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Percentage fat fraction in magnetic resonance imaging: an upgrade of the osteoporosis detecting parameter1Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an，Shaanxi, China, 2First Affiliated Hospital, Medical College Xi'an Jiaotong University, Xi'an, Shaanxi, China
Synopsis
The diagnosis of osteoporosis (OP) is mainly based on orthopedic imaging approaches. The percentage fat fraction (FF%) in magnetic resonance imaging (MRI) has the potential to be used to predict and diagnose OP. In both 1-H MRS and mDIXON Quant MRI, the FF% exhibited a negative correlation with BMD. Among the three groups, the OP patients had significantly higher FF% compared to healthy subjects. In addition, the FF% according to mDIXON exhibited a positive correlation with age, and BMD showed a negative linear relationship with age. Furthermore, females had a higher FF% level compared to males. Furthermore, height was correlated with BMD but not FF%. MRI investigation (especially the FF% according to the mDIXON Quant imaging system) is useful in OP assessment. Parameters including gender and age, as well as height, are important factors for OP prediction and diagnosis.
Introduction
The diagnosis of osteoporosis (OP) is mainly based on orthopedic imaging approaches. The percentage fat fraction (FF%) in magnetic resonance imaging (MRI) has the potential to be used to predict and diagnose OP.Methods
We enrolled 76 subjects and used quantitative computed tomography (QCT) to determine the bone mineral density (BMD). Patients with BMD higher than 120 mg/cm3 were categorized as normal controls, those with BMD between 80-120 mg /cm3 were diagnosed with osteopenia, and those with BMD lower than 80 mg/cm3 as having OP. The following parameters were recorded: gender, age, height, body weight, waist circumference, hip circumference. The FF% values as determined by 1-H MRS examination and mDIXON Quant scanning were acquired at the same time.Results
In both 1-H MRS and mDIXON Quant MRI, the FF% exhibited a negative correlation with BMD. Among the three groups, the OP patients had significantly higher FF% compared to healthy subjects. In addition, the FF% according to mDIXON exhibited a positive correlation with age, and BMD showed a negative linear relationship with age. Furthermore, females had a higher FF% level compared to males. Furthermore, height was correlated with BMD but not FF%.Conclusion
MRI investigation (especially the FF% according to the mDIXON Quant imaging system) is useful in OP assessment. Parameters including gender and age, as well as height, are important factors for OP prediction and diagnosis.Acknowledgements
We thank Prof. Ming Zhang for the critical review of this paper.References
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