Roberto Sarnari1, Muhannad Abbasi 1, Arif Jivan 1, Rahim Gulamali1, Alexander Ruh1, Julie Anne Blaisdell1, Brandon Clifford Benefield1, Ryan Dolan1, Kambiz Ghafourian1, Jane Wilcox1, Sadiya Sana Khan1, Esther Vorovich1, Jonathan Rich1, Allen Anderson1, Clyde Yancy1, James Carr1, Daniel Lee1, and Michael Markl1
1Northwestern University, Chicago, IL, United States
Synopsis
Coronary
allograft vasculopathy (CAV) is responsible for long term mortality after heart
transplant (HTx). Myocardial perfusion impairment resulting from CAV can lead
to early graft dysfunction. Our study aimed to quantify perfusion and
3-directional myocardial velocities by cardiac magnetic resonance perfusion and
tissue phase mapping (TPM) sequences and describe the relationship at global
and segmental level. Thirty two HTx patients affected by CAV were analyzed. Myocardial
perfusion reserve was reduced in CAV patients and associated with reduced left
ventricular twist during contraction. LV diastolic radial velocities and
interventricular synchrony were associated as to rest and to stress myocardial perfusion
variations
Purpose
Coronary allograft vasculopathy (CAV)
is a leading cause of long term mortality in patients after heart
transplantation (HTx). CAV alters myocardial perfusion, at rest or stress, which
is a major cause of graft dysfunction in the long term1. Cardiovascular
magnetic resonance (CMR) allows for myocardial perfusion and perfusion reserve
(MPR) quantification2 using rest and stress first pass perfusion
sequences. CAV severity is currently classified by epicardial coronary invasive
study and global cardiac function analysis, which don’t allow for adequate
assessment of the coronary microcirculation3. Discrepancies between
left ventricular (LV) perfusion and LV function are reported in CAV patients. Moreover, global and segmental right ventricular (RV)
function alterations in relation to LV perfusion abnormalities have not been
clarified in HTx patients developing CAV. CMR
has high potential to better characterize CAV4 due to its ability to
quantify rest/stress blood flow, cardiac global and regional function, and myocardial
velocities by tissue phase mapping (TPM)5,6. The aim of our study
was to quantify RV and LV myocardial velocities and verify myocardial velocity/perfusion
relationships in HTx patients affected by CAV by using TPM and myocardial
perfusion CMR.
Methods
Thirty two patients affected by CAV were analyzed. All patients
underwent coronary angiography and CMR. CAV severity was classified based on coronary
angiography and global cardiac function, as previously recommended3.
Five patients were classified as CAV grade 0, 23 patients as CAV grade 1, 4
patients as CAV grade 2-3. Patients had undergone first-pass stress perfusion CMR
using Regadenoson7 (turbo fast low-angle single-shot gradient-echo
sequence; Gadobuterol contrast agent), short axis CINE covering the RV and LV (steady
state free precession sequence), and TPM5,6 (2D cine phase contrast with 3-directional
velocity encoding) in 3 short axis locations (base, mid, apex). Global and
segmental LV and RV myocardial velocities were calculated in long-axis (vz),
radial (vr) and circumferential (vš) directions8. Data
analysis included: CINE SFFP calculated parameters: LV and RV ejection fraction
(EF%); First pass perfusion parameters: global and segmental rest and stress
myocardial blood flow, MPR; TPM parameters: radial and long axis peak
velocities in systole and diastole, myocardial twist (difference between
average circumferential velocity time courses from base and apex),
interventricular synchrony (cross correlation coefficient between slice-averaged
LV and RV velocity time courses).
Results
There was no significant difference between CAV groups
regarding age, time after HTx, heart rate, systolic and diastolic blood
pressure and ejection fraction [Table 1]. CAV patients showed reduced
myocardial perfusion reserve compared to values reported in healthy controls9
and reduction was inversely associated with increased CAV severity [Table 2]. In all cohort analysis [Fig.1] myocardial
perfusion during stress and myocardial perfusion reserve correlated positively
with LV systolic twist (both r=0.36, p<0.05). There was a positive significant
relationship between rest and stress perfusion values with LV diastolic peak radial
velocity (r=0.47, p<0.01 and r=0.41, p<0.05, respectively) and with
interventricular synchrony in radial direction (r=0.37, p<0.05 and r=0.44,
p<0.05, respectively). LV stress perfusion values also correlated positively
with RV diastolic peak untwist (r=0.38, p<0.05) [Figure 1]. At segmental
level [Fig.2], significant correlation between diastolic radial velocity and
rest perfusion was found in all segments of the anterior wall (and in the
antero-septal basal segment) and in apical and mid (and infero-lateral mid) segments
of the inferior wall. Stress perfusion and diastolic peak radial velocity
correlation was significant at basal and mid (and antero-lateral mid) level of
the anterior wall and at basal inferior wall.Discussion
Our study showed that global and
segmental abnormalities of myocardial velocities and correspondence with
perfusion parameters occur in different CAV classes, including patients with
normal cardiac function. Specific parts of the cardiac cycle were affected by
different type of perfusion alteration. LV perfusion variation also showed an
impact on RV diastolic performance. Quantification of myocardial perfusion and
relationships with myocardial velocities may add significant information to the
current CAV classification, allowing for a more complete disease staging based
on myocardial tissue blood flow and motion parameters. Cases of reported discrepancies
between CAV grade and global cardiac function may also be addressed by this
approach and possibly clarified.Conclusion
Simultaneous quantification of myocardial blood
flow and 3-directional velocities may lead to a different classification of CAV
in HTx patients, focused on the pathophysiological effects exerted at
myocardial level. Larger studies are needed to further explore how CAV
classification could be optimized.Acknowledgements
No acknowledgement found.References
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