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Intravoxel incoherent motion MR imaging for diffusion and perfusion assessment of renal function of diabetes mellitus with normal serum creatinine1First Affiliated Hospital of Dalian Medical University, Dalian, China
Synopsis
Comparing the parameters of IVIM-MRI between diabetes mellitus with normal creatinine and healthy controls, we found that they may provide more useful information to assess renal function. IVIM-MRI can evaluating renal function of diabetes mellitus with normal creatinine noninvasively in order to diabetic nephropathy early detection and early prevention.
Objective
To investigate the value of introvoxel incoherent motion magnetic resonance imaging (IVIM-MRI) in evaluating renal function of diabetes mellitus with normal serum creatinine.Methods
Thirty-three consecutive patients (13 men: 21 women, mean age, 67 years) with 17 cases of diabetes mellitus with normal creatinine (diabetic group) and 16 healthy controls (control group) were enrolled in this study and inspected IVIM-MR examination with 1.5-T MR imager from January 2016 to October 2017. MRI was performed using a 1.5-T MR imager (GE-Signa HDXT) in a protocol containing the routine T1WI, T2WI, IVIM (b = 0, 10, 30, 50, 80, 100, 120, 150, 180, 200, 300, 500, 800, 1000 s/mm2). IVIM parameters (ADC standard, D, D* and f) of diabetic group and control group were measured by using the FuncTool on GE AW 4.6 workstation. The SPSS17.0 statistical software has been used for the data analysis, p value less than 0.05 was considered statistically significant. Compared these parameters of the diabetic group and control group by Mann-Whitney test. The ROC curves of all the parameters were drew and analyzed. ICC test was performed to examine the consistency of the measurements between the two observers, ICC≥ 0.75 was defined as good, 0.75 > ICC ≥ 0.40 was as defined as general, ICC<0.4 was defined as bad.Results
The ICC values of the IVIM parameters were all greater than 0.75 in the two groups, exhibiting an amenable consistency. The D* value of diabetic group (median = 6.38×10-3 mm2/s, range = 2.36×10-3 mm2/s) were significantly higher (p < 0.05) than control group (median = 5.09×10-3 mm2/s, range = 8.43×10-3 mm2/s), while the ADC standard, D and f value of diabetic group were lower than that of control group, but with no significant differences (p > 0.05). The area under the ROC curve of D* value was 74.6%, When threshold value was 5.59×10-3 mm2/s, the sensitivity and specificity were 76.5% and 75.0%.Conclusion
Introvoxel incoherent motion MR imaging can evaluate the renal function of diabetic patients with normal creatinine non-invasively.Acknowledgements
No acknowledgement found.References
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