Spirometry is a routine tool in pulmonology to challenge lung function. It is sensitive and specific to several common lung diseases. Nevertheless, spirometry provides a global measurement at the mouth that only characterizes the pulmonary response as a whole, and cannot specifically address regional affections. We developed a 3D MRI-based technique to non-invasively perform local spirometry throughout the lung. The final outcome is a 3D map with voxel-wise flow-volume loops over the organ. The potential of this technique is demonstrated by its sensitivity to normal, thoracic, and diaphragmatic breathings and its related regional specificity in a healthy subject.
Spirometry is today the most frequently-used tool for pulmonary function testing. It usually consists in measuring, through a mouthpiece, air volumes and flows in and out the lung along several forced respiratory cycles1. The main outcome of this measurement is the flow-volume loop, a graphical representation of the recorded air flow as a function of the air volume variation along a full respiratory cycle. The shape of the loop is analyzed by the pulmonologist to characterize and diagnose different families of lung diseases. However, this loop is obtained for the whole organ and it does not provide any local information, which would differentiate affected and healthy regions within the organ.
Here we propose 3D MR spirometry to map local flow-volume loops within the lung. It sets the grounds for regional spirometry and comparative studies of the pulmonary function throughout the lung.
MR acquisitions were performed in a GE Signa PET/MR 3.0 T on a human volunteer, lying supine, along either normal, thoracic, or diaphragmatic breathings. Data sets were acquired by a 3D radial UTE sequence2,3, with an imaging matrix of (212×212×142) isotropic voxels of 1.5 mm, TE = 12 µs, TR = 2 ms, BW = ±100 kHz and 11 min scan time. A 30-channel thoracic coil was used as receiver. The respiratory motion was monitored by self-navigation upon the k-space center4 so 32 temporal gates were defined along the respiratory cycle with respect to the gate for the end of expiration, taken as time reference. Retrospectively self- and soft-gated5 images were reconstructed with a l1-ESPIRiT algorithm provided by the BART toolbox6. On the reference image, at the volunteer’s current functional residual capacity (FRC), a 3D mask of the lung was processed.
Each gated 3D image was non-rigidly registered onto the FRC image with the Elastix toolbox7. The resulting 31 3D deformation fields were filtered8 along the respiratory cycle to ensure spatio-temporal smoothing and continuity.
For each voxel of the FRC image, 31 estimates of volume expansion and flow were thus obtained along a gated-average respiratory cycle of the pseudo-periodic lung motion during the MR acquisition. It led to the representation of voxel-by-voxel flow-volume loops over the entire lung.
Volume expansions and air flows are noticeably non-uniform over the lung. Particularly-low values are revealed in regions where the pulmonary alveolar density is expected to be weak (large blood vessels, large airways …). With normal breathing as reference, flow-volume loop areas are relatively larger in the anterior region of the lung for a thoracic breathing and relatively larger in the posterior region for diaphragmatic breathing. Area maps could interestingly be inferred for normal breathing by combining maps for thoracic and diaphragmatic breathings as normal breathing advantageously makes use of both the diaphragm and the intercostal muscles.
Previous studies were undertaken several years ago to perform MR-based spirometry9–11. Nevertheless, to our knowledge, this is the first time this technique is developed in 3D, from a direct and quantitative measurement of regional lung deformation in the three dimensions of space and without additional image contrast modification.
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