Synopsis

Correlation study between parameters of intravoxel incoherent motion diffusion-weighted imaging and different pathological differentiation of cervical squamous cell carcinoma

Objective To evaluate the correlation between parameters of intravoxel incoherent motion diffusion-weighted imaging and different pathological differentiation degree of cervical squamous cancer. Methods Retrospective analysis of 87 cases patients of cervical squamous cell cancer confirmed by surgery and pathology in our hospital were included in this study, which fifty cases were in the low differentiation group(Fig A1-A7), twenty six cases were in the middle differentiation group(Fig B1-B7) and eleven cases were highly differentiation(Fig C1-C7),the conventional magnatic resonance imaging and intravoxel incoherent motion diffusion-weighted imaging examinations were performed in all patients, intravoxel incoherent motion diffusion-weighted imaging was performed by using 10 b values（b=0,10,20,50,100,200,400,800,1200,2000s/mm2）. ADCstand, pure water molecular diffusion coefficient (D), perfusion diffusion coefficient (D*) and perfution fraction (f) of IVIM - DWI related parameter values were measured with functool software of GE ADW4.5 workstation respectively.Statistical analysis software SPSS 22.0 was used in differential cervical squamous cell carcinoma diffentiation and IVIM - DWI related parameters.The receiver operating characteristic curve(ROC) was used to distinguish the efficiency of differentiation degree of cervical squamous cell carcinoma. Results The ADCstand, D, D*and f values of low differentiation group were (0.72±0.11) ×10-3mm2/s, (0.45±0.067) ×10-3mm2/s, (7.56±3.09) ×10-3mm2/s and (39.55,14.25)%; The ADCstand, D, D*and f values of middle differentiation group were (0.74±0.11)×10-3mm2/s, (0.58±0.036)×10-3mm2/s, (17.19±4.37) ×10-3mm2/s and (24.05,3.73)%; The ADCstand, D, D*and f values of highly differentiation were (0.78±0.073) ×10-3mm2/s, (0.74±0.024) ×10-3mm2/s, (39.18±10.09) ×10-3mm2/s and (18.70,1.60)%; There are statistical significance in the D, D*and f values of inter-groups(P<0.05),but there is no statistical significance in the ADCstand of inter-groups(P=0.19). The D and D* values were positively correlated with the pathological differentiation of squamous cell carcinoma (r was 0.853,0.880), and the f value was moderately negative correlation (r = -0.730). In the diagnosis of low differentiation and high differentiation of cervical squamous cell carcinoma, the D value had the best diagnostic efficiency; In the diagnosis of cervical squamous cell carcinoma, f value has the best diagnostic efficiency. Conclusion The D, D * and f values of IVIM-DWI can non-invasively assess the pathological differentiation degree of cervical squamous cell cancers,It is helpful for the clinican to develop a scientific and individualized treatment plan of cervical cancer, so as to improve the efficacy of it.

Key words Intravoxel incoherent motion; Diffusion weighed imaging; cervical squamous cell carcinoma; pathological histological differentiation

Acknowledgements

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