In Breast MRI, Dixon fat-water separation techniques have been invaluable for the measurement of breast-density in studies of breast cancer risk. A fundamental source of error in Dixon methods arises from differences in the signal intensity from water and fat, associated with differences in proton density and relaxation times. We propose an automated method to introduce a scaling factor that minimizes these errors. We demonstrate our method in a group of 14 subjects, imaged at 3T with different levels of T1-weighting.
High breast-density has been shown to be a risk factor for the development of breast cancer. The breast-density, defined as % breast-volume occupied by parenchyma1, can be measured with great accuracy in three-dimensional MRI datasets, and was shown to correlate with breast-density measured in X-Ray Mammography2-4.
A Dixon-based approach that produces “water” and “fat” images can account for partial volume effects in low resolution images by obtaining a water fraction ($$$\%W$$$) for every voxel5. For breast-density measurements relying on water-fraction estimates, the fact that voxels containing either 100% water or 100% fat do not yield the same signal intensity is a fundamental problem6,7. Because Dixon images can be generated with different contrast characteristics, and because the proton density and relaxation times may vary over the breast parenchyma, any scaling of the water signals must be undertaken on a patient-by-patient basis.
Here, we propose and implement an automated method designed to determine a scaling factor to compensate for the difference between water and fat signal in Dixon breast MRI.
Breast Segmentation: Simple segmentation was performed in OsiriX (OsiriX Foundation, Geneva) using a single plane to separate each breast from the chest wall. These volumes were reproduced for all images in MATLAB (Mathworks, MA) using a binary mask constructed from the sum of the high-FA fat and high-FA scaled-water volumes.
Data Correction: To account for the fact water and fat voxels yield different signal intensities, water images were multiplied by a scaling factor (SF). Considering that breast is occupied by either water (parenchyma/skin) or fat, the sum of fat and SF-corrected water (F+SFW) must produce an image with few image-intensity variations. The calculation of SF thus aims to identify a value that yields a relatively featureless F+SFW image.
Calculating SF: Software was written in MATLAB to perform the following steps, where SFs are iteratively tested from 1.0 to 6.0. 1) Multiply water image volume by SF. 2) Sum water and fat image volumes and smooth resulting volume. 3) Multiply smoothed volume by the previous mask that is eroded in an attempt to remove voxels near the tissue-air boundary. 4) Calculate the map of the absolute value of the image-intensity spatial gradient as $$$|G|=\sqrt{G_x^2+G_y^2+G_z^2}$$$. 5) Choose the SF which yields the lowest 95th-percentile voxel-value of the gradient magnitude histogram.
Calculating Breast-Density: Water image volumes were multiplied by their respective SF. Maps of $$$\%W$$$ (with and without SFs) were calculated voxelwise as $$\%W=100\times{I_W/(I_W+I_F)}$$ where $$$I_W$$$/$$$I_F$$$ are intensity of water/fat images. Finally, breast-density was calculated as the mean $$$\%W$$$ within the masked volume.
Figure 1 illustrates how SF-correction affects a $$$\%W$$$ map. Figure 2 shows the range of SFs calculated for the low- and high-FA data (1.6±0.1, 3.8±0.7, mean±absdev, respectively). As expected, there is less variability of SF for the low-FA data due to the almost complete absence of T1-weighting. Figure 3 demonstrates the steepness of the breast-density change with SFs from 1.0 to 6.0. The error associated with the precision in the determination of the SF is <~5%. Figure 4 shows the breast-density values calculated with and without SFs. For the majority of the patients, the change in breast-density % is >5% (2.5-8.3%, 3.6-25.7% absolute increases for low and high-FA data, respectively). Figure 5 shows the breast-density values calculated with high- and low-FA data. Breast-density values are closer after SF correction with the method we propose, but do not coincide. It is expected that the effects of T1-weighting cannot be completely removed from the high-FA data. In the absence of a true gold-standard, we expect the low-FA data to be more reliable, as it is less affected by T1-weighting8.
Calculation of SFs for Dixon breast imaging has been employed previously6,7, where a region-of-interest based approach was used to estimate the ratio between the intensity of “pure” parenchyma and “pure” fat. Our approach is expected to hold two main advantages over these methods. First, automation removes errors that may occur due to intra- and inter-user variation. Second, our approach does not require that such pure regions in fat and water images are present.
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