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Altered gray matter volume and the relationship with the psychiatric symptoms in methamphetamine use disorder individuals
Shan Dang1, Wei Li1, Jia Zhu1, Qiang Li1, Wei Wang1, and Jing Chen1

1Department of Radiology, Tangdu Hospital, the Air Force Medical University, Xian, China

Synopsis

The study used voxel-based morphological to explore the differences in gray matter volume and psychiatric symptoms of Self-reporting Inventory-90 between methamphetamine use disorders and healthy controls. It was found that many of the SCL-90 symptoms and the grey matter volume have changed in methamphetamine use disorder individuals. Meanwhile, the abnormal grey matter volume is associated with psychiatric symptoms.

Objective

Methamphetamine has become the most popular abused drug in China, and the methamphetamine-associated psychosis (MAP) has become one of the important factors which endangering public safety. Despite the neuroimaging studies found that methamphetamine use disorder is associated with the altered brain structure and function, only a few studies focused on MAP. The relationship between altered grey matter volume and psychiatric symptoms was unknown. The voxel-based morphological (VBM) technique combine with psychiatric evaluation was used to explore the underlying neural mechanisms of MAP.

Materials and Methods

Twenty male methamphetamine use disorder based on DSM-V criteria and 21 male demography matched healthy controls participated in a study. 3D structural data were acquired on 3.0 T MRI system. The status of the psychology was evaluated by the self-reporting inventory-90 (SCL-90). The brain grey matter volume was measured by VBM based on SPM. The difference of grey matter volume between two groups was analyzed by two sample t-test. Partial correlation analysis was used to measure the relationship between grey matter volume and the SCL-90 scores as well as drug use situation in the methamphetamine group.

Results

Higher score was found in MA group in extensive dimension, included interpersonal sensitivity, compulsion, depression, anxiety, hostility, paranoia and schizophrenia nuclear symptoms (P＜0.05). Compared with HC, the grey matter volume of right cerebellum crus I, thalamus, postcentral gyrus and left middle frontal gyrus were decreased in MA group. The grey matter volume were increased in cerebellum vermis, right inferior occipital gyrus, left middle occipital gyrus and left supplementary motor area (AlphaSim corrected, P＜0.01). Within the MA group, the grey matter volume in right thalamus was negatively correlated with the daily dose of methamphetamine (r=-0.528, P=0.036), the grey matter volume in cerebellum vermis was positively correlated with the schizophrenia nuclear symptoms (r=0.508, P=0.045), the grey matter volume in left supplementary motor area was positively correlated with the somatization (r=0.516, P=0.041).

Conclusions

This study demonstrated that the grey matter volume was changed in MA group and was associated with the psychotic symptoms, which may contribute to the mechanism of MAP.

Acknowledgements

No acknowledgement found.

References

No reference found.

Figures

MA：methamphetamine addiction HC: healthy controls; *represent P＜0.05; The normal distribution is denoted by “mean ±SD”, The partial distribution is represented by the median (P25, P75)


Figure 1: Compared with HC group,the grey matter volume of right cerebellum crusI, right thalamus, right postcentral gyrus and left middle frontal gyrus were decreased in MA group. The grey matter volume wereincreased in cerebellum vermis, right inferior occipital gyrus, left middle occipital gyrus and left supplementary motor area.

Proc. Intl. Soc. Mag. Reson. Med. 27 (2019)
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