, United States; 3VA San Diego Healthcare System, San Diego, CA, United States


UTE MRI enables direct evaluation of osteochondral junction of the knee.  This study compared UTE MR morphology and histopathologic changes of the osteochondral junction, including duplication of tidemark and vascular invasion. While the occurrence of tidemark duplication was similar between UTE-normal and –abnormal samples, vascular invasion was significantly greater in UTE-abnormal samples. Further investigation is warranted to fully understand relationship between osteochondral changes and UTE MR morphology.

15:39           0154.   Longitudinal Texture Changes to UTE-T2* Following ACL Reconstruction

                                Ashley Williams1, Yongxian Qian2, Constance R. Chu1

                                1Department of Orthopedic Surgery, Stanford University, Stanford, CA, United States; 2Radiology, University of Pittsburgh, Pittsburgh, PA, United States


This study tests the hypothesis that evaluation of the spatial distribution of cartilage UTE-T2* values, assessed via grey-level co-occurrence matrix texture statistics, will better detect sub-surface damage and disease progression to cartilage in ACL-injured subjects than mean UTE-T2* alone. Both cross-sectional comparisons with uninjured controls and longitudinal evaluations of ACL-injured subjects over 2 years after ligament reconstruction indicate that texture analyses provide evidence of progressive cartilage degeneration following ACL-injury that is not reflected in  mean UTE-T2* value. Texture evaluations in this work augmented the ability of UTE-T2* mapping to quantitatively monitor cartilage status in knees at risk of developing OA.


15:51           0155.   Delayed Gadolinium-Enhanced MRI of Cartilage (DGEMRIC) Is Superior to T1rho-Mapping in Measuring Cartilage Sulphated Glycosaminoglycan Content: Preliminary Results of an In-Vivo Validation Study Using an Ex-Vivo Reference Standard for Cartilage Sulphated Glycosaminoglycan Content

                                Jasper van Tiel1, 2, Gyula Kotek1, Max Reijman2, Pieter K. Bos2, Esther E. Bron1, 3, Stefan Klein1, 3, Jan A. Verhaar2, Gabriel P. Krestin1, Harrie Weinans, 24, Edwin H. Oei1

                                1Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands; 2Orthopedic Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands; 3Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Zuid-Holland, Netherlands; 4Orthopedic Surgery, University Medical Center Utrecht, Utrecht, Netherlands


Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has become a standard to quantitatively measure cartilage sulphated glycosaminoglycan (sGAG) content. T1rho-mapping has been proposed as non-contrast-enhanced alternative to dGEMRIC to also quantitatively measure cartilage sGAG content. However, no thorough validation studies comparing both techniques acquired in-vivo against a tissue reference standard for sGAG have been performed. Our preliminary results suggest that dGEMRIC can accurately measure articular cartilage sGAG content, whereas T1rho-mapping is not suitable for this purpose. Therefore, despite the need to use a contrast agent, we consider dGEMRIC to be superior to T1rho-mapping for quantitatively measuring cartilage sGAG content.

16:03           0156.   Combination of a Radial Sequence for In Vivo DTI of Articular Cartialge with an Iterative Model-Based Reconstruction

                                Jose G. Raya1, Florian Knoll1, Lauren Burcaw1, Sina Milani1, Daniel K. Sodickson1, Tobias K. Block1

                                1New York University Langone Medical Center, New York, NY, United States


We combine of a radial spin echo diffusion tensor imaging (RAISED) sequence for DTI of articular cartilage with a model-based iterative reconstruction, which directly calculates the diffusion tensor without reconstructing the intermediate diffusion-weighted images. This adds flexibility to the data acquisition. Purpose of this work was to assess value of different acquisition strategies for a model-based reconstruction. We tested four protocols with different resolutions, b-values and acquisitions times. We compared our model-based approach with the standard gridding reconstruction. We found improvement of the DTI parameters with the model based reconstruction and identify an optimal protocol for RAISED.

Educational Course

Neurodegenerative Disease & Movement Disorders

Space 4                                14:15-16:15                                                                                               Moderators:Maria A. Rocca, M.D. & Norbert Schuff, Ph.D.

14:15                       A Clinical Perspective Into Early Stages of Neurodegerative Disease

                                Vincenzo Silani, M.D.


14:45                       Neurodegeneration in Preclinical Stages of Parkinson's Disease

                                Stephane Lehericy, M.D., Ph.D.


15:15                       Presymptomatic Imaging in ALS

                                Federica Agosta, M.D.

15:45                       The Presymptomatic Phase of Huntington Disease

                                Herminia Diana Rosas, M.D.


16:15                       Adjournment


Educational Course


Brown 1 & 2                       14:15-16:15                                                                                              
Moderators:Christine Chung, M.D., Cindy R. Comeau, B.S., R.T. (N)(MR), FSMRT, & James J. Stuppino, B.S., R.T.(R)(MR)

14:15                       Clinician Applications & Challenge in the USA

                                David A. Bluemke, M.D., Ph.D.


14:35                       Clinician Applications & Challenge in Europe

                                Gustav K. von Schulthess, M.D., Ph.D., M.D. Hon.


14:55                       PET/MR Technology Challenges & Comparison of Systems

                                David W.  Jordan, Ph.D.


15:15                       PET/MR Technologists Challenges from a MRI Technologist

                                John J. Totman, Ph.S.


15:35                       PET/MR Technologists Challenges from a Nuclear Medicine Technologist Point of View

                                Kimberly Jackson, B.S., RT(N)


15:55                       Roundtable Discussion


16:15                       Adjournment




Educational Course

Imaging of Cancer: Beyond Anatomy & Morphology

Brown 3                               14:15-16:15                                                                                               Moderators:Robert E. Lenkinski, Ph.D. & Daniel M. Spielman, Ph.D.

14:15                       Focus on DCE-MRI in Breast Cancer

                                Francesco Sardanelli, M.D.


14:45                       Focus on ASL in Cancer

                                David C. Alsop, Ph.D.


15:15                       Focus on MRS in Cancer

                                Carolyn E. Mountford, D.Phil.


15:45                       Focus on DWI in Cancer

                                Brian D. Ross, Ph.D.


16:15                       Adjournment



Traditional Poster Session: MR Engineering; MR Safety: Safety & Bioeffects; Ultra-High Field

Traditional Poster Hall     16:30-18:30                           (no CME credit)                                         


Electronic Poster Session: Body

Exhibition Hall                   16:30-18:30                           (no CME credit)                                       


Electronic Poster Session: Interventional

Exhibition Hall                   16:30-18:30                           (no CME credit)                                       


Study Group Session: MR in Drug Research

Amber 1 & 2                       16:30-18:30                           (no CME credit)                                       


Power Poster Session: Functional Connectivity: Clinical & Preclinical

Space 1/Power Poster Theater and Traditional Poster Hall                                  16:30-17:30                             (no CME credit)
Moderators: Gwenaelle L. Douaud, Ph.D. & TBA

16:30           0157.   Complex Interplay Between Structural and Functional Brain Connectivity in Acallosal BTBR T+tf/J Mice

                                Francesco Sforazzini1, Luca Dodero2, Alberto Galbusera1, Angelo Bifone1, Alessandro Gozzi1

                                1MRI Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Sciences, Rovereto, Trento, Italy; 2Pavis Lab, Istituto Italiano di Tecnologia, Genova, Italy


Iinvestigations in healthy humans have highlighted an overall good correspondence between functional and structural connectivity. However, recent studies examining congenital or surgical alteration of the corpus callosum have produced conflicting results that challenge this view. Here we used high-resolution DTI and fMRI to probe structural and functional brain connectivity in BTBR mice, an acallosal strain widely used to mimic autism-like symptoms. We provide evidence of adaptive structural and functional cortico-cortical connectivity together with the presence of severely impaired antero-posterior and subcortical functional correlations. Our results highlight a complex region-dependent interplay between function and structure in congenital acollosal brains.

                    0158.   Impaired Synaptic Pruning Produces Long-Range Functional Connectivity Deficits in the Mouse Brain

                                Alessandro Gozzi1, Yang Zhan2, Rosa C. Paolicelli2, Francesco Sforazzini1, Alexei Vyssotski3, Angelo Bifone1, Cornelius Gross2

                                1MRI Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Sciences, Rovereto, Trento, Italy; 2Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, Italy, Roma, Italy; 3Institute of Neuroinformatics, University of Zürich and Swiss Federal Institute of Technology (ETH), Zurich, Switzerland


Human fMRI studies have revealed impaired long-range functional connectivity in neuro-developmental disorders such as schizophrenia and autism. Deficits in the postnatal elimination of synapses (i.e. “pruning”), are thought to play an etiopathological role in these conditions. We used resting-state fMRI (rsfMRI) to test whether impaired synaptic maturation is sufficient to induce functional connectivity deficits. We found that Cx3cr1-KO mice, a line characterised by marked deficits in synaptic pruning, exhibit reduced long-range rsfMRI and LFP coherence in fronto-hippocampal areas. These results demonstrate that disruption in synaptic pruning is sufficient to produce connectional deficits reminiscent of those observed in human neurodevelopmental disorders

                    0159.   GABAergic Effect on Resting-State Functional Connectivity

ISMRM_MagnaLogo.jpg                                 Fatima Nasrallah1, Kavita Kaur D/O Ranjit Singh2, Yeow Ling Yun2, Kai-Hsiang Chuang2

                                1Clinical Imaging Research Center, Singapore, Singapore; 2Singapore Bioimaging Consortium, Singapore, Singapore


To understand the neurotransmission basis of resting-state functional connectivity, BOLD and EEG were measured when GABAA receptor system was antagonized by bicuculline. We found that inhibition of the GABAergic system in the brain increases both neural activity and functional connectivity. EEG shows intact neurovascular coupling and increased beta and gamma oscillation at resting state. This supports the neural basis and the role of inhibitory system on functional connectivity.


                    0160.   Assessment of Cholinergic Synaptic Transmission Modulation in the Mouse Brain Using Resting-State Functional  Magnetic Resonance Imaging (RsfMRI)

                                Disha Shah1, Rafael Delgado y Palacios1, Pieter-Jan Guns1, Elisabeth Jonckers1, Marleen Verhoye1, Annemie Van der Linden1

                                1University of Antwerp, Bio-Imaging Lab, Wilrijk, Antwerp, Belgium


We hypothesize that synaptic transmission deficits in neurodegenerative disorders (ND) could be reflected as altered brain functional connectivity (FC) and can be detected using resting-state fMRI (rsfMRI). We investigate this hypothesis by pharmacologically modulating cholinergic synaptic transmission in the mouse brain using scopolamine and milameline. Scopolamine induced a decrease of FC between the hippocampus and thalamus and the hippocampus bilaterally, connections involved in learning/memory. The scopolamine-induced FC deficits are reversed by milameline. These results have implications for studies in animal models of ND, where rsfMRI can be used as a non-invasive tool to detect the modulation of synaptic transmission.

ISMRM_MagnaLogo.jpg                     0161.   Functional Connectivity of Consolidated Memory Circuits in Rabbit After Trace Eyeblink Conditioning

                                Matthew P. Schroeder1, Craig Weiss1, Daniel Procissi2, John F. Disterhoft1

                                1Physiology, Northwestern University, Chicago, IL Illinois, United States; 2Radiology, Northwestern University, Chicago, IL Illinois, United States


Memory acquisition initially depends on the hippocampus but long-term memory resides in a distributed cortical network. This study characterized functional connectivity changes at sites mediating long-term memory. New Zealand White rabbits underwent trace eyeblink conditioning for ten days. Resting state scans were acquired following each session in a 7T Bruker MRI. Rabbits demonstrated greater hippocampal connectivity with HVI cerebellum, perirhinal cortex and thalamus and greater prefrontal connectivity with cholinergic basal forebrain after conditioning. Connectivity gradually and significantly changed as a result of learning a forebrain-dependent task. Future studies may identify additional regions showing connectivity changes as a result of learning.

ISMRM_SummaLogo.jpg                     0162.   Optogenetic Manipulation of VTA Dopaminergic Neurons and Global Patterns of Functional Neural Connectivity

                                Heather K. Decot1, Yen-Yu Ian Shih2, 3, Wei Gao2, 4, Pranish Kantak5, Ian Jiang, Karl Deisseroth6, Ilana B. Witten7, Garret D. Stuber1, 5

                                1Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; 2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, United States; 3Neurology, University of North Carolina at Chapel Hill, NC, United States; 4Radiology, University of North Carolina at Chapel Hill, NC, United States; 5Psychiatry, University of North Carolina at Chapel Hill, NC, United States; 6Bioengineering, Stanford University, CA, United States; 7Psychology, Princeton University, Princeton, NJ, United States


Here, we coupled optogenetic stimulation techniques with functional magnetic resonance imaging (fMRI) technology in an in vivo rat model to selectively activate dopaminergic  neurons within the ventral tegmental area (VTA).  This study demonstrates that transient optogenetic activation of DA neurons within the midbrain causes significant regional CBV increases in downstream targets of the VTA including the dorsal and ventral striatum.  Future directions include exploring how DA neuromodulation promotes or suppresses functional connectivity within the intact brain.


                    0163.   Restoration of Interhemispheric Resting-State fMRI Connectivity After Patrial Corpus Callosotomy Via Intrahemispheric Reorganization

ISMRM_SummaLogo.jpg                                 Iris Y. Zhou1, 2, Mengye Lyu1, 2, Russell W. Chan1, 2, Y X. Liang3, Adrian Tsang1, 2, K F. So3, Ed X. Wu1, 2

                                1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China; 3Department of Anatomy, The University of Hong Kong, Hong Kong SAR, China


Resting-state fMRI (rsfMRI) has shown potentials in revealing the functional plasticity after brain injury and training. Our previous study on a rat model of corpus callosotomy has demonstrated that disrupted rsfMRI connectivity can be partially restored atop the axonal connections as indispensable foundation. In this study, we further investigated the rsfMRI network reorganization after complete and partial callosotomy, aiming to identify the rewiring mechanism and topological alterations of rsfMRI networks if any. The results showed the restoration of disrupted interhemispheric connectivity may stem from the remodeling of intrahemispheric rsfMRI connectivity together with the remaining interhemispheric axonal pathways.

                    0164.   Spontaneous Activity in the Delta Band Drives the Resting State MRI (RsMRI) Signal: A Combined RsMRI and Electrophysiological Study in Rat Whisker Barrel Cortex

                                Hanbing Lu1, William Rea1, Leiming Wang1, Elliot A. Stein1, Yihong Yang1

                                1National Institute on Drug Abuse, Baltimore, MD, United States


The physiological basis of resting state MRI (rsMRI) signal remains poorly understood. Several lines of evidence suggest the important role of spontaneous slow and infraslow EEG oscillation underlying the low-frequency BOLD fluctuations; Contrasting hypotheses emphasize the roles of higher frequency (gamma) activity. One approach to disentangle the relationship between electrophysiological and rsMRI signal is to investigate how evoked responses interact with ongoing spontaneous brain activity. We employ a whisker barrel cortex stimulation model to investigate this question. Our findings support the view that spontaneous activity in the delta band drives the rsMRI signal as manifested in functional connectivity.

                    0165.   Neuroadaptation to Single Traumatic Stressor Revealed by Resting-State fMRI in Awake Rats

ISMRM_MagnaLogo.jpg                                 Zhifeng Liang1, Nanyin Zhang1

                                1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States


Alterations of resting-state functional connectivity (RSFC) have been implicated in a wide range of psychiatric disorders. However, RSFC studies focusing on animal models of psychiatric disorders have been sparse, possibly due to confounding effects of widely used anesthesia in animal imaging. To bridge the gap between basic biomedical and human imaging research, in the present study we utilized the awake animal imaging approach established in our lab to evaluate an animal model of post-traumatic stress disorder. We revealed long-lasting impairment of RSFC within the amygdala-mPFC circuit and heightened anxiety level assessed by behavioral measurement after a single-episode predator odor exposure.

                    0166.   BOLD Alterations in Schizophrenia: Spectral Changes in Resting-State fMRI Signal

ISMRM_MagnaLogo.jpg                                 Chen-Yuan Kuo1, Tsuo-Hung Lan1, Changwei W. Wu2, Kun-Hsien Chou3, Chun-Yi Lo3, Ching-Po Lin3

                                1Institution of Brain Science, National Yang-Ming University, Taipei, Taiwan; 2Graduate Institute of Biomedical Engineering, National Central University, Taoyuan, Taiwan; 3Institution of Neuroscience, National Yang-Ming University, Taipei, Taiwan


Schizophrenia is a complex mental illness, including the disorganize of thinking, behavior, and cognition. Recent study showed that functional abnormality of thalamus could be one of the underlying mechanisms in schizophrenia, and such conjecture can be further investigated using the resting-state fMRI technique. In this project, we examined the spectral distributions in the resting-state fMRI signals and conducted the comparison between schizophrenia patients and normal control. We discovered that spectral specificity exhibited in low-frequency oscillations of thalamus between the two groups, providing further evidence to study the functional alterations in schizophrenia.

                    0167.   Accounting for Arterial Transit Delays Is Crucial for Identifying Functional Connectivity Networks: A Resting-State fMRI Study of the Default Mode Network in Moyamoya Disease Patients

                                Hesamoddin Jahanian1, Thomas Christen1, Michael E. Moseley1, Greg Zaharchuk1

                                1Stanford University, Department of Radiology, Stanford, CA, United States


In an effort to investigate the effects of regional arterial arrival delays on identification of resting state functional connectivity networks, we studied the default mode network in a group of Moyamoya patients and compared it with normal healthy volunteers. We found that in the presence of significant delays, using standard seed-based method or independent component analysis (ICA), may lead to erroneous identification of functional connectivity networks. To solve this issue, we also propose a modified version of seed-based analysis method that accounts for the transit delays. Our results indicate that accounting for transit delays is crucial for analyzing the rsfMRI data in Moyamoya patients.

                    0168.   DMN Functional Connectivity Changes Previous to Clinical Diagnosis of Alzheimer's Disease

ISMRM_MagnaLogo.jpg                                 Eva Manzanedo1, Alexandra Cristobal1, Daniel García Frank1, Elena Molina Molina2, Ana Beatriz Solana, 23, Norberto Malpica1, Juan Álvarez-Linera4, Juan Antonio Hernández Tamames2, 4

                                1Universidad Rey Juan Carlos, Móstoles, Madrid, Spain; 2CTB, Madrid, Spain; 3General Electric, Munich, Germany; 4Fundación Reina Sofía, Madrid, Spain


DMN functional connectivity differences between healthy subjects with significantly different normalized hippocampal volume (NHV) are analyzed in this work. Two groups of 25 subjects have been extracted out of the 632 subjects based on the NHV. A connectivity decrease in the DMN is statistically significant in the group of subjects with lower NHV. Considering that these subjects are more prone to develop AD, we have corroborated that DMN functional changes are an early biomarker for AD, which happen at the same time as structural changes, or maybe even before, because no structural changes in DMN areas have been appraised yet.


ISMRM_MagnaLogo.jpg                     0169.   Changes in Anatomical and Functional Connectivity Related to Lower Hippocampal Volume

                                José Angel Pineda Pardo1, 2, Miguel Molina2, Alexandra Cristobal2, Eva Manzanedo2, Francisco del Pozo1, Juan Álvarez-Linera2, Juan Antonio Hernández-Tamames2

                                1Laboratory of Neuroimaging, Center for Biomedical Technology, Pozuelo de Alarcón, Madrid, Spain; 2Laboratory of Neuroimaging, Fundación CIEN-Fundación Reina Sofía, Madrid, Spain


Hippocampal atrophy is an early biomarker of Alzheimer's. According to this, we defined two groups of healthy elderly subjects with a normalized hippocampal volume (NHV) located at the top and bottom of the population distribution. We built structural networks using deterministic tractography and functional networks through fMRI correlations. The networks were compared between groups using a Wilcoxon test. In the higher NHV group we found higher anatomical connections between hippocampus and temporal cortices, and lower functional connections between entorhinal and cingulate cortices. The lower SC might be representative of an upcoming neurodegenerative process, being the higher FC a compensatory mechanism.

                    0170.   Disrupted Intra- And Extra- Amygdaloid Effective Connectivity in Presence of Early Life Stress

                                Karthik R. Sreenivasan1, Merida M. Grant2, Kimberly H. Wood3, Muriah Wheelock3, Joshua R. Shumen3, Richard C. Shelton2, David C. Knight3, Gopikrishna Deshpande1, 4

                                1AU MRI Research Center, Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States; 2Department of Psychiatry and Behavioral Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, United States; 3Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, United States; 4Department of Psychology, Auburn University, Auburn, AL, United States


Although we know that presence of early life stress (ELS) modulates amygdala activity, it is unclear if the amygdala connectivity is affected and which amygdala nuclei cause these differences. In this study we perform effective connectivity analysis of fMRI data obtained from healthy controls with and without history of ELS. The analysis showed increased connectivity from right central nucleus and also enhanced amygdala connectivity in participants exposed to ELS. Our results showed intra- and extra- amygdaloid connectivity disruptions in the presence of ELS which could play a major role in understanding disorders caused by altered fear circuitry.

                    0171.   How the Cleaning of Resting State fMRI Data Affects the Detection of Functional Connectivity Alterations in Alzheimer's Disease

                                Ludovica Griffanti1, 2, Ottavia Dipasquale1, 2, Maria Marcella Laganà1, Raffaello Nemni1, 3, Mario Clerici1, 3, Stephen Smith4, Giuseppe Baselli2, Francesca Baglio1

                                1IRCCS, Fondazione don Carlo Gnocchi, Milano, Milan, Italy; 2Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy; 3Physiopatholgy Department, Università degli Studi di Milano, Milan, Italy; 4FMRIB (Centre for Functional MRI of the Brain), Oxford University, Oxford, United Kingdom

                                -An effective cleaning of resting state fMRI data should remove only inter-subject variability due to the artefacts, preserving the ability to capture between-subject variability of interest (e.g. healthy subjects vs patients). We compared four data-driven cleaning procedures on data relative to elderly healthy subjects and Alzheimer's disease (AD) patients, evaluating BOLD signal fluctuation reduction after cleaning and functional connectivity of the default mode network (DMN) on cleaned and uncleaned data. Our results showed that, among the tested methods, FMRIB’s ICA-based Xnoiseifier (FIX) was the most effective approach in detecting the typical DMN functional connectivity alterations in AD.



Electronic Power Poster Session: Functional Connectivity: Clinical & Pre-Clinical

Traditional Poster Hall     17:30-18:30                           (no CME credit)                                       


MR Safety

Space 2                                16:30-18:30                                                                                               Moderators: Ingmar Graesslin, Dipl.-Ing. & Cornelis A. T. van den Berg, Ph.D.

16:30           0172.   Radiofrequency Heating During Body Imaging in a 3T Body Coil and Patient Safety

                                Devashish Shrivastava1, Jinfeng Tian1, John Hughes1, J Thomas Vaughan1

                                1University of Minnesota, Minneapolis, MN, United States


In vivo radiofrequency (RF) heating was simulated by solving the first principles based generic bioheat transfer model (GBHTM) in a digital pig due the power deposition from a 3T body coil. The simulations were validated by measuring the heating using fluoroptic probes in anesthetized swine due to the whole-body average power deposition of 2.77 W/kg for an hour in a 3T scanner. The GBHTM predicted the RF heating accurately. The simulations and measurements provided fundamental understanding of the RF energy transport and related heating in vivo to make MRI more powerful as well as improve patient safety.

16:42           0173.   Cerebral Tissue Contrast Is Mostly Preserved in Low SAR Inversion Recovery MRI for Parkinson’s Patients with Deep Brain Stimulators

                                Subhendra N. Sarkar1, Ron L. Alterman2, Efstathios Papavassiliou2, Douglas L. Teich1, Rafael Rojas1, Rafeeque A. Bhadelia1, Jeremy Stormann1, Ines Cabral-Goncalves1, David B. Hackney1

                                1Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, BOSTON, MA, United States; 2Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, BOSTON, MA, United States


Treatment efficacy for deep brain stimulators (DBS) in medically refractory Parkinson’s is high when surgical planning and further assessments are done by high quality MRI with adequate RF power although there exist severe SAR restrictions for that. Sentinel events after MRI seems rare but neurologic deficits previously attributed to surgery could have been from routine MRI. We have developed and tested the utility of a modified FSTIR sequence within low SAR guidelines on patients with DBS and observed similar tissue contrasts from the low and high SAR sequences with low SAR images being equally useful for diagnosis and neurosurgical planning.

16:54           0174.   Reduced Heating of Implanted Electrical Conductors Using Parallel Radiofrequency Transmission

ISMRM_MagnaLogo.jpg                                 Clare McElcheran1, Laleh Golestanirad2, Simon Graham, 12

                                1Medical Biophysics, University of Toronto, Toronto, ON, Canada; 2Sunnybrook Health Science Centre, Toronto, ON, Canada


Deep Brain Stimulation (DBS), a treatment for movement disorders (eg Parkinson’s Disease) consists of leads and electrodes that send electrical impulses to deep brain nuclei.  During MRI, the electric field (E) created by radiofrequency (RF) excitation couples with the leads, amplifies E, and can cause dangerous heating of nearby tissues.  Parallel RF transmission (PTX) is investigated to suppress heating by varying the amplitude and phase of each transmit element.  In an 8-element PTX with a uniform cylindrical phantom, E is reduced 97% compared to a linear birdcage transmitter, with <10% transmit magnetic field inhomogeneity in the chosen field of view.

17:06           0175.   Comprehensive RF Safety Concept for Parallel Transmission MR

                                Ingmar Graesslin1, Peter Vernickel1, Peter Börnert1, Kay Nehrke1, Giel Mens2, Paul Harvey2, Ulrich Katscher1

                                1Philips Research Laboratories, Hamburg, Germany; 2Philips Healthcare, Best, Netherlands


Achieving RF patient safety in parallel transmission is difficult, due to the freedom in tailoring the RF transmit fields. Before and during the scan, its conformity with existing SAR limits has to be verified to ensure patient safety. We developed, implemented, and verified a new comprehensive RF patient-safety-supervision concept that combines real-time global SAR and local SAR supervision with real-time RF supervision. This new concept allows for a significantly increased permissible RF duty cycle, improves the detection of SAR limit violations and patient-unsafe conditions, and reduces the number of false-positive scan interruptions.

17:18           0176.   Safety of Tattoos in MRI: An Interim Report on a Prospective Study

                                Nikolaus Weiskopf1, David Bradbury1, Sheila Burns1, Janice Glensman1

                                1Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom


Only few studies are published on the safety of tattoos in MRI. We present an interim report on a prospective study on all healthy volunteers with tattoos who were scanned at our lab. From our sample of 127 volunteers the probability of a tattoo related adverse reaction is estimated to be lower than 4.5% when additional precautions are applied. Although this is the first prospective study on this topic avoiding several potential confounds of previous studies, the particular sample and conditions studied may still limit general conclusions.


17:30           0177.   En Route to Ultrahigh Field Cardiac MR in Patients: RF Safety Assessment of Intracoronary Stents at 7.0 T Using Numerical Simulations and E-Field Measurements

                                Eva Oberacker1, Lukas Winter1, Frank Seifert2, Jaroslav Marek1, Gerd Weidemann2, Eugen Hofmann3, Thoralf Niendorf1, 4

                                1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany; 2Physikalisch Technische Bundesanstalt, Berlin, Germany; 3Biotronik AG, Bülach, Switzerland; 4Experimental and Clinical Research Center, a cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany


This work performs a careful safety evaluation of RF induced heating of coronary stents including electromagnetic (EM) simulations and E-field measurements. Complex electromagnetic field coupling is investigated depending on stent type, length, location, orientation, vessel diameter and RF coil used. Electromagnetic (EM) and thermal simulations were performed in phantoms and human voxel models and validated in ASTM phantom measurements. The results are transferrable to various RF coil designs and may be utilized to estimate safe RF exposure levels for SAR personalized UHF-MR exams including patients with intracoronary and other vascular stent implants.

17:42           0178.   A Simulation Based Validation of a PTx Pulse Design Strategy Using Implant-Friendly Modes for Patients with DBS Implants

ISMRM_MagnaLogo.jpg                                 Yigitcan Eryaman1, 2, Bastien Guerin2, Can Akgun3, Joaquin L. Herraiz1, Adrian Martin1, 4, Angel Torrado-Carvajal1, 5, Norberto Malpica1, 5, Juan A. Hernandez-Tamames1, 5, Emanuele Schiavi1, 4, Elfar Adalsteinsson6, 7, Lawrence L. Wald2, 7

                                1Madrid-MIT M+Vision Consortium in RLE, MIT, Cambridge, MA, United States; 2Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Charlestown, MA, United States; 3Invenshure, MN, United States; 4Dept. of Applied Mathematics, Rey Juan Carlos University, Madrid, Spain; 5Dept. of Electronic Technology, Rey Juan Carlos University, Madrid, Spain; 6Dept. of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States; 7Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States


We present a pulse design strategy that can be used to safely scan patients with implants. Our strategy is based on utilizing implant friendly modes which are defined as the modes of an array that cancel the local SAR around the implant lead tip. We performed EM simulations using a multi-tissue realistic head model with a generic deep brain stimulator implant. As a result of the pulse design, local SAR at the lead tip is reduced below SAR limits. A uniform axial flip angle distribution is obtained.

17:54           0179.   SAR Optimised Local B1+ Shimming for Cardiac Imaging at 3T – a Multi-Model Study

ISMRM_MagnaLogo.jpg                                 Arian Beqiri1, Francesco Padormo1, 2, Jeff W. Hand1, Joseph V. Hajnal1, 2, Shaihan J. Malik1

                                1Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom; 2Centre for the Developing Brain, King's College London, London, United Kingdom


Cardiac imaging at high field suffers from image quality issues due to greater B1+ inhomogeneities and is frequently limited by SAR, which constrains the speed at which scans can be run without exceeding regulatory limits. By using parallel transmission MRI, we demonstrate the ability to significantly reduce SAR whilst simultaneously improving B1+ homogeneity in order to optimise imaging over the cardiac region for two differently sized subjects. We also show the effects of selecting the wrong SAR model for each subject.


18:06           0180.   Temperature Measurements of Deep Brain Stimulator Lead Tip in Phantom with MR Body Coil RF Transmit

                                Robert A. Pooley1, Krzysztof R. Gorny2, Christopher P. Favazza2, Joel P. Felmlee2, Chen Lin3, Matt A. Bernstein2, Robert E. Wharen4

                                1Radiology, Mayo Clinic, Jacksonville, FL, United States; 2Radiology, Mayo Clinic, Rochester, MN, United States; 3Radiology and Imaging Science, IU School of Medicine, Indianapolis, IN, United States; 4Neurosurgery, Mayo Clinic, Jacksonville, FL, United States


Temperature measurements were made in a phantom at the tip of a deep brain stimulator lead. The DBS components were arranged in various configurations and scanned at high and low SAR with body coil transmit. The temperature increase for the lead only and lead + insertion stylet was in the range of 0.5 - 3.2C at high SAR and < 0.1C at low SAR. The full DBS system resulted in heating of 14.4C at high SAR and 0.25C at low SAR. There is increasing interest in evaluating heating of leads with body coil RF transmit, which is contraindicated.

18:18           0181.   Virtual Tissue Electrical Properties: A New Concept for Fast, Robust Local SAR Estimation Based on B1 Measurement

ISMRM_MagnaLogo.jpg                                 Xiaotong Zhang1, Pierre-Francois Van de Moortele2, Jiaen Liu1, Sebastian Schmitter2, Bin He1, 3

                                1Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States; 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States; 3Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN, United States


It has been shown that Electrical Properties (EPs) of biological tissues can be derived from MR-based B1 measurement. A strong appeal for these ‘Electrical Property Tomography’ (EPT) methods is to predict in real-time on a per-subject basis local SAR induced by RF pulsing. To reduce error propagation along the reconstruction, we eliminate the need for computing EPs by introducing the concept of ‘virtual tissue EPs’ (VEPs), tailored to provide max local SAR estimation based on measured B1 maps, with a safety margin. We evaluate the concept on electromagnetic models (EM) and in-vivo data of head imaging at 7T.

Myocardial Tissue Characterization

Space 3                                16:30-18:30                                                                                               Moderators:Jeanette Shulz-Menger, M.D. & Richard B. Thompson, Ph.D.

16:30           0182.   Correlation Between Cardiovascular T1ρ MRI, Histology and Future Ventricular Remodeling in Ischemic Heart Disease.

                                Walter RT Witschey1, Jeremy R. McGarvey1, Madonna Lee1, Francisco Contijoch2, Victor Ferrari3, Yuchi Han3, Julio A. Chirinos3, Chikashi Aoki1, Satoshi Takebayashi4, Joseph H. Gorman III1, James J. Pilla4, Robert C. Gorman1

                                1Surgery, University of Pennsylvania, Philadelphia, PA, United States; 2Bioengineering, University of Pennsylvania, Philadelphia, PA, United States; 3Cardiology, University of Pennsylvania, Philadelphia, PA, United States; 4Radiology, University of Pennsylvania, Philadelphia, PA, United States


T1rho MRI has been shown to detect myocardial fibrosis and has potential to be used as a biomarker for heart disease. The progression of T1rho relaxation times in inflammation, wound healing and scar have been reported for direct ligation animal models, mimicking only the most severe types of human ischemic heart disease. Our objective was to determine the relationship between T1rho relaxation times and pathology, at 1 day, 1 and 4 weeks post-infarction in an ischemia-reperfusion pig model. We found that there was a significant increase in T1rho relaxation times at 1 week in pigs and this was indicative of future ventricular remodeling. There was excellent correlation between T1rho MRI-determined infarction area, coronary artery perfusion watershed and fibrosis.

16:42           0183.   Chronic Myocardial Infarctions Can Be Reliably Characterized Using Contrast-Free T1 Mapping at 3T

ISMRM_SummaLogo.jpg                                 Avinash Kali1, 2, Ivan Cokic1, Richard Tang1, Hsin-Jung Yang1, 2, Behzad Sharif1, Eduardo Marbán1, Debiao Li1, 3, Daniel Berman3, 4, Rohan Dharmakumar1, 5

                                1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Department of Bioengineering, University of California, Los Angeles, CA, United States; 3Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 4Department of Medicine, University of California, Los Angeles, CA, United States; 5Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States


We tested whether contrast-freeT1 maps at 3T can detect chronic MIs (CMI) with high diagnostic accuracy relative to Late Gadolinium Enhancement (LGE) images in a canine model. At 3T, T1 maps showed no difference in infarct size (IS) and transmurality (IT) relative to LGE images in CMI, but overestimated IS and IT in AMI. At 1.5T, T1 maps underestimated IS and IT relative to LGE images in AMI and CMI. Relative to the remote territories, T1 of the infarcted myocardium was elevated in AMI and CMI at 3T and 1.5T. Contrast-free T1 maps can reliably characterize CMIs at 3T relative to LGE images.


16:54           0184.   Noninvasive Assessment of Myocardial Fibrosis Using Cardiovascular Magnetic Resonance (CMR) T1rho-Mapping Techniques in End-Stage Renal Disease (ESRD) Hemodialysis Patients

ISMRM_SummaLogo.jpg                                 Lin Wang1, Shijun Zhang1, Yixiang Wang2, Shenghong Ju1

                                1Radiology, Zhongda Hospital, Nanjing, Jiangsu, China; 2Prince of Wales Hospital, the Chinese University  of Hong Kong, Hong Kong, China


Autopsy studies demontstrated that the typical pathologic characteristic of the myocardium of End-Stage Renal Disease (ESRD) hemodialysis patients was left ventricular hypertrophy (LVH) and diffused collagen and fibrosis deposition in extracellular matrix. Due to the contraindication of the contrast medium of this kind of patients, the myocardial fibrosis is hardly evaluated with current modalities. The purpose of this study was to determine whether T1rho imaging can be used as a noninvasive method with no contrast enhancement to detect myocardial fibrosis in ESRD maintained on hemodialysis patients.

17:06           0185.   Characterization of Late Gadolinium Enhancement Heterogeneity in Hypertrophic Cardiomyopathy Using Quantitative Texture Analysis

                                Rebecca E. Thornhill1, 2, Myra Cocker3, Girish Dwivedi3, 4, Carole Dennie1, 2, Lyanne Fuller3, Alexander Dick3, 4, Terrence Ruddy3, 4, Elena Pena-Fernandez1, 2

                                1Medical Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada; 2Radiology, University of Ottawa, Ottawa, Ontario, Canada; 3University of Ottawa Heart Institute, Ottawa, Ontario, Canada; 4Medicine, University of Ottawa, Ottawa, Ontario, Canada


Late gadolinium enhanced MRI (LGE) can assess the presence and extent of fibrosis in hypertrophic cardiomyopathy (HCM), which is associated with the development of arrhythmias and sudden cardiac death. One of the challenges is how best to describe LGE patterns in HCM, as enhancement may appear subtle or heterogeneous in distribution. Texture analysis was applied to quantify gray-level heterogeneity metrics in both HCM patients and healthy volunteers. These features were significantly elevated in patients with HCM, even in non-hypertrophic, non-fibrotic segments (ie, normal appearing), compared to healthy volunteers. Thus, textural features show potential for markers of cardiomyopathic changes in HCM.

17:18           0186.   3D-QALAS: Full 3D Myocardial T1 and T2 Quantification in a Single Breath-Hold

                                J.B.M. Warntjes1, 2, S. Kvernby1, 2, C.J. Carlhäll1, 2, J. Engvall1, 2, T. Ebbers1, 2

                                1Center for Medical Image Science and Visualisation, Linköping, Östergötland, Sweden; 2Department of Medical and Health Sciences, Division of Cardiovascular Medicine, Linköping, Östergötland, Sweden


A single breath-hold 3D method was developed for simultaneous quantification of the T1 and T2 relaxation time over the complete myocardial volume. T1 and T2 maps of 13 slices were acquired in 15 heart-beats. The method was based on a 3D cardiac triggered, interleaved Look-Locker sequence, combined with T2 prep pulses. The measured T1 and T2 values correlated well with T1 and T2 measurements using other methods such as inversion recovery and multi-echo CPMG.


17:30           0187.   Quantification of Diffuse Myocardial Fibrosis and Its Association with Diastolic Dysfunction in Patients with Diastolic Heart Failure Using Cardiovascular Magnetic Resonance

                                Mao-Yuan Marine Su1, Lian-Yu Lin2, Chin-Chen Chang1, Yao-Hui Elton Tseng1, Cho-Kai Wu2, Jiunn-Lee Lin2, Wen-Yih Isaac Tseng, 13

                                1Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; 2Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 3Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan


This study investigated whether the diastolic dysfunction of left ventricular (LV) was associated with diffuse myocardial fibrosis in patients with diastolic heart failure (DHF). Forty patients with DHF, 27 patients with systolic heart failure (SHF) and 22 patients without heart failure (control) were studied using cardiovascular magnetic resonance. Patients with SHF and DHF both showed increased diffuse myocardial fibrosis and decreased diastolic function as compared to controls. Correlation analysis demonstrated that the extracellular volume fraction (ECV) was significantly correlated with systolic and diastolic function in DHF. There was no significant correlation between ECV and the other functional indices in SHF and non-HF controls. Our findings support that increased diffuse myocardial fibrosis may impair the diastolic function but also affect the systolic function in patients with DHF.

17:42           0188.   Impact of the Connective Tissue Matrix in the Myocardium on the Restriction of Water Revealed with Diffusion Tensor MRI of a Decellularized Human Heart

                                Choukri Mekkaoui1, Marcel P. Jackowski2, Sava Sakadzic3, Christian T. Stoeck4, Timothy G. Reese3, Sebastian Kozerke, Harald C. Ott5, David E. Sosnovik6

                                1Harvard Medical School - Massachusetts General Hospital, Boston, MA, United States; 2Department of Computer Science, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil; 3Athinoula A Martinos center for Biomedical imaging, Boston, United States; 4Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 5Massachusetts General Hospital, Boston, United States; 6Harvard Medical School - Massachusetts General Hospital, Boston, United States


The myocardium consists of a branching network of muscle fibers and a supporting network of connective tissue fibers, whose relative contributions to diffusion restriction remain unknown. We performed high-resolution DTI and two-photon microscopy of a decellularized human heart and compared the findings with normal human hearts and patients with recent myocardial infarction. Diffusion in the decellularized heart was minimally restricted, despite a fairly dense, ordered and anisotropic collagen network. Diffusion restriction in the myocardium thus reflects its cellular components with little impact from the connective tissue network at commonly-used b-values.

ISMRM_MagnaLogo.jpg 17:54           0189.   Preliminary Application of In Vivo Cardiac Diffusion Weighted MRI at 3T in Chronic Myocardial Infarction Porcine Model

                                Christopher Nguyen1, 2, Yibin Xie1, 2, Zhaoyang Fan1, Behzad Sharif1, James Dawkins3, Eleni Tseliou3, Xiaoming Bi4, Rohan Dharmakumar1, Eduardo Marban3, Debiao Li1, 2

                                1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Bioengineering, University of California Los Angeles, Los Angeles, CA, United States; 3Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 4MR R&D, Siemens Healthcare, Los Angeles, CA, United States


Using a chronic myocardial infarction (MI) pig model, we demonstrated that motion compensated cardiac diffusion-prepared turbo-spin echo was able to reveal statistically significant increases (~50%) in trace apparent diffusion coefficient (trADC) in late gadolinium enhanced (LGE)-defined chronic MI regions. Because the infarcted region is akinetic, bulk motion corruption would have resulted in a decrease in trADC, which is opposite to the expected and reported increase in trADC. Furthermore, the agreement in trADC-defined MI location and area with LGE-defined MI regions suggests that the proposed technique delineated infarct tissue. This may potentially allow for non-contrast tissue characterization of chronic MI.

18:06           0190.   Cardiac MR Elastography: Estimation of Myocardial Stiffness Throughout Cardiac Cycle as a Function of Age

                                Peter A. Wassenaar1, Chethanya N. Eleswarpu1, Richard D. White1, Arunark Kolipaka1

                                1Radiology, The Ohio State University, Columbus, OH, United States


Myocardial stiffness has been a significant biomarker for various cardiovascular disease processes, such as myocardial infarction, hypertension, diastolic dysfunction and tissue rejection in heart transplant patients. Pressure/volume based techniques are commonly used to measure left ventricular chamber stiffness, but are limited to global measurements, are invasive, and do not provide true intrinsic properties of the myocardium. Recently, Cardiac MR Elastography was used to estimate stiffness of the myocardium. In this study, a retrogated, multi-phase MRE sequence was developed and used to measure LV myocardial stiffness across the cardiac cycle as a function of age in healthy subjects.

18:18           0191.   Monitoring the Efficacy and Retention of Collagen I-Matrigel for Treating Myocardial Infarction

                                Marloes Marteijn1, Carlijn CV Bouten2, Klaas Nicolay1, Gustav J. Strijkers1

ISMRM_SummaLogo.jpg                                 1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2Soft Tissue Biomechanics & Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands


Hydrogels have the potential to improve cardiac function after myocardial infarction (MI). Furthermore, hydrogels can be used to improve cell engraftment in case of stem cell therapy post-MI. In this study, we investigated the efficacy and retention of collagen I-Matrigel after intramyocardial injection post-MI in a mouse model by applying multiple in vivo cardiac MRI techniques. Here, we show that collagen I-Matrigel treatment resulted in a temporary increased cardiac function post-MI, but also provoked an enhanced edema and/or inflammatory response in the cardiac tissue surrounding the collagen I-Matrigel as indicated by T2-mapping as well as by histology.


Molecular Imaging: New Agents & New Targets

Silver                                    16:30-18:30                                                                                               Moderators: Christian T. Farrar, Ph.D. & Michael T. McMahon, Ph.D.

16:30           0192.   Manganese(II)-Block Copolymer Complexes and Their Use for MRI of Biological Processes

ISMRM_MagnaLogo.jpg                                 Nikorn Pothayee1, Der-Yow Chen1, Maria Aronovo2, Chunqi Qian1, Richard Leapman2, Alan Koretsky1

                                1Laboratory of Functional and Molecular Imaging, NINDS, NIH, Bethesda, MD, United States; 2Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, NIH, Bethesda, MD, United States


In this work,we describe a ‘one-pot’ and aqueous-based preparation of paramagnetic metal ion-block copolymer complexes for potential use as MRIcontrast agent. The pH-sensitive nature of soft particles was exploited in response to neuronal uptake and subsequent transport of Mn ions, which can be visualized by MRI.

16:42           0193.   Targeted MRI In Vivo by Hyperpolarized Silicon Nanoparticles

                                Jingzhe Hu1, Maja Cassidy2, Nicholas Whiting3, Pamela Constantinou4, Niki Zacharias Millward3, David Volk5, David Gorenstein5, Daniel Carson4, Charles Marcus6, Pratip Bhattacharya3

                                1Cancer Systems Imaging, The University of Texas, MD Anderson Cancer Center, Houston,, TX , United States; 2Kavli Institute of Nanoscience, Delft University of Technology, Delft, Netherlands; 3Cancer Systems Imaging, The University of Texas, MD Anderson Cancer Center, Houston,, TX, United States; 4Biochemistry and Cell Biology, Rice University, Houston, TX, United States; 5Institute of Molecular Medicine and Department of NanoMedicine and Biomedical Engineering, The University of Texas Health Science Center at Houston, Houston, TX, United States; 6Center for Quantum Devices, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark


Nanomedicine is an emerging field that offers great promise in the development of non-invasive strategies for the diagnosis and treatment of disease. Hyperpolarized silicon nanoparticles are one such material that has emerged as a platform technology for targeting that may suit a wide range of potential applications. They can be easily surface functionalized, are biocompatible and biodegradable and has opened up the possibility of performing in vivo targeted MRI in real time with over 10,000 fold sensitivity enhancement via dynamic nuclear polarization (DNP).


16:54           0194.   In Vivo  Overhauser-Enhanced MRI of Proteolytic Activity

ISMRM_MagnaLogo.jpg                                 Neha Koonjoo1, Elodie Parzy1, Philippe Massot1, Matthieu Lepetit-Coiffé1, 2, Sylvain R.A Marque3, Jean-Michel Franconi1, Eric Thiaudiere1, Philippe Mellet1, 4

                                1Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS, University Bordeaux Segalen, Bordeaux, France, Metropolitan; 2Siemens France, Saint-Denis, France, Metropolitan; 3UMR 7273 Aix-Marseille Université, Marseille, France, Metropolitan; 4University Bordeaux Segalen, INSERM, France, Metropolitan


Proteolysis of a nitroxide-labeled macromolecule was detected in the intestinal tract of living mice by Overhauser-enhanced MRI. Using an Overhauser-effect switch, namely a nitroxide with an unpaired electron bound to the macromolecule, here elastin, Overhauser enhancement was generated only after the protein carrier was digested. A high signal enhancement indicated elastin proteolysis by pancreatic elastase secreted in the duodenum. Highly resolved 3D keyhole OMRI images of resolution 0.5mm3 were acquired with a fully balanced steady state sequence – TrueFISP at 0.2T (Magnetom Open Viva Siemens) in 18 seconds. This current research is a step towards in vivo pathology-related proteolysis detection.

17:06           0195.   Nature-Inspired Nanoformulations for Contrast-Enhanced In Vivo MR Imaging of Macrophages

                                Alexander B. Sigalov1

                                1SignaBlok, Inc., Shrewsbury, MA, United States


Macrophage imaging has important diagnostic and prognostic value in cardiology, oncology and other diseases. Nanoparticles that mimic native high density lipoproteins (HDL) are a versatile delivery platform for Gd-based MRI contrast agents (GBCA) but require targeting moieties to direct the particles to macrophages. In this study, using in vivo MRI, immunohistology and confocal fluorescence microscopy, we show that a naturally occurring modification of apo A-I in GBCA-HDL targets the particles to intraplaque macrophages in an apo E-deficient atherosclerotic mouse. Synthetic apo A-I peptides were demonstrated to functionally replace native apo A-I in these contrast agents, encouraging their further development.

17:18           0196.   Relaxometry of Bacterially Derived Organelles: A Novel Class of MRI Contrast Agent for Cell Labeling and Tracking

ISMRM_MagnaLogo.jpg                                 Kimberly Brewer1, Rehan Ali2, James A. Rioux1, Sui Seng Tee1, Alexey Bazarov2, Suleyman Felek2, Caleb Bell2, Brian K. Rutt1

                                1Radiology, Molecular Imaging Program, Stanford University, Stanford, CA, United States; 2Bell Biosystems Inc, Palo Alto, CA, United States


Bacterial-derived pseudo-organelles, “Magnelles®”, were recently developed as a novel, magnetite-based MRI contrast agent. Since Magnelles were derived from magnetotactic bacteria, they have the ability to self-replicate, making them interesting candidates for labeling and longitudinal evaluation of cells. This is crucial for applications such as evaluation of stem cell and other cell-based therapies. We characterized the MRI relaxivity properties (both r1 and r2) of Magnelles, their cell loading and ex vivo imaging characteristics using a model breast cancer cell line. Magnelles were found to have similar r2 relaxivity values to conventional SPIO agents and demonstrated strong MR contrast for implanted cells.

17:30           0197.   Anthranilic Acid Analogues as Uncommonly Shifted HYdrogen Bonded (U SHY) Diamagnetic CEST (DiaCEST) MRI Contrast Agents Based on the N-H Exchange

ISMRM_MagnaLogo.jpg                                 Xiaolei Song1, 2, Xing Yang1, Sangeeta Ray Banerjee1, Martin G. Pomper1, 3, Michael T. McMahon1, 2

                                1The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Institute for Nanobiotechnology, The Johns Hopkins University, Baltimore, MD, United States


Diamagnetic chemical exchange saturation transfer (diaCEST) agents form a new class of imaging agents with unique magnetic resonance properties.  Here we present a series of anthranilic acid analogues as examples of Uncommonly Shifted HYdrogen-bonded (U SHY) diaCEST agents, which produce significant and tunable contrast between 4.8 - 9.3 ppm from water. Five of these analogues, N-sulfonyl anthranilic acids, are highly soluble and produce strong CEST contrast. We also discovered that flufenamic acid, a commercial non-steroidal anti-inflammatory drug, displays CEST contrast at 4.8 ppm. These N-H U SHY agents, with contrast insensitive to pH, are complementary to existing diaCEST probes.

17:42           0198.   MR Molecular Imaging of Breast Cancer Metastases with Peptide Targeted Tripod Macrocyclic Gd(III) Chelates

                                Zhuxian Zhou1, Mohammed Qutaish1, David L. Wilson1, Zheng-Rong Lu1

                                1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States


MRI is a powerful medical imaging modality for the detection and characterization of diseased soft tissues such as solid tumors. MR molecular imaging has a great potential for detection and characterization of metastatic breast cancer if a suitable molecular target can be identified. However, currently available targeted contrast agents could not generate sufficient contrast enhancement for molecular MRI of the biomarkers on cancer cell surface due to low concentration of the biomarkers and low sensitivity of MRI. The extracellular matrix of malignant tumors has abundant accumulation of fibrin-fibronectin complexes that can be used as a suitable biomarker for effective molecular MRI of small breast cancer metastases. CREKA is a tumor-homing pentapeptide (Cys-Arg-Glu-Lys-Ala) specifically homes to tumors by binding to fibrin and fibronectin associated plasma protein clots in tumor stroma. Here, we synthesized and evaluated a tumor-targeted contrast agent CREKA-Tris(Gd-DOTA)3 for MR molecular imaging of breast cancer metastases.

17:54           0199.   Towards Early Detection of Pancreatic Cancers by CA19-9 Conjugated Magnetic Nanoparticles and Active Feedback MR

ISMRM_SummaLogo.jpg                                 Zhao Li1, Chaohsiung Hsu1, Vay Liang W. Go2, Yung-Ya Lin1

                                1Chemistry and Biochemistry, UCLA, Los Angeles, CA, United States; 2UCLA Center for Excellence in Pancreatic Diseases, UCLA, Los Angeles, CA, United States


Early detection of pancreatic cancers using enhanced MRI techniques increases not only the treatment options available, but also the patients’ survival rate. This can be achieved with antibody-conjugated superparamagnetic iron oxide (SPIO) nanoparticles capable of binding to early stage pancreatic cancer cells to improve imaging specificity and innovation methods that can sensitively detect SPIO to improve imaging sensitivity. The enhanced contrast from SPIO can then be used to visually assess the distribution and magnitude of SPIO-targeted tumor cells. In vivo subcutaneous and orthotopic xenografts mouse models validated the superior contrast/sensitivity and robustness of this approach towards early pancreatic cancers detection.


18:06           0200.   PARASHIFT Contrast Agents - A New Approach for Molecular Imaging by MRI

                                Ian Wilson1, Peter Harvey2, Katie-Lousie Finney2, Alexander M. Funk2, P Kanthi Senanayake2, Ross J. Maxwell1, David Parker2, Andrew M. Blamire3

                                1Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom; 2Dept of Chemistry, Durham University, Durham, United Kingdom; 3Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom


A new class of contrast agents are demonstrated which present new opportunities for molecular imaging by MRI. By placing a tert-Butyl reporter group at a controlled distance from a lanthanide ion, the dipolar interaction gives rise to a frequency shifted reporter resonance with short T1 which can be directly detected in vivo without contamination from endogenous water or fat signal and with good sensitivity.  These agents are denoted PARASHIFT  agents.  An example of in vivo detection of a dysprosium based agent is presented.  Comparison of in vivo spectral peak areas against a reference standard suggested that a tissue concentration of 1 micromolar was detectable in a scan duration of only ~3 mins.

18:18           0201.   Simultaneous Detection of Multiple Metal Ions Using a Single 19F-ICEST Probe

                                Amnon Bar-Shir1, 2, Nirbhay N. Yadav1, 3, Assaf A. Gilad1, 2, Peter CM van Zijl1, 3, Michael T. McMahon1, 3, Jeff WM Bulte1, 2

ISMRM_SummaLogo.jpg                                 1Russell H. Morgan Department of Radiology and Radiological Science, the Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Cellular Imaging Section, Institute for Cell Engineering, the Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States


Metal ion levels in biological systems have been extensively studied using optical probes. However, specific detection of low levels of metal ions in vivo using non-invasive methodologies remains a formidable challenge. We present an approach for specifically sensing the presence of Zn2+ and Fe2+ using the single fluorinated chelate TF-BAPTA. By exploiting the dynamic exchange between the ion-bound and free TF-BAPTA, and capitalizing on the different chemical shifts of 19F upon binding of Zn2+ or Fe2+, we were able to detect both ions simultaneously using ion CEST (iCEST) 19F MRI.


Magnetization Transfer

Red 1 & 2                            16:30-18:30                                                                                               Moderators:Seth A. Smith, Ph.D. & Greg J. Stanisz, Ph.D.

16:30           0202.   Quantitative Magnetization Transfer Imaging of Human Sciatic Nerve at 3 Tesla

                                Richard D. Dortch1, 2, Lindsey M. Dethrage2, Ke Li1, 2, Bruce M. Damon1, 2, John C. Gore1, 2, Seth A. Smith1, 2

                                1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 2Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States


Previous work has demonstrated that the macromolecular-to-free proton pool size ratio (PSR) is related to myelin content; yet, no studies have reported PSR mapping in peripheral nerves in vivo. This can be attributed to the challenges of quantitative magnetization transfer (qMT) imaging in nerve, including the influence of fat and the need for higher resolution. The goal of this work was to develop qMT approaches for the currently inaccessible (via electrophysiology) sciatic nerves of healthy controls as a baseline for future studies in neuropathy patients. Our findings demonstrate that PSR can be robustly measured in the sciatic nerve in vivo.

16:42           0203.   Reproducibility of in Vivo Inner and Outer Cortical Magnetisation Transfer Ratio Measurements

                                Rebecca Sara Samson1, Manuel Jorge Cardoso2, 3, Nils Muhlert1, Varun Sethi1, Maria A. Ron1, Sebastian Ourselin2, 3, David H. Miller1, Declan T. Chard1, Claudia A M Wheeler-Kingshott1

                                1NMR Research Unit, Department of Neuroinflammation,  Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom; 2Centre for Medical Image Computing, UCL Department of Computer Sciences, UCL, London, United Kingdom; 3Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom


A previous study suggests that outer cortical magnetization transfer ratio (MTR) has the potential to be a sensitive measure of pathology that is linked to clinical disease progression in relapse-onset multiple sclerosis. However, to determine the utility of the inner and outer cortical MTR measurement method it is important to determine the reproducibility of the technique. Here we demonstrate that inner and outer cortical MTR have coefficients of variation of 1.23% and 0.99% respectively.

16:54           0204.   Magnetization Transfer Ratio (MTR) with a Periodic MT Pulse and Zero Echo Time (ZTE) Acquisition for Imaging White Matter Disease

                                James H. Holmes1, Alexey Samsonov2, Patrick A. Turski2, Aaron S. Field2, Kevin M. Johnson3

                                1Global MR Applications and Workflow, GE Healthcare, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States


We demonstrate the combination of a magnetization transfer (MT) preparation pulse and a zero TE (ZTE) imaging data acquisition. This work shows the potential for a MR ratio (MTR) imaging of white mater disease using an intermittent MT preparation pulse to reduce SAR and scan time. The ZTE acquisition enables visualization of short T2 species while providing the benefit of low acoustic noise to improve patient comfort.

17:06           0205.   Biophysical Abnormalities in Fronto-Striato-Thalamic Circuits in Type 2 Diabetes Revealed by Magnetization Transfer Imaging

                                Shaolin Yang1, 2, Olusola Ajilore1, Minjie Wu1, Melissa Lamar1, Anand Kumar1

                                1Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States; 2Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States


A cross-sectional study using magnetization transfer ratio (MTR) imaging was performed to examine the biophysical integrity of macromolecular protein pools in gray matter and white matter of the fronto-striato-thalamic circuits in patients with type 2 diabetes mellitus (T2DM) and comparison controls to determine the impacts of T2DM on the abnormalities of human brain. Compared with non-diabetic controls, T2DM patients had significantly lower MTR in dorsal anterior cingulate cortex (ACC) and head of caudate nucleus (hCaud), also with a tendency to significance in rostral ACC. The compromised MTRs were correlated with T2DM-related clinical measures and neuropsychological performance in distinct domains.

17:18           0206.   Age-Related Changes of the Bound Pool Fraction in White Matter

ISMRM_MagnaLogo.jpg                                 Lukas Pirpamer1, Florian Franz Erich Borsodi1, Gernot Reishofer2, Christian Langkammer1, Reinhold Schmidt1, Stefan Ropele1

                                1Department of Neurology, Medical University of Graz, Graz, Austria; 2Department of Radiology, Medical University of Graz, Graz, Austria


The bound pool fraction (BPF) is a fundamental parameter for magnetization transfer and therefore expected to be more sensitive for age-related tissue changes compared to the conventional MTR. This study investigated the change of the BPF in several white-matter regions assessed over age in a normal aging cohort. This study confirms the higher sensitivity of the BPF in particular for WM regions that are susceptible for developing age related white matter hyperintensities.

17:30           0207.   Analysis and Optimization of Quantitative Magnetization Transfer Imaging Considering the Effect of Non-Exchanging Component

ISMRM_MagnaLogo.jpg                                 Pouria Mossahebi1, Andrew L. Alexander2, 3, Aaron S. Field1, 4, Alexey A. Samsonov4

                                1Biomedical Engineering, University of Wisconsin, Madison, WI, United States; 2Medical Physics, University of Wisconsin, Madison, WI, United States; 3Waisman Lab for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United States; 4Radiology, University of Wisconsin, Madison, WI, United States


Gray matter demyelination has recently been recognized as an important pathological substrate of MS disease. MT imaging approaches has demonstrated high sensitivity to myelination in white matter.  Its applications to cortical GM characterization, however, we have to take into account additional factors related to anatomical organization of cortical GM such as partial volume effect (PVE) with CSF.  We have proposed a qMT imaging (NE-mCRI) approach that allows isolating a non-exchanging (NE) voxel compartment with distinct relaxation properties such as CSF. In this work, we analyze the effect of NE component on MTR and mCRI parameters and provide results of numerical, phantom and in-vivo validation of the approach as a way to minimize underestimation of qMT measures due to PVE. Additionally, we developed a fast-optimized protocol for in-vivo application of NE-mCRI.


17:42           0208.   High-Resolution Quantitative Magnetization Transfer Imaging of Post-Mortem Marmoset Brain

                                Henrik Marschner1, André Pampel1, Roland Müller1, Nicholas A. Bock2, Marcel Weiss1, 3, Stefan Geyer1, Harald E. Möller1

                                1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Saxony, Germany; 2McMaster University, Ontario, Canada; 3University of Amsterdam, North Holland, Netherlands


We present results of quantitative magnetization transfer imaging (qMTI) in high resolution for quantification of (qMT) parameters of otherwise MR-invisible macromolecules. qMTI was performed on a post-mortem marmoset brain at 3T and the results are compared to T1 mapping results obtained at 7T. The high resolution of 200 µm permits visualization of cortical substructures in the marmoset brain, as presented for the stria of Gennari. An analysis of correlation between the macromolecular pool-size fraction and T1 shows different linear regressions in white and gray matter. This suggests i) different myelination contribution in both contrast parameters, or ii) other contributing factors.

17:54           0209.   Magnetization Transfer from Inhomogeneously Broadened Lines (IhMT): Effect of MT Asymmetry on the IhMT Signal

                                Guillaume Duhamel1, Valentin Prevost1, Gopal Varma2, David C. Alsop2, Olivier Girard1

                                1CRMBM, CNRS 7339, Aix-Marseille Université, Marseille, 13005, France; 2Radiology, Beth Israel Deaconess Med. Center, Harvard Medical School, Boston, MA, United States


A recent MT technique, referred as inhomogeneous MT (ihMT) and able to reveal the inhomogenous component of the MR spectrum has been proposed to specifically image the myelinated structures. Contribution of MT asymmetry effects in the ihMT signal is assessed in this study.


18:06           0210.   Quantitative Magnetization Transfer Imaging of Rodent Glioma Using Selective Inversion Recovery

                                Junzhong Xu1, Ke Li1, Zhongliang Zu1, Xia Li1, Dainel F. Gochberg1, John C. Gore1

                                1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States


This study demonstrates the first implementation of quantitative MT imaging of cancer using selective inversion recovery. In addition, a new SIR-EPI sequence was developed to accelerate the acquisition but retain the fitting accuracy of qMT parameters. The results presented not only assist better understanding of the changes in the macromolecular contents of tumors, but also are important for quantifying other imaging contrasts such as chemical exchange saturation transfer (CEST) of tumors.

18:18           0211.   In-Vivo Quantitative Magnetization Transfer Imaging of De- And Re-Myelination in Cuprizone-Treated Mice and Correlation with Histology

                                Laura Turati1, Fulvio Baggi1, Marco Moscatelli1, Alfonso Mastropietro2, 3, Ileana Zucca2, Alessandra Erbetta4, Chiara Cordiglieri1, Greta Brenna1, Nicholas Dowell5, Renato Mantegazza1, Ludovico Minati, 25, Mara Cercignani5, 6

                                1Neuroimmunology and Neuromuscular Diseases Unit, Neurological Institute "Carlo Besta", Milan, Italy; 2Scientific Department, Neurological Institute "Carlo Besta", Milan, Italy; 3Department of Electronic, Information and Bioengineering, Politecnico of Milan, Milan, Italy; 4Neuroradiology Unit, Neurological Institute "Carlo Besta", Milan, Italy; 5CISC, Brighton and Sussex Medical School, Falmer, East Sussex, United Kingdom; 6Neuroimaging Laboratory, IRCCS Santa Lucia, Rome, Italy


This paper presents a validation of the macromolecular pool ratio (F) derived from quantitative magnetization transfer (MT) imaging as myelin marker. In contrast with previous work in this area, which focused on ex-vivo validation, we used a reversible model of demyelination, namely cuprizone-treated mice, to investigate changes in F in the corpus callosum during demyelination and remyelination in vivo. A strong linear relationship was found between F and histological markers of myelin,  providing the first direct confirmation that F estimated from quantitative MT imaging performed in-vivo is a viable proxy of myelin.

Perfusion & Permeability: Applications

Blue 1 & 2                           16:30-18:30                                                                                               Moderators: David L. Buckley, Ph.D. & C. Chad Quarles, Ph.D.

16:30           0212.   Cerebral Blood Flow Using PCASL MRI and Phase Contrast Angiography in a Large Cohort

ISMRM_MagnaLogo.jpg                                 Sudipto Dolui1, Raghav Mattay2, Ze Wang3, Mack Finkel4, Alex Smith2, Mark Elliott2, Lisa Desiderio2, Ben Inglis5, Bryon Mueller6, Danny J.J. Wang7, Lenore J. Launer8, Robert Kramer8, R. Nick Bryan2, John A. Detre9

                                1Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States; 4Germantown Friends School, Philadelphia, PA, United States; 5Department of Neuroscience, University of California, Berkeley, CA, United States; 6Department of Psychiatry, University of Minnesota, Minneapolis, MN, United States; 7Department of Neurology, University of California, Los Angeles, CA, United States; 8Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, United States; 9Departments of Neurology and Radiology, University of Pennsylvania, Philadelphia, PA, United States


We compared whole brain cerebral blood flow (CBF) measurements obtained using pCASL MRI and phase contrast angiography (PCA) measurements in a large cohort of 544 subjects from the CARDIA study. CBF values showed highly significant correlations throughout the velocity range, providing no suggestion that pCASL labeling efficiency drops at higher mean arterial velocities.  There was also considerable individual variability between CBF measured by pCASL versus PCA, suggesting that PCA-based CBF calibration of pCASL labeling efficiency may not be justified at the single subject level.

16:42           0213.   The Dependency of Cerebral Blood Flow on End-Tidal CO2 Pressure

                                Eidrees Ghariq1, Xingxing Zhang1, Andrew G. Webb1, Mark A. Van Buchem1, Albert Dahan2, Matthias J.P. Van Osch1

ISMRM_SummaLogo.jpg                                 1C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, Zuid-Holland, Netherlands; 2Deparment of Anesthesiology, Leiden University Medical Center (LUMC), Leiden, Zuid-Holland, Netherlands


Regional cerebrovascular reactivity (CVR) to CO2 is increasingly measured with BOLD and ASL MRI. The data processing is based on the assumption of a linear relationship between BOLD/CBF and CO2. However, we show that the BOLD CO2 reactivity curve has a sigmoidal shape, but the CBF-CO2 relationship is linear in the CO2 range of 3 kPa to 8 kPa. These findings underline a cautious approach to interpreting the CO2 CVR data measured with BOLD and support the conclusion that CBF is a more robust tool for CO2 CVR measurements.

16:54           0214.   Are Blood Flow Measurements by Means of Transcranial Doppler Valid Under Different Levels of End-Tidal CO2? a High Resolution MRI Study at 7 Tesla of the Middle Cerebral Artery Diameter Under Hypo- And Hypercapnic Conditions

ISMRM_MagnaLogo.jpg                                 Jasper Verbree1, 2, Eidrees Ghariq1, 2, Anne-Sophie Bronzwaer3, 4, Maarten Versluis1, 2, Mat Daemen5, Mark van Buchem1, Albert Dahan6, Johannes van Lieshout, 34, Matthias van Osch1, 2

                                1Radiology, Leiden University Medical Center, Leiden, Netherlands; 2C.J. Gorter Center for High-Field MRI, Leiden University Medical Center, Leiden, Netherlands; 3Laboratory for Clinical Cardiovascular Physiology, Academic Medical Center, Amsterdam, Netherlands; 4Internal Medicine, Academic Medical Center, Amsterdam, Netherlands; 5Pathology, Academic Medical Center, Amsterdam, Netherlands; 6Anesthesiology, Leiden University Medical Center, Leiden, Netherlands


Changes in blood flow velocity measured with Transcranial Dopper (TCD) are frequently interpreted as being proportional to cerebral blood flow assuming a constant diameter of the insonated vessel. Reported data on vessel diameter changes under influence of CO2 are inconsistent. High resolution MR imaging was used to measure the diameter of the middle cerebral artery (MCA) in healthy volunteers. Four levels of end-tidal CO2 were administered via a face mask. Results indicate that moderate hypercapnia (+2 kPa above resting concentration) increases MCA diameter 17%. A quadratic model is proposed to correct for diameter changes under different end-tidal CO2 conditions.


17:06           0215.   Quantification of CBF Changes in the Human Brain During Moderate Exercise with PCASL

                                Nuno A. da Silva1, Ke Zhang1, Pavel Chervakov1, Eleonora Maggioni1, 2, Thomas W. Okell3, N Jon Shah1, 4

                                1Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine - 4, Jülich, Germany; 2Politecnico di Milano, Milano, Italy; 3Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; 4RWTH Aachen, Department of Neurology, Aachen, Germany


In this study we investigate the effect of moderate exercise on brain cerebral blood flow (CBF) using arterial spin labeling (ASL) measurements. A dedicated setup with an ergometer pedal platform in the MR-BrainPET scanner was utilised. We demonstrated that with this setup and by measuring with pseudo-continuous arterial spin labeling (pCASL), the variations of CBF in a healthy brain during exercise and following exercise can be detected and evaluated.

17:18           0216.   Multi-Parametric Assessment of Vascular Reactivity in Peripheral Artery Disease

ISMRM_MagnaLogo.jpg                                 Erin K. Englund1, Michael C. Langham2, Thomas F. Floyd3, Felix W. Wehrli2, Emile R. Mohler III4

                                1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Department of Anesthesiology, Stony Brook University, Stony Brook, NY, United States; 4Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States


A comprehensive investigation of peripheral microvascular function in patients with peripheral artery disease (PAD) is presented. The rate of recovery following induced ischemia is monitored by dynamic acquisition with Perfusion, Intravascular Venous Oxygen saturation, and T2* (PIVOT). Analysis of the association between the ankle-brachial index (ABI), which is the clinical mainstay of PAD detection and diagnosis, and PIVOT-derived time-course metrics found significant correlations between ABI and time to peak perfusion and between ABI and time to peak T2*.


17:30           0217.   Interleaved Variable Density Sampling for Combined Dynamic Contrast Enhanced MRI and MRA of the Liver

ISMRM_MagnaLogo.jpg                                 Mahdi Salmani Rahimi1, Frank R. Korosec2, 3, Kang Wang4, James H. Holmes4, Utaroh Motosugi2, Peter Bannas2, 5, Scott B. Reeder, 12

                                1Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States; 2Radiology, University of Wisconsin-Madison, Madison, WI, United States; 3Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 4Global MR Applications and Workflow, GE Heatlhcare, Madison, WI, United States; 5Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany


High spatial and temporal resolution contrast enhanced MRI is the cornerstone of detection and characterization of focal liver lesions. An interleaved variable density undersampling pattern with dual-echo bipolar readouts and data-driven parallel imaging was modified to acquire volumetric images of the liver every four seconds. Parallel imaging calibration lines were only acquired once during the breath-hold. Images acquired in ten patients with focal nodular hyperplasia showed significant improvement in overall quality compared to clinical DCE images. MR angiograms were also obtained from the arterial phase of the time-resolved series, and were found to be comparable to the dedicated conventional MRA.

17:42           0218.   Cortical Bone Perfusion Assessment Using Inversion Recovery Ultrashort TE Imaging

                                Vipul R. Sheth1, Qun He1, Olivier M. Girard1, Robert F. Mattrey1, Graeme M. Bydder1, Jiang Du1

                                1Department of Radiology, University of California San Diego, San Diego, CA, United States


We used an inversion recovery prepared UTE sequence to perform perfusion MRI in cortical bone.  This method produced imaging results with fewer artifacts than previous UTE methods.  It showed evidence for bi-component behavior (vascular and organic matrix).  The method should allow detailed study of cortical bone perfusion.

17:54           0219.   Pharmacokinetic Analysis for Differentiating Benign and Malignant Spinal Tumors Measured by DCE-MRI

                                Ning Lang1, Min-Ying Lydia Su2, Hon J. Yu2, Huishu Yuan1

                                1Department of Radiology, Peking University Third Hospital, Beijing, China; 2Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States


DCE-MRI was performed to differentiate 4 spinal lesions (9 myeloma, 22 metastatic cancer, 7 lymphoma, 22 benign tuberculosis). The peak signal enhancement, the steepest wash-in slope and wash-out slope were measured. Two-compartmental pharmacokinetic model was used to obtain Ktrans and kep, by using three different blood curves (fast, medium, and slow). The results showed that kep analyzed by using fast or medium blood curves is the best parameter to differentiate these 4 lesion groups. Ktrans is associated with wash-in slope and kep is associated with wash-out slope. The slow blood curve is not suitable for a short DCE period.

18:06           0220.   DCE-MRI Before and After Induction Chemotherapy in Squamous Cell Carcinoma of the Head and Neck

                                Lucy E. Kershaw1, Jonathan M. Bernstein2, Stephanie B. Withey3, Nicholas J. Slevin4, Suzanne C. Bonington5, Bernadette M. Carrington5, Catharine M. West2

                                1Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, Gtr Manchester, United Kingdom; 2Translational Radiobiology Group, University of Manchester, Manchester, Gtr Manchester, United Kingdom; 3RRPPS63, University Hospitals Birmingham, Birmingham, United Kingdom; 4Clinical Oncology, The Christie NHS Foundation Trust, Manchester, United Kingdom; 5Radiology, The Christie NHS Foundation Trust, Manchester, Gtr Manchester, United Kingdom


This study investigated the changes in DCE-MRI parameters due to induction chemotherapy for head and neck squamous cell carcinoma.  In RECIST responders, extravascular-extracellular volume was significantly different before and after therapy whereas in non-responders it was not.  A third examination at the end of therapy, long-term followup and histological markers of hypoxia might reveal further correlations with early imaging.

18:18           0221.   Quantifying Variability in DCEMRI of the Breast Between 1.5T and 3T

ISMRM_MagnaLogo.jpg                                 Federico D. Pineda1, Milica Medved1, Xiaobing Fan1, Marko Ivancevic2, Hiroyuki Abe1, Akiko Shimauchi1, Charlene Sennet1, Gillian Newstead1, Gregory S. Karczmar1

                                1Radiology, The University of Chicago, Chicago, IL, United States; 2Philips Healthcare, Netherlands


DCEMRI of the breast is a valuable tool in the detection and staging of breast cancer. Radiologists rely on measures of uptake and washout of contrast media by analyzing the signal enhancement of suspicious lesions. Signal enhancement can vary due to scanner and acquisition parameters. Eleven volunteers were scanned at both 1.5T and 3T to quantify the variability in signal enhancement measures. We found that SER and time to peak enhancement had the lowest variability. Conversion from signal enhancement to concentration of contrast media did not significantly reduce variability, likely due to B1 inhomogeneity and uncertainty in native T1 estimation.

Neuro Developmental & Pediatric Disorders

Yellow 1, 2 & 3                  16:30-18:30                                                                                               Moderators:Hao Huang, Ph.D. & Petra S. Hüppi, M.D.

16:30           0222.   Cerebral Blood Flow Deficits in the Tc1 Mouse Model of Down’s Syndrome

ISMRM_MagnaLogo.jpg                                 Holly E. Holmes1, Frances Wiseman2, James M. O'Callaghan1, Jack A. Wells1, Victor LJ Tybulewicz3, Elizabeth MC Fisher2, Mark F. Lythgoe1

                                1Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom; 2Department of Neurodegenerative Disease, Institute of Neurology, London, Greater London, United Kingdom; 3MRC National Institute for Medical Research, London, Greater London, United Kingdom


Down's syndrome (DS) is a genetic condition caused by the presence of a third copy of chromosome 21. Individuals with DS have a greater predisposition to Alzheimer's disease (AD). This is believed to be caused by the extra dosage of the amyloid precursor protein (APP) gene: a known AD risk factor which lies on chromosome 21. AD-like blood flow changes have previously been observed in clinical DS studies. We unveil cerebral blood flow changes in the Tc1 mouse model of DS in the absence of APP. These results suggest that other genes on chromosome 21 may be contributing to these AD-like patterns of hypoperfusion.

16:42           0223.   V1a Antagonism Normalizes a Social Brain Network in Valproate Rat Model of Autism Revealed by Functional MRI

                                Thomas Mueggler1, Dany D. D'Souza1, Barbara Biemans1, Andreas Bruns1, Basil Künnecke1, Patrick Schnider2, Christophe Grundschober1, Markus von Kienlin1

                                1Pharma Research & Early Development, DTA Neuroscience, Hoffmann-La Roche, Basel, Basel-City, Switzerland; 2Pharma Research & Early Development, Small Molecule Research, Hoffmann-La Roche, Basel, Basel-City, Switzerland


The neuropeptide vasopressin is thought to play an important role in regulating social behavior. Here we investigated its role in the rat valproate (VPA) model of autism which has phenotypical changes similar to the human condition. In VPA rats we identified altered perfusion as a surrogate of disturbed neural activity in brain regions implicated in social behavior. Chronic treatment with a vasopressin V1a receptor-specific antagonist, reversed perfusion deficits in key regions such as the striatum, ventral tegmental area and superior colliculus suggesting that V1a antagonists have the potential to improve core symptoms of autism such as social interaction.

16:54           0224.   Age-Related Abnormalities of White Matter Tracts in Autism Spectrum Disorder: A Diffusion Spectrum Imaging Study Using Whole Brain Tract-Specific Analysis

                                Chien-Hung Lu1, Yu-Jen Chen2, Yu-Chun Lo2, Yung-Chin Hsu2, Susan Shur-Fen Gau3, 4, Wen-Yih Isaac Tseng2, 4

                                1School of Medicine, National Taiwan University, Taipei, Taiwan; 2Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; 3Department of Psychiatry, National Taiwan University College of Medicine, Taipei, Taiwan; 4Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan


This study aimed to investigate the differences of white matter tracts across a wide range of age between autism spectrum disorder and typically developing participants using diffusion spectrum imaging. In our findings, with a large sample size (63 : 63) and a broad range of age (7-29 years). GFA presented an atypical growth pattern in ASD compared to TD in several white matter tracts. The present data suggested that the time trajectory may differentiate brain maturation in ASD.




17:06           0225.   Diffusion MR of Auditory and Language Pathways in Children with 16p11.2 Deletions and Duplications

                                Jeffrey I. Berman1, 2, Darina Chudnovskaya1, Wendy K. Chung3, John E. Spiro4, Timothy PL Roberts1, 2, Simons VIP Consortium4

                                1Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States; 2Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Columbia University, NY, United States; 4Simons Foundation, New York, United States


Genetic copy number variation of 16p11.2 has been associated with developmental disorders such as autism spectrum disorders (ASD). This study uses diffusion tensor imaging (DTI) and high angular resolution diffusion imaging (HARDI) to quantify microstructural alterations to the auditory radiation, Heschl’s gyrus, and arcuate fasciculus in children with 16p11.2 deletion or duplication.  A significant effect of genetic copy number variation on FA, MD, and radial diffusivity was observed in each of the regions measured (p<0.05).  Mean and radial diffusivities were consistently higher in the copy number variation groups indicating alterations of white matter microstructure which may impair function.

17:18           0226.   Glutamate and GABA in Children with ADHD and Complex Motor Stereotypies: A 7T ¹H MRS Study

                                Alena Horska1, Xin Wang1, Matthew Ryan2, Martha B. Denckla2, Peter B. Barker1, Harvey S. Singer1, E Mark Mahone2

                                1Johns Hopkins University, Baltimore, MD, United States; 2Kennedy Krieger Institute, Baltimore, MD, United States


Using single voxel ¹H MRS at 7T, concentrations of the neurotransmitters glutamate (Glu) and GABA were measured in prefrontal and fronto-striatal regions in pediatric patients 5-10 years old, diagnosed with ADHD and complex motor stereotypies (CMS). The control group was comprised of age-matched healthy typically developing children. Compared with controls, both patient groups had a lower overall mean GABA/Cr ratio (calculated from the 4 regions examined) and a lower striatal GABA/Cr ratio. No group differences in the GABA/Cr and NAA/Cr ratios were detected.

17:30           0227.   Multimodal Imaging Classification of ADHD: Brain Functional Connectivity and Cortical Thickness

ISMRM_MagnaLogo.jpg                                 Po-Hsiang Chan1, Yu-Sheng Tseng1, Chun-jung Chen1, Teng-Yi Huang1, Tzu-Chao Chuang2

                                1Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipe, Taipei, Taiwan; 2Department of Electrical Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan, R.O.C, Taipei, Taiwan


This study aims to develop a classification method based on support vector machine (SVM) for attention deficit hyperactivity disorder (ADHD) patients. We proposed to use SVM to classify subject groups based on the brain functional connectivity obtained from resting-state fMRI datasets and brain cortical thickness obtained from 3D T1 MPRAGE datasets. We identified that SVM classifier did not perform well (accuracy of ~ 57%) if all the available features were selected into SVM training. Using the proposed feature selection approach, the maximum accuracies increased to 68 ¡V 99 %. The results support that feature selection according to absolute weightings of a pre-trained SVM hyperplane is an efficient method to increase the classification accuracies.

17:42           0228.   Medication with Stimulants Modifies the Mean Diffusivity in Children with Attention Deficit/Hyperactivity Disorder: A DTI Study

                                Rodrigo de Luis-Garcia1, Gemma Cabus-Pinol2, Carlos Imaz-Roncero2, Daniel Argibay-Quinones1, Gonzalo Barrio-Arranz1, Santiago Aja-Fernandez1, Carlos Alberola-Lopez1

                                1Laboratorio de Procesado de Imagen, Universidad de Valladolid, Valladolid, Spain; 2Hospital Clinico Universitario, Valladolid, Spain


The impact of ADHD on white matter connectivity has not been well stablished yet, and the effects of treatment on the brain structure have not been sufficiently explored.

We investigated the effects of ADHD and treatment with methylphenidate in the white matter of children using a tractography selection method that allows the robust extraction of several fiber bundles of interest. Differences in the Mean Diffusivity were found between ADHD patients under treatment and normal controls and between ADHD patients under treatment and drug-naive ADHD patients, indicating that the use of psychostimulants may modify the brain connectivity.

ISMRM_MagnaLogo.jpg 17:54           0229.   Conduct Disorder and Callous Unemotional Traits Are Related to the Microstructure of the Dorsal Default-Mode Network

                                Arjun Sethi1, Quinton Deeley1, Sagari Sarkar1, Marco Catani1, Flavio Dell'Acqua1, Declan DGM Murphy1, Michael C. Craig1

                                1Institute of Psychiatry, King's College London, London, England, United Kingdom


This work supports the importance of the white matter underpinning a mediodorsal component of the default-mode network (the dorsal cingulum) in conduct disorder and callous unemotional traits.   Diffusion MRI tractography shows that decreased radial diffusivity in this tract portion is reduced in adolescents with conduct disorder, and that radial diffusivity is negatively correlated with callous-unemotional traits in the whole sample.

18:06           0230.   Differentiation of White-Matter Differences Across Sub-Clinical Psychotic Experiences Using Diffusion Tensor and Quantitative Relaxometry Imaging

ISMRM_SummaLogo.jpg                                 Mark Drakesmith1, Anirban Dutt2, Glyn Lewis3, Anthony S. David2, Derek K. Jones1

                                1CUBRIC, Cardiff University, Cardiff, Wales, United Kingdom; 2Institute of Psychiatry, Kings College London, London, United Kingdom; 3Academic Unit of Psychiatry, University of Bristol, Bristol, United Kingdom


Few studies have examined white-matter correlates of psychotic experiences in an at-risk population. We show using DTI and quantitative T1 white-matter differences associated with sub-clinical psychotic experiences. Individuals with psychotic experiences show reduced FA, AD and increased RD in left medial frontal white matter. No differences in T1 were identified. A number of variables, especially auditory hallucinations, negatively correlate with FA, globally. Some variables also negatively correlate with T1, suggesting a positive correlation with myelination. Future identification of subjects who transition to full psychosis will enable isolation of more specific white-matter predictors of psychosis.

18:18           0231.   Longitudinal Comparison of the “default Mode” Deactivations in Adolescents Prenatally Exposed to Cocaine

                                Zhihao Li1, Priya Santhanam1, Claire Coles2, Mary Ellen Lynch2, Stephan Hamann3, Xiaoping Hu1

                                1Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, United States; 2Psychiatry and Behavioral Science, Emory University, Atlanta, GA, United States; 3Psychology, Emory University, Atlanta, GA, United States


The present fMRI study examined the developmental effect of prenatal cocaine exposure (PCE) on default mode network (DMN) deactivations in longitudinally followed adolescents. Comparing age 17 to 15 while performing the same memory task, DMN deactivation was reduced in the control group but increased in the adolescents with PCE. The present results provide direct evidence supporting the view of a long-term effect of PCE on arousal regulation.


Educational Course

Advanced Cartilage Imaging

Space 4                                16:30-18:30                                                                                               Moderators:Sharmila Majumdar, Ph.D. & Hollis G. Potter, M.D.

16:30                       Technical Aspects

                                Miika T. Nieminen, Ph.D.


17:00                       Clinical Applications

                                Carl S. Winalski, M.D.


17:30                       Cartilage Repair & Management

                                Hollis G. Potter, M.D.


18:00                       New Emerging Techniques

                                Sharmila Majumdar, Ph.D.


18:30                       Adjournment


Educational Course

Quantitative Biomarkers of Diffuse Liver Disease

Brown 1 & 2                       16:30-18:30                                                                                               Moderators:Claude Sirlin, M.D. & Takeshi Yokoo, M.D., Ph.D.

16:30                       Fat & Iron

                                Claude B. Sirlin, M.D.


17:00                       Fibrosis: Elastography & DWI

                                Sudhakar Kundapur Venkatesh, M.D., F.R.C.R.


17:30                       Contrast Enhanced Functional Imaging of the Liver

                                Eduard Jonas, M.D., Ph.D.


18:00                       Flow Quantification in Portal Hypertension

                                Zoran Stankovic


18:30                       Adjournment


Educational Course

MR Physics & Techniques for Clinicians

Brown 3                               16:30-18:30                                                                                               Moderators:Marcus T. Alley, Ph.D. & Nicole Seiberlich, Ph.D.

16:30                       Spin Gymnastics 1

                                Walter Kucharczyk, M.D., FRCPC


17:10                       Spin Gymnastics 2

                                Donald B. Plewes, Ph.D.


17:50                       K-Space

                                Kevin M. Koch, Ph.D.


18:30                       Adjournment





Sunrise Educational Course

Hot Topics in Body MRI

Brown 1 & 2                       07:00-07:50                           Moderator:John P. Mugler, III, Ph.D.  

MR-Guided High-Intensity Focused Ultrasound

07:00                       MR-Guided HIFU: Technical Overview

                                Rajiv Chopra, Ph.D.



07:25                       Treatment of Uterine Fibroids with MR-Guided HIFU

                                Pejman Ghanouni, M.D., Ph.D.


07:50                       Adjournment


Sunrise Educational Course

Clinical Utility of CEST in Oncology: The CEST Debate

Silver                                    07:00-07:50                                                                                              
Moderators:Robert E. Lenkinski, Ph.D. & Anwar R. Padhani, M.B.B.S., FRCP, FRCR


07:00                       Pro-CEST

                                Michael T. McMahon, Ph.D.


07:25                       Contra-CEST

                                Kimberly L. Desmond, M.Sc.


07:50                       Adjournment


Sunrise Educational Course

Cardiac MRI: A Dialogue Between a Radiologist & a Physicist

Red 1 & 2                            07:00-07:50                                                                                               Moderators:Martin J. Graves, Ph.D. & Valentina Taviani, Ph.D.

Comprehensive Cardiac MRI

07:00                       Clinical Viewpoint

                                Bernd J. Wintersperger, M.D.


07:25                       Technical Viewpoint

                                Marshall S. Sussman, Ph.D.


07:50                       Adjournment


Sunrise Educational Course

Clinical Imaging for Engineers & Scientists

Brown 3                               07:00-07:50                                                                                               Moderators:Brian A. Hargreaves, Ph.D. & James G. Pipe, Ph.D.

07:00                       Neuro: Stroke

                                John P. Karis, M.D.


07:25                       What’s Under the Hood:  Understanding the Correlates and Applications of MRI in Glioblastoma

                                Leland S. Hu, M.D.


07:50                       Adjournment


Sunrise Educational Course

Translational Pathways & Validation

Blue 1 & 2                           07:00-07:50                                                                                               Moderators:Robia G. Pautler, Ph.D. & C. Chad Quarles, Ph.D.

Cool Image- Now What!?

07:00                       Magnetic Resonance Histology: Cool Images- But Who Cares?

                                Kai-Hsiang Chuang, Ph.D.


07:25                       Aligning MRI & Histology

                                Mallar Chakravarty, Ph.D.


07:50                       Adjournment


Sunrise Educational Course

Quantitative Imaging & Modeling

Yellow 1, 2 & 3                  07:00-07:50                                                                                               Moderators:Joseph J.H. Ackerman, Ph.D. & Kevin M. Bennett, Ph.D.

Modeling MRI Contrast from the Cellular Microenvironment

07:00                       Modeling Structure & Physiology from MRI Data: How to See the Invisible

                                Valerij G. Kiselev, Ph.D.


07:25                       Modeling Tissue Microstructure & Morphology (Lung)

                                Dmitriy A. Yablonskiy, Ph.D.


07:50                       Adjournment


Sunrise Educational Course

CNS Connectivity: The MR Connectome

Space 3                                07:00-07:50                                                                                               Moderators:Pratik Mukherjee, M.D., Ph.D. & Jeffrey J. Neil, M.D., Ph.D.

07:00                       What Are We Trying to Learn from the Connectome?

                                An T. Vu, Ph.D.


07:25                       How Do We Construct a Connectome?

                                Patric Hagmann, M.D., Ph.D.


07:50                       Adjournment


Sunrise Educational Course

High Field Strength 7T MSK Imaging

Space 2                                07:00-07:50                                                                                              
Moderators:Richard Kijowski, M.D., William B. Morrison, M.D., & Ravinder Regatte, Ph.D.

07:00                       Technical Challenges

                                Klaus Scheffler, Ph.D.


07:25                       Clinical Applications

                                Siegfried Trattnig, M.D.


07:50                       Adjournment


Sunrise Educational Course

Absolute Beginners Guide to Neuroimaging Methods

Space 1                                07:00-07:50                                                                                               Moderators:David L. Buckley, Ph.D. & Alexander Leemans, Ph.D.

07:00                       Diffusion Basics

                                Seth A. Smith, Ph.D.


07:25                       Diffusion Analysis

                                David Raffelt, Ph.D.


07:50                 Adjournment


Sunrise Educational Course

Nuts & Bolts of Advanced Imaging

Space 4                                07:00-07:50                                                                                               Moderators:Alexey Samsonov, Ph.D. & Jeffrey Tsao, Ph.D., M.B.A.

07:00                       Coils, RF Shimming & SAR

                                Tamer S. Ibrahim, Ph.D.


07:25                       Parallel Transmit Pulse Design

                                William A. Grissom, Ph.D.


07:50                       Adjournment


Plenary Session

Magnet Technology: Where We Came From, Where We Are, Where We Are Going To

Gold Plenary                       08:15-09:30                                                                                              
Moderators: Richard W. Bowtell, Ph.D., M.A., Xiaoping P. Hu, Ph.D. & Keith R. Thulborn, M.D., Ph.D.

08:15           0232.   The Human-Compatible Magnet

                                Simon Pittard, Ph.D.


08:40           0233.   The Physicist's View of UHF of Humans

                                Peter R. Luijten, Ph.D.


09:30           0234.   The Physician's Expectations for Human UHF

                                Paul M. Matthews, M.D., D.Phil.


10:00                 Adjournment


Traditional Poster Session: Pulse Sequences & Reconstruction

Traditional Poster Hall     10:00-12:00                           (no CME credit)                                       


Electronic Poster Session: Molecular Imaging

Exhibition Hall                   10:00-12:00                           (no CME credit)                                       


Electronic Poster Session: MR Spectroscopy, Spectroscopic & Non-Proton Imaging, ESR

Exhibition Hall                   10:00-12:00                           (no CME credit)                                       


Study Group Session: MR of Cancer

Amber 1 & 2                       10:00-12:00                           (no CME credit)                                       


Study Group Session: MR Engineering

Amber 7 & 8                       10:00-12:00                           (no CME credit)                                       


Power Poster Session: Cardiovascular

Space 1/Power Poster Theater and Traditional Poster Hall                                      10:00-11:00                         (no CME credit)
Moderators: Machel Salerno, M.D., Ph.D. & TBA

10:00           0235.   Non-Contrast Myocardial Fibrosis Imaging Using MT-Weighted Balanced Steady State Free Precession MRI

                                Steve W. Leung1, Richard Lawless1, Vincent L. Sorrell1, Moriel Vandsburger1

                                1University of Kentucky, Lexington, KY, United States


The development of myocardial fibrosis significantly heightens the risk of sudden cardiac death. Late gadolinium enhanced (LGE) MRI has become the reference standard for detection of fibrotic tissue, however, multiple high risk patient cohorts are contraindicated to LGE-CMR. We developed a novel fibrosis imaging technique that utilizes magnetization transfer (MT) from fibrotic tissue for completely non-invasive diagnosis of fibrotic remodeling. In this preliminary study, demonstrate excellent correlation of fibrosis as identified with MT-weighted bSSFP MRI with LGE-CMR and measurement of gadolinium partition coefficient.


                    0236.   Electrical Characteristics of Chronic Iron-Laden Myocardial Infarcts: Initial Study in Canine Hearts

                                Ivan Cokic1, Avinash Kali2, Xunzhang Wang2, Hsin-Jung Yang2, Richard L. Q. Tang2, Anees Thajudeen2, Michael Shehata2, Allen M. Amorn2, Enzhao Liu2, Brian Stewart3, Nathan Bennett3, Doron Harlev3, Sotirios A. Tsaftaris4, Warren M. Jackman5, Sumeet S. Chugh2, Rohan Dharmakumar2

                                1Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Cedars-Sinai Medical Center, CA, United States; 3Rhythmia Medical-Boston Scientific, Inc., MA, United States; 4Institute for Advanced Studies, Lucca, Italy; 5Heart Rhythm Institute, OK, United States


Myocardial infarction can lead to chronic iron deposition that can be accurately quantified with T2* MRI. However, its long-term fate and influence on myocardial electrical properties remain largely unexplored. In this study we used T2* MRI to characterize chronic iron deposition in canines with chronic myocardial infarction in combination with impedance spectroscopy, surface ECG indices and electroanatomical maps to demonstrate that the electrical behavior of infarcted hearts with iron appear to be different from those without iron.

                    0237.   Effects of Age and Smoking on Endothelial Function Assessed by Quantitative MRI in the Peripheral and Central Vasculature

                                Yongxia Zhou1, Michael C. Langham1, Erica N. Chirico1, 2, Erin K. Englund1, Emile R. Mohler III3, Jeremy F. Magland1, Wensheng Guo4, Felix W. Wehrli1

                                1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2School of Nursing, University of Pennsylvania, Philadelphia, PA, United States; 3Medicine, University of Pennsylvania, Philadelphia, PA, United States; 4Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States


The purpose was to assess various surrogates of endothelial dysfunction using parameters derived from dynamic MRI sequences. Measures of peripheral vascular reactivity were assessed via dynamic venous oximetry, arterial hyperemia and multi-segment pulse-wave velocity (PWV) of thoracic and abdominal aorta in the form of a single, integrated MR protocol in 132 subjects consisting of young and old smokers and nonsmokers. Our results demonstrate significant aging and smoking effects based on parameters determined from dynamic MRI measures, thereby providing new vascular biomarkers for the effect of age and smoking on vascular endothelial function.

                    0238.   A New Perspective on the 4-Point Balanced Velocity-Encoding

                                Yu Ding1, Rizwan Ahmad1, Ning Jin2, Orlando Simonetti1

                                1The Ohio State University, Columbus,, OH, United States; 2Siemens Healthcare, Chicago, IL, United States


This study provides a new perspective on the 4-point balanced velocity-encoding technique from the Fourier transform/frequency domain point of view. We show that, from a Fourier encoding point of view, each of the velocity directions is encoded into a sub-band centered on a different frequency by amplitude modulation. Velocity reconstruction is shown to be equivalent to a traditional filter design problem in the Fourier domain. A straight-forward velocity reconstruction algorithm based on a simple Fourier domain filter is described and tested in a volunteer. Comparing to the traditional sliding window reconstruction, the proposed method eliminates artifactual oscillations in the velocity curves.

                    0239.   Detection of Infarcted and Arrhythmogenic Myocardium with DTI Tractography and Electroanatomical Voltage Mapping

                                Choukri Mekkaoui1, Marcel P. Jackowski2, Christian T. Stoeck3, Aravinda Thiagalingam4, William J. Kostis5, Jeremy N. Ruskin5, Timothy G. Reese6, Sebastian Kozerke, David E. Sosnovik7

                                1Harvard Medical School - Massachusetts General Hospital, Boston, MA, United States; 2Department of Computer Science, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil; 3Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 4University of Sydney, Sydney, Australia; 5Massachusetts General Hospital, Boston, United States; 6Athinoula A Martinos center for Biomedical imaging, Boston, United States; 7Harvard Medical School - Massachusetts General Hospital, Boston, United States


The tractographic propagation angle (PA) is a topographic measure of myocardial fiber architecture. Here, we demonstrate the correlation of PA with late gadolinium enhancement and electroanatomical voltage mapping in the detection of infarcted myocardium (PA>4o), as well as its ability to delineate regions of heterogeneous scar (4o&#8804;PA&#8804;10o) and dense scar (PA>10o). PA detects infarction and defines the substrate for reentrant ventricular arrhythmias without the need for exogenous contrast agents. PA could become a valuable tool in cardiovascular imaging, especially among patients with renal dysfunction and those at risk of sudden cardiac death.

                    0240.   SNR and CNR Comparison of Single-Echo Dixon and Subtraction Contrast-Enhanced MR Angiography

ISMRM_SummaLogo.jpg                                 Eric G. Stinson1, Joshua D. Trzasko1, Paul T. Weavers1, Stephen J. Riederer1

                                1Mayo Clinic, Rochester, MN, United States


Single-echo Dixon-based methods can provide the benefits (improved SNR, subtraction error reduction) of Dixon-based contrast-enhanced MR angiography (CE-MRA) without extending scan time. A theoretical SNR and CNR analysis of single-echo Dixon compared to subtraction CE-MRA was performed and compared to phantom and in vivo results. Single-echo Dixon CE-MRA provides a contrast concentration-dependent SNR and CNR boost of at least √2 over subtraction CE-MRA. At high contrast concentrations (>3-4mmol) Gadolinium-induced susceptibility artifacts can reduce the SNR and CNR of pre-calibrated Dixon CE-MRA. This technique may allow time-resolved CE-MRA with higher SNR and CNR and improved resistance to motion than subtraction-based methods.

                    0241.   Time-Resolved Dixon MR Angiography of Patients with Peripheral Vascular Disease at 3.0 T

ISMRM_MagnaLogo.jpg                                 Courtney K. Morrison1, Mahdi S. Rahimi1, Kang Wang2, James H. Holmes2, Peter Bannas3, 4, Utaroh Motosugi3, Frank R. Korosec1, 3

                                1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States; 2Global MR Applications and Workflow, GE Healthcare, Madison, WI, United States; 3Radiology, University of Wisconsin-Madison, Madison, WI, United States; 4Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany


Conventional contrast-enhanced peripheral MR angiography (MRA) typically uses subtraction-based methods, which are susceptible to misregistration from patient motion and suffer from decreased signal-to-noise ratio (SNR) relative to non-subtractive methods.  Previous work has demonstrated the use of non-subtractive contrast-enhanced peripheral MRA at 3.0 T during the steady state and at 1.5 T using a bolus-chase method.  This work investigates the clinical feasibility of using a contrast-enhanced, time-resolved, non-subtractive method for MRA at 3.0 T in patients with peripheral vascular disease.

                    0242.   Repeatability of 4D Flow MRI Quantification of Venous and Arterial Flow in the Abdomen

                                Alejandro Roldán-Alzate1, Camilo A. Campo1, Kevin M. Johnson2, Scott B. Reeder1, 2, Oliver Wieben1, 2

                                1Radiology, University of Wisconsin, Madison, WI, United States; 2Medical Physics, University of Wisconsin, Madison, WI, United States


The purpose of this study was to evaluate the repeatability of 4D PC flow measurements in both arteries and veins of the abdominal circulation. 10 subjects, 3 patients with portal hypertension and 7 controls were included in the study. Excellent correlation and low percent difference between repeated measurements within the same day for both arterial and venous circulation demonstrates the repeatability of radial 4D flow MRI for quantifying blood flow in the abdominal circulation. Similarly comparison of day-to-day variation show that radial 4D flow MRI is repeatable for assessing mesenteric hemodynamics in controlled fasting states.

                    0243.   Quantification of Energy Loss in Hypertrophic Cardiomyopathy Using 4D Flow MRI

                                Carla Contaldi1, Pim van Ooij2, Bradley Allen2, Julio Garcia2, Jeremy Collins2, James Carr3, Daniel C. Lee4, Brandon Benefield2, Lubna Choudhury5, Michael Markl6, Alex J. Barker2, Robert O. Bonow5

                                1Department of  Medicine – Cardiology, Northwestern University Feinberg School of  Medicine, Chicago, IL  , Chicago, IL, United States; 2Radiology, Northwestern University Feinberg School of  Medicine, Chicago, IL, Chicago, IL, United States; 3Radiology and Medicine, Northwestern University Feinberg School of  Medicine, Chicago, IL, Chicago, IL, United States; 4Department of  Medicine – Cardiology and Radiology, Northwestern University Feinberg School of  Medicine, Chicago, IL, Chicago, IL, United States; 5Department of  Medicine – Cardiology, Northwestern University Feinberg School of  Medicine, Chicago, IL, Chicago, IL, United States; 6Radiology and Biomedical Engineering, Northwestern University Feinberg School of  Medicine, Chicago, IL, Chicago, IL, United States


The aim of this study was to characterize obstructive hypertrophic cardiomyopathy (HCM) severity by irreversible energy loss, caused by viscous dissipation, and calculated from 4D Flow MRI velocity fields covering the entire left ventricular outflow tract (LVOT). The difference in energy loss between HCM patients and controls was significant. Energy loss showed a strong correlation with LVOT gradient calculated from 4D Flow MRI and a good correlation with myocardial fibrosis as quantified by extracellular volume fraction by T1 mapping MRI. Elevated energy loss may indicate increased hemodynamic loading and left ventricular remodeling and may be useful in HCM severity assessment.

                    0244.   High-Permittivity Thin Dielectric Pad Improves Peripheral Non-Contrast MRA at 3T

                                Marc D. Lindley1, 2, Daniel Kim1, Glen Morrell1, Marta E. Heilbrun1, Pippa Storey3, Christopher J. Hanrahan1, Vivian S. Lee1

                                1UCAIR, Radiology, University of Utah, Salt Lake City, UT, United States; 2Physics, University of Utah, Salt Lake City, UT, United States; 3Radiology, New York University, NY, United States


Non-contrast MRA based on subtraction of two FSE acquisitions of the thigh at 3T suffers from signal loss in right femoral common artery due to B1+ inhomogeneities. We propose to recover the signal loss with high-permittivity dielectric padding. In 11 subjects, apparent CNR, normalized B1, and image quality scores verified superior  performance with custom-made high-permittivity dielectric padding in comparison with baseline and commercially available dielectric padding. Our study shows that signal loss in right common femoral artery in non-contrast MRA at 3T is recovered with high-permittivity dielectric padding.

                    0245.   Deep Vein Thrombosis (DVT): Comparison of MR Direct Thrombus Imaging and Non-Contrast-Enhanced MRA

                                Andrew Nicholas Priest1, Sally Hunter1, Ilse Joubert1, Sarah Hilborne1, David J. Bowden1, Martin John Graves1, Trevor Baglin2, David John Lomas1

                                1Radiology, Addenbrooke's Hospital and University of Cambridge, Cambridge, United Kingdom; 2Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom


Both non-contrast-enhanced MR venography (NCE-MRV) and MR direct thrombus imaging (MR-DTI) can image deep vein thrombosis (DVT). The MR-DTI signal varies with thrombus age. We measured the size and location of a first DVT assessed by NCE-MRV and MR-DTI acquired at three different time-points. The two methods always agreed at the first time-point, within a week of diagnosis, but at later time-points (three and six months) most of the thrombus was not seen on MR-DTI, with only very small bright-signal regions. This may be important for the clinically-important question of distinguishing between acute recurrent thrombus and a residual previous DVT.

                    0246.   ECG/Navigator-Free 4D Whole-Heart Coronary MRA with Simultaneous Visualization of Cardiac Function and Anatomy

ISMRM_SummaLogo.jpg                                 Jianing Pang1, 2, Zhaoyang Fan2, Reza Arsanjani2, Daniel S. Berman2, Debiao Li2, 3

                                1Radiology and Biomedical Engineering, Northwestern University, Chicago, IL, United States; 2Biomedical Imaging Research Institiute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 3Bioengineering, University of California, Los Angeles, CA, United States


We have demonstrated a fully self-gated 4D whole-heart imaging technique with high isotropic spatial resolution and near 100% imaging efficiency through respiratory motion correction and retrospective cardiac gating. No ECG or diaphragm navigator is needed. The 4D visualization allows one to determine the precise quiescent period retrospectively. Future efforts will be focused on optimizing of the sequence and reconstruction parameters, as well as comparing the dual-mode reconstruction against existing coronary MRA and cine protocols.

                    0247.   Hemodynamic Fingerprinting of Altered 3D Blood Characteristics in Aortic Disease

ISMRM_MagnaLogo.jpg                                 Julio Garcia1, Alex J. Barker1, Pim van Ooij1, Susanne Schnell1, S. Chris Malaisrie2, Jeremy Collins1, James Carr1, Michael Markl1

                                1Radiology, Northwestern University, Chicago, IL, United States; 2Division of Cardiac Surgery, Northwestern University, Chicago, IL, United States


Time-resolved 3D PC-MRI data analysis can be time consuming and often relies on the manual placement of 2D analysis planes at user defined vascular regions of interest. The inherent volumetric 3D coverage of the vascular system of interest provided by 4D flow MRI is not fully utilized by analysis based on 2D planes. It was thus the aim of this study to evaluate a novel automated flow distribution analysis based on the evaluation the blood flow velocity distributions in the entire 3D vessel segments to identify hemodynamic 'fingerprints' of different aortic pathologies.

                    0248.   Unsupervised Ischemia Detection at Rest with CP-BOLD Cardiac MRI: A Simulation Study Employing Independent Component Analysis

ISMRM_MagnaLogo.jpg                                 Rita Morisi1, Rohan Dharmakumar2, 3, Sotirios A. Tsaftaris1, 4

                                1IMT Institute for Advanced Studies , Lucca, LU, Italy; 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 3Medicine, University of California  , Los Angeles, CA, United States; 4Electrical Engineering and Computer Science, Northwestern University,  Evanston, Evanston, IL, United States


Cardiac-phase resolved Blood Oxygen-Level-Dependent (CP-BOLD) MRI is a new approach capable of detecting an ongoing ischemia without the need for provocative stress. Current disease assessment relies on segmental analysis and uses only a few cardiac phases of the cine acquisition. It is expected that using all phases can permit pixel-level characterization. This work explores Independent Component Analysis (ICA) for pixel-level ischemia characterization. Using simulated data we demonstrate the potential utility of ICA for overcoming existing limitations in discriminating ischemic territories on the basis of CP-BOLD

                    0249.   Combined MRI and TCD to Assess Association Between Different Vulnerable Plaque Features in Stroke Patients

                                Martine Truijman1, 2, Alexandra de Rotte3, Rune Aaslid4, Anouk van Dijk5, 6, Madieke Liem7, Floris Schreuder2, 8, Robert van Oostenbrugge8, Joachim Wildberger1, Paul Nederkoorn7, Jeroen Hendrikse9, Aad van der Lugt5, Werner Mess2, Marianne Eline Kooi1

Vulnerable carotid atherosclerotic plaque features, such as intraplaque haemorhage, fibrous cap status and microembolic signals, are frequently studied to identify those patients with an increased risk of a recurrent stroke.

The purpose of this study was to investigate the relationship between these MRI and transcranial Doppler ultrasound determined features. The results show no significant difference in MES between patients with intraplaque haemorrhage or thin/ruptured fibrous cap. This indicates that MRI and transcranial Doppler ultrasound provide additive information on plaque vulnerability.

Electronic Power Poster Session: Cardiovascular

Traditional Poster Hall     11:00-12:00                           (no CME credit)                                       



Brain Integrity with Trauma & Aging

Space 2                                10:00-12:00                                                                                               Moderators: Carlo Pierpaoli, M.D., Ph.D. & Michael Zeineh, M.D., Ph.D.

10:00           0250.   Multi-Parametric MRI Characterization of Methylene Blue Treatment of Mild Traumatic Brain Injury

                                Lora Talley Watts1, Justin Alexander Long1, Jonathan Chemello1, Qiang Shen1, Shiliang Huang1, Timothy Duong1

                                1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States


This study investigated the spatiotemporal dynamics of diffusion, T2 and fractional anisotropy associated with mild traumatic brain injury (TBI) following methylene blue treatment. Lesion volume, diffusion, T2 and fractional anisotropy changes and behavioral scores generally correlated well with the improvement by methylene blue treatment compared to placebo controls. However, despite the presence of some lesions on day 7 and 14, behavioral measures mostly returned to normal in both groups, suggesting that there is functional compensation in our mild TBI model. Multi-parametric MRI offers a range of biomarkers that are sensitive to different tissue types and to different stages of TBI.


10:12           0251.   Acute DKI Alterations in Mild Traumatic Brain Injury Patients with and Without Eventual Symptomatic Improvement

                                Joseph H. Rosenberg1, Jiachen Zhuo1, Chandler R. Sours1, Steven Roys1, Elijah O. George1, Kathirkamanthan Shanmuganathan1, Rao P. Gullapalli1

                                1Deagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, United States


DKI parameters were evaluated in mild traumatic brain injury patients. Patients were compared to controls, and patients with symptomatic improvement between sub-acute and chronic injury stages were compared to those without. Patients showed alterations in DKI parameters in the genu of the corpus callosum. Patients experiencing later symptom improvement showed DKI alterations at the acute stage distinct from those whose symptoms did not improve. Commonly affected regions were the corpus callosum body and genu and bilateral anterior corona ratiata. These DKI alterations may indicate greater acute microstructural damage to white matter tracts in those without eventual symptomatic improvement.

10:24           0252.   Self-Regulation of Amygdala Activation with Real-Time fMRI Neurofeedback in Combat-Related PTSD

                                Raquel Phillips1, Vadim Zotev1, Han Yuan1, Kymberly Young1, Chung Ki Wong1, Brent Wurfel1, Frank Krueger1, 2, Matthew Feldner, 13, Jerzy Bodurka1, 4

                                1Laureate Institute for Brain Research, Tulsa, OK, United States; 2Neuroscience Dept., George Mason University, Fairfax, VA, United States; 3Department of Psychological Science, University of Arkansas, Fayetteville, AR, United States; 4College of Engineering, University of Oklahoma, Tulsa, OK, United States


Post-traumatic stress disorder (PTSD) is a chronic and disabling psychiatric condition. Individuals with PTSD suffer from the dysregulation of several types of emotion including fear, anxiety, and depression. Neurocircuit models of PTSD emphasize the role of the amygdala. We utilize advances in real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) to directly modulate amygdala activity. This technique measures neuronal activity with sufficiently high temporal resolution that information from the amygdala is immediately available to form a feedback loop. We show that individuals with PTSD are able to use rtfMRI-nf training to enhance the control of the hemodynamic response of the amygdala.

10:36           0253.   Demonstration of Differentially Degenerated Corpus Callosam in Patients with Moderate Traumatic Brain Injury: With a Premise of Cortical-Callosal Relationship

ISMRM_MagnaLogo.jpg                                 Kavita Singh1, Richa Trivedi1, Maria M. D’souza1, Ajay Chaudhary2, Pawan Kumar1, Ram KS Rathore3, Rajendra P. Tripathi1, Subash Khushu1

                                1Institute of Nuclear Medicine & Allied Sciences, Delhi, India; 2Dr. Ram Manohar Lohia Hospital, Delhi, Delhi, India; 3Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India


Aim our study was to assess the degenerative changes, secondary to TBI in subdivisional fibres of CC, corresponding to cortical brain area primarily injured in chronic moderate TBI patients. DTT was done in 18 TBI (A: frontal lobe injury,n=6; B: occipito-temporal lobe injury, n=5; C: fronto-parieto-temporal lobe injury, n=7) and 11 healthy participants. Diffusion metrices of 7 sub-divisions of CC (Witelson’s scheme) were acquired using in-house developed software. The study showed significantly reduced FA and increased MD in the sub-divisions of CC corresponding to cortical brain area primarily injured. Reduced FA and increased MD values may represent regional Wallerian Degeneration.

10:48           0254.   Discrete Wavelet Analysis of Longitudinal Resting State fMRI in Mild TBI Patients

                                Chandler Sours1, 2, Haoxing Chen, Steven Roys1, Rao P. Gullapalli1, 2

                                1Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; 2Magnetic Resonance Research Center (MRRC), Baltimore, MD, United States


We investigated the mechanisms of recovery following mild traumatic brain injury (mTBI) using discrete wavelet analysis of resting state fMRI and its relationship with post concussive syndrome (PCS).  Our results demonstrate reduced strength of resting state coherence within the Default Mode Network in mTBI with PCS compared to those without PCS within multiple frequency ranges. These findings stress the importance of investigating resting state coherence using discrete wavelet analysis: however, further research is needed incorporating cardiac and respiratory monitoring as well as a sliding window analysis to fully characterize the dynamic properties of resting state coherence in mTBI patients.

11:00           0255.   The Dynamically Changing Default-Mode Network After Concussion in Sports: A Resting-State fMRI and DTI Integration Study

                                David C. Zhu1, Tracey Covassin1, Sally Nogle1, Scarlett Doyle1, Doozie Russell1, Randy Pearson1, Jeffrey Monroe1, Christine Liszewski1, J. Kevin DeMarco1, David Kaufman1

                                1Michigan State University, East Lansing, MI, United States


Resting-state fMRI (rs-fMRI) and diffusion tensor imaging (DTI) were applied to understand the dynamics of functional and structural connectivity of the default-mode network (DMN) after concussion. The functional connectivity within DMN was significantly higher on Day 1 comparing to Days 7 and 30 after concussion. Noticeable change in structural connectivity and gross anatomy were not seen. This sequential change of DMN functional connectivity was not seen in the control group.  Based on our results, the functional connectivity of DMN measured with sequential rs-fMRI can potentially serve as a biomarker to monitor the dynamically changing brain function after sports-related concussion.

11:12           0256.   Age-Related Hypermetabolism in the Human Brain

ISMRM_MagnaLogo.jpg                                 Shin-Lei Peng1, 2, Julie Dumas3, Denise Park1, 4, Peiying Liu1, Francesca Filbey4, Carrie McAdams1, Amy Pinkham1, 5, Bryon Adinoff1, 6, Rong Zhang7, Hanzhang Lu1

                                1UT Southwestern Medical Center, Dallas, TX, United States; 2National Tsing Hua University, Taiwan; 3University of Vermont College of Medicine, VT, United States; 4University of Texas Dallas, TX, United States; 5Southern Methodist University, TX, United States; 6VA North Texas Health Care System, Dallas, TX, United States; 7Texas Health Presbyterian Hospital Dallas, TX, United States


In this study, we provide evidence that the brain of older adults works ¡§harder¡¨ when compared to younger adults, as manifested by an age-related increase in cerebral metabolic rate of oxygen (CMRO2) (N=118). We further showed that, prior to the typical menopausal age of 51 years old, female and male groups have similar rates of CMRO2 increase (P=0.003). However, for the entire age range, women have a slower rate of CMRO2 change, when compared to men (P<0.001). Our data also revealed a possible circadian rhythm of CMRO2 in that brain metabolic rate is greater at noon than in the morning.

11:24           0257.   More Frequent Cognitive Activity in Late Life Is Associated with Higher Brain Microstructural Integrity in Non-Demented Older Adults

ISMRM_MagnaLogo.jpg                                 C. M. Barth1, R. S. Wilson2, A. Capuano2, S. Zhang2, D. A. Bennett2, K. Arfanakis1

                                1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States; 2Rush