Tom Scheenen1,2, Bart Philips1, Rutger Stijns1, Ansje Fortuin1, Marloes Van Der Leest1, Mark Ladd3, Harald Quick2,4, Jelle Barentsz1, Stefan Rietsch2,4, Sacha Brunheim2,4, Stephan Orzada2, and Marnix Maas1
1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Erwin L Hahn Institute, Essen, Germany, 3German Cancer Research Center, Heidelberg, Germany, 4University Hospital Essen, Essen, Germany
Synopsis
The presence of metastases in
pelvic lymph nodes marks the transition from local to systemic disease in many
primary cancers in the lower abdomen. This crucial step in disease progression
determines prognosis and the choice of treatment. Detection of metastatic lymph
nodes is currently done with invasive diagnostic surgery, but could profit from
USPIO-enhanced MRI. In this 7T study we present an in vivo anatomical baseline
of number, size and location of visible lymph nodes in healthy volunteers, as
well as the feasibility of using USPIO-enhanced MRI to detect suspicious lymph
nodes in patients with prostate and rectal cancer.
Introduction
The presence of metastases of primary cancers in pelvic lymph nodes is a
crucial step in disease progression1. Currently, staging of lymph
nodes is performed with diagnostic lymph node dissections. A reliable
non-invasive imaging method to detect metastases in pelvic lymph nodes would be
of great benefit in the field of oncology. In the context of the ongoing debate2
on the validity and therapeutic effect of pelvic lymph node dissections, the current
study was performed to: 1. Define an in vivo nodal anatomical baseline for
validation of representative lymph node dissections and accompanying pathology
reports, as well as for assessing a potential therapeutic effect of extended
lymph node dissections. 2. Develop
high resolution USPIO-enhanced MR imaging at ultra-high magnetic field strength
(7T) to detect pelvic lymph node metastases in rectal and prostate cancer.Methods
We used 2 static alternating RF shims at 7 Tesla for homogeneous pelvic imaging3
in 11 young healthy volunteers (mean age 31, range 25-39 years), 3 patients
with prostate cancer and 3 patients with rectal cancer. The patients were
measured 24-36 hours after administration of ferumoxtran-10 nanoparticles4
(USPIO) with a custom-made 8-channel TxRx body-array coil5. An
advanced imaging protocol with water-selective iron-sensitive computed echo
time (TE) imaging and lipid-selective imaging was developed6 to
perform 3D MRI at a spatial resolution of 0.66x0.66x0.66mm3 to
detect nodal structures in the pelvis. For water-selective imaging 5 echoes were acquired
using a multi-gradient echo (mGRE) sequence from which, after fitting an
exponential R2*-decay using a Weighted Linear Least
Squares (WLLS) algorithm7, computed echo time images were
reconstructed at various TEs.
Number and short axis diameter of detected nodes (2 radiologists) in
volunteers was measured and size distribution in each of six anatomical regions
was assessed. An average volunteer-normalized nodal size distribution was
determined. In patients, the T2* decay of the signal of lymph
nodes was used to assess USPIO uptake: an indication of a normal functional
lymph node.Results
In total, 564 lymph nodes were detected in six pelvic regions of the 11
volunteers. The mean number was 51.3 lymph nodes per volunteer with a wide range of 19-91. Mean diameter was 2.3 mm with a range of 1 to 7 mm. 69% of the lymph
nodes were 2 mm or smaller. The overall size distribution was very similar to
the average volunteer-normalized nodal size distribution (Fig. 1). Most and on average
largest lymph nodes were detected in the external iliac artery region (mean number
12.4, mean size 3.0 mm) and least as well as smallest lymph nodes were detected
in the presacral region (mean number 5.9, mean size 1.7 mm) (Fig. 2).
Using the lipid series in patients, lymph nodes could be detected
irrespective of the USPIO uptake. Normal lymph nodes with USPIO uptake appeared
black on the computed TE imaging at TE=8 ms and had high R2* values, whereas
suspicious lymph nodes without USPIO uptake had a high signal intensity with
low R2* values. With extrapolation to TE=0 ms, the signal intensity of lymph
nodes with USPIO uptake was recovered, such that computed TE imaging might also
be useful for detecting normal lymph nodes (Fig. 3). In 4/6 patients, lymph nodes suspect for metastases
down to 1.5 mm in short axis were detected in the iliac and mesorectal regions.
Discussion
The number of in vivo visible lymph nodes varies largely between
subjects, whereas the normalized size distribution of nodes does not. The
presence of many small lymph nodes (≤2 mm) in all anatomical regions in the
pelvis renders representative or complete removal of pelvic lymph nodes extremely
difficult.
USPIO-enhanced
MRI of the pelvis at 7 Tesla is feasible and offers opportunities for detecting
very small lymph node metastases, due to its high intrinsic signal-to-noise
ratio and high spatial resolution. This may enable more accurate pelvic lymph
node staging of cancers in the lower abdomen than MR imaging at current
clinical field strengths.Conclusion
The value of extended lymph node dissections in the pelvis is under
debate, both from a diagnostic perspective as well as from a treatment
perspective. With this work, we could question the current validity of
representative lymph node dissections and accompanying pathology reports by
setting the in vivo nodal anatomical baseline in young volunteers. Moreover, we
demonstrated the feasibility of performing USPIO-enhanced MRI of patients with
prostate and rectal cancer at 7T.Acknowledgements
No acknowledgement found.References
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