There remain significant residual motion effects in the resting-state fMRI signal after motion correction, motion censoring, and motion regression. Due to the residual motion in the BOLD signal, use of data-driven nuisance regressors for physiological noise correction can potentially be effective in removing the residual motion. The aim of the current study is to investigate the effect of different regressors on residual motion. Our data show that the residual motion is removed by aCompCor and GSR. We recommend the output of the preprocessing pipelines be correlated against framewise motion to ensure any residual motion is removed prior to subsequent analysis.
Data acquisition
Fifteen healthy volunteers were scanned using a Siemens TIM Trio 3T scanner (Erlangen, Germany) using a resting-state GE-EPI sequence limiting the acquisition to 7 oblique axial slices over the bilateral sensorimotor areas (TR=323ms). External cardiac and respiratory signals were recorded. Written consent was obtained according to institutional ethics.
Preprocessing
rs-fMRI preprocessing involved core preprocessing followed by different correction methods, amounting to a total of nine pipelines including no correction (“NoCor”), RETROICOR1, aCompCor2, tCompCor2, PHYCAA+3, CSF-WM regression (“CSFWMR”)4–8, global signal regression (“GSR”)9–11, regression of six rigid-body motion parameters ("M6R"), and regression of the six rigid-body motion parameters and their derivatives ("M12R"), as outlined in Fig.1.
Motion-related analysis
Framewise motion was quantified using FSL tool fsl_motion_outliers based on the RMS intensity difference to the reference middle volume (REFRMS)12. The relation between framewise motion and "regressors" and the mean gray matter (GM) and the mean CSF-WM signals was quantified for each subject using Pearson correlation. Significance of findings was assessed by bootstrapping.
Bootstrapped confidence intervals suggest there remains significant positive correlation between the mean GM signal and REFRMS after RETROICOR, tCompCor, PHYCAA+, CSFWMR, M6R, and M12R (Fig.2(a)). Lack of significant correlation between the mean GM signal and REFRMS after aCompcor (95%-CI=[-0.043,0.0059]), and GSR (95%-CI=[-0.10,0.037]) suggest that these corrections can remove the residual motion in GM. CSFWMR, on the other hand, results in significant negative correlation between the mean GM signal and REFRMS (Fig.2(a)). Moreover, GSR does not remove framewise motion in CSF-WM (Fig.2(b)).
There is a significant positive correlation between REFRMS and mean CSF-WM and global signals (Fig.3), with the former correlation being significantly higher than that between REFRMS and mean GM (two-sample t-test, p<0.05) (Fig.4). Limited variance in REFRMS is explained by the six motion parameters (group-level average 12%) (Fig.5).
Similar results were obtained using frame displacement (FD) as metric for framewise motion (not reported due to space limitations).
The observation that the CSF-WM signal is more correlated with REFRMS than the GM signal indicates a higher fractional variance explained by REFRMS in the CSF-WM signal than in the GM signal, which can be attributed to the relative absence of neuronal processes (that have very different temporal features than motion) in CSF-WM. Consequently, CSFWMR results in significant negative correlation of the GM signal with REFRMS (over-correction) (Fig.2(a)). Moreover, while GSR removes the residual motion in GM, there remains significant correlation with REFRMS in CSF-WM after GSR (Fig.2(b)), which can also be attributed to the higher fractional variance explained by motion in the CSF-WM signal than in the global signal (Fig.4). This is consistent with Power et al.’s study showing that CSF-WM regression is not effective in removing motion effects while they can be effectively removed by GSR13.
While aCompCor PCs do not show significant group-level correlation with REFRMS (Fig.3(b)), PC1 shows strong positive correlation with REFRMS for some subjects and strong negative correlation for some other subjects (Fig.3(a)). This indicates that lack of group-level correlation is (at least in PC1) due to the arbitrary signs of the PCs rather than true lack of correlation, explaining the efficacy of aCompCor in removing motion (Fig.2).
While respiration can induce bulk head motion, our data do not show strong correlation between cardiac/respiratory signals and framewise motion, explaining the inefficacy of RETRORICOR in removing the residual motion. tCompCor and PHYCAA+ presume to specifically target physiological noise and the observation that they cannot remove residual motion is consistent with that presumption.
Counter-intuitively, limited variance in the framewise motion is explained by the motion parameters (Fig.5), explaining the observation that M6R and M12R cannot remove the residual motion.
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