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MRI Quantitative Parameters of Small-Bowel Perfusion for Early Diagnosing and Assessing Activity of Crohn’s Disease: A Preliminary Study1Radiology, First Affiliate Hospital of Fujian Medical University, Fuzhou, Fujian, China
Synopsis
The purpose of this present study is to explore the potential of MR small-bowel perfusion, and to achieve more insights in MRE of CD patients. To this end, the changes of microcirculation of CD are investigated by comparing the quantitative parameters of MR perfusion of inflammatory segments with normal ones and the correlation of the former with CDAI and intestinal wall thickness.
Objective
To explore the relationship between MRI quantitative parameters such as the volume transfer constant (Ktrans), the reflux constant (Kep) and the extravascular space volume fraction (Ve) and the change of blood perfusion and permeability of Crohn’s Disease (CD), and evaluate the value of small-bowel perfusion for early diagnosing and assessing activity of CD.Methods
48 patients who underwent bowel examination with magnetic resonance enterography (MRE) were recruited. Ktrans, Kep and Ve of normal and terminal small-bowel were collected and compared. According to Crohn’s disease activity index (CDAI), all patients were divided into three groups such as remissive group, mild group and moderate-severe group. The differences of Ktrans, Kep and Ve among the three groups were compared. The correlations between quantitative parameters and CDAI and small-bowel wall thickness were respectively evaluated.Results
In 48 patients, Ktrans, Kep and Ve of terminal small-bowel were higher significantly than that of normal bowel (P<0.05) with the most remarkable increase in Ve. There were 13 cases of remissive group, 20 cases of mild group and 15 cases of moderate-severe group. Ktrans, Kep and Ve of remissive group were lower than active group (P<0.05). With the progress of CD, Ktrans, Kep and Ve also increased (P=0.000). All quantitative parameters had high positive correlation with CDAI (P<0.05). However, it was not statistically significant in correlation between Ktrans and small-bowel wall thickness(P=0.471).Conclusion
MRI quantitative parameters of small-bowel perfusion can reflect the change of blood perfusion and permeability of CD, and have a certain value for early diagnosing and assessing activity of CD.Acknowledgements
No acknowledgement found.References
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