Mathias Davids1,2, Bastien Guérin2,3, Axel vom Endt4, Lothar R. Schad1, and Lawrence L. Wald2,3,5
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany, 2Dept. of Radiology, A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Siemens Healthcare, Erlangen, Germany, 5Harvard-MIT Division of Health Sciences Technology, Cambridge, MA, United States
Synopsis
Peripheral Nerve
Stimulation (PNS) has become the major limitation in many fast MRI sequences
for state-of-the-art gradient systems. We present the first (to our knowledge)
full PNS model for assessing magnetostimulation thresholds and a method to
incorporate these thresholds as constraints in the coil-winding design phase.
Our model consists of comprehensive female and male body models for EM
simulations, co-registered atlases of peripheral nerves, and a neurodynamic
model describing the nerve responses to induced electric fields. We validated
our framework based on three commercial MR gradient systems and found close
resemblance between simulated thresholds and experimentally obtained group PNS
thresholds.
Purpose
Rapid switching of MR gradient coils induces
electric fields in the human body strong enough to induce peripheral nerve
stimulation (PNS)1,2. The
occurrence of PNS often limits the usable performance of the gradient system,
leading to longer scan-times or reduced spatial and temporal resolution3. Despite its impact, PNS metrics
are only indirectly addressed during the coil design phase, e.g., by reducing
the linear volume4 or by
conducting stimulation experiments using healthy human subjects on coil prototypes.
We developed the first framework to fully model PNS and predict stimulation
thresholds and sites in the whole body, allowing predictions from hypothetical
coil layouts without constructing expensive coil prototypes and facilitating
development of other PNS mitigation strategies5,6. We show that the PNS estimates can be pre-computed
for stream-function basis sets, allowing rapid determination of a PNS
constraint during design optimization with the standard Boundary Element Method
Stream Function (BEM-SF) approach7.Methods
PNS Simulation Framework:
Our PNS modeling framework has three components: 1) detailed male and female surface
body models for simulation of the induced EM-fields (Fig. 1B); 2) comprehensive
atlases of peripheral nerves co-registered to the body models; each nerve labeled
by the axon diameter; 3) a neurodynamic model of myelinated mammalian nerves
(MRG model8,9) to predict
the nerve’s response to the imposed E-fields (including generation of action
potentials, APs). After simulation of the induced E-fields using a magneto
quasi-static solver (Sim4Life, Zurich MedTech), we calculate the resulting
electric potential changes along the nerves by projecting the E-field onto the
nerves and integration. These potentials change both spatially along the nerves
and temporally (the applied current waveform). The PNS threshold for a given
coil waveform is determined by iteratively increasing the waveform amplitude until
an AP is generated in any nerve. Threshold curves are plotted as the minimum stimulating
gradient amplitude as a function of the gradient rise-time (“pulse duration”). Gradient
Coils: We simulated PNS thresholds for two Siemens body gradients and one
head gradient (Fig. 1A) and compared the simulated thresholds with the known
experimental thresholds (averaged over 65 healthy adult subjects). Both
simulations and experiments used sinusoidal and trapezoidal ramp times between
100us and 1000us (with constant 500us flat top duration) played in both single
axis and combined axes (“X+Y”) gradient operation modes.Results
Figure 2 summarizes our
PNS simulation workflow, starting
with the E-fields in the male arm (outlines indicate tissue boundaries),
including an exemplary nerve fiber path (dots). Projection and integration of
the E-field along the nerve yields the electric potential (Fig. 2B). Figure 2C
shows the neural activation function, NAF10 (defined as the second
spatial derivative of the potential), an indicator of where the nerve is being stimulated.
Excitation of this nerve fiber with a sinusoidal waveform and evaluation of the
MRG neurodynamic model yields the membrane dynamics shown in Fig. 2D (plotted
as the nerve’s transmembrane potential difference as a function of location
along the nerve and time). Four APs are clearly visible in the membrane
dynamics.
Figure 3 shows maps of the PNS
oracle11 for BG1 and HG1 in the male body. This metric is similar
to the NAF, but is adjusted to better correlate with the PNS thresholds. BG1 primarily
stimulates nerves in the shoulders via the Y-axis, whereas HG1 stimulates the
facial nerves via the X-axis (which correlates well with experimental
observations). Figure 4 shows
experimental thresholds (blue, incl. SD over all subjects) and simulated thresholds
(female, male, and average
between genders). There is good agreement between the
average experimental and simulated thresholds:
for all axes, axes combinations, and coil waveforms the NRMSE was ≤ 5% for
BG1 and BG2 (not shown here, see [6]), and ≤ 10% for HG1.
Conclusion
We demonstrate
that PNS thresholds of MR gradient coils can be accurately predicted using
coupled electromagnetic and neurodynamic simulations. Our PNS modeling tool can
be used to study the mechanisms behind PNS and to identify degrees-of-freedom
in MR gradient encoding that can be translated to PNS mitigation. We have
recently extended the standard BEM-SF coil design approach12,13 to include the PNS oracle as
a constraint. The PNS oracle can quickly compute PNS thresholds for a trial
winding pattern as a linear combination from the stream function bases (see
Fig. 5). In addition to introducing PNS as an explicit constraint in the
optimization process (alongside traditional constraints such as gradient
efficiency, linearity, inductance, and torque), this approach allows evaluating
the tradeoffs between PNS and these constraints.Acknowledgements
The authors would like to acknowledge the help
of past and present members of the gradient coil group at Siemens Healthineers,
including Eva Eberlein, Peter Dietz, Ralph Kimmlingen, and Franz Hebrank.
Research reported in this publication was supported by National Institute of
Biomedical Imaging and Bioengineering, and the National Institute for Mental
Health of the National Institutes of Health under award numbers R24MH106053, R00EB019482,
U01EB025121, and U01EB025162. The content is solely the responsibility of the
authors and does not necessarily represent the official views of the National Institutes
of Health.References
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